Death Studies,
Год журнала:
2022,
Номер
47(5), С. 618 - 623
Опубликована: Авг. 8, 2022
Cannabis
use
has
been
indicated
as
a
risk
factor
for
suicide
in
veterans.
This
study
of
Gulf
War
veterans
tested
the
relationship
between
self-report
past
year
cannabis
and
(a)
suicidal
ideation
(b)
behavior.
Data
were
from
national
sample
(N
=
1126)
Logistic
regression
models
was
associated
with
elevated
behavior,
independent
key
covariates.
In
corroboration
research
on
other
military
populations,
this
indicates
potentially
concerning
association
Frontiers in Public Health,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 5, 2024
Background
There
are
well-established
literatures
documenting
the
associations
between
mental
disorders
and
unhealthy
behaviors
such
as
poor
diet
quality,
sedentary
behavior,
cannabis
tobacco
use.
Few
studies
have
attempted
to
understand
respective
findings
in
light
of
each
other,
however.
Objective
The
purpose
this
review
was
assemble
comparable
data
for
behavior-disorder
association
assess
terms
their
overall
strength.
aimed
include
a
representative,
but
not
exhaustive,
range
that
would
allow
explorative
comparisons.
Methods
Eligible
were
identified
via
Pubmed
searches
citation
searching,
restricted
publications
no
older
than
2015
written
English.
To
obtain
data,
only
reported
odds
ratios
included,
risk
bias
related
study
samples,
behavioral
measurement
disparities,
control
variables
assessed
sensitivity
analyses.
Findings
disorder
compared
on
basis
different
measures
central
tendency.
Results
From
3,682
records,
294
included.
found
evidence
four
psychosis,
depression,
anxiety,
bipolar
disorder,
attention-deficit/hyperactivity
(ADHD),
post-traumatic
stress
(PTSD),
while
personality
investigated
relation
In
comparison,
generally
similar
strength,
use
exceptional
being
significantly
stronger
its
counterparts
across
behaviors.
Analyses
some
influence
from
disparities
lack
adequate
statistical
control,
robust
Conclusion
This
comparative
about
equally
strongly
associated
with
disorders.
Given
general
nature
these
associations,
we
should
probably
them
reflect
shared
etiology.
However,
be
regarded
tentative
until
confirmed
by
more
comprehensive
investigations.
Cannabis and Cannabinoid Research,
Год журнала:
2024,
Номер
9(4), С. 1015 - 1027
Опубликована: Янв. 22, 2024
Objective:
Δ9-tetrahydrocannabinol
(THC)
and
cannabidiol
(CBD)
have
varying
pharmacological
actions
with
differential
effects
on
acute
extended
affective
states,
incuding
anxiety.
We
aimed
to
study
these
anxiety
in
legal
market
forms
of
cannabis.
Method:
This
makes
use
a
nonequivalent
control
group
quasiexperimental
design.
Forty-two
participants
symptions
who
were
not
using
cannabis
compared
258
symptoms
used
flower
(∼3–4
times
per
week).
Participants
randomly
assigned
one
three
conditions;
THC-dominant
(24%
THC,
<1%
CBD),
THC+CBD
(12%
12%
or
CBD-dominant
(<1%
24%
CBD).
Changes
over
4-weeks
measured
by
the
Patient
Global
Impression
Change
(PGIC)
scale
Depression,
Anxiety,
Stress
Scale
(DASS).
Acute
changes
subjective
mood
immediately
after
Profile
Mood
States
(POMS)
Elation,
Tension,
Paranoia
subscales
Addiction
Research
Center
Inventory
intoxication
scale.
Results:
While
all
reported
reductions
4-week
PGIC
(F=30.65,
p<0.001)
DASS
measures
(F=115.88,
p<0.001),
ad
libitum
was
associated
lower
scores
subscale
when
accounting
for
frequency
(difference=−1.03,
SE=0.45,
p=0.02).
Similarly,
POMS
tension
paranoia
(POMS
tension:
vs.
THC-dominant:
difference=−0.41
SE=0.1,
p<0.001;
THC+CBD:
difference=−0.28,
SE=0.07,
p=0.04;
paranoia:
difference=−0.49,
difference=−0.33,
SE=0.09,
p=0.01).
conditions
experienced
positive
drug
effects.
