One-dimensional nanomaterials for cancer therapy and diagnosis

Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4488 - 4514

Опубликована: Янв. 1, 2023

One-dimensional (1-D) nanomaterials possess unique shape-dependent phyicochemical properties and are increasingly recognized as promising materials for nanotechnology. 1-D can be classified according to their shape, such nanorods, nanotubes, nanowires, self-assembled nanochains, etc., have been applied in electronics, photonics, catalysis. The biological characteristics of nanomaterials, including high drug loading efficiency, prolonged blood circulation, the ability capture cancer cells, cellular uptake mechanisms, efficient photothermal conversion, material tunability, aided extending potential biomedical applications, particularly therapy diagnosis. This review highlights a novel perspective on emerging diagnosis by introducing definition physicochemical properties, recent advances also proposes unexplored nanomaterial types therapeutic applications nanomaterials. In particular, most significant exciting years, ultrasound-enabled sonodynamic therapy, magnetic field-based bioresponsive intracellular self-assembly situ, discussed along with concepts, piezoelectric nanozyme-based nanomedicine, others.

Язык: Английский

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M2 macrophage-derived exosome-encapsulated microneedles with mild photothermal therapy for accelerated diabetic wound healing

Materials Today Bio, Год журнала: 2023, Номер 20, С. 100649 - 100649

Опубликована: Апрель 30, 2023

Due to local overactive inflammatory response and impaired angiogenesis, current treatments for diabetic wounds remain unsatisfactory. M2 macrophage-derived exosomes (MEs) have shown considerable potential in biomedical applications, especially since they anti-inflammatory properties that modulate macrophage phenotypes. However, exosome-based strategies still limitations, such as short half-lives instability. Herein, we develop a double-layer microneedle-based wound dressing system (MEs@PMN) by encapsulating MEs the needle tips polydopamine (PDA) nanoparticles backing layer simultaneously suppress inflammation improve angiogenesis at site.

Язык: Английский

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Precision-engineered metal and metal-oxide nanoparticles for biomedical imaging and healthcare applications

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 332, С. 103263 - 103263

Опубликована: Июль 31, 2024

The growing field of nanotechnology has witnessed numerous advancements over the past few years, particularly in development engineered nanoparticles. Compared with bulk materials, metal nanoparticles possess more favorable properties, such as increased chemical activity and toxicity, owing to their smaller size larger surface area. Metal exhibit exceptional stability, specificity, sensitivity, effectiveness, making them highly useful biomedical field. are high demand nanotechnology, including Au, Ag, Pt, Cu, Zn, Co, Gd, Eu, Er. These particles excellent physicochemical amenable functionalization, non-corrosiveness, varying optical electronic properties based on shape. can be modified different targeting agents antibodies, liposomes, transferrin, folic acid, carbohydrates. Thus, hold great promise for various applications photoacoustic imaging, magnetic resonance computed tomography (CT), photothermal, photodynamic therapy (PDT). Despite potential, safety considerations, regulatory hurdles must addressed safe clinical applications. This review highlights nanoparticle engineering explores integration emerging technologies bioimaging, cancer therapeutics nanomedicine. By offering valuable insights, this comprehensive offers a deep understanding potential research.

Язык: Английский

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Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 2, 2024

Abstract Spinal cord injury (SCI) is a catastrophic to the central nervous system (CNS) that can lead sensory and motor dysfunction, which seriously affects patients' quality of life imposes major economic burden on society. The pathological process SCI divided into primary secondary injury, cascade amplified responses triggered by injury. Due complexity mechanisms SCI, there no clear effective treatment strategy in clinical practice. Exosomes, are extracellular vesicles endoplasmic origin with diameter 30–150 nm, play critical role intercellular communication have become an ideal vehicle for drug delivery. A growing body evidence suggests exosomes great potential repairing SCI. In this review, we introduce exosome preparation, functions, administration routes. addition, summarize effect mechanism various repair review efficacy combination other strategies Finally, challenges prospects use described.

Язык: Английский

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Emerging trends and future challenges of advanced 2D nanomaterials for combating bacterial resistance

Bioactive Materials, Год журнала: 2024, Номер 38, С. 225 - 257

Опубликована: Май 7, 2024

The number of multi-drug-resistant bacteria has increased over the last few decades, which caused a detrimental impact on public health worldwide. In resolving antibiotic resistance development among different bacterial communities, new antimicrobial agents and nanoparticle-based strategies need to be designed foreseeing slow discovery functioning antibiotics. Advanced research studies have revealed significant disinfection potential two-dimensional nanomaterials (2D NMs) severed as effective antibacterial due their unique physicochemical properties. This review covers current progress 2D NMs-based based an inclusive explanation NMs' agents, including detailed introduction each possible well-known mechanism. properties NMs activities been deliberated while explaining toxic effects discussing biomedical significance, dysbiosis, cellular nanotoxicity. Adding challenges, we also discussed major issues regarding quality availability nanotoxicity data. However, smart advancements are required fabricate biocompatible exploit combat clinically.

