Pueraria lobata-derived exosome-like nanovesicles alleviate osteoporosis by enhacning autophagy DOI Creative Commons

Weiqiang Zhan,

Mingzhu Deng, Xinqia Huang

и другие.

Journal of Controlled Release, Год журнала: 2023, Номер 364, С. 644 - 653

Опубликована: Ноя. 16, 2023

Osteoporosis (OP) is the most common bone disorder worldwide, especially in postmenopausal women. However, many OP drugs are not suitable for long term use due to major adverse effects. Therefore, there an urgent need identify more effective and safe therapeutic drugs. Pueraria lobata has been reported promote osteoblast growth regeneration, but exact mechanisms still further exploration. The current study found that lobata-derived exosome-like nanovesicles (PELNs) promoting primary human mesenchymal stem cells (hBMSCs) differentiation mineralization both vitro ovariectomized (OVX)-induced osteoporotic rats. Interestingly, relative abundance of harmful strains significantly decreased intestine osteoporosis SD rat model administrated PELNs via regulation trimethylamine-N-oxide (TMAO), a metabolite gut microbiota. Moreover, RNA sequencing revealed osteogenic activity autophagy signaling. In vivo experiments also showed treatment with promoted function hBMSCs by elevating degradation TMAO. Collectively, demonstrate promise as approach OP, TMAO emerging potential target treatment.

Язык: Английский

Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota DOI Creative Commons

Jinli Huang,

Juan Zhang, Xingzhi Wang

и другие.

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Фев. 22, 2022

Allergy is a hypersensitivity reaction triggered by specific cell or antibody-mediated immune mechanisms. Allergies have increased in industrialized countries recent decades. The rise allergic respiratory diseases such as rhinitis (AR) and asthma (AA) potential threat to public health. Searches were conducted using PubMed, Google Scholar Medline the following key terms: OR AND probiotics, airway inflammation disorders, probiotics gut microbiota disease, inflammatory. Studies from all years included, specifically those published within last 10 years. Some review articles their reference lists searched identify related articles. role of has attracted more attention. Pieces evidence suggested that development causes possible imbalance composition microbiota. Compared colonized mice, germ-free mice exhibit exaggerated responses, suggesting microbial host interactions play an important diseases. Probiotics modulate both innate adaptive inflammatory often used dietary supplements provide health benefits gastrointestinal disorders. may serve immunomodulators activators defense pathways. Besides, oral can response system. Recently, studies humans animals demonstrated probiotic RA AA. To understand characterization, microbiota, intervention AA/AR, this provides overview clinical features AA AR, for prevention treatment AA, changes mechanisms action.

Язык: Английский

Процитировано

50
Gut microbiota supports male reproduction via nutrition, immunity, and signaling DOI Creative Commons
Hui Cai,

Xuanhong Cao,

Dezhe Qin

и другие.

Frontiers in Microbiology, Год журнала: 2022, Номер 13

Опубликована: Авг. 18, 2022

Gut microbiota (GM) is a major component of the gastrointestinal tract. Growing evidence suggests that it has various effects on many distal organs including male reproductive system in mammals. GM and testis form gut-testis axis involving production key molecules through microbial metabolism or de novo synthesis. These have nutrition, immunity, hormone-related functions promote via circulatory system. helps maintain integral structure testes regulates testicular immunity to protect spermatogenic environment. Factors damaging negatively impact function, however, related mechanism unknown. Also, correlation between remains be yet investigated. This review discusses complex influence highlighting fertility.

Язык: Английский

Процитировано

42
The bridge of the gut–joint axis: Gut microbial metabolites in rheumatoid arthritis DOI Creative Commons
Xiaoyu Xu, Miao Wang, Zikang Wang

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Окт. 6, 2022

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint destruction, synovitis, and pannus formation. Gut microbiota dysbiosis may exert direct pathogenic effects on gut homeostasis. It trigger the host’s innate immune system activate “gut–joint axis”, which exacerbates RA. However, although importance of in development progression RA widely recognized, mechanisms regulating interactions between host remain incompletely defined. In this review, we discuss role microbiota-derived biological mediators, such as short-chain fatty acids, bile tryptophan metabolites, maintaining intestinal barrier integrity, balance bone destruction patients bridge gut–joint axis.

Язык: Английский

Процитировано

41
Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer® and the Role of Microbiota in Regenerative Dentistry. A Systematic Review DOI Creative Commons
Angelo Michele Inchingolo, Assunta Patano, Chiara Di Pede

и другие.

Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(3), С. 132 - 132

Опубликована: Фев. 27, 2023

Different biomaterials, from synthetic products to autologous or heterologous grafts, have been suggested for the preservation and regeneration of bone. The aim this study is evaluate effectiveness tooth as a grafting material examine properties its interactions with bone metabolism. PubMed, Scopus, Cochrane Library, Web Science were searched find articles addressing our topic published 1 January 2012 up 22 November 2022, total 1516 studies identified. Eighteen papers in all considered review qualitative analysis. Demineralized dentin can be used graft material, since it shows high cell compatibility promotes rapid by striking an ideal balance between resorption production; also has several benefits, such quick recovery times, high-quality newly formed bone, low costs, no risk disease transmission, ability performed outpatient procedure, donor-related postoperative complications. Demineralization crucial step treatment process, which includes cleaning, grinding, demineralization. Since presence hydroxyapatite crystals prevents release growth factors, demineralization essential effective regenerative surgery. Even though relationship system dysbiosis not yet fully explored, highlights association gut microbes. creation additional scientific build upon enhance findings should future objective research.

Язык: Английский

Процитировано

35
Pueraria lobata-derived exosome-like nanovesicles alleviate osteoporosis by enhacning autophagy DOI Creative Commons

Weiqiang Zhan,

Mingzhu Deng, Xinqia Huang

и другие.

Journal of Controlled Release, Год журнала: 2023, Номер 364, С. 644 - 653

Опубликована: Ноя. 16, 2023

Osteoporosis (OP) is the most common bone disorder worldwide, especially in postmenopausal women. However, many OP drugs are not suitable for long term use due to major adverse effects. Therefore, there an urgent need identify more effective and safe therapeutic drugs. Pueraria lobata has been reported promote osteoblast growth regeneration, but exact mechanisms still further exploration. The current study found that lobata-derived exosome-like nanovesicles (PELNs) promoting primary human mesenchymal stem cells (hBMSCs) differentiation mineralization both vitro ovariectomized (OVX)-induced osteoporotic rats. Interestingly, relative abundance of harmful strains significantly decreased intestine osteoporosis SD rat model administrated PELNs via regulation trimethylamine-N-oxide (TMAO), a metabolite gut microbiota. Moreover, RNA sequencing revealed osteogenic activity autophagy signaling. In vivo experiments also showed treatment with promoted function hBMSCs by elevating degradation TMAO. Collectively, demonstrate promise as approach OP, TMAO emerging potential target treatment.

Язык: Английский

Процитировано

31