Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms

Environmental Pollution, Год журнала: 2023, Номер 338, С. 122694 - 122694

Опубликована: Окт. 4, 2023

Lambda-cyhalothrin, also known as cyhalothrin, is an efficient, broad-spectrum, quick-acting pyrethroid insecticide and acaricide the most powerful in world. However, there increasing evidence that lambda-cyhalothrin closely related to a variety of toxicity drawbacks (hepatotoxicity, nephrotoxicity, neurotoxicity reproductive toxicity, among others) non-target organisms, oxidative stress seems be main mechanism toxicity. This manuscript reviews mitochondrial damage induced by signalling pathways involved this process, indicating occupies important position The antioxidants alleviate discussed. In addition, metabolites major metabolic enzymes reactions are summarized. review article reveals key toxicity-oxidative suggests use effective method for preventing

Язык: Английский

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Ferroptosis and endoplasmic reticulum stress in ischemic stroke

Neural Regeneration Research, Год журнала: 2023, Номер 19(3), С. 611 - 618

Опубликована: Июль 20, 2023

Abstract Ferroptosis is a form of non-apoptotic programmed cell death, and its mechanisms mainly involve the accumulation lipid peroxides, imbalance in amino acid antioxidant system, disordered iron metabolism. The primary organelle responsible for coordinating external challenges internal demands endoplasmic reticulum, progression inflammatory diseases can trigger reticulum stress. Evidence has suggested that ferroptosis may share pathways or interact with stress many plays role survival. occur after ischemic stroke. However, there are few reports on interactions This review summarized recent research relationships between stroke, aiming to provide reference developing treatments

Язык: Английский

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Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue

Environmental Toxicology, Год журнала: 2023, Номер 38(11), С. 2656 - 2667

Опубликована: Июль 20, 2023

In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality histopathology in testicular tissue rats was tried to be determined. PbAc administered at a dose 30 mg/kg/bw for 7 days induce toxicity rats. Oral doses 5 10 SNP were after administration. According our findings, while increased MDA content rats, it decreased GPx, SOD, CAT activity GSH content. NF-kB, IL-1β, TNF-α, COX-2, which are among inflammation parameters that due PbAc, with SNP. Nrf2, HO-1, NQO1 mRNA transcript levels but treatments these dose-dependent manner. RAGE NLRP3 gene expression upregulated treated MAPK14, MAPK15, JNK relative treatment While apoptosis markers Bax, Caspase-3, Apaf-1 level Bcl-2 decreased, inhibited markers. caused histopathological deterioration testis negatively affected spermatogenesis. When examined, decrease motility spermatozoon density by increase ratio dead abnormal spermatozoa As result, inducing stress testicles, changes quality.

Язык: Английский

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Cypermethrin induces apoptosis, autophagy and inflammation via ERS-ROS-NF-κB axis in hepatocytes of carp (Cyprinus carpio)

Pesticide Biochemistry and Physiology, Год журнала: 2023, Номер 196, С. 105625 - 105625

Опубликована: Сен. 22, 2023

Язык: Английский

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A New Perspective in the Treatment of Ischemic Stroke: Ferroptosis

Neurochemical Research, Год журнала: 2024, Номер 49(4), С. 815 - 833

Опубликована: Янв. 3, 2024

Язык: Английский

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The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 pathways

Journal of Biochemical and Molecular Toxicology, Год журнала: 2024, Номер 38(10)

Опубликована: Сен. 24, 2024

Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in the body liver. Carvacrol natural phytocompound that stands out with antioxidant, anti-inflammatory, antiapoptotic properties. The current study aims to investigate protective feature carvacrol against sodium arsenite-induced liver toxicity. Thirty-five Sprague-Dawley male rats were divided into five groups: Control, Sodium arsenite (SA), CRV, SA + CRV25, CRV50. was administered via oral gavage at dose 10 mg/kg for 14 days, 30 min later, CRV 25 or 50 gavage. Oxidative stress, inflammation, apoptosis, autophagy damage pathways parameters, tissue integrity analyzed using biochemical, molecular, western blot, histological, immunohistological methods. decreased oxidative stress by suppressing malondialdehyde levels increasing superoxide dismutase, catalase, glutathione peroxidase activities, levels. reduced inflammation reducing increased NF-κB cytokines (TNF-α, IL-1β, IL-6, RAGE, NLRP3) it stimulates. also autophagic (Beclin-1, LC3A, LC3B) apoptotic (P53, Apaf-1, Casp-3, Casp-6, Casp-9, Bax) parameters. preserved impaired structure. alleviated increases parameters rat tissues. beneficial preserving integrity.

