Desulfovibrio in the Gut: The Enemy within?

Microorganisms, Год журнала: 2023, Номер 11(7), С. 1772 - 1772

Опубликована: Июль 7, 2023

Desulfovibrio (DSV) are sulfate-reducing bacteria (SRB) that ubiquitously present in the environment and as resident commensal within human gastrointestinal tract. Though they minor residents of healthy gut, DSV opportunistic pathobionts may overgrow setting various intestinal extra-intestinal diseases. An increasing number studies have demonstrated a positive correlation between overgrowth (bloom) While relationship bloom disease pathology has not been clearly established, mounting evidence suggests causal role for these development. As most predominant genera SRB this review summarizes current knowledge regarding variety In study, we also discuss mechanisms by which contribute to pathology.

Язык: Английский

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Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

Cell Host & Microbe, Год журнала: 2024, Номер 32(4), С. 506 - 526.e9

Опубликована: Март 12, 2024

To understand the dynamic interplay between human microbiome and host during health disease, we analyzed microbial composition, temporal dynamics, associations with multi-omics, immune, clinical markers of microbiomes from four body sites in 86 participants over 6 years. We found that stability individuality are body-site specific heavily influenced by host. The stool oral more stable than skin nasal microbiomes, possibly due to their interaction environment. identify individual-specific commonly shared bacterial taxa, individualized taxa showing greater stability. Interestingly, dynamics correlate across sites, suggesting systemic host-microbial-environment interactions. Notably, insulin-resistant individuals show altered among microbiome, molecular markers, features, disrupted metabolic disease. Our study offers comprehensive views multi-site relationship

Язык: Английский

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Foodborne Carbon Dot Exposure Induces Insulin Resistance through Gut Microbiota Dysbiosis and Damaged Intestinal Mucus Layer

ACS Nano, Год журнала: 2023, Номер 17(6), С. 6081 - 6094

Опубликована: Март 10, 2023

Foodborne carbon dots (CDs), an emerging food nanocontaminant, are increasing risk factor for metabolic toxicity in mammals. Here, we report that chronic CD exposure induced glucose metabolism disorders via disruption of the gut–liver axis mice. 16s rRNA analysis demonstrated decreased abundance beneficial bacteria (Bacteroides, Coprococcus, and S24-7) increased harmful (Proteobacteria, Oscillospira, Desulfovibrionaceae, Ruminococcaceae), as well Firmicutes/Bacteroidetes ratio. Mechanistically, pro-inflammatory release endotoxin lipopolysaccharide, which induces intestinal inflammation mucus layer, activating systemic inducing hepatic insulin resistance mice TLR4/NFκB/MAPK signaling pathway. Furthermore, these changes were almost completely reversed by probiotics. Fecal microbiota transplantation from CD-exposed intolerance, damaged liver function, layer injury, inflammation, recipient However, microbiota-depleted exposed to CDs had normal levels biomarkers consistent with control mice, revealed gut dysbiosis contributes CD-induced inflammation-mediated resistance. Together, our findings attempted elucidate specific underlying mechanism. emphasized importance assessing hazards associated foodborne CDs.

Язык: Английский

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Amelioration of obesity and inflammation by polysaccharide from unripe fruits of raspberry via gut microbiota regulation

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129825 - 129825

Опубликована: Фев. 1, 2024

Язык: Английский

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Effects of intestinal Desulfovibrio bacteria on host health and its potential regulatory strategies: A review

Microbiological Research, Год журнала: 2024, Номер 284, С. 127725 - 127725

Опубликована: Апрель 12, 2024

Язык: Английский

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Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice

Nature Metabolism, Год журнала: 2024, Номер 6(8), С. 1601 - 1615

Опубликована: Июль 19, 2024

Язык: Английский

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Desulfovibrio desulfuricans and its derived metabolites confer resistance to FOLFOX through METTL3

