Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Tendinopathy
is
a
common
disorder
that
causes
local
dysfunction
and
reduces
quality
of
life.
Recent
research
has
indicated
alterations
in
the
inflammatory
microenvironment
play
vital
role
pathogenesis
tendinopathy.
Herein,
injectable
methacrylate
gelatin
(GelMA)
microspheres
(GM)
were
fabricated
loaded
with
heparin-dopamine
conjugate
(HDC)
hepatocyte
growth
factor
(HGF).
GM@HDC@HGF
designed
to
balance
by
inhibiting
oxidative
stress
inflammation,
thereby
regulating
extracellular
matrix
(ECM)
metabolism
halting
tendon
degeneration.
Combining
factors
heparin
was
expected
improve
encapsulation
rate
maintain
long-term
efficacy
HGF.
In
addition,
catechol
groups
on
dopamine
have
adhesion
antioxidant
properties,
allowing
potential
attachment
at
injured
site,
better
function
synergized
injected
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(31), P. 20101 - 20110
Published: July 23, 2024
Osteoarthritis
(OA)
is
a
prevalent
degenerative
disease
that
afflicts
more
than
250
million
people
worldwide,
impairing
their
mobility
and
quality
of
life.
However,
conventional
drug
therapy
palliative.
Exosomes
(Exo),
although
with
the
potential
to
fundamentally
repair
cartilage,
face
challenges
in
efficient
enrichment
delivery.
In
this
study,
we
developed
magnetic
polysaccharide
hydrogel
particles
as
microcarriers
for
synergistic
OA.
The
were
composed
modified
natural
polysaccharides,
hyaluronic
acid
(HAMA),
chondroitin
sulfate
(CSMA),
generated
from
microfluidic
electrospray
combination
cryogelation
process.
Magnetic
nanoparticles
spiny
structures
capable
capturing
stem
cell
Exo
encapsulated
within
together
an
anti-inflammatory
diclofenac
sodium
(DS).
released
DS
had
effect
alleviating
OA
symptoms
promoting
cartilage
repair.
vitro
vivo
results
demonstrated
excellent
performance
microcarrier
treatment.
We
believe
work
has
other
related
diseases.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 15, 2024
Abstract
Hydrogels
are
a
class
of
highly
absorbent
and
easily
modified
polymer
materials
suitable
for
use
as
slow-release
carriers
drugs.
Gene
therapy
is
specific
can
overcome
the
limitations
traditional
tissue
engineering
techniques
has
significant
advantages
in
repair.
However,
therapeutic
genes
often
affected
by
cellular
barriers
enzyme
sensitivity,
carrier
loading
essential.
Therapeutic
gene
hydrogels
well
these
difficulties.
Moreover,
gene-therapeutic
have
made
considerable
progress.
This
review
summarizes
recent
research
on
treatment
damage
through
summary
most
current
frontiers.
We
initially
introduce
classification
their
cross-linking
methods,
followed
detailed
overview
types
modifications
genes,
discussion
characterization
features,
design
release,
an
applications
engineering.
Finally,
we
provide
comments
look
forward
to
shortcomings
future
directions
therapy.
hope
that
this
article
will
researchers
related
fields
with
more
comprehensive
systematic
strategies
repair
further
promote
development
field
Graphical
abstract
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(5)
Published: Dec. 11, 2023
Abstract
Destruction
of
cartilage
due
to
the
abnormal
remodeling
subchondral
bone
(SB)
leads
osteoarthritis
(OA),
and
restoring
chondro‐bone
metabolic
homeostasis
is
key
treatment
OA.
However,
traditional
intra‐articular
injections
for
OA
cannot
directly
break
through
barrier
reach
SB.
In
this
study,
hydrothermal
method
used
synthesize
ultra‐small
size
(≈5
nm)
selenium‐doped
carbon
quantum
dots
(Se‐CQDs,
SC),
which
conjugated
with
triphenylphosphine
(TPP)
create
TPP‐Se‐CQDs
(SCT).
