Advanced Materials,
Год журнала:
2023,
Номер
35(33)
Опубликована: Май 6, 2023
Extracellular
vesicle
(EV)-based
therapies
have
emerged
as
a
promising
means
in
regenerative
medicine.
However,
the
conventional
EV
therapy
strategy
displays
some
limitations,
such
inefficient
production
and
lack
of
tissue-specific
repair
effects.
Here,
it
is
reported
that
neonatal-tissue-derived
(NEXT)
potent
for
precision
tissue
repair.
In
brief,
large
amounts
EVs
with
higher
yield/purity
can
be
readily
isolated
from
desired
tissues
less
time/cost
compared
to
cell-culture-based
method.
Moreover,
source
factors,
age
type,
affect
efficacy
tissue-derived
different
injury
models
(skin
wounds
acute
kidney
injury),
show
superior
potency
adult-tissue-derived
EVs.
Different
age-
or
tissue-type-derived
distinct
composition
(e.g.,
protein)
signatures
are
likely
due
diverse
metabolic
patterns
donor
tissues,
which
may
contribute
specific
action
modes
NEXT
types
injury.
Furthermore,
incorporated
bioactive
materials
advanced
This
study
highlights
provide
new
avenue
many
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(21), С. 15930 - 15930
Опубликована: Ноя. 3, 2023
In
recent
years,
skin
aging
has
received
increasing
attention.
Many
factors
affect
aging,
and
research
shown
that
metabolism
plays
a
vital
role
in
but
there
needs
to
be
more
systematic
review.
This
article
reviews
the
interaction
between
from
perspectives
of
glucose,
protein,
lipid
explores
relevant
strategies
for
regulation.
We
found
affects
three
major
substances,
which
are
lipids,
substances
also
process
aging.
Some
drugs
or
compounds
can
regulate
metabolic
disorders
mentioned
above
exert
anti-aging
effects.
Currently,
variety
products,
most
them
focus
on
improving
collagen
levels.
Skin
is
closely
related
metabolism,
they
interact
with
each
other.
Regulating
specific
an
important
strategy.
Research
development
have
focused
levels,
while
regulation
other
glycosylation
including
key
membrane
cytoskeleton
proteins
relatively
rare.
Further
expected.
Phenomics,
Год журнала:
2022,
Номер
2(6), С. 363 - 382
Опубликована: Окт. 10, 2022
Abstract
Skin
is
a
complex
ecosystem
colonized
by
millions
of
microorganisms,
including
bacteria,
fungi,
and
viruses.
microbiota
believed
to
exert
critical
functions
in
maintaining
host
skin
health.
Profiling
the
structure
microbial
community
first
step
overview
ecosystem.
However,
composition
highly
individualized
extremely
complex.
To
explore
fundamental
factors
driving
complexity
ecosystem,
namely
selection
pressures,
we
review
present
studies
on
microbiome
from
perspectives
ecology.
This
summarizes
following:
(1)
substances/nutrients
cutaneous
ecological
environment
that
are
derived
environment,
highlighting
their
proposed
function
microbiota;
(2)
features
dominant
commensals
occupy
niches,
through
self-adaptation
microbe–microbe
interactions;
(3)
how
microbes,
structures
or
bioactive
molecules,
reshape
phenotypes,
immunity,
maintenance
physiology
such
as
pH
hydration,
ultraviolet
(UV)
protection,
odor
production,
wound
healing.
aims
re-examine
host–microbe
interactions
hopefully
give
new
inspiration
this
field.
Plants,
Год журнала:
2023,
Номер
12(9), С. 1744 - 1744
Опубликована: Апрель 24, 2023
Amino
acids
are
an
essential
group
of
compounds
involved
in
protein
synthesis
and
various
metabolic
immune
reactions
the
human
body.
Chinese
jujubes
(Ziziphus
jujuba
Mill.)
important
fruit
medicinal
plant
which
native
to
China
have
been
introduced
into
around
50
countries.
