Focus on the Contribution of Oxidative Stress in Skin Aging

Antioxidants, Год журнала: 2022, Номер 11(6), С. 1121 - 1121

Опубликована: Июнь 6, 2022

Skin aging is one of the most evident signs human aging. Modification skin during life span characterized by fine lines and wrinkling, loss elasticity volume, laxity, rough-textured appearance, pallor. In contrast, photoaged associated with uneven pigmentation (age spot) markedly wrinkled. At cellular molecular level, it consists multiple interconnected processes based on biochemical reactions, genetic programs, occurrence external stimulation. The principal perturbation in driving senescence alteration oxidative balance. chronological aging, reactive oxygen species (ROS) are produced mainly through metabolism adenosine triphosphate (ATP) generation from glucose mitochondrial dysfunction, whereas extrinsic redox equilibrium caused environmental factors, such as ultraviolet radiation, pollution, cigarette smoking, inadequate nutrition. During process, stress attributed to both augmented ROS production reduced levels enzymatic non-enzymatic protectors. Apart appearance structural change, throughout gradually loses its natural functional characteristics regenerative potential. With immune system also undergoes manifested a ability counteract infections frequency autoimmune neoplastic diseases. This review proposes an update role clinical manifestation well mechanisms that underline this phenomenon sometimes accelerated factors.

Язык: Английский

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Evaluating Silymarin Extract as a Potent Antioxidant Supplement in Diazinon-Exposed Rainbow Trout: Oxidative Stress and Biochemical Parameter Analysis

Toxics, Год журнала: 2023, Номер 11(9), С. 737 - 737

Опубликована: Авг. 28, 2023

This study aimed to investigate the effects of diazinon on fish, focusing hepatotoxic biomarkers and potential protective silymarin supplementation. One hundred eighty rainbow trout were randomly assigned four groups: control, exposed (0.1 mg L-1), supplemented (400 kg-1), + silymarin. Blood samples liver tissue collected after 7, 14, 21 days exposure analyze biochemical parameters oxidative biomarkers. Diazinon in fish resulted damage, as indicated by increased antioxidant enzyme activities hepatocytes. Silymarin showed mitigate this damage reducing stress restoring activities. Nevertheless, creatine phosphokinase activity, which may not be normalized Exposure glucose, triglyceride, cholesterol levels, whereas total protein, albumin, globulin levels significantly decreased fish. However, controlled maintained these within normal range. creatinine, urea, uric acid, ammonia contents. could regulate acid while having limited effectiveness excretion. Furthermore, malondialdehyde hepatocytes, administration restore levels. Overall, a therapeutic treatment for mitigating induced but its phosphokinase, glutathione reductase, limited.

Язык: Английский

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Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms

Environmental Pollution, Год журнала: 2023, Номер 338, С. 122694 - 122694

Опубликована: Окт. 4, 2023

Lambda-cyhalothrin, also known as cyhalothrin, is an efficient, broad-spectrum, quick-acting pyrethroid insecticide and acaricide the most powerful in world. However, there increasing evidence that lambda-cyhalothrin closely related to a variety of toxicity drawbacks (hepatotoxicity, nephrotoxicity, neurotoxicity reproductive toxicity, among others) non-target organisms, oxidative stress seems be main mechanism toxicity. This manuscript reviews mitochondrial damage induced by signalling pathways involved this process, indicating occupies important position The antioxidants alleviate discussed. In addition, metabolites major metabolic enzymes reactions are summarized. review article reveals key toxicity-oxidative suggests use effective method for preventing

Язык: Английский

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Thiacloprid impairs honeybee worker learning and memory with inducing neuronal apoptosis and downregulating memory-related genes

The Science of The Total Environment, Год журнала: 2023, Номер 885, С. 163820 - 163820

Опубликована: Май 2, 2023

Язык: Английский

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Remediation technologies for neonicotinoids in contaminated environments: Current state and future prospects

Environment International, Год журнала: 2023, Номер 178, С. 108044 - 108044

Опубликована: Июнь 16, 2023

Neonicotinoids (NEOs) are synthetic insecticides with broad-spectrum insecticidal activity and outstanding efficacy. However, their extensive use persistence in the environment have resulted accumulation biomagnification of NEOs, posing significant risks to non-target organisms humans. This review provides a summary research history, advancements, highlighted topics NEOs remediation technologies mechanisms. Various approaches been developed, including physiochemical, microbial, phytoremediation, microbial physicochemical being most extensively studied. Recent advances physiochemical led development innovative adsorbents, photocatalysts, optimized treatment processes. High-efficiency degrading strains well-characterized metabolic pathways successfully isolated cultured for remediation, while many plant species shown great potential phytoremediation. challenges gaps remain this field. Future should prioritize isolating, domesticating or engineering high efficiency, NEO degradation, as well developing synergistic techniques enhance removal efficiency on multiple varying concentrations different environmental media. Furthermore, shift from pipe-end pollution prevention strategies is needed, green economically efficient alternatives such biological insecticides. Integrated case-specific that can be applied practical projects need along clarifying degradation mechanisms improve efficiency. The successful implementation these will help reduce negative impact human health.

