Autoimmunity Reviews,
Год журнала:
2024,
Номер
23(6), С. 103584 - 103584
Опубликована: Июнь 1, 2024
Systemic
autoimmune
diseases
are
complex
conditions
characterized
by
an
immune
system
dysregulation
and
aberrant
activation
against
self-antigens,
leading
to
tissue
organ
damage.
Even
though
genetic
predisposition
plays
a
role,
it
cannot
fully
explain
the
onset
of
these
diseases,
highlighting
significant
impact
non-heritable
influences
such
as
environment,
hormones
infections.
The
exposome
represents
all
those
factors,
ranging
from
chemical
pollutants
dietary
components
psychological
stressors
infectious
agents.
Epigenetics,
which
studies
changes
in
gene
expression
without
altering
DNA
sequence,
is
crucial
link
between
development
diseases.
Key
epigenetic
mechanisms
include
methylation,
histone
modifications,
non-coding
RNAs.
These
modifications
could
provide
potential
piece
puzzle
understanding
systemic
their
connection
with
exposome.
In
this
work
we
have
collected
most
important
recent
evidence
linked
(systemic
lupus
erythematosus,
idiopathic
inflammatory
myopathies,
ANCA-associated
vasculitis,
rheumatoid
arthritis),
emphasizing
roles
may
play
disease
pathogenesis,
diagnostic
biomarkers
prospective
targeted
therapies.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Фев. 17, 2023
Abstract
Rheumatoid
arthritis
(RA)
is
an
incurable
systemic
autoimmune
disease.
Disease
progression
leads
to
joint
deformity
and
associated
loss
of
function,
which
significantly
impacts
the
quality
life
for
sufferers
adds
losses
in
labor
force.
In
past
few
decades,
RA
has
attracted
increased
attention
from
researchers,
abnormal
signaling
pathways
are
a
very
important
research
field
diagnosis
treatment
RA,
provides
evidence
understanding
this
complex
disease
developing
novel
RA-linked
intervention
targets.
The
current
review
intends
provide
comprehensive
overview
including
general
introduction
disease,
historical
events,
epidemiology,
risk
factors,
pathological
process,
highlight
primary
progress
various
molecular
mechanisms,
genetic
epigenetic
summarize
most
recent
developments
identifying
new
inhibitors
treating
RA.
therapeutic
interventions
approved
drugs,
clinical
pre-clinical
cutting-edge
technologies.
These
will
hopefully
drive
strategically
targeted
therapies
hope
ideas
options
future.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
153, С. 113290 - 113290
Опубликована: Июнь 17, 2022
The
prevalence
of
metabolic
diseases,
including
obesity,
dyslipidemia,
type
2
diabetes
mellitus
(T2DM),
and
non-alcoholic
fatty
liver
disease
(NAFLD),
is
a
severe
burden
in
human
society
owing
to
the
ensuing
high
morbidity
mortality.
Various
factors
linked
disorders,
particularly
environmental
(such
as
diet
gut
microbiota)
epigenetic
modifications,
contribute
progression
diseases.
Dietary
components
habits
regulate
alterations
microbiota;
turn,
microbiota-derived
metabolites,
such
short-chain
acids
(SCFAs),
are
influenced
by
diet.
Interestingly,
diet-derived
microbial
metabolites
appear
produce
substrates
enzymatic
regulators
for
modifications
DNA
methylation,
histone
non-coding
RNA
expression).
Epigenetic
changes
mediated
participate
disorders
via
intestinal
permeability,
immune
responses,
inflammatory
reactions,
insulin
resistance.
In
addition,
can
trigger
responses
microbiota
dysbiosis
directly
binding
G-protein-coupled
receptors
(GPCRs).
Hence,
diet-gut
microbiota-epigenetics
may
play
role
However,
their
complex
relationships
with
diseases
remain
largely
unknown
require
further
investigation.
This
review
aimed
elaborate
on
interactions
among
diet,
microbiota,
epigenetics
uncover
mechanisms
therapeutics
Cells,
Год журнала:
2022,
Номер
11(16), С. 2518 - 2518
Опубликована: Авг. 13, 2022
Mitochondria
are
not
only
the
main
energy
supplier
but
also
cell
metabolic
center
regulating
multiple
key
metaborates
that
play
pivotal
roles
in
epigenetics
regulation.
These
metabolites
include
acetyl-CoA,
α-ketoglutarate
(α-KG),
S-adenosyl
methionine
(SAM),
NAD+,
and
O-linked
beta-N-acetylglucosamine
(O-GlcNAc),
which
substrates
for
DNA
methylation
histone
post-translation
modifications,
essential
gene
transcriptional
regulation
fate
determination.
Tumorigenesis
is
attributed
to
many
factors,
including
mutations
tumor
microenvironment.
initiation,
evolution,
metastasis,
recurrence.
Targeting
mitochondrial
metabolism
promising
therapeutic
strategies
treatment.
In
this
review,
we
summarize
of
mitochondria
required
modification
discuss
current
strategy
cancer
therapies
via
targeting
epigenetic
modifiers
related
enzymes
This
review
an
important
contribution
understanding
metabolic-epigenetic-tumorigenesis
concept.
Frontiers in Genetics,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 23, 2022
Whether
under
anaerobic
or
aerobic
conditions,
glycolysis
results
in
production
of
lactate.
Increasing
evidence
suggests
that
lactate
serves
as
a
multifunctional
signaling
molecule
develops
non-metabolic
activities
addition
to
serving
key
metabolite
link
and
oxidative
phosphorylation.
