Advanced Functional Materials,
Год журнала:
2024,
Номер
34(34)
Опубликована: Март 10, 2024
Abstract
Native
bone
inherently
requires
a
balanced
ionic
microenvironment
to
maintain
homeostasis.
Hence,
scaffolds
designed
for
the
sustained
release
of
therapeutic
ions
into
defects
hold
great
promise
regeneration.
Magnesium
(Mg)
and
silicon
(Si)
are
essential
elements,
which
play
crucial
roles
in
process
regeneration,
impacting
immunomodulation,
angiogenesis,
osteogenesis.
Herein,
porous
cryogel‐type
organic–inorganic
composite
microspheres
developed
as
injectable
microscaffolds
(denoted
GMN).
GMN
enables
Mg/Si
at
an
optimized
ratio,
achieving
most
significant
synergistic
effect
on
vascularized
Various
conditioned
media
obtained
explore
angiogenesis‐osteogenesis
coupling,
well
crosstalk
between
marrow
mesenchymal
stromal
cells
(BMSCs)
macrophages.
Meanwhile,
autocrine
paracrine
effects
simultaneously
modulating
functions
determining
cell
fates
under
guidance
biofactors
secreted
by
cells.
Overall,
ion‐engineering
create
conducive
efficiently
augment
regeneration
tissue
vivo,
offering
versatile
platform
engineering.
Advanced Engineering Materials,
Год журнала:
2023,
Номер
25(21)
Опубликована: Авг. 29, 2023
Stimuli‐responsive
polymers
(SRPs)
are
special
types
of
soft
materials,
which
have
been
extensively
used
for
developing
flexible
actuators,
robots,
wearable
devices,
sensors,
self‐expanding
structures,
and
biomedical
thanks
to
their
ability
change
shapes
functional
properties
in
response
external
stimuli
including
light,
humidity,
heat,
pH,
electric
field,
solvent,
magnetic
field
or
combinations
two
more
these
stimuli.
In
recent
years,
additive
manufacturing
(AM)
aka
3D
printing
technology
SRPs,
also
known
as
4D
printing,
has
gained
phenomenal
attention
different
engineering
fields,
its
unique
develop
complex,
personalized,
innovative
undergo
twisting,
elongating,
swelling,
rolling,
shrinking,
bending,
spiraling,
other
complex
morphological
transformations.
Herein,
an
effort
made
provide
insightful
information
about
the
AM
techniques,
type
applications
including,
but
not
limited
tissue
engineering,
bionics,
construction,
smart
textiles.
This
article
incorporates
current
challenges
prospects,
hoping
basis
utilization
this
fields.
It
is
expected
that
amalgamation
with
SRPs
would
unparalleled
advantages
arenas.
Materials Research Express,
Год журнала:
2023,
Номер
10(2), С. 024003 - 024003
Опубликована: Фев. 1, 2023
Abstract
Hydrogel
is
being
broadly
studied
due
to
their
tremendous
properties,
such
as
swelling
behavior
and
biocompatibility.
Numerous
review
articles
have
discussed
hydrogel
polymer
types,
synthesis
methods,
applications.
can
be
synthesized
by
physical
chemical
cross-linking
methods.
One
type
of
the
method
freeze-thaw
(F–T),
which
works
based
on
crystallization
process
precursor
solution
form
a
cross-link.
To
date,
there
has
been
no
paper
discusses
F–T
technique
specifically
comprehensively.
Most
previous
that
exposed
usually
mentioned
small
part
method.
This
attempts
discuss
In
more
detail,
this
covers
basic
principles
formation
in
an
way,
parameters
influence
formation,
properties
hydrogel,
its
application
biomedical
field.
Materials Horizons,
Год журнала:
2023,
Номер
10(9), С. 3325 - 3350
Опубликована: Янв. 1, 2023
This
review
provides
a
brief
overview
of
the
recent
developments
in
hydrogel
systems
that
respond
dynamically
to
various
stimuli,
including
some
interesting
fabrication
strategies,
and
their
application
cardiac,
bone,
neural
tissue
regeneration.
Giant,
Год журнала:
2023,
Номер
17, С. 100209 - 100209
Опубликована: Ноя. 15, 2023
Additive
manufacturing
(AM)
aka
three-dimensional
(3D)
printing
has
been
a
well-established
and
unparalleled
technology,
which
is
expanding
the
boundaries
of
materials
science
exhibiting
an
enormous
potential
to
fabricate
intricate
geometries
for
healthcare,
electronics,
construction
sectors.
In
contemporary
era,
combination
AM
technology
stimuli-responsive
hydrogels
(SRHs)
helps
create
dynamic
functional
structures
with
extreme
accuracy,
are
capable
changing
their
shape,
functional,
or
mechanical
properties
in
response
environmental
cues
such
as
humidity,
heat,
light,
pH,
magnetic
field,
electric
etc.
3D
SRHs
permits
creation
on-demand
dynamically
controllable
shapes
excellent
control
over
various
self-repair,
self-assembly,
multi-functionality,
These
accelerate
researchers
think
unthinkable
applications.
