Real-time genomic surveillance for enhanced control of infectious diseases and antimicrobial resistance
Frontiers in Science,
Год журнала:
2024,
Номер
2
Опубликована: Апрель 25, 2024
This
article
advocates
for
mobilizing
pathogen
genomic
surveillance
to
contain
and
mitigate
health
threats
from
infectious
diseases
antimicrobial
resistance
(AMR),
building
upon
successes
achieved
by
large-scale
genome
sequencing
analysis
of
SARS-CoV-2
variants
in
guiding
COVID-19
monitoring
public
responses
adopting
a
One
Health
approach.
Capabilities
laboratory-based
epidemic
alert
systems
should
be
enhanced
fostering
(i)
universal
access
real-time
whole
sequence
(WGS)
data
pathogens
inform
clinical
practice,
infection
control,
policies,
vaccine
drug
research
development;
(ii)
integration
diagnostic
microbiology
data,
testing
asymptomatic
individuals,
epidemiological
into
programs;
(iii)
stronger
cross-sectorial
collaborations
between
healthcare,
health,
animal
environmental
using
approaches,
toward
understanding
the
ecology
transmission
pathways
AMR
across
ecosystems;
(iv)
international
collaboration
interconnection
networks,
harmonization
laboratory
methods,
standardization
methods
global
reporting,
including
on
variant
or
strain
nomenclature;
(v)
responsible
sharing
databases,
platforms
according
FAIR
(findability,
accessibility,
interoperability,
reusability)
principles;
(vi)
system
implementation
its
cost-effectiveness
different
settings.
Regional
policies
governance
initiatives
foster
concerted
development
efficient
utilization
protect
humans,
animals,
environment.
Язык: Английский
A Review of the Molecular Understanding of the Mpox Virus (MPXV): Genomics, Immune Evasion, and Therapeutic Targets
Zoonotic Diseases,
Год журнала:
2025,
Номер
5(1), С. 3 - 3
Опубликована: Янв. 16, 2025
The
Mpox
virus
(MPXV),
a
zoonotic
pathogen
from
the
Orthopoxvirus
genus,
has
emerged
as
significant
global
public
health
concern,
especially
after
unprecedented
outbreak
in
2022.
This
review
synthesizes
MPXV’s
molecular
features,
focusing
on
its
genomic
structure,
replication
mechanisms,
immune
evasion
strategies,
and
implications
for
diagnostics
therapeutics.
study
examines
virus’s
organization
utilizing
recent
peer-reviewed
literature,
highlighting
essential
genes
like
OPG027
D1L,
which
contribute
to
host
adaptation,
increased
transmissibility,
evasion.
Advances
diagnostics,
including
real-time
PCR
genome
sequencing,
are
reviewed,
emphasizing
their
critical
role
monitoring
control.
However,
challenges
persist,
such
diagnostic
limitations
resource-constrained
settings
lack
of
targeted
vaccines
antivirals.
discusses
new
antiviral
candidates,
confirmed
through
computational
vitro
techniques,
identifying
thymidine
kinase
VP39
key
therapeutic
targets.
Emphasizing
need
surveillance
track
adaptive
evolution,
results
show
that
particular
mutations,
D1L
genes,
increase
transmissibility
MPXV.
These
revelations
highlight
urgent
necessity
better
catered
towards
addressing
present
constraints
developing
focused
treatments
reduce
effect
virus.
emphasizes
how
these
underscore
combined
plans
handle
changing
MPXV
epidemiology
properly.
Язык: Английский
Mpox: A case study for a one health approach to infectious disease prevention
One Health,
Год журнала:
2025,
Номер
20, С. 101059 - 101059
Опубликована: Май 2, 2025
Язык: Английский
The resurgence of monkeypox virus: a critical global health challenge and the need for vigilant intervention
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Май 30, 2025
The
resurgence
of
the
monkeypox
virus
(MPXV),
a
zoonotic
Orthopoxvirus
historically
regarded
as
endemic
to
tropical
rainforests
Central
and
West
Africa,
represents
significant
evolving
global
health
challenge.
Waning
immunity
following
cessation
smallpox
vaccination
inequitable
vaccine
access
have
increased
susceptibility,
especially
in
resource-limited
settings.
Combined
with
urbanization,
environmental
degradation,
travel,
human-wildlife
interactions,
these
factors
driven
MPXV
beyond
its
traditional
regions.
Notably,
recent
outbreaks
non-endemic
countries
exhibited
distinct
epidemiological
shift,
higher
incidence
among
men
who
sex
men,
often
absence
travel
history
areas,
underscoring
transmission
dynamics.
This
review
provides
comprehensive
examination
MPXV’s
epidemiology,
clinical
features,
mechanisms,
highlighting
complexities
containment.
Key
challenges—including
surveillance
gaps,
inequities,
limited
diagnostics
therapeutics—are
compounded
by
unresolved
controversies
over
natural
reservoirs
respiratory
transmissibility,
well
critical
research
gaps
spillover
mechanisms
long-term
immunity.
Addressing
issues
demands
collaboration
leverage
next-generation
vaccines
antivirals,
paired
an
integrated
public
response:
enhanced
surveillance,
targeted
education,
equitable
resource
allocation.