Язык: Английский

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Antitumor Effects of Carrier-Free Functionalized Lignin Materials on Human Hepatocellular Carcinoma (HepG2) Cells

ACS Nano, Год журнала: 2024, Номер 18(5), С. 4329 - 4342

Опубликована: Янв. 23, 2024

Lignin, as an abundant aromatic biopolymer in plants, has great potential for medical applications due to its active sites, antioxidant activity, low biotoxicity, and good biocompatibility. In this work, a simple ecofriendly approach lignin fractionation modification was developed improve the antitumor activity of lignin. The fraction KL-3 obtained by gradient acid precipitation at pH = 9–13 showed cytotoxicity. Furthermore, cell-feeding after additional structural modifications such demethylation (DKL-3), sulfonation (SL-3), demethylsulfonation (DSKL-3) could exhibit higher glutathione responsiveness tumor microenvironment, resulting reactive oxygen species accumulation mitochondrial damage eventually leading apoptosis HepG2 cells with minimal normal cells. IC50 values KL-3, SL-3, DSKL-3 were 0.71, 0.57, 0.41 mg/mL, respectively, which superior those other biomass extractives or unmodified Importantly, vivo experiments conducted nude mouse models demonstrated biosafety effective destruction. This work provides promising example constructing carrier-free functionalized materials different structures inhibiting growth human hepatocellular carcinoma (HepG2) cells, is expected cancer therapy outcomes.

Язык: Английский

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Interactive effects of dinotefuran and Nosema ceranae on the survival status and gut microbial community of honey bees

Pesticide Biochemistry and Physiology, Год журнала: 2024, Номер 200, С. 105808 - 105808

Опубликована: Фев. 1, 2024

Язык: Английский

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Spatiotemporal distribution and fates of neonicotinoid insecticides during the urban water cycle in the lower reaches of the Yangtze River, China

Water Research, Год журнала: 2022, Номер 226, С. 119232 - 119232

Опубликована: Окт. 9, 2022

Язык: Английский

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Mitigation of Imidacloprid Toxicity in Poultry Chicken by Selenium Nanoparticles: Growth Performance, Lipid Peroxidation, and Blood Traits

Biological Trace Element Research, Год журнала: 2023, Номер 201(11), С. 5379 - 5388

Опубликована: Фев. 15, 2023

Abstract Imidacloprid is an insecticide that protects against insects in the agriculture, animal, and poultry production sectors. Since accumulation of imidacloprid induces adverse impacts on general health status quality food chain, this study tested broilers. Besides, selenium nanoparticles were fed to birds relieve negative growth performance status. Birds (1-day age, initial weight 46.05 ± 1.0 g) divided into four groups (triplicates) where 15 chicks each replicate (45 for group). The first group (control) was basal diet without either or toxicity. second nano form at 3 mg/kg. third exposed 1/10 LT 50 (3 mg/kg body weight). fourth mg/kg) All kept under same conditions 35 days. final gain showed marked improvement compared imidacloprid-exposed group, while feed intake conversion ratio markedly reduced. red blood cells higher values than control those imidacloprid. Interestingly, hemoglobulin hematocrit increased with exposure. Furthermore, white total protein, albumin, globulin feeding. had aspartate aminotransferase (AST), alanine (ALT), malondialdehyde levels remaining groups. Accordingly, dietary are suggested broiler cope effects

Язык: Английский

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Chronic larval exposure to thiacloprid impairs honeybee antennal selectivity, learning and memory performances

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Апрель 20, 2023

The use of agricultural neonicotinoid insecticides has sub-lethal chronic effects on bees that are more prevalent than acute toxicity. Among these insecticides, thiacloprid, a commonly used compound with low toxicity, attracted significant attention due to its potential impact the olfactory and learning abilities honeybees. effect larval exposure thiacloprid antennal activity adult honeybees ( Apis mellifera L.) is not yet fully understood. To address this knowledge gap, laboratory-based experiments were conducted in which honeybee larvae administered (0.5 mg/L 1.0 mg/L). Using electroantennography (EAG), impacts selectivity common floral volatiles evaluated. Additionally, odor-related memory also assessed. results study reveal, for first time, decreased antenna EAG responses scents, leading increased high-dose (1.0 mg/L) group compared control (0 vs . mg/L: p = 0.042). suggest negatively affected odor-associated paired acquisition, as well medium-term (1 h) 0.019) long-term (24 0.037) amplitudes dramatically reduced following R-linalool training 0.001; 0 0.5 0.027), while activities only differed significantly between unpaired groups. Our indicated concentrations may affect perception behaviors These findings have important implications safe agrochemicals environment.

Язык: Английский

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