Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 97, С. 105753 - 105753
Опубликована: Май 8, 2024
Язык: Английский
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(3)
Опубликована: Май 1, 2024
Abstract The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning electrospraying, are facile in manipulate products' shapes. In this review, generated using EHDA for modifying drug release profiles reviewed. These linear nanofibers, round micro‐/nano‐particles, beads‐on‐a‐string hybrids. They can be further divided into different kinds sub‐shapes, explored providing desired pulsatile release, sustained biphasic delayed pH‐sensitive release. Additionally, resulted from organizations electrospun nanofibers discussed delivery, inner structures considered together developing novel delivery systems. future, related shape–performance relationships at nanoscale, besides size, structure structure–performance relationships, would play important roles promoting developments field. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies
Язык: Английский
Процитировано
63
Biomolecules, Год журнала: 2024, Номер 14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate is a natural polymer with good biocompatible properties and potential polymeric material for the sustainable development replacement of petroleum derivatives. However, non-spinnability pure alginate solutions has hindered expansion applications. With continuous electrospinning technology, synthetic polymers, such as PEO PVA, are used co-spinning agents to increase spinnability alginate. Moreover, coaxial, parallel Janus, tertiary other diverse novel electrospun fiber structures prepared by multi-fluid have found new breakthrough problem poor spinning polymers. Meanwhile, effectively achieve multiple release modes drugs. The powerful combination electrostatic widely in many biomedical fields, tissue engineering, regenerative bioscaffolds, drug delivery, research fever continues climb. This particularly true controlled delivery aspect review provides brief overview alginate, introduces advances spinning, highlights progress alginate-based nanofibers achieving various modes, pulsed release, sustained biphasic responsive targeted release.
Язык: Английский
Процитировано
48
Chemical Engineering Journal, Год журнала: 2024, Номер 492, С. 152359 - 152359
Опубликована: Май 18, 2024
Язык: Английский
Процитировано
44
Nanocomposites, Год журнала: 2024, Номер 10(1), С. 240 - 253
Опубликована: Июнь 12, 2024
Язык: Английский
Процитировано
39
International Journal of Pharmaceutics, Год журнала: 2024, Номер 658, С. 124180 - 124180
Опубликована: Май 4, 2024
Язык: Английский
Процитировано
38
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 132113 - 132113
Опубликована: Май 6, 2024
Язык: Английский
Процитировано
37
Nanomaterials, Год журнала: 2024, Номер 14(7), С. 646 - 646
Опубликована: Апрель 8, 2024
Dressings with multiple functional performances (such as hemostasis, promoting regeneration, analgesia, and anti-inflammatory effects) are highly desired in orthopedic surgery. Herein, several new kinds of medicated nanofibers loaded active ingredients for providing functions were prepared using the modified coaxial electrospinning processes. With an electrospinnable solution composed polycaprolactone fenoprofen core working fluid, different types unspinnable fluids (including pure solvent, nanosuspension containing tranexamic acid hydroxyapatite, dilute polymeric comprising acid, polyvinylpyrrolidone) explored to implement processes creating multifunctional nanofibers. Their morphologies inner structures assessed through scanning transmission electron microscopes, which all showed a linear format without discerned beads or spindles diameter smaller than 1.0 μm, some them had incomplete core–shell nanostructures, represented by symbol @. Additionally, strange details about sheaths’ topographies observed, included cracks, adhesions, embedded nanoparticles. XRD FTIR verified that drugs presented amorphous state, resulted from fine compatibility among involved components. All samples demonstrated have hydrophilic property exhibited lower water contact angle 40° 300 ms. In vitro dissolution tests indicated was released sustained manner over 6 h typical Fickian diffusion mechanism. Hemostatic intentional distribution on shell sections able endow rapid hemostatic effect within 60 s.
Язык: Английский
Процитировано
33
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Июнь 13, 2024
Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency patients. The combination pharmaceutical techniques advanced material conversion methods can provide new solutions to this issue. In research, kind hybrid film was created via coaxial electrospraying, followed by casting process. films were composed Reglan 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in polyvinylpyrrolidone (PVP) matrix. Microscopic observations these demonstrated solid cross section loaded particles. X-ray diffraction Fourier-transform infrared tests verified that 5-FU showed amorphous states fine compatibilities polymeric matrices, i.e., PVP CA, respectively. vitro dissolution indicated able desired asynchronous dual-drug delivery, fast release Reglan, sustained 5-FU. controlled mechanisms shown be an erosion mechanism typical Fickian diffusion protocols reported herein pioneer approach fabricating biomaterials multiple drugs, each its own behavior, synergistic cancer treatment.
Язык: Английский
Процитировано
30
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9524 - 9524
Опубликована: Сен. 1, 2024
Core–shell nanostructures are powerful platforms for the development of novel nanoscale drug delivery systems with sustained release profiles. Coaxial electrospinning is facile and convenient creating medicated core–shell elaborate designs which sustained-release behaviors molecules can be intentionally adjusted. With resveratrol (RES) as a model poorly water-soluble cellulose acetate (CA) PVP polymeric carriers, brand-new electrospun nanostructure was fabricated in this study. The guest RES host CA were designed to have reverse gradient distribution within nanostructures. Scanning electron microscope transmission evaluations verified that these nanofibers had linear morphologies, without beads or spindles, an obvious double-chamber structure. X-ray diffraction patterns Fourier transform infrared spectroscopic results indicated involved components highly compatible presented amorphous molecular state. In vitro dissolution tests new structures able prevent initial burst release, extend continuous-release time period, reduce negative tailing-off effect, thus ensuring better profile than traditional blended drug-loaded nanofibers. mechanism underlying influence structure RES/CA on proposed. Based proof-of-concept demonstration, series advanced functional nanomaterials similarly developed based distributions multi-chamber
Язык: Английский
Процитировано
24
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 135753 - 135753
Опубликована: Окт. 17, 2024
Язык: Английский
Процитировано
24