ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(8), С. 5662 - 5678
Опубликована: Авг. 4, 2024
Quercetin,
recognized
for
its
antioxidant,
anti-inflammatory,
and
antibacterial
properties,
faces
limited
biomedical
application
due
to
low
solubility.
Cotton,
a
preferred
wound
dressing
material
over
synthetic
ones,
lacks
inherent
wound-healing
attributes
can
benefit
from
quercetin
features.
This
study
explores
the
potential
of
overcoming
these
challenges
through
inclusion
complexation
with
cyclodextrins
(CDs)
development
nanofibrous
coating
on
cotton
nonwoven
textile.
Hydroxypropyl-beta-cyclodextrin
(HP-β-CD)
hydroxypropyl-gamma-cyclodextrin
(HP-γ-CD)
formed
complexes
quercetin,
chitosan
added
enhance
properties.
Phase
solubility
results
showed
that
up
20
times,
HP-γ-CD
forming
more
stable
compared
HP-β-CD.
Electrospinning
nanofibers
HP-β-CD/Quercetin
HP-γ-CD/Quercetin
aqueous
solutions
without
use
polymeric
matrix
yielded
uniform,
smooth
fiber
morphology.
The
structural
thermal
analyses
confirmed
presence
between
each
CDs
(HP-β-CD
HP-γ-CD).
Moreover,
near-complete
loading
efficiency
followed
fast-releasing
profile
quercetin.
Both
significantly
higher
antioxidant
activity
pristine
also
activity,
addition
in
system,
Chitosan/HP-γ-CD/Quercetin
completely
eliminated
investigated
bacteria
species.
were
nontoxic
well-tolerated
by
cells,
exploiting
anti-inflammatory
activities
resulted
downregulation
IL-6
NO
secretion
both
immune
as
well
regenerative
cells.
Overall,
CD
markedly
enhances
solubility,
resulting
biofunctional
antibacterial,
textiles.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate
is
a
natural
polymer
with
good
biocompatible
properties
and
potential
polymeric
material
for
the
sustainable
development
replacement
of
petroleum
derivatives.
However,
non-spinnability
pure
alginate
solutions
has
hindered
expansion
applications.
With
continuous
electrospinning
technology,
synthetic
polymers,
such
as
PEO
PVA,
are
used
co-spinning
agents
to
increase
spinnability
alginate.
Moreover,
coaxial,
parallel
Janus,
tertiary
other
diverse
novel
electrospun
fiber
structures
prepared
by
multi-fluid
have
found
new
breakthrough
problem
poor
spinning
polymers.
Meanwhile,
effectively
achieve
multiple
release
modes
drugs.
The
powerful
combination
electrostatic
widely
in
many
biomedical
fields,
tissue
engineering,
regenerative
bioscaffolds,
drug
delivery,
research
fever
continues
climb.
This
particularly
true
controlled
delivery
aspect
review
provides
brief
overview
alginate,
introduces
advances
spinning,
highlights
progress
alginate-based
nanofibers
achieving
various
modes,
pulsed
release,
sustained
biphasic
responsive
targeted
release.
Progress in Materials Science,
Год журнала:
2024,
Номер
147, С. 101350 - 101350
Опубликована: Авг. 6, 2024
Wound
healing
is
a
complex
biological
process
that,
when
impaired,
can
lead
to
the
formation
of
scars.
Electrospun
nanofibrous
wound
dressings
have
emerged
as
promising
option
for
promoting
scar-free
healing.
This
paper
explores
role
physical,
compositional,
and
chemical
cues,
each
contributing
remarkable
potential
these
dressings.
The
physical
properties
dressings,
such
porosity
mechanical
characteristics,
guide
cellular
behaviors
promote
vascularization,
fostering
conducive
environment
reduced
scarring.
Furthermore,
integration
natural
polymers
that
mimic
skin's
extracellular
matrix,
known
compositional
adds
another
layer
complexity
As
therapeutic
agents
demonstrated
their
combat
chronic
scenarios
leading
scar
formation.
However,
achieving
desired
effect
hinges
on
nature
controlled
release.
Therefore,
also
delves
into
various
loading
techniques
tailoring
release
profiles
bioactive
agents.
Although
electrospun
are
viable
commercial
product
remains
elusive.
gap
be
attributed
lack
comprehensive
in
vivo
studies,
particularly
animal
models
human
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 13, 2024
Combination
therapy
with
oral
administration
of
several
active
ingredients
is
a
popular
clinical
treatment
for
cancer.
However,
the
traditional
method
has
poor
convenience,
less
safety,
and
low
efficiency
patients.
The
combination
pharmaceutical
techniques
advanced
material
conversion
methods
can
provide
new
solutions
to
this
issue.
In
research,
kind
hybrid
film
was
created
via
coaxial
electrospraying,
followed
by
casting
process.
films
were
composed
Reglan
5-fluorouracil
(5-FU)-loaded
cellulose
acetate
(CA)
core-shell
particles
in
polyvinylpyrrolidone
(PVP)
matrix.
Microscopic
observations
these
demonstrated
solid
cross
section
loaded
particles.
X-ray
diffraction
Fourier-transform
infrared
tests
verified
that
5-FU
showed
amorphous
states
fine
compatibilities
polymeric
matrices,
i.e.,
PVP
CA,
respectively.
vitro
dissolution
indicated
able
desired
asynchronous
dual-drug
delivery,
fast
release
Reglan,
sustained
5-FU.
controlled
mechanisms
shown
be
an
erosion
mechanism
typical
Fickian
diffusion
protocols
reported
herein
pioneer
approach
fabricating
biomaterials
multiple
drugs,
each
its
own
behavior,
synergistic
cancer
treatment.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9524 - 9524
Опубликована: Сен. 1, 2024
Core–shell
nanostructures
are
powerful
platforms
for
the
development
of
novel
nanoscale
drug
delivery
systems
with
sustained
release
profiles.
