Biomaterials, Год журнала: 2024, Номер 316, С. 122974 - 122974
Опубликована: Ноя. 26, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 303, С. 140674 - 140674
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
9
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Сен. 30, 2024
Язык: Английский
Процитировано
16
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 16, 2025
Chronic diabetic wounds are characterized by prolonged inflammation and excessive accumulation of M1 macrophages, which impede the healing process. Therefore, resolving promptly transitioning to proliferative phase critical steps for effective wound healing. Exosomes have emerged as a promising therapeutic strategy. In this study, smart hydrogel capable responding pathological cues in inflammatory microenvironment promote transition from proliferation delivering M2 macrophage-derived exosomes (M2-Exos) is developed. The synthesized through cross-linking oxidized dextran, matrix metalloproteinase (MMP)-9-sensitive peptide, carboxymethyl chitosan containing M2-Exos. response elevated MMP-9 concentrations microenvironment, demonstrates diagnostic logic, adjusting release kinetics M2-Exos accordingly. on-demand facilitated macrophage polarization phenotype, thereby promoting accelerating transcriptomic analysis further reveals that MMP-9-responsive with delivery exerts anti-inflammatory regenerative effects downregulating inflammation-related pathways. This study introduces an innovative, microenvironment-responsive exosome system enables precise control agent release, offering personalized approach treatment chronic wounds.
Язык: Английский
Процитировано
2
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114571 - 114571
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 24, 2025
Exosomes-loaded hydrogels have potential value in wound treatment. Current studies focus on improving hydrogels' biocompatibility and optimizing different stem cell-derived exosomes for better therapeutic effect. Herein, we present a novel biocompatible recombinant human collagen (RHC) hydrogel loading with MSCs-derived promoting healing. We modify the RHC methacrylate anhydride (MA) at optimal concentration, generating (RHCMA) ideal physiochemical properties exosome delivery (MSC-exos@RHCMA). Exosomes derived from adipose-derived MSCs (ADSC-exos), bone marrow-derived (BMSC-exos) umbilical cord (ucMSC-exos) are harvested culture supernatants loaded into RHCMA, respectively. These three systems exhibit desired sustained release features, can significantly improve cell proliferation migration. In addition, these MSC-exos@RHCMAs show excellent performance treating wounds of rats. Notably, demonstrated that healing effect occurs best under treatment ucMSC-exos@RHCMA, following inflammatory resolution, angiogenesis, formation. results would supply important clinical application MSC-exos future.
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2024, Номер 18(50), С. 33907 - 33921
Опубликована: Дек. 3, 2024
Acute liver failure (ALF) is a serious global disease characterized by rapid onset and high mortality. Currently, the clinical treatment of ALF faces considerable hurdles due to limited medication options scarcity transplants. Despite biomacromolecules such as hepatocyte growth factor (HGF) glutathione (GSH) having been applied for symptom relief in clinic, they still face substantial challenges including poor stability, difficulty acting on intracellular targets, inadequate therapeutic outcome. In this work, taking advantage innate targeting regenerative capabilities mesenchymal stem cells (MSCs), we harnessed MSC-derived exosomes natural bioactive carriers simultaneous delivery HGF GSH, forming fully nanodrug termed HG@Exo. Impressively, HG@Exo demonstrated potent effects against both carbon tetrachloride (CCl
Язык: Английский
Процитировано
4
Materials Today Bio, Год журнала: 2024, Номер 28, С. 101210 - 101210
Опубликована: Авг. 28, 2024
Skin aging is the phenomenon of degenerative changes in structure and function skin tissues over time manifested by a gradual loss elasticity firmness, an increased number wrinkles, hyperpigmentation. anti-aging refers to reduction through medical cosmetic technologies. In recent years, new biomaterials have been continuously developed for improving appearance mechanical tissue filling, regulating collagen synthesis degradation, inhibiting pigmentation, repairing barrier. This review summarizes mechanisms associated with aging, describes that are commonly used aesthetics their possible modes action, discusses application strategies this area. Moreover, synergistic effects such other active ingredients, as stem cells, exosomes, growth factors, antioxidants, on regeneration evaluated. Finally, challenges development prospects field discussed, novel ideas future innovations area summarized.
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135146 - 135146
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11799 - 11799
Опубликована: Ноя. 2, 2024
Osteoarthritis (OA), a common and disabling degenerative joint disease, affects millions of people worldwide imposes considerable burden on patients society due to its high prevalence economic costs. The pathogenesis OA is closely related the progressive degradation articular cartilage accompany inflammation; however, itself cannot heal modulate inflammation lack nerves, blood vessels, lymph-vessels. Therefore, reliable effective methods treat remain highly desired. Local administration drugs or bioactive materials by intra-articular injection delivery system represents promising approach OA, especially considering prolonged retention, chondrocytes targeting, stimuli-responsive release achieve precision therapy. This article summarizes discusses advances in currently used systems (nanoparticle, hydrogel, liposome, microsphere) then focuses their applications treatment from perspective endogenous stimulus (redox reactions, pH, enzymes, temperature) exogenous (near-infrared, magnetic, ultrasound)-responsive release. Finally, challenges potential future directions for development nano-delivery are summarized.
Язык: Английский
Процитировано
3
Life Sciences, Год журнала: 2025, Номер 362, С. 123365 - 123365
Опубликована: Янв. 4, 2025
Язык: Английский
Процитировано
0