Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning

iScience, Год журнала: 2020, Номер 23(6), С. 101199 - 101199

Опубликована: Май 23, 2020

The human gut microbiome is a complex ecosystem that both affects and affected by its host status. Previous metagenomic analyses of microflora revealed associations between specific microbes age. Nonetheless there was no reliable way to tell host's age based on the community composition. Here we developed method predicting hosts' taxonomic profiles using cross-study dataset deep learning. Our best model has an architecture neural network achieves mean absolute error 5.91 years when tested external data. We further advance procedure for inferring role particular during aging defining them as potential biomarkers. described intestinal clock represents unique quantitative provides starting point building succession into single narrative.

Язык: Английский

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Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Май 13, 2023

Abstract In the past period, due to rapid development of next-generation sequencing technology, accumulating evidence has clarified complex role human microbiota in cancer and therapeutic response. More importantly, available seems indicate that modulating composition gut improve efficacy anti-cancer drugs may be feasible. However, intricate complexities exist, a deep comprehensive understanding how interacts with is critical realize its full potential treatment. The purpose this review summarize initial clues on molecular mechanisms regarding mutual effects between development, highlight relationship microbes immunotherapy, chemotherapy, radiation therapy surgery, which provide insights into formulation individualized strategies for management. addition, current emerging microbial interventions as well their clinical applications are summarized. Although many challenges remain now, great importance cannot overstated strategies, it necessary explore holistic approach incorporates modulation cancer.

Язык: Английский

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Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry

Microorganisms, Год журнала: 2022, Номер 10(2), С. 395 - 395

Опубликована: Фев. 8, 2022

The gut microbiota has been designated as a hidden metabolic 'organ' because of its enormous impact on host metabolism, physiology, nutrition, and immune function. connection between the intestinal their respective animals is dynamic and, in general, mutually beneficial. This complicated interaction seen determinant health disease; thus, dysbiosis linked with several diseases. Therefore, tractable strategies targeting regulation can control diseases that are closely related to inflammatory disorders. As result, animal performance improved. One these dietary supplementation prebiotics, probiotics, phytogenic substances. These supplements exert effects indirectly through manipulation quality improvement epithelial barrier. Several substances, such berberine, resveratrol, curcumin, carvacrol, thymol, isoflavones hydrolyzed fibers, have identified potential may also act welcome means reduce usage antibiotics feedstock, including poultry farming, microbiome. In addition, compounds improve integrity tight junctions by controlling junction-related proteins signaling pathways animals. this review, we discuss role substances optimizing function poultry.

Язык: Английский

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Involvement of Probiotics and Postbiotics in the Immune System Modulation

Biologics, Год журнала: 2021, Номер 1(2), С. 89 - 110

Опубликована: Июль 6, 2021

Intestinal microbiota interacts with other systems, especially the immune system, which is responsible for protecting body by recognizing “stranger” (pathogen associated molecular patterns-PAMPs) and “danger” (damage-associated patterns-DAMPs) motifs. In this manner, it plays an important role in pathogenesis of various diseases health. Despite use probiotics that modulate intestinal providing health benefits treatment diseases, there are some possible concerns about possibility developing adverse effects, people suppressed systems. Since provide bioactive compounds, studies carried out on products containing non-living probiotic microorganisms (paraprobiotics) and/or their metabolites (postbiotics) instead products. It even reported these microbial compounds have more immunomodulatory activities than living via mechanism eliminates disadvantages probiotics. Considering increasing functional foods disease, further needed respect to advantages parabiotic postbiotic food pharmaceutical industry as well system modulation. Although been extensive studied a long time, seems postbiotics promising tools future research applications according recent literature. This review aimed evaluate interaction systems also area food-pharmaceutical

Язык: Английский

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The causal role of gut microbiota in development of osteoarthritis

Osteoarthritis and Cartilage, Год журнала: 2021, Номер 29(12), С. 1741 - 1750

Опубликована: Авг. 21, 2021

Язык: Английский

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Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Май 9, 2022

Abstract The gut microbiota has been linked to many cancers, yet its role in acute myeloid leukaemia (AML) progression remains unclear. Here, we show decreased diversity the of AML patients or murine models. Gut dysbiosis induced by antibiotic treatment accelerates while faecal transplantation reverses this process. Butyrate produced (especially Faecalibacterium ) significantly decreases faeces patients, gavage with butyrate postpones progression. Furthermore, find intestinal barrier is damaged mice AML, which lipopolysaccharide (LPS) leakage into blood. increased LPS exacerbates vitro and vivo. can repair damage inhibit absorption mice. Collectively, demonstrate that promotes a metabolite-dependent manner targeting might provide therapeutic option for AML.

