Advances in neurotoxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1121 - 1121
Published: June 6, 2022
Skin aging is one of the most evident signs human aging. Modification skin during life span characterized by fine lines and wrinkling, loss elasticity volume, laxity, rough-textured appearance, pallor. In contrast, photoaged associated with uneven pigmentation (age spot) markedly wrinkled. At cellular molecular level, it consists multiple interconnected processes based on biochemical reactions, genetic programs, occurrence external stimulation. The principal perturbation in driving senescence alteration oxidative balance. chronological aging, reactive oxygen species (ROS) are produced mainly through metabolism adenosine triphosphate (ATP) generation from glucose mitochondrial dysfunction, whereas extrinsic redox equilibrium caused environmental factors, such as ultraviolet radiation, pollution, cigarette smoking, inadequate nutrition. During process, stress attributed to both augmented ROS production reduced levels enzymatic non-enzymatic protectors. Apart appearance structural change, throughout gradually loses its natural functional characteristics regenerative potential. With immune system also undergoes manifested a ability counteract infections frequency autoimmune neoplastic diseases. This review proposes an update role clinical manifestation well mechanisms that underline this phenomenon sometimes accelerated factors.
Language: Английский
Citations
194
Toxics, Journal Year: 2023, Volume and Issue: 11(9), P. 737 - 737
Published: Aug. 28, 2023
This study aimed to investigate the effects of diazinon on fish, focusing hepatotoxic biomarkers and potential protective silymarin supplementation. One hundred eighty rainbow trout were randomly assigned four groups: control, exposed (0.1 mg L-1), supplemented (400 kg-1), + silymarin. Blood samples liver tissue collected after 7, 14, 21 days exposure analyze biochemical parameters oxidative biomarkers. Diazinon in fish resulted damage, as indicated by increased antioxidant enzyme activities hepatocytes. Silymarin showed mitigate this damage reducing stress restoring activities. Nevertheless, creatine phosphokinase activity, which may not be normalized Exposure glucose, triglyceride, cholesterol levels, whereas total protein, albumin, globulin levels significantly decreased fish. However, controlled maintained these within normal range. creatinine, urea, uric acid, ammonia contents. could regulate acid while having limited effectiveness excretion. Furthermore, malondialdehyde hepatocytes, administration restore levels. Overall, a therapeutic treatment for mitigating induced but its phosphokinase, glutathione reductase, limited.
Language: Английский
Citations
38
Environmental Pollution, Journal Year: 2023, Volume and Issue: 338, P. 122694 - 122694
Published: Oct. 4, 2023
Lambda-cyhalothrin, also known as cyhalothrin, is an efficient, broad-spectrum, quick-acting pyrethroid insecticide and acaricide the most powerful in world. However, there increasing evidence that lambda-cyhalothrin closely related to a variety of toxicity drawbacks (hepatotoxicity, nephrotoxicity, neurotoxicity reproductive toxicity, among others) non-target organisms, oxidative stress seems be main mechanism toxicity. This manuscript reviews mitochondrial damage induced by signalling pathways involved this process, indicating occupies important position The antioxidants alleviate discussed. In addition, metabolites major metabolic enzymes reactions are summarized. review article reveals key toxicity-oxidative suggests use effective method for preventing
Language: Английский
Citations
38
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 676 - 676
Published: Jan. 15, 2025
Long non-coding RNAs (lncRNAs) are emerging as critical regulators in honeybee physiology, influencing development, behavior, and stress responses. This study investigates the role of lncRNA LOC113219358 immune response neurophysiological regulation Apis mellifera brains. Using RNA interference (RNAi) sequencing (RNA-seq), we demonstrate that silencing lncLOC113219358 significantly alters expression 162 mRNA transcripts, including genes associated with detoxification, energy metabolism, neuronal signaling. Functional enrichment analysis revealed involvement neuropeptide signaling, ATP synthesis, oxidative phosphorylation pathways. Acetylcholinesterase (AChE), Glutathione-S-transferase (GST) cytochrome P450 (CYP450) activities were downregulated 48 h RNAi treatment. Additionally, pull-down assays identified 113 proteins interacting lncLOC113219358, synthase subunits, heat shock proteins, major royal jelly suggesting its cellular responses neural activity modulation. These findings provide mechanistic insights into how mediates to environmental stressors, contributing our understanding lncRNA-regulated functions pollinators.