Further,
SCT
dynamically
complexed
hyaluronic
acid
modified
aldehyde
methacrylic
anhydride
(AHAMA)
construct
highly
permeable
micro/nano
hydrogel
microspheres
(SCT@AHAMA)
homeostasis.
vitro
experiments
confirmed
that
selenium
atoms
scavenged
reactive
oxygen
species
(ROS)
from
mitochondria
mononuclear
macrophages,
inhibited
osteoclast
differentiation
function,
suppressed
early
chondrocyte
apoptosis
maintain
a
balance
between
matrix
synthesis
catabolism.
vivo
further
demonstrated
delivery
system
osteoclastogenesis
H‐vessel
invasion,
thereby
regulating
initiation
process
inhibiting
degeneration
in
conclusion,
based
on
facilitate
efficient
penetration
articular
SB
regulate
metabolism
treatment.
Small,
Journal Year:
2023,
Volume and Issue:
20(19)
Published: Dec. 6, 2023
Abstract
The
occurrence
of
osteoarthritis
(OA)
is
highly
associated
with
the
inflammatory
hypoxic
microenvironment.
Yet
currently
no
attention
has
been
paid
to
fabricating
hypoxia‐responsive
platforms
for
OA
treatment.
Herein,
an
injectable
hydrogel
microsphere
system
(HAM‐SA@HCQ)
focusing
on
inflamed
joint
prepared
methacrylate‐modified
sulfonated
azocalix[4]arene
(SAC4A‐MA),
methacrylated
hyaluronic
acid
(HA‐MA),
and
dithiol‐terminated
matrix
metalloproteinase
13
(MMP‐13)
sensitive
peptide
via
a
microfluidic
device
photo
crosslinking
technique,
followed
by
encapsulation
anti‐inflammatory
drug
hydroxychloroquine
(HCQ)
through
host–guest
interaction.
Owing
hydrophobic
deep
cavity,
phenolic
units,
azo
bonds
SAC4A‐MA,
microspheres
show
strong
loading
capacity,
prominent
reactive
oxygen
species
(ROS)
scavenging
capability,
specific
release
ability.
In
tissue
microenvironment,
undergo
degradation
excessive
MMP‐13
HCQ
under
hypoxia
condition,
which
synergizes
ROS‐scavenging
calixarene
inhibit
response
macrophages.
After
being
injected
into
OA‐inflamed
joint,
HAM‐SA@HCQ
can
significantly
attenuate
oxidative
stress,
downregulate
expression
hypoxia‐induced
factor‐1α
cytokines,
prevent
cartilage
from
destroyed.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 27, 2024
With
the
accelerated
aging
tendency,
osteoarthritis
(OA)
has
become
an
intractable
global
public
health
challenge.
Stem
cells
and
their
derivative
exosome
(Exo)
have
shown
great
potential
in
OA
treatment.
Research
this
area
tends
to
develop
functional
microcarriers
for
stem
cell
Exo
delivery
improve
therapeutic
effect.
Herein,
we
a
novel
system
of
Exo-encapsulated
cell-recruitment
hydrogel
from
liquid
nitrogen-assisted
microfluidic
electrospray
Benefited
advanced
droplet
generation
capability
microfluidics
mild
cryogelation
procedure,
resultant
particles
show
uniform
size
dispersion
excellent
biocompatibility.
Moreover,
acryloylated
recruitment
peptides
SKPPGTSS
are
directly
crosslinked
within
by
ultraviolet
irradiation,
thus
simplifying
peptide
coupling
process
preventing
its
premature
release.
The
SKPPGTSS-modified
can
recruit
endogenous
promote
cartilage
repair
released
further
enhances
performance
through
synergistic
effects.
These
features
suggest
that
proposed
microcarrier
is
promising
candidate
