Acta Biomaterialia, Год журнала: 2022, Номер 147, С. 258 - 269
Опубликована: Май 21, 2022
Язык: Английский
Small, Год журнала: 2021, Номер 18(6)
Опубликована: Ноя. 2, 2021
Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related
Язык: Английский
Процитировано
471
Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 190, С. 114496 - 114496
Опубликована: Авг. 12, 2022
Язык: Английский
Процитировано
204
Advanced Healthcare Materials, Год журнала: 2021, Номер 11(2)
Опубликована: Ноя. 9, 2021
Abstract Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy, and photothermal are developed used to treat different types of cancer. Recently, chemodynamic therapy (CDT) has been emerged as a novel cancer therapeutic strategy. CDT utilizes Fenton or Fenton‐like reaction generate highly cytotoxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O ) kill cells, which displays promising potentials for treatment. However, the low catalytic efficiency off‐target side effects limit biomedical application CDT. In this regard, various strategies implemented potentiate against tumor, retrofitting microenvironment (e.g., increasing H level, decreasing reductive substances, reducing pH), enhancing nanocatalysts, other strategies. This review aims summarize development these recent progresses nanocatalyst‐mediated antitumor application. The future trend challenges also discussed.
Язык: Английский
Процитировано
187
Coordination Chemistry Reviews, Год журнала: 2022, Номер 473, С. 214784 - 214784
Опубликована: Сен. 13, 2022
Язык: Английский
Процитировано
97
Coordination Chemistry Reviews, Год журнала: 2022, Номер 474, С. 214861 - 214861
Опубликована: Окт. 1, 2022
Язык: Английский
Процитировано
90
Coordination Chemistry Reviews, Год журнала: 2023, Номер 484, С. 215098 - 215098
Опубликована: Март 14, 2023
Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic (CDT) based Fenton/Fenton-like reactions a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals (OH) through exploitation of transition metal ions catalysts acidic microenvironment (TME) suitable effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise CDT account their unique properties. Among them, stimuli-responsive nature and porosity MOFs make them ideal TME-targeted cargo delivery. In addition, ability to select appropriate organic ligands makes it possible prepare intrinsic antitumor activity. This review primarily summarizes latest progress application microenvironment-oriented CDT, including or chemodynamic Furthermore, remaining challenges suggestions future applications are also presented.
Язык: Английский
Процитировано
83
Biomaterials, Год журнала: 2022, Номер 287, С. 121687 - 121687
Опубликована: Июль 19, 2022
Язык: Английский
Процитировано
80
Chinese Journal of Cancer Research, Год журнала: 2023, Номер 35(1), С. 19 - 43
Опубликована: Янв. 1, 2023
Immunotherapy has efficiently revolutionized the treatment of human neoplastic diseases. However, overall responsive rate current immunotherapy is still unsatisfactory, benefiting only a small proportion patients. Therefore, significant attention been paid to modulation tumor microenvironment (TME) for enhancement immunotherapy. Interestingly, recent studies have shown that cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING) was initially found as an innate immune sensor recognize cytoplasmic DNA (such bacterial, viral, micronuclei, and mitochondrial). It promising signaling pathway activate antitumor responses via type I production. Notably, Mn2+ be critical molecule sensitize activation cGAS-STING better This led development Mn2+-based strategies pathway. In this review, we aimed summarize progress field, focusing on following three aspects. First, briefly introduced activation, its regulation effect immunity cycle discussed. Along with this, several agonists were their potential immunotherapeutic drugs. Then, basic biological functions illustrated, roles in activation. Next, systematically reviewed immunotherapy, which can classified by methods based alone or combined other therapeutic modalities. We finally speculated future perspectives field provided rational suggestions develop therapeutics.
Язык: Английский
Процитировано
48
Coordination Chemistry Reviews, Год журнала: 2023, Номер 497, С. 215434 - 215434
Опубликована: Сен. 17, 2023
Язык: Английский
Процитировано
44
Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215771 - 215771
Опубликована: Март 17, 2024
Язык: Английский
Процитировано
27