Language: Английский
Citations
1
Water Research, Journal Year: 2022, Volume and Issue: 226, P. 119232 - 119232
Published: Oct. 9, 2022
Language: Английский
Citations
30
The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 885, P. 163820 - 163820
Published: May 2, 2023
Language: Английский
Citations
23
Environment International, Journal Year: 2023, Volume and Issue: 178, P. 108044 - 108044
Published: June 16, 2023
Neonicotinoids (NEOs) are synthetic insecticides with broad-spectrum insecticidal activity and outstanding efficacy. However, their extensive use persistence in the environment have resulted accumulation biomagnification of NEOs, posing significant risks to non-target organisms humans. This review provides a summary research history, advancements, highlighted topics NEOs remediation technologies mechanisms. Various approaches been developed, including physiochemical, microbial, phytoremediation, microbial physicochemical being most extensively studied. Recent advances physiochemical led development innovative adsorbents, photocatalysts, optimized treatment processes. High-efficiency degrading strains well-characterized metabolic pathways successfully isolated cultured for remediation, while many plant species shown great potential phytoremediation. challenges gaps remain this field. Future should prioritize isolating, domesticating or engineering high efficiency, NEO degradation, as well developing synergistic techniques enhance removal efficiency on multiple varying concentrations different environmental media. Furthermore, shift from pipe-end pollution prevention strategies is needed, green economically efficient alternatives such biological insecticides. Integrated case-specific that can be applied practical projects need along clarifying degradation mechanisms improve efficiency. The successful implementation these will help reduce negative impact human health.
Language: Английский
Citations
23
ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 4329 - 4342
Published: Jan. 23, 2024
Lignin, as an abundant aromatic biopolymer in plants, has great potential for medical applications due to its active sites, antioxidant activity, low biotoxicity, and good biocompatibility. In this work, a simple ecofriendly approach lignin fractionation modification was developed improve the antitumor activity of lignin. The fraction KL-3 obtained by gradient acid precipitation at pH = 9–13 showed cytotoxicity. Furthermore, cell-feeding after additional structural modifications such demethylation (DKL-3), sulfonation (SL-3), demethylsulfonation (DSKL-3) could exhibit higher glutathione responsiveness tumor microenvironment, resulting reactive oxygen species accumulation mitochondrial damage eventually leading apoptosis HepG2 cells with minimal normal cells. IC50 values KL-3, SL-3, DSKL-3 were 0.71, 0.57, 0.41 mg/mL, respectively, which superior those other biomass extractives or unmodified Importantly, vivo experiments conducted nude mouse models demonstrated biosafety effective destruction. This work provides promising example constructing carrier-free functionalized materials different structures inhibiting growth human hepatocellular carcinoma (HepG2) cells, is expected cancer therapy outcomes.
Language: Английский
Citations
7
Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 200, P. 105808 - 105808
Published: Feb. 1, 2024
Language: Английский
Citations
7
Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 104606 - 104606
Published: Dec. 1, 2024
Neonicotinoid insecticides (NNIs) are the fastest-growing class in agricultural protection. They target nicotinic acetylcholine receptors (nAChR) pests, stimulating nervous system at low doses and causing paralysis death higher concentrations. NNIs used crop protection, seed treatment, forestry, agriculture, flea control domestic cattle. Effective lower concentrations offering long-term control, favoured for their systemic activity. However, due to water solubility, mobility, moderate persistence, easily contaminate adjacent aquatic environments via runoff, leaching, or spray drift. While less toxic vertebrates, widespread use poses threats terrestrial organisms, neurotoxicity, nephrotoxicity, cytotoxicity, genotoxicity, immunotoxicity, hepatotoxicity, endocrine disruption, reproductive malformations. This review synthesizes research address knowledge gaps on environmental impact of proposes policies mitigate harmful effects non-target species.
Language: Английский
Citations
7