Coaxial
electrospinning
is
facile
and
convenient
creating
medicated
core–shell
elaborate
designs
which
sustained-release
behaviors
molecules
can
be
intentionally
adjusted.
With
resveratrol
(RES)
as
a
model
poorly
water-soluble
cellulose
acetate
(CA)
PVP
polymeric
carriers,
brand-new
electrospun
nanostructure
was
fabricated
in
this
study.
The
guest
RES
host
CA
were
designed
to
have
reverse
gradient
distribution
within
nanostructures.
Scanning
electron
microscope
transmission
evaluations
verified
that
these
nanofibers
had
linear
morphologies,
without
beads
or
spindles,
an
obvious
double-chamber
structure.
X-ray
diffraction
patterns
Fourier
transform
infrared
spectroscopic
results
indicated
involved
components
highly
compatible
presented
amorphous
molecular
state.
In
vitro
dissolution
tests
new
structures
able
prevent
initial
burst
release,
extend
continuous-release
time
period,
reduce
negative
tailing-off
effect,
thus
ensuring
better
profile
than
traditional
blended
drug-loaded
nanofibers.
mechanism
underlying
influence
structure
RES/CA
on
proposed.
Based
proof-of-concept
demonstration,
series
advanced
functional
nanomaterials
similarly
developed
based
distributions
multi-chamber
Langmuir,
Год журнала:
2024,
Номер
40(32), С. 16670 - 16689
Опубликована: Июнь 24, 2024
Waste
polystyrene
contributes
considerably
to
environmental
pollution
due
its
persistent
nature,
prompting
a
widespread
consensus
on
the
urgent
need
for
viable
recycling
solutions.
Owing
aromatic
groups
structure
of
polystyrene,
hyper-cross-linked
polymers
can
be
synthesized
through
Friedel–Crafts
cross-linking
reaction
using
Lewis
acids
as
catalysts.
In
addition,
and
carbonaceous
counterparts
used
in
several
important
applications,
which
helps
their
efficient
recycling.
This
review
systematically
explores
methods
preparing
multifunctional
from
waste
applications
sustainable
We
have
comprehensively
outlined
various
synthetic
approaches
these
investigated
physical
chemical
properties.
These
not
only
exhibit
structural
flexibility
but
also
demonstrate
diversity
performance,
making
them
suitable
applications.
Through
systematic
examination
methods,
we
showcase
cutting-edge
positions
materials
field
polymers.
Additionally,
provide
in-depth
insights
into
potential
intentional
recycling,
highlighting
contributions
protection
development.
research
provides
valuable
references
fields
science
management,
encouraging
further
exploration
innovative
utilization
discarded
polystyrene.
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2614 - 2614
Опубликована: Сен. 15, 2024
Polymeric
composites
for
manipulating
the
sustained
release
of
an
encapsulated
active
ingredient
are
highly
sought
after
many
practical
applications;
particularly,
water-insoluble
polymers
and
core–shell
structures
frequently
explored
to
manipulate
behaviors
drug
molecules
over
extended
time
period.
In
this
study,
electrospun
nanostructures
were
utilized
develop
a
brand-new
strategy
tailor
spatial
distributions
both
insoluble
polymer
(ethylcellulose,
EC)
soluble
(polyvinylpyrrolidone,
PVP)
within
nanofibers,
thereby
extended-release
loaded
ingredient,
ferulic
acid
(FA).
Scanning
electron
microscopy
transmission
assessments
revealed
that
all
prepared
nanofibers
had
linear
morphology
without
beads
or
spindles,
those
from
coaxial
processes
obvious
structure.
X-ray
diffraction
attenuated
total
reflectance
Fourier
transform
infrared
spectroscopic
tests
confirmed
FA
fine
compatibility
with
EC
PVP,
presented
in
amorphous
state.
vitro
dissolution
indicated
radical
(decreasing
shell
core)
PVP
(increasing
able
play
their
important
role
elaborately.
On
one
hand,
F3
advantages
homogeneous
composite
F1
higher
content
solutions
inhibit
initial
burst
provide
longer
period
release.
other
F2
core
negative
tailing-off
The
key
element
was
water
permeation
rates,
controlled
by
ratios
polymers.
new
based
on
structure
paves
way
developing
wide
variety
polymeric
heterogeneous
realizing
desired
functional
performances.
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
8, С. 100265 - 100265
Опубликована: Июнь 26, 2024
Cancer
remains
a
major
global
health
challenge,
and
despite
available
treatments,
its
prognosis
poor.
Recently,
researchers
have
turned
their
attention
to
intelligent
nanofibers
for
cancer
drug
delivery.
These
exhibit
remarkable
capabilities
in
targeted
controlled
release.
Their
inherent
characteristics,
such
as
high
surface
area-to-volume
ratio,
make
them
attractive
candidates
delivery
applications.
Smart
can
release
drugs
response
specific
stimuli,
including
pH,
temperature,
magnetic
fields,
light.
This
unique
feature
not
only
reduces
side
effects
but
also
enhances
the
overall
efficiency
of
systems.
Electrospinning,
widely
used
method,
allows
precision
fabrication
smart
nanofibers.
Its
advantages
include
efficiency,
user-friendliness,
ability
control
various
manufacturing
parameters.
In
this
review,
we
explore
latest
developments
producing
electrospun
treatment.
Additionally,
discuss
materials
these
critical
parameters
involved
electrospinning
process.
