Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia DOI
Luigi Lorenzini, Alessio Maranzano, Silvia Ingala

и другие.

Neurology, Год журнала: 2024, Номер 103(7)

Опубликована: Сен. 17, 2024

Vascular risk factors (VRFs) and cerebral small vessel disease (cSVD) are common in patients with Alzheimer (AD). It remains unclear whether this coexistence reflects shared or a mechanistic relationship vascular amyloid pathologies have independent synergistic influence on subsequent AD pathophysiology preclinical stages. We investigated links between VRFs, cSVD, levels (Aβ1-42) their combined effect downstream biomarkers, that is, CSF hyperphosphorylated tau (P-tau181), atrophy, cognition. This retrospective study included nondemented participants (Clinical Dementia Rating < 1) from the European Prevention of Alzheimer's (EPAD) cohort assessed VRFs Framingham score (FRS) cSVD features MRI using visual scales white matter hyperintensity volumes. After preliminary linear analysis, we used structural equation modeling (SEM) to create "cSVD severity" latent variable assess direct indirect effects FRS severity Aβ1-42, P-tau181, gray volume (baseline longitudinal), cognitive performance longitudinal). A total 1,592 were evaluated (mean age = 65.5 ± 7.4 years; 56.16% F). observed positive associations all (all p 0.05) negative association Aβ1-42 (β -0.04 0.01). All negatively associated 0.05). Using SEM, fully mediated (indirect effect: β -0.03 0.01), also when omitting amyloid-related markers. significant P-tau181 0.12 0.03), baseline longitudinal -0.10 0.03; -0.12 0.05), -0.16 0.03) through Aβ1-42. In large population, our findings suggest is mediator affects neurodegeneration impairment. provide evidence indirectly affecting pathogenesis AD, highlighting importance considering burden memory clinics for evaluation as an early window intervention. These results stress role cerebrovascular pathology key biomarkers accurate design anti-amyloid clinical trials offer new perspectives patient stratification.

Язык: Английский

Progression of cerebral amyloid angiopathy: a pathophysiological framework DOI
Emma A. Koemans, Jasmeer P. Chhatwal, Susanne J. van Veluw

и другие.

The Lancet Neurology, Год журнала: 2023, Номер 22(7), С. 632 - 642

Опубликована: Май 23, 2023

Язык: Английский

Процитировано

94
The Role of Glymphatic System in Alzheimer’s and Parkinson’s Disease Pathogenesis DOI Creative Commons

Francesca R. Buccellato,

Marianna D’Anca, María Serpente

и другие.

Biomedicines, Год журнала: 2022, Номер 10(9), С. 2261 - 2261

Опубликована: Сен. 13, 2022

Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia, whilst Parkinson's (PD) a movement disorder. These two disorders share accumulation toxic proteins as pathological hallmark. The lack definitive disease-modifying treatments for these neurogenerative diseases has led to hypothesis new pathogenic mechanisms target and design potential therapeutic approaches. recent observation that glymphatic system supposed be responsible cerebrospinal fluid into brain clearance metabolic waste study its involvement in pathogenesis classic proteinopathies. Aquaporin-4 (AQP4), water channel located endfeet astrocyte membrane, considered primary driver system, defective AQP4-mediated drainage been linked objective present review body knowledge links AD PD other lifestyle factors such sleep deprivation exercise may influence function. We will also focus on neuroimaging approaches could identify marker detect changes.

Язык: Английский

Процитировано

83
Imaging perivascular space structure and function using brain MRI DOI Creative Commons
Giuseppe Barisano, Kirsten M. Lynch,

Francesca Sibilia

и другие.

NeuroImage, Год журнала: 2022, Номер 257, С. 119329 - 119329

Опубликована: Май 21, 2022

In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. recent years, increasing number studies highlighted the role PVS cerebrospinal/interstial fluid circulation and clearance cerebral waste products their association with neurological diseases. Novel strategies techniques have been introduced to improve quantification investigate function morphological features physiological pathological conditions. After a brief introduction on anatomy physiology PVS, examine latest technological developments quantitatively analyze structure We describe applications, advantages, limitations these methods, providing guidance suggestions acquisition protocols analysis that can be applied study vivo. Finally, review human across normative lifespan context disorders.

Язык: Английский

Процитировано

75
Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method DOI Creative Commons
Toshiaki Taoka, Rintaro Ito, Rei Nakamichi

и другие.

Magnetic Resonance in Medical Sciences, Год журнала: 2024, Номер 23(3), С. 268 - 290

Опубликована: Янв. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Язык: Английский

Процитировано

72
The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle DOI Creative Commons
Yu Cai, Yin Zhang,

Shuo Leng

и другие.

