Hydroxyproline in animal metabolism, nutrition, and cell signaling

Amino Acids, Год журнала: 2021, Номер 54(4), С. 513 - 528

Опубликована: Авг. 3, 2021

Язык: Английский

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Neonatal‐Tissue‐Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Май 6, 2023

Extracellular vesicle (EV)-based therapies have emerged as a promising means in regenerative medicine. However, the conventional EV therapy strategy displays some limitations, such inefficient production and lack of tissue-specific repair effects. Here, it is reported that neonatal-tissue-derived (NEXT) potent for precision tissue repair. In brief, large amounts EVs with higher yield/purity can be readily isolated from desired tissues less time/cost compared to cell-culture-based method. Moreover, source factors, age type, affect efficacy tissue-derived different injury models (skin wounds acute kidney injury), show superior potency adult-tissue-derived EVs. Different age- or tissue-type-derived distinct composition (e.g., protein) signatures are likely due diverse metabolic patterns donor tissues, which may contribute specific action modes NEXT types injury. Furthermore, incorporated bioactive materials advanced This study highlights provide new avenue many

Язык: Английский

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Research Progress in Skin Aging, Metabolism, and Related Products

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15930 - 15930

Опубликована: Ноя. 3, 2023

In recent years, skin aging has received increasing attention. Many factors affect aging, and research shown that metabolism plays a vital role in but there needs to be more systematic review. This article reviews the interaction between from perspectives of glucose, protein, lipid explores relevant strategies for regulation. We found affects three major substances, which are lipids, substances also process aging. Some drugs or compounds can regulate metabolic disorders mentioned above exert anti-aging effects. Currently, variety products, most them focus on improving collagen levels. Skin is closely related metabolism, they interact with each other. Regulating specific an important strategy. Research development have focused levels, while regulation other glycosylation including key membrane cytoskeleton proteins relatively rare. Further expected.

Язык: Английский

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Self-assembling Bletilla polysaccharide nanogels facilitate healing of acute and infected wounds via inflammation control and antibacterial activity

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 299, С. 140125 - 140125

Опубликована: Янв. 20, 2025

Язык: Английский

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Nutrition and Metabolism: Foundations for Animal Growth, Development, Reproduction, and Health

Advances in experimental medicine and biology, Год журнала: 2021, Номер unknown, С. 1 - 24

Опубликована: Ноя. 22, 2021

Язык: Английский

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Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem

Phenomics, Год журнала: 2022, Номер 2(6), С. 363 - 382

Опубликована: Окт. 10, 2022

Abstract Skin is a complex ecosystem colonized by millions of microorganisms, including bacteria, fungi, and viruses. microbiota believed to exert critical functions in maintaining host skin health. Profiling the structure microbial community first step overview ecosystem. However, composition highly individualized extremely complex. To explore fundamental factors driving complexity ecosystem, namely selection pressures, we review present studies on microbiome from perspectives ecology. This summarizes following: (1) substances/nutrients cutaneous ecological environment that are derived environment, highlighting their proposed function microbiota; (2) features dominant commensals occupy niches, through self-adaptation microbe–microbe interactions; (3) how microbes, structures or bioactive molecules, reshape phenotypes, immunity, maintenance physiology such as pH hydration, ultraviolet (UV) protection, odor production, wound healing. aims re-examine host–microbe interactions hopefully give new inspiration this field.

Язык: Английский

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Composition Analysis and Nutritional Value Evaluation of Amino Acids in the Fruit of 161 Jujube Cultivars

Plants, Год журнала: 2023, Номер 12(9), С. 1744 - 1744

Опубликована: Апрель 24, 2023

Amino acids are an essential group of compounds involved in protein synthesis and various metabolic immune reactions the human body. Chinese jujubes (Ziziphus jujuba Mill.) important fruit medicinal plant which native to China have been introduced into around 50 countries. However, systematic research on composition content diversity amino jujube is still lacking. In this experiment, acid contents dominant 161 cultivars were determined by HPLC. Of twenty-one kinds detected, a total fourteen eight relatively high, including five (threonine, valine, isoleucine, leucine, phenylalanine) three nonessential (glycine, alanine, proline). remaining six low (aspartic acid, glutamic histidine, serine, arginine, tryptophan). Therefore, primary used as index evaluate varieties. Proline accounts for 56.8% among acids. The most varieties was 1-1.5 g/100 g, highest 'Zaoqiangmalianzao' 2.356 g. average proline 6.01-14.84 times that other seven According WHO/FAO revised model spectrum ideal humans, 19 met E/T (essential acids/total acids) standard, their values ranged from 35% 45%; 12 meet E/NE (non-essential ≥ 60%. All reached requirement BC (branched-chain acids)/E 40% with 15 over 68%. One hundred fifty-seven reach standard BC/A (aromatic ≈ 3.0~3.5. ratio coefficient analysis showed phenylalanine first limiting all cultivars. SRC (the score coefficient) 134 between 50% 70%, indicating fruits high nutritional value terms Based principal component comprehensive ranking value, top screened ones tested, i.e., 'Tengzhouchanghongzao', 'Xinzhengxiaoyuanzao', 'Hanguowudeng', 'Xuputiansuanzao', 'Lichengxiaozao'. This study established, firstly, complete basic data could be select germplasm resources suitable developing functional food, provide theoretical support utilization jujubes.

