Osteoarthritis and social disadvantage interactions: retrospective overview and emergent findings and health implications DOI Open Access
Ray Marks

International Physical Medicine & Rehabilitation Journal, Год журнала: 2024, Номер 9(1), С. 39 - 45

Опубликована: Март 22, 2024

Osteoarthritis, a widespread arthritic disease commonly resulting in considerable pain and functional disability is often found to vary among those deemed affected. While age, gender, genetics explain this, what does the research show specifically terms of extrinsic factors such as social disadvantage? This report aimed update known about context its role possible remediable osteoarthritis determinant if suboptimal. Using PUBMED data base others, studies published between January 1, 2000 March 20, 2024 concerning disadvantage linkages were sought carefully examined. As well, drawn from researcher’s repository reviewed. The search results revealed growing interest this topic where can be observed negatively influenced face one or more forms deprivation. Yet, very few clinical trials prevail either test validity idea apply these understandings preventing suffering. In light increasing burden, despite years research, it appears that maximize wellbeing for all, limit obviate unwanted associated health costs, resounding along with focus on advancing equity mitigating all deprivation strongly indicated.

Язык: Английский

Osteoarthritis year in review 2024: Epidemiology and therapy DOI

Alice Courties,

I. Kouki,

N. Abd El Monem Soliman

и другие.

Osteoarthritis and Cartilage, Год журнала: 2024, Номер 32(11), С. 1397 - 1404

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

22
Chitosan-based hydrogels: A comprehensive review of transdermal drug delivery DOI
Dahlang Tahir,

Ardiansyah Ardiansyah,

Heryanto Heryanto

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 298, С. 140010 - 140010

Опубликована: Янв. 17, 2025

Язык: Английский

Процитировано

4
Osteoarthritis burden and inequality from 1990 to 2021: a systematic analysis for the global burden of disease Study 2021 DOI Creative Commons

Ruijun Wu,

Yuming Guo, Yi Chen

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 10, 2025

Osteoarthritis (OA) is a major global health burden, affecting millions and causing significant disability. Understanding its trends determinants crucial for effective management prevention. We analyzed data from the Global Burden of Diseases (GBD) study 2021 to assess OA incidence, Years Lived with Disability (YLDs), age-standardized rates (ASIR/ASYR) 1990 2021. explored across gender, region, Socio-Demographic Index (SDI) quintiles using Joinpoint regression, Age-Period-Cohort (APC) modeling, decomposition, inequality analyses. The incidence surged 20.9 million in 46.6 cases 2021, an AAPC 0.29%. Correspondingly, YLDs escalated 8.92 21.30 million, reflecting 0.30%. Disparities exist SDI quintiles, higher observed high countries. Women consistently experience burden compared men. Asian regions demonstrate fastest rise ASYR. High BMI contributes significantly particularly rising necessitates urgent attention. Interventions targeting modifiable risk factors, such as obesity, early detection strategies are crucial. Addressing gender disparities inequalities, countries, essential prevention control.

Язык: Английский

Процитировано

1
Epidemiological trends and characteristics of osteoarthritis in China during 1990–2021 DOI Creative Commons
Sheng Chen, Mingjue Chen, Chao Chen

и другие.

Journal of Orthopaedic Translation, Год журнала: 2025, Номер 51, С. 218 - 226

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Jianpi Qingre Tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway DOI
Qiao Zhou, Jian Liu,

Yajun Qi

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 118953 - 118953

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

4
Extracellular Vesicles Derived from Human Umbilical Mesenchymal Stem Cells Transfected with miR-7704 Improved Damaged Cartilage and Reduced Matrix Metallopeptidase 13 DOI Creative Commons
Kun‐Chi Wu,

Hui-I Yang,

Yu-Hsun Chang

и другие.