Neurobiology of Disease, Год журнала: 2024, Номер 192, С. 106426 - 106426

Опубликована: Фев. 6, 2024

The term "glymphatic" emerged roughly a decade ago, marking pivotal point in neuroscience research. glymphatic system, glial-dependent perivascular network distributed throughout the brain, has since become focal of investigation. There is increasing evidence suggesting that impairment system appears to be common feature neurodegenerative disorders, and this exacerbates as disease progression. Nevertheless, factors contributing dysfunction across most disorders remain unclear. Inflammation, however, suspected play role. Dysfunction can lead significant accumulation protein waste products, which trigger inflammation. interaction between inflammation cyclical potentially synergistic. Yet, current research limited, there lack comprehensive models explaining association. In perspective review, we propose novel model inflammation, impaired function, interconnected vicious cycle. By presenting experimental from existing literature, aim demonstrate that: (1) aggravates dysfunction, (2) exacerbated progression, (3) progression promotes Finally, implication proposed discussed.

Язык: Английский

Процитировано

21
Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease DOI
D. Botta,

Ioana Hutuca,

Elyas El Ghoul

и другие.

Journal of Neuroradiology, Год журнала: 2025, Номер 52(3), С. 101322 - 101322

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

3
Association of Data-Driven White Matter Hyperintensity Spatial Signatures With Distinct Cerebral Small Vessel Disease Etiologies DOI Creative Commons
Chia‐Ling Phuah, Yasheng Chen, Jeremy F. Strain

и другие.

Neurology, Год журнала: 2022, Номер 99(23)

Опубликована: Сен. 19, 2022

Topographical distribution of white matter hyperintensities (WMH) are hypothesized to vary by cerebrovascular risk factors. We used an unbiased pattern discovery approach identify distinct WMH spatial patterns and investigate their association with different etiologies.

Язык: Английский

Процитировано

63
Gut–Brain Axis as a Pathological and Therapeutic Target for Neurodegenerative Disorders DOI Open Access

Alma Rosa Lezama Toledo,

Germán Rivera Monroy, Félipe Esparza Salazar

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1184 - 1184

Опубликована: Янв. 21, 2022

Human lifestyle and dietary behaviors contribute to disease onset progression. Neurodegenerative diseases (NDDs), considered multifactorial disorders, have been associated with changes in the gut microbiome. NDDs display pathologies that alter brain functions a tendency worsen over time. are worldwide health problem; US alone, 12 million Americans will suffer from by 2030. While etiology may vary, microbiome serves as key element underlying NDD development prognosis. In particular, an inflammation-associated plagues NDDs. Conversely, sequestration of this inflammatory correction dysbiotic state render therapeutic effects on To end, treatment short-chain fatty acid-producing bacteria, main metabolites responsible for maintaining homeostasis, ameliorates This intimate pathological link between suggests gut-brain axis (GBA) acts underexplored area developing therapies Traditionally, classification depends their clinical presentation, mostly manifesting extrapyramidal pyramidal movement neuropathological evaluation at autopsy gold standard diagnosis. review, we highlight evolving notion GBA stands equally sensitive marker NDDs, particularly Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis chronic stroke. Additionally, represents potent target treating

Язык: Английский

Процитировано

62
Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ISMRM Imaging Neurofluids Study group” Workshop in Rome DOI Creative Commons
Nivedita Agarwal, Laura D. Lewis, Lydiane Hirschler

и другие.

Journal of Magnetic Resonance Imaging, Год журнала: 2023, Номер 59(2), С. 431 - 449

Опубликована: Май 4, 2023

Neurofluids is a term introduced to define all fluids in the brain and spine such as blood, cerebrospinal fluid, interstitial fluid. Neuroscientists past millennium have steadily identified several different fluid environments that interact synchronized harmonious manner assure healthy microenvironment required for optimal neuroglial function. Neuroanatomists biochemists provided an incredible wealth of evidence revealing anatomy perivascular spaces, meninges glia their role drainage neuronal waste products. Human studies been limited due restricted availability noninvasive imaging modalities can provide high spatiotemporal depiction neurofluids. Therefore, animal key advancing our knowledge temporal spatial dynamics fluids, example, by injecting tracers with molecular weights. Such sparked interest identify possible disruptions neurofluids human diseases small vessel disease, cerebral amyloid angiopathy, dementia. However, differences between rodent physiology should be considered when extrapolating these findings understand brain. An increasing armamentarium MRI techniques being built markers altered pathways. During three‐day workshop organized International Society Magnetic Resonance Medicine was held Rome September 2022, concepts were discussed distinguished international faculty lay basis what known where we still lack evidence. We envision next decade, will allow neurofluid pathways true pathological processes underlying disease discover new avenues early diagnoses treatments including drug delivery. Evidence level: 1 Technical Efficacy: Stage 3

Язык: Английский

Процитировано

40
Correlation of glymphatic system abnormalities with Parkinson’s disease progression: a clinical study based on non-invasive fMRI DOI

Jing‐Cai Meng,

Mingqiang Shen,

Yanli Lu

и другие.

Journal of Neurology, Год журнала: 2023, Номер 271(1), С. 457 - 471

Опубликована: Сен. 27, 2023

Язык: Английский

Процитировано

30