Язык: Английский

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Comparative Study of Essential Oils from Different Organs of Syzygium cumini (Pamposia) Based on GC/MS Chemical Profiling and In Vitro Antiaging Activity

Molecules, Год журнала: 2023, Номер 28(23), С. 7861 - 7861

Опубликована: Ноя. 30, 2023

Syzygium cumini L. is an evergreen tree belonging to family Myrtaceae, employed for different traditional uses like diabetes, inflammation, and fever. The current study aimed compare the chemical compositions of essential oils (EOs) isolated from organs (leaves (Scl), fruits (Scf), seeds (Scs), bark (Scb)) using a GC/MS analysis. Also, chemometric analysis was applied explore main similarities differences among Principal Component Analysis (PCA) hierarchal cluster (HCA). Furthermore, in vitro antiaging activities were investigated via anti-collagenase, anti-elastase, anti-hyaluronidase assays. GC-MS revealed 82 compounds representing 92.13%, 99.42%, 100%, 92.97% Scl, Scf, Scs, Scb, respectively. predominant components α-pinene, β-pinene, (E)-β-caryophyllene, α-caryophyllene, caryophyllene oxide, α-humulene epoxide II with variable percentages. All EOs positioned on positive PC1, except which negative side separate quadrant. HCA dendrogram displayed closeness Scl not clearly recognized PCA score plot. Moreover, Scs totally discriminated other parts. showed superior activities. Thus, S. should be considered cosmetic preparations retard skin aging manifestations.

Язык: Английский

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Characterization of Amino Acid Composition, Nutritional Value, and Taste of Fruits from Different Actinidia arguta Resources

Journal of Food Quality, Год журнала: 2024, Номер 2024, С. 1 - 21

Опубликована: Фев. 29, 2024

The nutritional value and flavor texture characteristics of fruits from different Actinidia argute resources were scientifically evaluated compared. Using 35 A. arguta as materials, the amino acid composition content determined by an automatic analyzer, differentiation analysis, evaluation, TAV correlation PCA comprehensive cluster analysis conducted to clarify diversity in terms content, composition, characteristics. Analysis differential results showed that resource contained 17 acids with a total 384.20∼2590.56 mg/100 g. evaluation Leu all conformed ideal model proposed FAO/WHO, exceeded human body’s needs, it was also found first limiting Ile second Lys. flavor-presenting calculated evaluate taste characteristics, influenced fruit Glu Cys. 2 principal components could better reflect information arguta, cumulative variance contribution rate 87.88%, which represent main trend arguta. A established, composite scores indicated top 5 excellent S4, S10, S18, S25, S30. Hierarchical classified into 4 categories, reflected differences value, among collection sites.

Язык: Английский

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Application of mesenchymal stem cell exosomes in the treatment of skin wounds

Smart Materials in Medicine, Год журнала: 2023, Номер 4, С. 578 - 589

Опубликована: Янв. 1, 2023

Mesenchymal stem cell exosomes (MSC-Exos) are a type of vesicle with biological function secreted by mesenchymal cells (MSCs). In tissue repair, MSC-Exos more effective than MSCs, and they can be used as cell-free alternative therapy to MSCs. This therapeutic system has stable membrane structure that is coated proteins, miRNAs, mRNA, lncRNA, DNA, other macromolecular active substances. These molecules have powerful effect on regeneration. regulate the target through direct recognition, fusion, secretion communication mediators. Skin wound healing consists mainly blood coagulation, inflammation response, proliferation, remodeling. By regulating four stages healing, effectively reduce inflammation, immune promote enhanced migration angiogenesis remodeling, thus shortening time reducing scar formation. A variety factors, genetic material signaling pathways involved in this process. article reviews efficacy mechanism promoting skin repair.

Язык: Английский

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