However,
systematic
research
on
composition
content
diversity
amino
jujube
is
still
lacking.
In
this
experiment,
acid
contents
dominant
161
cultivars
were
determined
by
HPLC.
Of
twenty-one
kinds
detected,
a
total
fourteen
eight
relatively
high,
including
five
(threonine,
valine,
isoleucine,
leucine,
phenylalanine)
three
nonessential
(glycine,
alanine,
proline).
remaining
six
low
(aspartic
acid,
glutamic
histidine,
serine,
arginine,
tryptophan).
Therefore,
primary
used
as
index
evaluate
varieties.
Proline
accounts
for
56.8%
among
acids.
The
most
varieties
was
1-1.5
g/100
g,
highest
'Zaoqiangmalianzao'
2.356
g.
average
proline
6.01-14.84
times
that
other
seven
According
WHO/FAO
revised
model
spectrum
ideal
humans,
19
met
E/T
(essential
acids/total
acids)
standard,
their
values
ranged
from
35%
45%;
12
meet
E/NE
(non-essential
≥
60%.
All
reached
requirement
BC
(branched-chain
acids)/E
40%
with
15
over
68%.
One
hundred
fifty-seven
reach
standard
BC/A
(aromatic
≈
3.0~3.5.
ratio
coefficient
analysis
showed
phenylalanine
first
limiting
all
cultivars.
SRC
(the
score
coefficient)
134
between
50%
70%,
indicating
fruits
high
nutritional
value
terms
Based
principal
component
comprehensive
ranking
value,
top
screened
ones
tested,
i.e.,
'Tengzhouchanghongzao',
'Xinzhengxiaoyuanzao',
'Hanguowudeng',
'Xuputiansuanzao',
'Lichengxiaozao'.
This
study
established,
firstly,
complete
basic
data
could
be
select
germplasm
resources
suitable
developing
functional
food,
provide
theoretical
support
utilization
jujubes.
Molecules,
Год журнала:
2023,
Номер
28(23), С. 7861 - 7861
Опубликована: Ноя. 30, 2023
Syzygium
cumini
L.
is
an
evergreen
tree
belonging
to
family
Myrtaceae,
employed
for
different
traditional
uses
like
diabetes,
inflammation,
and
fever.
The
current
study
aimed
compare
the
chemical
compositions
of
essential
oils
(EOs)
isolated
from
organs
(leaves
(Scl),
fruits
(Scf),
seeds
(Scs),
bark
(Scb))
using
a
GC/MS
analysis.
Also,
chemometric
analysis
was
applied
explore
main
similarities
differences
among
Principal
Component
Analysis
(PCA)
hierarchal
cluster
(HCA).
Furthermore,
in
vitro
antiaging
activities
were
investigated
via
anti-collagenase,
anti-elastase,
anti-hyaluronidase
assays.
GC-MS
revealed
82
compounds
representing
92.13%,
99.42%,
100%,
92.97%
Scl,
Scf,
Scs,
Scb,
respectively.
predominant
components
α-pinene,
β-pinene,
(E)-β-caryophyllene,
α-caryophyllene,
caryophyllene
oxide,
α-humulene
epoxide
II
with
variable
percentages.
All
EOs
positioned
on
positive
PC1,
except
which
negative
side
separate
quadrant.
HCA
dendrogram
displayed
closeness
Scl
not
clearly
recognized
PCA
score
plot.
Moreover,
Scs
totally
discriminated
other
parts.
showed
superior
activities.
Thus,
S.
should
be
considered
cosmetic
preparations
retard
skin
aging
manifestations.
Smart Materials in Medicine,
Год журнала:
2023,
Номер
4, С. 578 - 589
Опубликована: Янв. 1, 2023
Mesenchymal
stem
cell
exosomes
(MSC-Exos)
are
a
type
of
vesicle
with
biological
function
secreted
by
mesenchymal
cells
(MSCs).