Histone
posttranslational
modification
patterns
(HPTMs)
are
essential
epigenetic
processes
controlling
variety
biological
activities.
Proteomics
based
on
mass
spectrometry
(MS)
has
been
used
progressively
reveal
new
HPTMs.
Recent
discoveries
histone
lactylation
mediated
by
subsequent
research
demonstrating
its
involvement
cancer,
inflammation,
lung
fibrosis,
other
conditions
suggest
it
plays
significant
role
immune
regulation
homeostasis
maintenance.
This
review
provides
brief
overview
the
complicated
control
both
pathological
physiological
conditions.
Cell Proliferation,
Год журнала:
2023,
Номер
56(10)
Опубликована: Апрель 14, 2023
Lactate
is
not
only
an
endpoint
of
glycolysis
but
gradually
being
discovered
to
play
the
role
a
universal
metabolic
fuel
for
energy
via
'lactate
shuttle'
moving
between
cells
and
transmitting
signals.
The
glycolytic-dependent
metabolism
found
in
tumours
fast-growing
has
made
lactate
pivotal
player
reprogramming,
which
enables
obtain
abundant
short
time.
Moreover,
can
provide
favourable
conditions
tumorigenesis
by
shaping
acidic
tumour
microenvironment,
recruiting
immune
cells,
etc.
recently
lactate-induced
lactylation
moves
even
further
on
pro-tumorigenesis
mechanisms
production,
circulation
utilization.
As
with
other
epigenetic
modifications,
modify
histone
proteins
alter
spatial
configuration
chromatin,
affect
DNA
accessibility
regulate
expression
corresponding
genes.
What's
more,
degree
inseparable
from
spatialized
concentration,
builds
bridge
epigenetics
reprogramming.
Here,
we
review
important
summarize
latest
finding
try
explore
therapeutic
strategies
oncotherapy
that
kill
two
birds
one
stone.
Cell Death and Disease,
Год журнала:
2023,
Номер
14(2)
Опубликована: Фев. 11, 2023
Abstract
Sepsis
is
a
life-threatening
disorder
disease
defined
as
infection-induced
dysregulated
immune
responses
and
multiple
organ
dysfunction.
The
imbalance
between
hyperinflammation
immunosuppression
crucial
feature
of
sepsis
immunity.
Epigenetic
modifications,
including
histone
DNA
methylation,
chromatin
remodeling,
non-coding
RNA,
play
essential
roles
in
regulating
immunity
through
epi-information
independent
the
sequence.
In
recent
years,
mechanisms
modification
have
received
increasing
attention,
with
ongoing
discoveries
novel
types
modifications.
Due
to
capacity
for
prolonged
effects
on
cells,
modifications
can
induce
cell
reprogramming
participate
long-term
immunosuppressed
state
sepsis.
Herein,
we
systematically
review
current
involved
regulation
sepsis,
summarize
their
role
from
an
perspective
provide
potential
therapeutic
opportunities
targeting
treatment.
Translational Oncology,
Год журнала:
2023,
Номер
39, С. 101821 - 101821
Опубликована: Ноя. 4, 2023
Cancer
heterogeneity
and
drug
resistance
remain
pivotal
obstacles
in
effective
cancer
treatment
management.
One
major
contributor
to
these
challenges
is
epigenetic
modifications
-
gene
regulation
that
does
not
involve
changes
the
DNA
sequence
itself
but
significantly
impacts
expression.
As
we
elucidate
phenomena,
underscore
role
of
regulating
expression,
contributing
cellular
diversity,
driving
adaptive
can
instigate
therapeutic
resistance.
This
review
dissects
essential
methylation,
histone
modifications,
chromatin
remodeling
illustrating
their
significant
yet
complex
contributions
biology.
While
offer
potential
avenues
for
intervention
due
reversible
nature,
interplay
genetic
cells
presents
unique
must
be
addressed
harness
full
potential.
By
critically
analyzing
current
research
landscape,
identify
knowledge
gaps
propose
future
directions,
exploring
therapies
discussing
translating
concepts
into
treatments.
comprehensive
aims
stimulate
further
aid
developing
innovative,
patient-centered
therapies.
Understanding
critical
scientific
advancement
paves
way
towards
improving
patient
outcomes
fight
against
this
formidable
disease.
Cancers,
Год журнала:
2025,
Номер
17(1), С. 154 - 154
Опубликована: Янв. 6, 2025
Inflammation
plays
a
crucial
role
in
wound
healing
and
the
host
immune
response
following
pathogenic
invasion.
However,
unresolved
chronic
inflammation
can
result
tissue
fibrosis
genetic
alterations
that
contribute
to
pathogenesis
of
human
diseases
such
as
cancer.
Recent
scientific
advancements
exploring
underlying
mechanisms
malignant
cellular
transformations
cancer
progression
have
exposed
significant
disparities
between
pediatric
adult-onset
cancers.
For
instance,
cancers
tend
lower
mutational
burdens
arise
actively
developing
tissues,
where
cell-cycle
dysregulation
leads
gene,
chromosomal,
fusion
gene
development
not
seen
counterparts.
As
such,
findings
adult
cannot
be
directly
applied
cancers,
unique
mutations
inherent
etiologies
remain
poorly
understood.
Here,
we
review
processes
chromosomal
instability,
tumor
microenvironment,
tumorigenesis
transformation
explore
current
therapeutic
interventions
maintain
and/or
restore
inflammatory
homeostasis.