Additively
manufactured
objects
have
shown
applications
like
tissue
engineering,
drug
delivery,
soft
robots,
sensors,
other
biomedical
devices.
The
current
review
provides
recent
progress
SRHs,
more
focus
on
techniques,
stimuli
mechanisms,
shape
morphing
behaviors,
Finally,
trends
future
roadmap
additively
smart
different
also
presented,
will
be
helpful
research.
This
holds
great
promise
providing
fundamental
knowledge
about
diverse
Bioactive Materials,
Год журнала:
2023,
Номер
32, С. 242 - 259
Опубликована: Окт. 12, 2023
Regulating
macrophage
activation
precisely
is
crucial
in
treating
chronic
inflammation
osteoarthritis
(OA).
However,
the
stable
pro-inflammatory
state
and
deep
distribution
of
macrophages
vivo
pose
a
great
challenge
to
treatment.
In
this
study,
inspired
by
innate
immune,
immune
cell
mobilized
hydrogel
microspheres
were
constructed
microfluidic
methods
load
chemokines,
antibodies
engineered
membrane
vesicles
(sEVs)
via
covalent
non-covalent
junctions.
The
microspheres,
based
on
mixture
streptavidin
grafted
hyaluronic
acid
methacrylate
(HAMA-SA)
Chondroitin
sulfate
(ChSMA)
(HCM),
can
recruit,
capture
reprogram
proinflammatory
joint
cavity
improve
inflammatory
microenvironment.
vitro
experiments
demonstrated
that
had
excellent
recruitment,
capture,
reprogramming
abilities.
Pro-inflammatory
be
transformed
into
anti-inflammatory
with
an
efficiency
88.5
%.
Animal
also
revealed
significant
reduction
synovial
cartilage
matrix
degradation
OA.
Therefore,
may
effective
treatment
OA
for
future.
Bacteria-induced
epidemics
and
infectious
diseases
are
seriously
threatening
the
health
of
people
around
world.
In
addition,
antibiotic
therapy
has
been
inducing
increasingly
more
serious
bacterial
resistance,
which
makes
it
urgent
to
develop
new
treatment
strategies
combat
bacteria,
including
multidrug-resistant
bacteria.
Natural
extracts
displaying
antibacterial
activity
good
biocompatibility
have
attracted
much
attention
due
greater
concerns
about
safety
synthetic
chemicals
emerging
drug
resistance.
These
components
can
be
isolated
utilized
as
antimicrobials,
well
transformed,
combined,
or
wrapped
with
other
substances
by
using
modern
assistive
technologies
fight
bacteria
synergistically.
This
review
summarizes
recent
advances
in
natural
from
three
kinds
sources-plants,
animals,
microorganisms-for
applications.
work
discusses
corresponding
mechanisms
future
development
fields.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(22)
Опубликована: Май 9, 2024
Hydrogels
have
emerged
as
promising
candidates
for
biomedical
applications,
especially
in
the
field
of
antibacterial
therapeutics,
due
to
their
unique
structural
properties,
highly
tunable
physicochemical
and
excellent
biocompatibility.
The
integration
stimuli-responsive
functions
into
hydrogels
holds
potential
enhance
properties
therapeutic
efficacy,
dynamically
responding
different
external
or
internal
stimuli,
such
pH,
temperature,
enzymes,
light.
Therefore,
this
review
describes
applications
hydrogel
dressings
responsive
stimuli
therapy.
collaborative
interaction
between
materials
is
discussed.
This
synergistic
approach,
contrast
conventional
materials,
not
only
amplifies
effect
but
also
alleviates
adverse
side
effects
diminishes
incidence
multiple
infections
drug
resistance.
provides
a
comprehensive
overview
current
challenges
outlines
future
research
directions
hydrogels.
It
underscores
imperative
ongoing
interdisciplinary
aimed
at
unraveling
mechanisms
wound
healing.
understanding
crucial
optimizing
design
implementation
Ultimately,
aims
offer
scientific
guidance
development
practical
clinical
application
dressings.
Materials,
Год журнала:
2024,
Номер
17(2), С. 278 - 278
Опубликована: Янв. 5, 2024
Effective
wound
treatment
has
become
one
of
the
most
important
challenges
for
healthcare
as
it
continues
to
be
leading
causes
death
worldwide.
Therefore,
care
technologies
significantly
evolved
in
order
provide
a
holistic
approach
based
on
various
designs
functional
dressings.
Among
them,
hydrogels
have
been
widely
used
due
their
biocompatibility
and
similarity
extracellular
matrix.
The
hydrogel
formula
offers
control
an
optimal
moisture
level
its
ability
absorb
excess
fluid
from
or
release
needed.
Additionally,
can
successfully
integrated
with
plethora
biologically
active
components
(e.g.,
nanoparticles,
pharmaceuticals,
natural
extracts,
peptides),
thus
enhancing
performance
resulting
composite
healing
applications.
In
this
review,
the-state-of-the-art
discoveries
related
stimuli-responsive
hydrogel-based
dressings
summarized,
taking
into
account
antimicrobial,
anti-inflammatory,
antioxidant,
hemostatic
properties,
well
other
effects
re-epithelialization,
vascularization,
restoration
tissue)
use.
