Association between gut microbiota and onset of type 2 diabetes mellitus: a two-sample Mendelian randomization study

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Март 26, 2024

Aim Mendelian randomization (MR) analysis has been used in the exploration of role gut microbiota (GM) type 2 diabetes mellitus (T2DM); however, it was limited to genus level. This study herein aims investigate relationship GM, especially at species level, with T2DM order provide some evidence for further more specific GM taxa and pathway abundance T2DM. Methods two-sample MR based on summary statistics from available genome-wide association (GWAS) meta-analysis conducted by MiBioGen consortium as well Dutch Microbiome Project (DMP), whereas were obtained FinnGen released data. Inverse variance weighted (IVW), MR-Egger, strength test ( F ), median methods examine causal between onset Cochran’s Q employed quantify heterogeneity instrumental variables. Bonferroni’s correction correct bias multiple testing. We also performed reverse causality analysis. Results The corrected IVW estimates suggested increased relative family Oxalobacteraceae (OR = 1.0704) Oxalobacter 1.0874), respectively, associated higher odds T2DM, while that faecis 0.9460) had a negative relationships class Betaproteobacteria , Lactobacillaceae finegoldii longum significant according results (all P < 0.05). Conclusions potential . Further studies are still needed clarify certain contradictory previous findings.

Язык: Английский

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Prevalence of diabetes and prediabetes in South Asian countries: a systematic review and meta-analysis

Deleted Journal, Год журнала: 2025, Номер 22(1)

Опубликована: Янв. 31, 2025

South Asia is observing an epidemiological transition from communicable to non-communicable diseases where diabetes important marker. In this study, we estimate the overall prevalence of and prediabetes in Asian countries. A systematic literature review meta-analysis performed Bangladesh, India, Nepal, Pakistan, Sri Lanka, Bhutan, Maldives, Afghanistan using studies based on only nationally representative surveys published 2012 until June 2024. The quality included articles was assessed Newcastle–Ottawa Scale. Both random-effect (Der Simonian-Laird inverse variance) fixed-effect models were used perform meta-analyses followed by meta-regression. We identified 64 for 14 prediabetes, covering a total 4,613,487 156,407 participants, respectively. Overall, pooled 8.56% (95% CI 5.73–11.91; I2 = 99.99%) 18.99% 12.74–26.6; 99.87%), respectively, with high heterogeneity observed among models. also found that clinical methods higher than self-reported measures. analyses revealed throughout study period significantly elevated. This necessitates establishment comprehensive guidelines Asians mitigate escalating prediabetes.

Язык: Английский

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Prognostic implications of system inflammation response index in atrial fibrillation patients with type 2 diabetes mellitus

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 6, 2025

Systemic inflammation plays a crucial role in the pathogenesis and prognosis of diabetes cardiovascular diseases. System response index (SIRI), is an emerging biomarker designed to assess extent systemic inflammation. We aimed delineate prognostic significance SIRI patients with both AF type 2 mellitus (T2DM). Utilizing Medical Information Mart for Intensive Care IV (MIMIC-IV) (v2.2) repository, subjects divided into three groups based on index. The primary endpoint our study was all-cause mortality during hospitalization, one-year serving as secondary endpoint. A cohort 2054 T2DM participated. COX regression analysis revealed elevated levels independent risk factor in-hospital 1-year mortality. 192 died 265 follow-up 1 year. When treating continuous variable, higher significantly associated increased [hazard ratio (HR) 1.015, 95%CI 1.010–1.020, P = 0.015] (HR 1. 016, 1.008–1.015, 0.012). Additionally, compared lowest tertiles SIRI, those highest possessed after multivariable adjustment, this relationship remained pronounced [in-hospital (HR: 1.863, 95% CI 1.189–2.918, 0.007); 2.143, 1.621–2.831, < 0.001)]. Our RCS analyses indicated linear association between (p-value non-linear 0.001). In T2DM, high predictor poor survival may be helpful patient's stratification.

Язык: Английский

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Global trends in the incidence of hospital admissions for diabetes-related foot disease and amputations: a review of national rates in the 21st century

Diabetologia, Год журнала: 2022, Номер 66(2), С. 267 - 287

Опубликована: Дек. 13, 2022

Язык: Английский

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Chinese and Global Burdens of Gastrointestinal Cancers From 1990 to 2019

Frontiers in Public Health, Год журнала: 2022, Номер 10

Опубликована: Июль 13, 2022

Gastrointestinal (GI) cancers are an important component of the tumor. This study aimed to investigate burden six major GI in China and globally from 1990 2019.We conducted a cross-sectional based on Global Burden Disease Study (GBD) 2019. Indicators incidence, deaths, disability-adjusted life-years (DALYs), risk factors for esophageal, stomach, liver, pancreatic, colon rectum, gallbladder biliary tract were collected analyzed time trends. The contribution each cancer proportion cases among global further reported.Global incidence cases, death DALYs showed overall ascending trend over past 30 years, but there was temporal geographical variation across types. By 2019, rectum had overtaken stomach as most burdensome globally. However, narrowly continued be China. In addition, increased. It noteworthy that liver has been alleviated significantly.GI remain public health problem Despite geographic diversity different cancers, targeted primary secondary prevention still necessary future face these unknown challenges.

Язык: Английский

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