Cells, Год журнала: 2025, Номер 14(2), С. 82 - 82

Опубликована: Янв. 9, 2025

We aimed to explore the therapeutic efficacy of miR-7704-modified extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (HUCMSCs) for osteoarthritis (OA) treatment. In vitro experiments demonstrated successful transfection miR-7704 into HUCMSCs and isolation EVs these cells. vivo used an OA mouse model assess effects injection intra-articularly. Walking capacity (rotarod test), cartilage morphology, histological scores, expression type II collagen, aggrecan, interleukin-1 beta, matrix metalloproteinase 13 (MMP13) in were evaluated. The characterized confirm their suitability use. IL-1beta-treated chondrocytes increased collagen decreased MMP13 after treatment with miR-7704-overexpressed EVs. revealed that intra-articular significantly improved walking capacity, preserved resulted higher scores compared controls. Furthermore, post suggests a potential mechanism observed effects. Therefore, showed as innovative strategy treating OA. Further investigations should focus on optimizing dosage, understanding mechanisms, ensuring safety efficacy, developing advanced delivery systems, conducting early-phase clinical trials establish HUCMSC-derived management.

Язык: Английский

Процитировано

0
Barriers and facilitators to implementing core osteoarthritis treatments in China: a mixed-method study DOI
Ziru Wang, Shuyong Duan,

Xier Chen

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

ABSTRACT Objective To understand current practices and identify barriers facilitators to implementing guideline recommended core OA treatments in China. Methods An exploratory mixed-methods design was employed, involving healthcare professionals managing mainland The qualitative phase included semi-structured interviews (n=15) a survey (n=181). A quantitative (n=302) evaluated the clinical applicability of identified themes, common practices, knowledge, self-rated confidence capabilities about OA. Qualitative data were analyzed through thematic content analysis using NVivo, descriptive statistics applied RStudio. Results Participants representing six professions provided their perspectives qualitatively. Five themes emerged as barriers: widespread misconceptions OA; limitations medical insurance policies; insufficient multidisciplinary collaboration; lack workplace support; low patient adherence self-management. Three facilitators: telehealth community-based delivery pathways; professional training education resources; personalized services with positive feedback. Across 19 provinces China, participants seven different health completed survey. most commonly used for physical agent therapy (56%), while exercise utilized by only 9%. average knowledge score 31.2 (±8.9) out 55. Self-rated lowest “referrals interdisciplinary collaboration” (3.4±0.1, “somewhat confident”). applicable factors impacting implementation comorbidities, pain science therapy, financial support (all 2.8±0.8, “applicable”). Conclusion Core international guidelines are infrequently implemented SIGNIFICANCE AND INNOVATIONS This study is first explore osteoarthritis (OA) providing comprehensive insights into unique challenges within Chinese system. It highlights substantial underutilization care (9%), reflecting potential mismatch between recommendations practice, underscores need targeted strategies. Major include OA, limited collaboration, organizational non-pharmacological interventions. emphasizes address disparities management improve access evidence-based, guideline-recommended diverse settings across

Язык: Английский

Процитировано

0
Temporal trends of ischemic stroke attributable to diet high in sodium in China from the global burden of disease study 2021 DOI Creative Commons

Jiaming Cui,

Zhiwei Xu, Yang Dai

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 13, 2025

Background Ischemic stroke is a significant global health burden, with high sodium intake recognized as key risk factor. This study aimed to assess the disease burden of ischemic attributable diet in China from 1990 2021. Additionally, we analyzed influence age, period, and cohort effects on trends projected 2022 2036. Methods Data Global Burden Disease Study 2021 (GBD 2021) were used analyze among high-risk populations China. Annual average percent change (AAPC) was calculated using Joinpoint regression models evaluate Age-period-cohort employed estimate independent project 2036 Bayesian age-period-cohort models. Results From 2021, mortality showed continuous increase, while age-standardized disability-adjusted life years (DALYs) significantly declined. In analysis, age effect increased steadily over period. Period revealed an initial decline relative (RR) DALY rates, followed by increase cohorts born before 2004–2009, gradual after that Cohort demonstrated rates Conclusion found fluctuated declining trend observed recent years. Projections indicate this downward will continue. Age birth period are factors influencing older adults men being particularly affected. Future policy efforts should focus enhancing management further reduce linked intake.