Язык: Английский

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Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model

Journal of Biochemical and Molecular Toxicology, Год журнала: 2023, Номер 38(1)

Опубликована: Дек. 1, 2023

Abstract Oxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases. Naringin (4′,5,7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has wide range of biological and pharmacological activities, including antioxidant anti‐inflammatory potentials. This research aimed to investigate NRG activity OXL‐induced hepatorenal toxicity. Accordingly, OXL (4 mg/kg b.w.) 5% glucose was injected intraperitoneally on first, second, fifth, sixth days, (50 100 given orally 30 min before treatment. Biochemical, genetic, histological methods were utilized function tests, oxidant/antioxidant status, inflammation, apoptosis, endoplasmic reticulum (ER) stress pathways kidney liver tissues. Administration demonstrated an effect by increasing activities reduced enzymes (superoxide dismutase, catalase, glutathione peroxidase) decreasing elevated lipid peroxidation parameter malondialdehyde levels. Nuclear factor‐κB, tumor necrosis factor‐α, interleukin‐1β, inducible nitric oxide synthase levels increased administered groups but NRG‐treated groups. In OXL‐administered groups, apoptosis‐inducing factors Caspase‐3 B‐cell lymphoma 2 (Bcl‐2)‐associated X protein levels, while elevating antiapoptotic factor Bcl‐2 triggered prolonged ER parameters activating transcription 6, kinase R‐like kinase, inositol‐requiring enzyme 1α, glucose‐regulated 78. Therefore, with administration, this level decreased. Taken together, it found that induced toxicity urea creatinine, alanine transaminase, aspartate aminotransferase, alkaline phosphatase stress, oxidants tissue, had protective reversing deterioration these pathways.

Язык: Английский

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Dietary carvacrol essential oil alleviates thallium nitrate-induced toxicity in Oreochromis niloticus: Growth, hepatorenal, oxidative stress, gene expression, and histopathological study

Aquaculture, Год журнала: 2025, Номер unknown, С. 742175 - 742175

Опубликована: Янв. 1, 2025

Язык: Английский

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Potent Ameliorative Effects of Rosmarinic Acid on Tramadol-Induced Neurotoxicity in the Brain and Hippocampus; by Suppressing Oxidative stress, Apoptosis, ER stress, and Regulating Cognitive Functions

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract Tramadol (TRM) is a synthetic opioid analgesic that acts on the central nervous system and used to treat moderate or severe pain. However, incidence of its abuse increasing. Rosmarinic acid (RA) natural flavonoid known for antioxidant, anti-inflammatory, neuroprotective properties. In this study, we determined ameliorative effects RA against TRM-induced neurotoxicity. Thirty​​​​​​​ five rats were divided into 5 groups; control, RA, TRM, TRM + RA25 RA50. 50 mg/kg was administered intraperitoneally, 25 doses by oral gavage 14 days. Water Maze Test (WMT) performed assess cognitive function. Oxidative stress, inflammation, endoplasmic reticulum (ER) apoptosis damage pathways, glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF) activities in brain hippocampus tissues. The structural functional integrity tissues also analyzed. decreased increased ​​​​​​​oxidative ER apoptotic levels. addition, it improved neuronal survival activity bringing BDNF GFAP closer normal tissue. restored properties disrupted tramadol. These findings demonstrated using WMT, which arrival time quadrant platform located spent quadrant. reduces neurotoxicity reducing oxidative increases activity.

Язык: Английский

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Carvacrol showed a curative effect on reproductive toxicity caused by Bisphenol AF via antioxidant, anti-inflammatory and anti-apoptotic properties

Reproductive Toxicology, Год журнала: 2023, Номер 121, С. 108456 - 108456

Опубликована: Авг. 14, 2023

Язык: Английский

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