Conclusions:
provides
novel
information
impacts
ratios
THC
CBD
indviduals
symptoms.
Findings
suggest
that
did
increase
reduction
may
translate
longer-term
Clinical
Trial
Registration:
NCT03491384.
Glia,
Год журнала:
2022,
Номер
71(1), С. 103 - 126
Опубликована: Март 30, 2022
The
discovery
of
cannabinoid
receptors
as
the
primary
molecular
targets
psychotropic
Δ9
-tetrahydrocannabinol
(Δ9
-THC)
in
late
1980s
paved
way
for
investigations
on
effects
cannabis-based
therapeutics
brain
pathology.
Ever
since,
a
wealth
results
obtained
from
studies
human
tissue
samples
and
animal
models
have
highlighted
promising
therapeutic
potential
cannabinoids
endocannabinoids
variety
neurological
disorders.
However,
clinical
success
has
been
limited
major
questions
concerning
endocannabinoid
signaling
need
to
be
satisfactorily
addressed,
particularly
with
regard
their
role
modulators
glial
cells
neurodegenerative
diseases.
Indeed,
recent
brought
into
limelight
diverse,
often
unexpected
functions
astrocytes,
oligodendrocytes,
microglia
injury
disease,
thus
providing
scientific
basis
targeting
treat
This
Review
summarizes
current
knowledge
cellular
hallmarks
its
relevance
chronic
inflammatory
Addictive Behaviors,
Год журнала:
2023,
Номер
144, С. 107757 - 107757
Опубликована: Май 21, 2023
Emotion
dysregulation
(ED)
is
a
transdiagnostic
variable
that
accounts
for
the
onset
and
maintenance
of
mental
health
disorders.
The
interplay
between
ED,
cannabis
use
has
not
been
appraised
in
young
adult
population
whether
there
are
sex-dependent
effects
yet
to
be
examined.
This
study
looked
at
ED
mediates
association
past-month
health,
while
considering
sex
as
moderator.2,762
(64.2%
women)
undergraduate
Spanish
students
completed
an
online
battery.
Among
others,
they
fulfilled
Depression
Anxiety
Stress
Scale-21
(DASS-21)
Difficulties
Regulation
Scale
(DERS-28).
A
two-way
ANOVA
assessed
on
participants'
DASS-21
scores.
set
moderated
mediations
tested
indirect
effect
through
DERS
differed
by
sex.Past-month
female
users
showed
higher
levels
depression,
anxiety
stress
(M
=
51.10,
SD
26.72)
than
did
men
[(M
33.76,
20.31);
F(1,
2758)
5.119,
p
=.024,
η2p
=.002].
In
adults
only,
was
mediated
(total
score),
non-acceptance
emotional
responses,
lack
control,
difficulties
engaging
goal-directed
behavior,
clarity
(all
p's
<
0.005)
CONCLUSIONS:
Findings
indicate
importance
assessment
intervention
practices.
Interventions
targeting
may
particularly
effective
users.
Frontiers in Psychiatry,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 14, 2022
The
endocannabinoid
system
(ECS)
is
composed
of
the
two
canonical
receptor
subtypes;
type-1
cannabinoid
(CB1R)
and
type
2
(CB2R),
endocannabinoids
(eCBs)
enzymes
responsible
for
synthesis
degradation
eCBs.
Recently,
with
identification
additional
lipid
mediators,
receptors,
expanded
ECS
called
endocannabinoidome
(eCBome)
has
been
identified
recognized.
Activation
CB1R
associated
a
plethora
physiological
effects
some
central
nervous
(CNS)
side
effects,
whereas,
CB2R
activation
devoid
such
hence
CB2Rs
might
be
utilized
as
potential
new
targets
treatment
different
disorders
including
neuropsychiatric
disorders.
Previous
studies
suggested
that
were
absent
in
brain
they
considered
peripheral
however,
recent
confirmed
presence
regions.
Several
have
now
focused
on
characterization
its
pathological
roles.
Studies
done
role
therapeutic
target
treating
revealed
important
putative
requires
further
clinical
validation.
Here
we
provide
current
insights
knowledge
targeting
neurodegenerative
Its
non-psychoactive
effect
makes
CNS
disorders;
better
understanding
fundamental
pharmacology
essential
design
novel
strategies.
