High-Throughput Absolute Quantification Sequencing Revealed Osteoporosis-Related Gut Microbiota Alterations in Han Chinese Elderly

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: April 30, 2021

Objective Accumulative evidence suggests that gut microbiota play an important role in bone remodeling and hence health maintenance. This study aimed to explore the association of with risk osteoporosis identify potential disease-related taxa, which may be promising targets prevention treatment future. Methods Absolute quantification 16S ribosomal RNA gene sequencing was used detect absolute relative abundances 44 patients 64 controls. In combination one our previous studies, a total 175 samples were involved abundance analysis. Results Compared controls, had higher Bacteroidetes phylum, Bacteroides Eisenbergiella genera. The Clostridium_XlVa , Coprococcus Lactobacillus Eggerthella genera increased, Veillonella genus decreased group. As for abundance, Parabacteroides Flavonifractor whereas Raoultella Controlling confounders, associations did not maintain significance. Ridge regression analysis suggested is associated reduced mineral density (BMD) T-score at lumbar spines, Anaerovorax increased BMD femoral neck. Functional predictions revealed 10 Kyoto Encyclopedia Genes Genomes pathways enriched Conclusions Gut compositions contribute osteoporosis. Several specific taxa functional are identified associate density, thus providing epidemiologic aberrant pathogenesis.

Language: Английский

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Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Feb. 22, 2022

Allergy is a hypersensitivity reaction triggered by specific cell or antibody-mediated immune mechanisms. Allergies have increased in industrialized countries recent decades. The rise allergic respiratory diseases such as rhinitis (AR) and asthma (AA) potential threat to public health. Searches were conducted using PubMed, Google Scholar Medline the following key terms: OR AND probiotics, airway inflammation disorders, probiotics gut microbiota disease, inflammatory. Studies from all years included, specifically those published within last 10 years. Some review articles their reference lists searched identify related articles. role of has attracted more attention. Pieces evidence suggested that development causes possible imbalance composition microbiota. Compared colonized mice, germ-free mice exhibit exaggerated responses, suggesting microbial host interactions play an important diseases. Probiotics modulate both innate adaptive inflammatory often used dietary supplements provide health benefits gastrointestinal disorders. may serve immunomodulators activators defense pathways. Besides, oral can response system. Recently, studies humans animals demonstrated probiotic RA AA. To understand characterization, microbiota, intervention AA/AR, this provides overview clinical features AA AR, for prevention treatment AA, changes mechanisms action.

Language: Английский

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Gut microbiota supports male reproduction via nutrition, immunity, and signaling

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 18, 2022

Gut microbiota (GM) is a major component of the gastrointestinal tract. Growing evidence suggests that it has various effects on many distal organs including male reproductive system in mammals. GM and testis form gut-testis axis involving production key molecules through microbial metabolism or de novo synthesis. These have nutrition, immunity, hormone-related functions promote via circulatory system. helps maintain integral structure testes regulates testicular immunity to protect spermatogenic environment. Factors damaging negatively impact function, however, related mechanism unknown. Also, correlation between remains be yet investigated. This review discusses complex influence highlighting fertility.

Language: Английский

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The bridge of the gut–joint axis: Gut microbial metabolites in rheumatoid arthritis

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 6, 2022

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint destruction, synovitis, and pannus formation. Gut microbiota dysbiosis may exert direct pathogenic effects on gut homeostasis. It trigger the host’s innate immune system activate “gut–joint axis”, which exacerbates RA. However, although importance of in development progression RA widely recognized, mechanisms regulating interactions between host remain incompletely defined. In this review, we discuss role microbiota-derived biological mediators, such as short-chain fatty acids, bile tryptophan metabolites, maintaining intestinal barrier integrity, balance bone destruction patients bridge gut–joint axis.

Language: Английский

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Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer® and the Role of Microbiota in Regenerative Dentistry. A Systematic Review

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(3), P. 132 - 132

Published: Feb. 27, 2023

Different biomaterials, from synthetic products to autologous or heterologous grafts, have been suggested for the preservation and regeneration of bone. The aim this study is evaluate effectiveness tooth as a grafting material examine properties its interactions with bone metabolism. PubMed, Scopus, Cochrane Library, Web Science were searched find articles addressing our topic published 1 January 2012 up 22 November 2022, total 1516 studies identified. Eighteen papers in all considered review qualitative analysis. Demineralized dentin can be used graft material, since it shows high cell compatibility promotes rapid by striking an ideal balance between resorption production; also has several benefits, such quick recovery times, high-quality newly formed bone, low costs, no risk disease transmission, ability performed outpatient procedure, donor-related postoperative complications. Demineralization crucial step treatment process, which includes cleaning, grinding, demineralization. Since presence hydroxyapatite crystals prevents release growth factors, demineralization essential effective regenerative surgery. Even though relationship system dysbiosis not yet fully explored, highlights association gut microbes. creation additional scientific build upon enhance findings should future objective research.

Language: Английский

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