Piezoelectric dual network dressing with adaptive electrical stimulation for diabetic infected wound repair via antibacterial, antioxidant, anti-inflammation, and angiogenesis

Chemical Engineering Journal, Год журнала: 2024, Номер 491, С. 151801 - 151801

Опубликована: Апрель 30, 2024

Язык: Английский

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Copper‐Based Nanozymes: Potential Therapies for Infectious Wounds

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 5, 2025

Abstract Bacterial infections are a significant obstacle to the healing of acute and chronic wounds, such as diabetic ulcers burn injuries. Traditional antibiotics primary treatment for bacterial infections, but they present issues antibiotic resistance, limited efficacy, potential side effects. This challenge leads exploration nanozymes alternative therapeutic agents. Nanozymes nanomaterials with enzyme‐like activities. Owing their low production costs, high stability, scalability, multifunctionality, have emerged prominent focus in antimicrobial research. Among various types nanozymes, metal‐based offer several benefits, including broad‐spectrum activity robust catalytic properties. Specifically, copper‐based (CuNZs) shown considerable promoting wound healing. They exhibit strong effects, reduce inflammation, enhance tissue regeneration, making them highly advantageous use care. review describes dual functions CuNZs combating infection facilitating repair. Recent advancements design synthesis CuNZs, evaluating promotion, biosafety both vitro vivo on basis core components, critically important.

Язык: Английский

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Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms

Coordination Chemistry Reviews, Год журнала: 2024, Номер 522, С. 216205 - 216205

Опубликована: Сен. 11, 2024

Язык: Английский

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Electrospun PCL‐Based Materials for Health‐Care Applications: An Overview

Macromolecular Materials and Engineering, Год журнала: 2024, Номер 309(8)

Опубликована: Март 13, 2024

Abstract Polycaprolactone (PCL) is one of the durable polymers with potential in a plethora healthcare applications. Its biological properties, degradability, chemical and mechanical properties can further be modified to manufacture desired products for modern biomedical Electrospinning PCL offers opportunity design treatment materials that resemble human tissues facilitate regeneration at target site. The resultant also by loading other active functional broaden their Herein, recent advances preparation modification PCL‐based applications are elucidated. challenges future trends its application outlined.

Язык: Английский

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Advancements in nanozymes research for the management of chronic wounds

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157299 - 157299

Опубликована: Ноя. 1, 2024

Язык: Английский

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Recent Advances in Coaxial Electrospun Nanofibers for Wound Healing

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101309 - 101309

Опубликована: Окт. 28, 2024

Язык: Английский

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Electrospun nanofibrous membranes meet antibacterial nanomaterials: From preparation strategies to biomedical applications

Bioactive Materials, Год журнала: 2024, Номер 42, С. 478 - 518

Опубликована: Сен. 11, 2024

Язык: Английский

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Disulfiram-loaded CuO2 nanocarriers for enhanced synergistic chemodynamic chemotherapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 674, С. 9 - 18

Опубликована: Июнь 21, 2024

Язык: Английский

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Multidimensionally Nano-topologized Polycaprolactone Fibrous Membrane Anchored with Bimetallic Peroxide Nanodots for Microenvironment-Switched Treatment on Infected Diabetic Wounds

Advanced Fiber Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 10, 2024

Язык: Английский

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Multienzyme-Activity Sulfur Quantum Dot Nanozyme-Mediated Cascade Reactions in Whole-Stage Symptomatic Therapy of Infected Bone Defects

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Integrating the therapeutic efficacy of early bacterial clearance, midstage inflammatory remission, and late-stage effective tissue healing is considered a pivotal challenge in symptomatic treatment infected bone defects (IBDs). Herein, microenvironment-adaptive nanoplatform based on sulfur quantum dot (SQD) nanozyme was proposed for whole-stage therapy IBDs by mediating sequence enzyme cascade reactions. The SQD prepared size-engineering modification strategy exhibits enhanced multienzyme activity compared to conventional micrometer- nanometer-sized particles. In stages infection, self-activates superoxide dismutase-peroxidase activity, resulting production reactive oxygen species (ROS) that effectively eliminate bacteria. After disinfection, self-switched dismutase-catalase mimetic behavior eliminated excess ROS, efficiently promoting macrophage polarization an anti-inflammatory phenotype midinflammatory microenvironment. Importantly, nanozyme-mediated M2 significantly improved damaged immune microenvironment, accelerating repair at healing. Therefore, this offers promising viable approach infectious developing multienzyme-activity nanozymes respond intelligently microenvironment different stages, fighting bacteria, reducing inflammation, regeneration therapy.

Язык: Английский

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