In
tissue
repair,
MSC-Exos
more
effective
than
MSCs,
and
they
can
be
used
as
cell-free
alternative
therapy
to
MSCs.
This
therapeutic
system
has
stable
membrane
structure
that
is
coated
proteins,
miRNAs,
mRNA,
lncRNA,
DNA,
other
macromolecular
active
substances.
These
molecules
have
powerful
effect
on
regeneration.
regulate
the
target
through
direct
recognition,
fusion,
secretion
communication
mediators.
Skin
wound
healing
consists
mainly
blood
coagulation,
inflammation
response,
proliferation,
remodeling.
By
regulating
four
stages
healing,
effectively
reduce
inflammation,
immune
promote
enhanced
migration
angiogenesis
remodeling,
thus
shortening
time
reducing
scar
formation.
A
variety
factors,
genetic
material
signaling
pathways
involved
in
this
process.
article
reviews
efficacy
mechanism
promoting
skin
repair.
Journal of Food Quality,
Год журнала:
2024,
Номер
2024, С. 1 - 21
Опубликована: Фев. 29, 2024
The
nutritional
value
and
flavor
texture
characteristics
of
fruits
from
different
Actinidia
argute
resources
were
scientifically
evaluated
compared.
Using
35
A.
arguta
as
materials,
the
amino
acid
composition
content
determined
by
an
automatic
analyzer,
differentiation
analysis,
evaluation,
TAV
correlation
PCA
comprehensive
cluster
analysis
conducted
to
clarify
diversity
in
terms
content,
composition,
characteristics.
Analysis
differential
results
showed
that
resource
contained
17
acids
with
a
total
384.20∼2590.56
mg/100
g.
evaluation
Leu
all
conformed
ideal
model
proposed
FAO/WHO,
exceeded
human
body’s
needs,
it
was
also
found
first
limiting
Ile
second
Lys.
flavor-presenting
calculated
evaluate
taste
characteristics,
influenced
fruit
Glu
Cys.
2
principal
components
could
better
reflect
information
arguta,
cumulative
variance
contribution
rate
87.88%,
which
represent
main
trend
arguta.
A
established,
composite
scores
indicated
top
5
excellent
S4,
S10,
S18,
S25,
S30.
Hierarchical
classified
into
4
categories,
reflected
differences
value,
among
collection
sites.
Experimental Dermatology,
Год журнала:
2022,
Номер
31(5), С. 700 - 714
Опубликована: Янв. 14, 2022
The
skin's
ability
to
function
optimally
is
affected
by
many
diverse
factors.
Metabolomics
has
a
great
potential
improve
our
understanding
of
the
underlying
metabolic
changes
and
pathways.
Therefore,
objective
this
study
was
review
current
state
literature
perform
further
pathway
analysis
on
obtained
data.
aim
gain
an
overview
under
altered
conditions
identify
common
different
patterns
as
investigated
A
cross-study
comparison
extracted
studies
from
databases
identified
364
metabolites,
whose
concentrations
were
considerably
following
factor
groups:
irradiation,
xenobiotics,
ageing
skin
diseases
(mainly
psoriasis).
Using
tools,
individual
metabolites
assigned
corresponding
pathways
most
strongly
signalling
identified.
All
factors
induced
oxidative
stress.
Thus,
antioxidant
defence
systems,
especially
coenzyme
Q10
(ageing)
glutathione
system
(irradiation,
ageing,
xenobiotics),
impacted.
Lipid
metabolism
also
impacted
all
studied.
carnitine
shuttle
part
β-oxidation
activated
groups
except
ageing.
Glycolysis,
Krebs
(TCA)
cycle
purine
mainly
irradiation
xenobiotics.
pentose
phosphate
activated,
downregulated
in
response
In
summary,
it
can
be
ascertained
that
energy
metabolism,
lipid
antioxidative
DNA
repair
systems
