Dysbiosis in Inflammatory Bowel Disease: Pathogenic Role and Potential Therapeutic Targets

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 3464 - 3464

Опубликована: Март 23, 2022

Microbe–host communication is essential to maintain vital functions of a healthy host, and its disruption has been associated with several diseases, including Crohn’s disease ulcerative colitis, the two major forms inflammatory bowel (IBD). Although individual members intestinal microbiota have experimental IBD, identifying microorganisms that affect susceptibility phenotypes in humans remains considerable challenge. Currently, lack definition between what dysbiotic gut microbiome limits research. Nevertheless, although clear proof-of-concept causality still lacking, there an increasingly evident need understand microbial basis IBD at strain, genomic, epigenomic, functional levels specific clinical contexts. Recent information on role diet novel environmental risk factors affecting direct implications for immune response impacts development IBD. The complexity pathogenesis, involving multiple distinct elements, suggests integrative approach, likely utilizing computational modeling molecular datasets identify more therapeutic targets.

Язык: Английский

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A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress–induced depressive-like behavior in mice by regulating gut microbiota and metabolites

Applied Microbiology and Biotechnology, Год журнала: 2021, Номер 105(21-22), С. 8411 - 8426

Опубликована: Окт. 7, 2021

Язык: Английский

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Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts

Circulation Research, Год журнала: 2022, Номер 131(6), С. 492 - 506

Опубликована: Авг. 11, 2022

Background: Preeclampsia is one of the leading causes maternal and perinatal morbidity characterized by hypertension, inflammation, placental dysfunction. Gut microbiota plays key roles in inflammation hypertension. However, its mechanisms preeclampsia have not been fully elucidated. Methods: 16S rRNA gene sequencing targeted metabolomics were conducted on stool samples from 92 preeclamptic patients 86 normal late-pregnant women. Then, fecal transplantation vitro vivo functional experiments performed to explore gut development. Results: We revealed dysbiosis patients, including significant reductions short-chain fatty acid-producing bacteria acids. The significantly exacerbated pathologies symptoms rats, whereas healthy pregnant women had protective effects. Akkermansia muciniphila , propionate, or butyrate alleviated rats. Mechanistically, they promoted autophagy M2 polarization macrophages bed, thereby suppressing inflammation. Propionate also trophoblast invasion, improved spiral arterial remodeling. Additionally, we identified a marker set consisting Oscillibacter acids that could accurately diagnose preeclampsia. Conclusions: Our study an important etiology their active metabolites great potential for treatment diagnosis findings enrich gut–placenta axis theory contribute development microecological products

Язык: Английский

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Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3900 - 3900

Опубликована: Фев. 15, 2023

Appreciation of the importance Akkermansia muciniphila is growing, and it becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut–liver–brain axes for multiple diseases via muciniphila. In recent years, its components such as outer membrane proteins extracellular vesicles have been known ameliorate host metabolic health intestinal homeostasis. However, impacts on disease are complex, both potentially beneficial adverse effects mediated by derivatives, in some cases, these dependent upon physiology microenvironment forms, genotypes, strain sources Therefore, this review aims summarize current knowledge how interacts with influences homeostasis progression. Details will be discussed including biological genetic characteristics; functions anti-obesity, anti-diabetes, anti-metabolic-syndrome, anti-inflammation, anti-aging, anti-neurodegenerative disease, anti-cancer therapy functions; strategies elevate abundance. Key events referred specific states, should facilitate identification muciniphila-based probiotic axes.

Язык: Английский

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Mulberry Anthocyanins Ameliorate DSS-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Modulating Gut Microbiota

Antioxidants, Год журнала: 2022, Номер 11(9), С. 1674 - 1674

Опубликована: Авг. 27, 2022

Mulberry has attracted wide attention due to its substantial nutritional values. This work first studied the protective effect of mulberry anthocyanins (MAS) on dextran sulfate sodium (DSS)-induced colitis. The mice experiment was designed as four groups including normal (Control), (DSS)-fed mice, and DSS plus 100 mg/kg·bw MAS-fed (LMAS-DSS) or 200 (HMAS-DSS). Mice were given MAS by gavage for 1 week, then added drinking water 7 days. administered a total 17 results showed that oral reduced disease activity index (DAI), prevented colon shortening, attenuated tissue damage inflammatory response, suppressed colonic oxidative stress restored protein expression intestinal tight junction (TJ) (ZO-1, occludin claudin-3) in with DSS-induced In addition, analysis 16S rRNA amplicon sequences microbiota dysbiosis, reduction Escherichia-Shigella, an increase Akkermansia, Muribaculaceae Allobaculum. Collectively, alleviates colitis maintaining barrier, modulating cytokines, improving microbial community.

Язык: Английский

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Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation

Journal of Autoimmunity, Год журнала: 2023, Номер 141, С. 103062 - 103062

Опубликована: Май 27, 2023

Язык: Английский

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Excessive consumption of mucin by over-colonized Akkermansia muciniphila promotes intestinal barrier damage during malignant intestinal environment

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Март 2, 2023

Gut microbiota disorders damage the intestinal barrier, which causes disease. Thus, we screened with significant changes using an in situ malignant colorectal cancer (CRC) model. Among colonies increased abundance, Akkermansia muciniphila ( A. ) is known for its characteristic of breaking down mucin, essential component barrier. The role remains controversial. To investigate effect excess on established over-colonized mouse model by administering a live bacterial suspension after disrupting original gut microbiome antibiotics. results showed that over-colonization decreased mucin content. mRNA and protein expression levels tight junction proteins also significantly Our findings reveal colonization breaks dynamic balance between secretion degradation, reduces thickness mucus layer, damages would eventually aggravate development colitis CRC. These will raise awareness about safety serving as probiotic.

Язык: Английский

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Akkermansia muciniphilacounteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism

Gut, Год журнала: 2023, Номер 72(5), С. 906 - 917

Опубликована: Янв. 16, 2023

Background Accumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade inflammation and, subsequently, promotion of metabolic dysregulations. Detrimental impacts emulsifier consumption on gut include depletion the health-associated mucus-fortifying bacteria, Akkermansia muciniphila . Objective Investigate, in mice, potential administration exogenous A. as a means protect against detrimental emulsifiers. Results Daily oral prevented phenotypic consequences both CMC P80, hyperphagia, weight gain dysglycaemia. also counteracted inflammation-induced P80. Furthermore, supplementation proximal P80 are thought drive Specifically, alterations species composition encroachment were otherwise induced by Remarkably, we finally report altered colonic transcriptome, while largely protected these alterations. Conclusion protects host. These results support notion use probiotic help maintain health amidst broad array modern stresses promote inflammatory diseases.

Язык: Английский

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Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties

Nutrients, Год журнала: 2023, Номер 15(8), С. 1815 - 1815

Опубликована: Апрель 8, 2023

The gut microbiota plays a critical role in the modulation of host metabolism and immune response, its impairment has been implicated many gastrointestinal extraintestinal diseases. Current evidence shows well-documented A. muciniphila maintaining integrity intestinal barrier, modulating improving several metabolic pathways, making it key element pathogenesis human In this scenario, is most promising next-generation probiotic one first microbial species suitable for specific clinical use when compared with traditional probiotics. Further studies are needed to provide more accurate insight into mechanisms action better elucidate properties major areas, paving way integrated personalized therapeutic approach that finally makes our knowledge microbiota.

Язык: Английский

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Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota

Life Sciences, Год журнала: 2023, Номер 324, С. 121699 - 121699

Опубликована: Апрель 14, 2023

Язык: Английский

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