Язык: Английский

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Mesoporous Silica Nanoparticles‐Based Nanoplatforms: Basic Construction, Current State, and Emerging Applications in Anticancer Therapeutics

Advanced Healthcare Materials, Год журнала: 2022, Номер 12(16)

Опубликована: Дек. 19, 2022

In recent years, researchers are developing novel nanoparticles for diagnostic applications using imaging techniques and therapeutic purposes through drug delivery techniques. The unique physical chemical properties of mesoporous silica (MSNs) make it possible to integrate a variety commonly used agents construct multimodal synergistic anticancer system. Herein, advances in MSNs synthesis smart response reviewed. First, synthetic strategies the fabrication ordered MSNs, hollow core-shell structured dendritic biodegradable outlined. Then, research progress designing functional MSN materials with various controlled release mechanisms therapy is discussed, new introduced suggest latest design requirements as materials. review also highlights significant achievements bioimaging their multifunctional counterparts vehicles. Finally, personal views on key directions future work this area presented.

Язык: Английский

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Engineering of M2 Macrophages‐Derived Exosomes via Click Chemistry for Spinal Cord Injury Repair

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(11)

Опубликована: Март 6, 2023

Abstract Spinal cord injury (SCI) is one of the most common causes death and disability. The effective modulation complicated microenvironment, regeneration injured spinal tissue, functional recovery after SCI are still clinical challenges. Recently, macrophages‐derived exosomes have shown great potential for various diseases due to their inflammation‐targeting property. However, further modifications needed endow with neural regenerative recovery. In current study, a novel nanoagent (MEXI) designed treatment by conjugating bioactive IKVAV peptides surface M2 via an easy rapid click chemistry method. vitro, MEXI inhibits inflammation reprograming macrophages promotes neuronal differentiation stem cells. vivo, engineered target site tail vein injection. Furthermore, histological analysis reveals that improves motor mice reducing infiltration macrophages, downregulating pro‐inflammatory factors, improving nervous tissues. Taken together, this study provides strong evidence significance in

Язык: Английский

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A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair

Advanced Materials, Год журнала: 2023, Номер 36(3)

Опубликована: Сен. 1, 2023

Abstract Extracellular vesicles (EVs) have inherent advantages over cell‐based therapies in regenerative medicine because of their cargos abundant bioactive cues. Several strategies are proposed to tune EVs production vitro. However, it remains a challenge for manipulation vivo, which poses significant difficulties EVs‐based that aim promote tissue regeneration, particularly long‐term treatment diseases like peripheral neuropathy. Herein, superparamagnetic nanocomposite scaffold capable controlling on‐demand is constructed by incorporating polyethyleneglycol/polyethyleneimine modified nanoparticles into polyacrylamide/hyaluronic acid double‐network hydrogel (Mag‐gel). The Mag‐gel highly sensitive rotating magnetic field (RMF), and can act as mechano‐stimulative platform exert micro/nanoscale forces on encapsulated Schwann cells (SCs), an essential glial cell supporting nerve regeneration. By switching the ON/OFF state RMF, scale up local SCs‐derived (SCs‐EVs) both vitro vivo. Further transcriptome sequencing indicates enrichment transcripts favorable axon growth, angiogenesis, inflammatory regulation SCs‐EVs with ultimately results optimized repair Overall, this research provides noninvasive remotely time‐scheduled method fine‐tuning accelerate including nerves.

Язык: Английский

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Modulation of Macrophages by In Situ Ligand Bridging

Advanced Functional Materials, Год журнала: 2023, Номер 33(16)

Опубликована: Фев. 8, 2023

Abstract Extracellular matrix (ECM) proteins containing cell‐attachable Arg‐Gly‐Asp (RGD) sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen laminin‐collagen complexes that can regulate inflammation, tissue repair, wound healing. In this study, linking molecule‐mediated conjugation of 1D magnetic nanocylinders (MNCs) to material surfaces pre‐decorated with gold nanospheres (GNSs) is performed, thereby yielding RGD‐coated MNCs (RGD‐MNCs) over GNSs (RGD‐GNSs) a state. The RGD‐MNCs are drawn closer the RGD‐GNSs via field‐mediated compression molecules establish between them. Relative proportion optimized yield effective remote stimulation integrin binding variably bridged RGDs similar invariably used as control group. Remote manipulation RGD facilitates attachment structure assembly macrophages leads pro‐healing/anti‐inflammatory phenotype acquisition. contrast, non‐bridged inhibited macrophage acquired pro‐inflammatory phenotypes. use various nanomaterials constructing heterogeneous materials further offer modes switching understand dynamic integrin‐mediated modulation immunomodulatory responses, such foreign body

Язык: Английский

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Glycosylation in extracellular vesicles: Isolation, characterization, composition, analysis and clinical applications

Biotechnology Advances, Год журнала: 2023, Номер 67, С. 108196 - 108196

Опубликована: Июнь 10, 2023

This review provides a comprehensive overview of our understanding the role that glycans play in formation, loading and release extracellular vesicles (EVs). The capture EVs (typically with size 100-200 nm) is described, including approaches based on glycan recognition glycan-based analysis offering highly sensitive detection EVs. Furthermore, detailed information provided about use EV processing enzymes as potential biomarkers, therapeutic targets or tools applied for regenerative medicine. also short introduction into advanced methods characterization EVs, new insights biomolecular corona covering bioanalytical available analysis.

Язык: Английский

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