EBioMedicine, Год журнала: 2024, Номер 102, С. 105041 - 105041

Опубликована: Март 13, 2024

BackgroundChemoresistance is a critical factor contributing to poor prognosis in clinical patients with cancer undergoing postoperative adjuvant chemotherapy. The role of gut microbiota mediating resistance tumour chemotherapy remains be investigated.MethodsPatients CRC were categorised into benefit responders (CBR) and no (NCB) based on efficacy. Differential bacterial analysis using 16S rRNA sequencing revealed Desulfovibrio as distinct microbe between the two groups. Employing syngeneic transplantation model, we assessed effect by measuring burden, weight, Ki-67 expression. We further explored mechanisms underlying compromised chemotherapeutic efficacy metabolomics, western blotting, colony formation, cell apoptosis assays.FindingsIn comparison, was more abundant NCB group. In vivo experiments that colonisation weakened FOLFOX. Treatment desulfuricans elevates serum S-adenosylmethionine (SAM) levels. Interestingly, SAM reduced sensitivity cells FOLFOX, thereby promoting growth tumours. These suggest promotes metastasis driving expression methyltransferase-like 3 (METTL3).InterpretationA high abundance intestines indicates therapeutic outcomes for neoadjuvant FOLFOX CRC. drives manifestation METTL3 CRC, increasing concentration SAM.FundingThis study supported Wuxi City Social Development Science Technology Demonstration Project (N20201005).

Язык: Английский

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The Impact of Probiotic Bifidobacterium on Liver Diseases and the Microbiota

Life, Год журнала: 2024, Номер 14(2), С. 239 - 239

Опубликована: Фев. 8, 2024

Recent studies have shown the promising potential of probiotics, especially bacterial genus Bifidobacterium, in treatment liver diseases. In this work, a systematic review was conducted, with focus on that employed advanced Next Generation Sequencing (NGS) technologies to explore Bifidobacterium as probiotic for treating pathologies such Non-Alcoholic Fatty Liver Disease (NAFLD), Steatohepatitis (NASH), Alcoholic (ALD), Cirrhosis, and Hepatocelullar Carcinoma (HCC) its impact microbiota. Our results indicate is safe effective lesions. It successfully restored balance intestinal microbiota improved biochemical clinical parameters NAFLD, ALD, Cirrhosis. No significant adverse effects were identified. While more research needed establish efficacy NASH HCC, evidence suggests managing

Язык: Английский

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Exercise-driven gut microbiota alterations enhance colonization resistance against methicillin-resistant Staphylococcus aureus

Cell Reports, Год журнала: 2025, Номер 44(3), С. 115424 - 115424

Опубликована: Март 1, 2025

Highlights•Moderate exercise enhances gut colonization resistance against MRSA in mice•D. newyorkensis (L8) is the key bacterium mediating increased resistance•Probiotic strain L8 thwarts by competing for carbon source fucoseSummaryGut microbiota plays a crucial role resisting invasion of pathogens, particularly multidrug-resistant (MDR) bacteria, which pose significant threat to public health. While offers numerous health benefits, its impact on host remains largely unclear. In this study, we demonstrate that moderate significantly reduces methicillin-resistant Staphylococcus aureus (MRSA), clinically important MDR pathogen. Moreover, identify an understudied intestinal probiotic Dubosiella as critical factor exercise-induced MRSA. Mechanistically, deprivation fucose, essential growth and pathogenicity. This process relies high binding affinity pyruvate ILE257 site lactate dehydrogenase L8. Overall, our work highlights importance maintaining demonstrates protecting colonization.Graphical abstract

Язык: Английский

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Structural Insights into Amelioration Effects of Quercetin and Its Glycoside Derivatives on NAFLD in Mice by Modulating the Gut Microbiota and Host Metabolism

Journal of Agricultural and Food Chemistry, Год журнала: 2022, Номер 70(46), С. 14732 - 14743

Опубликована: Ноя. 9, 2022

The sugar moieties of natural flavonoids determine their absorption, bioavailability, and bioactivity in humans. To explore structure-dependent bioactivities quercetin, isoquercetin, rutin, which have the same basic skeleton linking different moieties, we systemically investigated ameliorative effects dietary these on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) mice. Our results revealed that isoquercetin exhibits strongest capability improving NAFLD phenotypes mice, including body weight gain, glucose intolerance, systemic inflammation comparison with quercetin rutin. At molecular level, markedly ameliorated dysfunction host metabolic disorders mice NAFLD. microbial three compounds, especially can effectively regulate gut microbiota composition, such as genera Akkermansia, Bifidobacterium, Lactobacillus, were significantly disrupted These comparative findings offer new insights into activities for treatment.

Язык: Английский

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