Sustaining
efforts
is
vital
curbing
preventing
entrenchment
threat.
Язык: Английский
Exploring monkeypox virus antibody levels: insights from human immunological research
Virology Journal,
Год журнала:
2025,
Номер
22(1)
Опубликована: Май 31, 2025
Monkeypox(mpox)
is
a
zoonotic
disease
caused
by
the
monkeypox
virus
(MPXV),
which
was
previously
endemic
to
West
and
Central
Africa.
However,
it
has
recently
appeared
in
several
non-endemic
countries
beyond
On
July
23,
202
WHO
declared
mpox
outbreak
public
health
emergency
of
international
concern,
declaration
reaffirmed
on
August
14,
2024.
In
this
context,
understanding
antibody
levels
MPXV
population
become
crucial,
especially
given
historical
cross-protection
provided
smallpox
vaccination.
To
provide
comprehensive
overview
current
protective
efficacy
vaccination,
we
conducted
review
existing
literature.
We
reviewed
relevant
studies
published
peer-reviewed
journals
from
1958
2025,
focusing
those
that
reported
research
antibodies
effects
Here,
progress
virus(VARV)
epidemiology,
etiology,
mutation
mechanism
infection,
clinical
characteristics
vaccine
application.
addition,
differences
different
populations
cross-protective
effect
against
were
also
discussed.
Our
indicates
are
closely
related
level
immunity
population,
particularly
among
individuals
who
have
received
This
narrative
aims
synthesize
evidence
role
vaccination
protecting
offer
evidence-based
guidance
for
policy.
aim
establish
theoretical
foundation
practical
recommendations
future
prevention
strategies.
Язык: Английский
An overview of the progress made in research into the Mpox virus
Medicinal Research Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 24, 2024
Abstract
Mpox
is
a
zoonotic
illness
caused
by
the
virus
(MPXV),
member
of
Orthopoxvirus
family.
Although
few
cases
have
been
reported
outside
Africa,
it
was
originally
regarded
as
an
endemic
disease
limited
to
African
countries.
However,
outbreak
2022
remarkable
in
that
infection
spread
more
than
123
countries
worldwide,
causing
thousands
infections
and
deaths.
The
ongoing
has
declared
public
health
emergency
international
concern
World
Health
Organization.
For
better
management
control
epidemic,
this
review
summarizes
research
advances
important
scientific
findings
on
MPXV
reviewing
current
literature
epidemiology,
clinical
characteristics,
diagnostic
methods,
prevention
treatment
measures,
animal
models
MPXV.
This
provides
useful
information
raise
awareness
about
transmission,
symptoms,
protective
measures
MPXV,
serving
theoretical
guide
for
relevant
institutions
Язык: Английский
Exploring the Transcriptomic Profile of Human Monkeypox Virus via CAGE and Native RNA Sequencing Approaches
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
Abstract
In
this
study,
we
employed
short-
and
long-read
sequencing
technologies
to
delineate
the
transcriptional
architecture
of
human
monkeypox
virus
identify
key
regulatory
elements
that
govern
its
gene
expression.
Specifically,
conducted
a
transcriptomic
analysis
annotate
transcription
start
sites
(TSSs)
end
(TESs)
by
utilizing
cap
expression
on
Illumina
platform
direct
RNA
Oxford
Nanopore
technology
device.
Our
investigations
uncovered
significant
complexity
in
use
alternative
TSSs
TESs
viral
genes.
research,
also
detected
promoter
poly(A)
signals
associated
with
Additionally,
identified
novel
genes
both
left
right
variable
regions
genome.
Importance
Generally,
gaining
insight
into
how
is
regulated
offers
insights
mechanisms
control
life
cycle.
The
recent
outbreak
has
underscored
necessity
understanding
basic
biology
causative
agent.
results
are
pivotal
for
constructing
comprehensive
atlas
virus,
providing
valuable
resources
future
studies.
Язык: Английский
Exploring the transcriptomic profile of human monkeypox virus via CAGE and native RNA sequencing approaches
mSphere,
Год журнала:
2024,
Номер
9(9)
Опубликована: Авг. 27, 2024
In
this
study,
we
employed
short-
and
long-read
sequencing
technologies
to
delineate
the
transcriptional
architecture
of
human
monkeypox
virus
identify
key
regulatory
elements
that
govern
its
gene
expression.
Specifically,
conducted
a
transcriptomic
analysis
annotate
transcription
start
sites
(TSSs)
end
(TESs)
by
utilizing
Cap
Analysis
expression
on
Illumina
platform
direct
RNA
Oxford
Nanopore
technology
device.
Our
investigations
uncovered
significant
complexity
in
use
alternative
TSSs
TESs
viral
genes.
research,
also
detected
promoter
poly(A)
signals
associated
with
Additionally,
identified
novel
genes
both
left
right
variable
regions
genome.IMPORTANCEGenerally,
gaining
insight
into
how
is
regulated
offers
insights
mechanisms
control
life
cycle.
The
recent
outbreak
has
underscored
necessity
understanding
basic
biology
causative
agent.
results
are
pivotal
for
constructing
comprehensive
atlas
virus,
providing
valuable
resources
future
studies.
Язык: Английский