Язык: Английский

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Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1222 - 1222

Опубликована: Янв. 22, 2022

Actions of symbiotic gut microbiota are in dynamic balance with the host’s organism to maintain homeostasis. Many different factors have an impact on this relationship, including bacterial metabolites. Several substrates for their synthesis been established, tryptophan, exogenous amino acid. biological processes influenced by action tryptophan and its endogenous metabolites, serotonin, melatonin. Recent research findings also provide evidence that bacteria-derived metabolites share effects precursor. Thus, review aims investigate actions indole-3-propionic acid (IPA), a microbiota-derived metabolite tryptophan. We searched PUBMED Google Scholar databases identify pre-clinical clinical studies evaluating IPA health pathophysiology immune, nervous, gastrointestinal cardiovascular system mammals. exhibits similar energetic precursor, Additionally, has positive cellular level, preventing oxidative stress injury, lipoperoxidation inhibiting proinflammatory cytokines. Its can be diminished presence risk atherosclerosis. On other hand, protective factors, such as introduction Mediterranean diet, tend increase plasma concentration. seems promising new target, linking system.

Язык: Английский

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Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

Biomedicines, Год журнала: 2023, Номер 11(2), С. 294 - 294

Опубликована: Янв. 20, 2023

Gut microbes and their metabolites are actively involved in the development regulation of host immunity, which can influence disease susceptibility. Herein, we review most recent research advancements gut microbiota–immune axis. We discuss detail how microbiota is a tipping point for neonatal immune as indicated by newly uncovered phenomenon, such maternal imprinting, utero intestinal metabolome, weaning reaction. describe shapes both innate adaptive immunity with emphasis on short-chain fatty acids secondary bile acids. also comprehensively delineate disruption axis results immune-mediated diseases, gastrointestinal infections, inflammatory bowel cardiometabolic disorders (e.g., cardiovascular diabetes, hypertension), autoimmunity rheumatoid arthritis), hypersensitivity asthma allergies), psychological anxiety), cancer colorectal hepatic). further encompass role fecal transplantation, probiotics, prebiotics, dietary polyphenols reshaping therapeutic potential. Continuing, examine modulates therapies, including checkpoint inhibitors, JAK anti-TNF therapies. lastly mention current challenges metagenomics, germ-free models, recapitulation to achieve fundamental understanding regulates immunity. Altogether, this proposes improving immunotherapy efficacy from perspective microbiome-targeted interventions.

Язык: Английский

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Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 153, С. 113290 - 113290

Опубликована: Июнь 17, 2022

The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), is a severe burden in human society owing to the ensuing high morbidity mortality. Various factors linked disorders, particularly environmental (such as diet gut microbiota) epigenetic modifications, contribute progression diseases. Dietary components habits regulate alterations microbiota; turn, microbiota-derived metabolites, such short-chain acids (SCFAs), are influenced by diet. Interestingly, diet-derived microbial metabolites appear produce substrates enzymatic regulators for modifications DNA methylation, histone non-coding RNA expression). Epigenetic changes mediated participate disorders via intestinal permeability, immune responses, inflammatory reactions, insulin resistance. In addition, can trigger responses microbiota dysbiosis directly binding G-protein-coupled receptors (GPCRs). Hence, diet-gut microbiota-epigenetics may play role However, their complex relationships with diseases remain largely unknown require further investigation. This review aimed elaborate on interactions among diet, microbiota, epigenetics uncover mechanisms therapeutics

Язык: Английский

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Interactive Relationships between Intestinal Flora and Bile Acids

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(15), С. 8343 - 8343

Опубликована: Июль 28, 2022

The digestive tract is replete with complex and diverse microbial communities that are important for the regulation of multiple pathophysiological processes in humans animals, particularly those involved maintenance intestinal homeostasis, immunity, inflammation, tumorigenesis. diversity bile acids a result joint efforts host microflora. There bidirectional relationship between community that, while flora tightly modulates metabolism synthesis acids, acid pool composition affect homeostasis flora. Homeostatic imbalances systems may lead to development variety diseases, such as inflammatory bowel disease (IBD), colorectal cancer (CRC), hepatocellular carcinoma (HCC), type 2 diabetes (T2DM), polycystic ovary syndrome (PCOS). interactions be (in)directly pathogenesis these diseases.

Язык: Английский

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