Язык: Английский

Процитировано

0
Effects of an e-learning program (PEAK, physiotherapy exercise and physical activity for knee osteoarthritis) on Chinese physical therapists' confidence and knowledge: a randomized controlled trial (Preprint) DOI Creative Commons
Ziru Wang, Yunqi Wang, Shuyong Duan

и другие.

Journal of Medical Internet Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Knee osteoarthritis (OA) presents a significant burden in China due to its high prevalence, aging population, and rising obesity rates. Despite clinical guidelines recommending evidence-based care, limited practitioner training inadequate telehealth integration hinder effective OA management. The aim of this study was evaluate the effectiveness an e-learning program improving confidence knowledge Chinese physical therapists managing knee explore their perceptions program. This randomized controlled trial with 2 parallel arms involving 81 rehabilitation practitioners from 18 provinces. intervention group completed 4-week web-based (Physiotherapy Exercise Physical Activity for Osteoarthritis [PEAK]-Chinese), while control received no training. primary outcome self-reported management (11-point scale). Secondary outcomes included (Chinese Knowledge Scale [KOAKS]) likelihood application core treatments. Process measures semistructured interviews captured participants' perceptions. Quantitative data were analyzed using regression models, 2-sided t tests, descriptive statistics, thematic analysis performed on interview 10 participants. A total 80 participants at 4 weeks. demonstrated improvements compared group, including exercise-based programs (adjusted mean difference=3.27, 95% CI 2.72-3.81), prescribing exercise difference=3.13, 2.55-3.72), delivering difference=4.41, 3.77-5.05). KOAKS scores also improved significantly (mean change=9.46); however, certain belief bias related concepts use scans remained unchanged (25/41, 61% 27/41, 66%, respectively). Approximately 73% (30/41) rated course as extremely useful. Interviews emphasized need cultural adaptation practical real-life scenarios enhance applicability. PEAK practitioners' OA, underscoring e-learning's potential support care China. To optimize future implementations, further research strategies could include enhancing relevance, addressing misconceptions, incorporating practical, real-world Clinical Trial Register ChiCTR2400091007; https://www.chictr.org.cn/showproj.html?proj=239680.

Язык: Английский

Процитировано

0
The value of super microvascular imaging and shear wave elastography in evaluating synovial lesions in knee osteoarthritis DOI
Min Jin,

Lei Mi,

Hanwen Li

и другие.

Journal of Back and Musculoskeletal Rehabilitation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Objective This study investigates the value of super microvascular imaging (SMI) and shear wave elastography (SWE) in evaluating relationship between synovial tissues disease severity knee osteoarthritis (KOA) patients. Materials Methods Patients with KOA who visited our hospital August 2022 May 2023 were enrolled. WOMAC (Western Ontario McMaster Universities Osteoarthritis Index) scores, X-ray images (Kellgren-Lawrence grading), power Doppler (PDI), SMI, SWE evaluated for each patient. Results A total 54 patients SMI detected more blood flow than PDI (79.62% vs. 62.96%, p < 0.001). upgraded 22.22% from level 0 to 1, 31.48% 1 2, 9.26% 2 3. There was a positive correlation scores Kellgren-Lawrence grading (KLG), (r = 0.79, showed no significant 0.26, 0.06) or KLG 0.12, 0.40). also 0.05) 0.06, 0.67). However, showcased 0.38, 0.04), 0.47, 0.001) pain scores. Additionally, exhibited correlations 0.74, 0.84, Conclusion In KOA, improved detection is significantly superior PDI, offering sensitive tool assessing flow. tissue severity, providing novel disease.

Язык: Английский

Процитировано

0