The incidence of outpatient care within 24 months from SARS-CoV-2 infection in the general population: a multicenter population-based cohort study DOI Creative Commons
Federico Banchelli, Carlo Gagliotti, Angela De Paoli

и другие.

BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 30, 2025

Abstract Background The long-term effects of COVID-19, which can vary significantly in type and timing, are considered relevant impacting on the well-being individuals. present study aims to assess incidence outpatient care post-acute phase SARS-CoV-2 infection two Italian regions. Methods has a multicentre, population-based, pre-post, repeated measures design compare rate access visits diagnostics before after infection, considering follow-up 24 months. made use previously recorded large-scale healthcare data available administrative databases Emilia-Romagna (E-R) Veneto Analyses were carried out separately regions results pooled using random meta-analysis. Results There 27,140 subjects E-R 22,876 who included analysis. outputs showed an increase rates starting from month 2 (IRR = 1.68, 95% CI 1.56–1.81) with peak at 4 2.05, 1.95–2.15); continued reduced intensity up 15. Stratified analysis revealed that severe acute COVID-19 had higher (up IRR 3.96, 2.89–5.44), as well patients no comorbidities 2.71, 2.60–2.83). Conclusion Long-term include burden especially first months infection. increased demand for resources last years particular subgroups such admitted hospital during due presentation disease.

Язык: Английский

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study DOI Open Access
Aranka V. Ballering, Sander K. R. van Zon, Tim olde Hartman

и другие.

The Lancet, Год журнала: 2022, Номер 400(10350), С. 452 - 461

Опубликована: Авг. 1, 2022

Язык: Английский

Процитировано

645
Long COVID: The Nature of Thrombotic Sequelae Determines the Necessity of Early Anticoagulation DOI Creative Commons
Chengyue Wang, Chengyuan Yu, Haijiao Jing

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Апрель 5, 2022

Many discharged COVID-19 patients affected by sequelae experience reduced quality of life leading to an increased burden on the healthcare system, their families and society at large. Possible pathophysiological mechanisms long COVID include: persistent viral replication, chronic hypoxia inflammation. Ongoing vascular endothelial damage promotes platelet adhesion coagulation, resulting in impairment various organ functions. Meanwhile, thrombosis will further aggravate vasculitis contributing deterioration. Thus, is essentially a thrombotic sequela. Unfortunately, there currently no effective treatment for COVID. This article summarizes evidence coagulation abnormalities COVID, with focus thrombosis. Extracellular vesicles (EVs) released types cells can carry SARS-CoV-2 through circulation attack distant tissues organs. Furthermore, EVs express tissue factor phosphatidylserine (PS) which Given persistence virus, inflammation are inevitable. Pulmonary structural changes such as hypertension, embolism fibrosis common The impaired lung function again aggravates abnormalities. In this article, we also summarize recent research antithrombotic therapy COVID-19. There increasing that early anticoagulation be improving outcomes. fact, systemic dysfunction caused key factors driving complications Early prophylactic prevent release or remove procoagulant substances, thereby protecting endothelium from damage, reducing sequelae, long-COVID patients.

Язык: Английский

Процитировано

100
S1-Leitlinie Long-/Post-COVID DOI Open Access
Andreas Rembert Koczulla,

Tobias Ankermann,

Uta Behrends

и другие.

Pneumologie, Год журнала: 2022, Номер 76(12), С. 855 - 907

Опубликована: Дек. 1, 2022

The German Society of Pneumology initiated 2021 the AWMF S1 guideline Long COVID/Post-COVID. In a broad interdisciplinary approach, this was designed based on current state knowledge.The clinical recommendations describe COVID/Post-COVID symptoms, diagnostic approaches, and therapies.In addition to general consensus introduction, subject-specific approach taken summarize has an explicit practical claim will be developed adapted by author team increase in knowledge.Die Deutsche Gesellschaft für Pneumologie hat die S1-Leitlinie Long-/Post-COVID initiiert. einem breiten interdisziplinären Ansatz wurde diese basierend auf dem aktuellen Wissensstand gestaltet.Die klinische Empfehlung beschreibt Long- bzw. Post-COVID-Symptome, diagnostische Ansätze und Therapien.Neben der allgemeinen konsentierten Einführung ein fachspezifischer Zugang gewählt, den zusammenfasst.Die Leitlinie einen explizit praktischen Anspruch wird Wissenszugewinn vom Autorenteam weiterentwickelt adaptiert.

Процитировано

80
Persistent physical symptoms: definition, genesis, and management DOI Creative Commons
Bernd Löwe,

Anne Toussaint,

Judith G.M. Rosmalen

и другие.

The Lancet, Год журнала: 2024, Номер 403(10444), С. 2649 - 2662

Опубликована: Июнь 1, 2024

Язык: Английский

Процитировано

72
Living with “long COVID”: A systematic review and meta-synthesis of qualitative evidence DOI Creative Commons
Md Mahbub Hossain, Jyoti Das, Farzana Rahman

и другие.

PLoS ONE, Год журнала: 2023, Номер 18(2), С. e0281884 - e0281884

Опубликована: Фев. 16, 2023

Objectives Long-term health consequences of coronavirus disease (COVID-19), also known as “long COVID,” has become a global concern. In this systematic review, we aimed to synthesize the qualitative evidence on lived experiences people living with long COVID that may inform policymaking and practice. Methods We searched six major databases additional sources systematically retrieved relevant studies conducted meta-synthesis key findings using Joanna Briggs Institute (JBI) guidelines reporting standards Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) checklist. Results found 15 articles representing 12 out 619 citations from different sources. These provided 133 were categorized into 55 categories. All categories aggregated following synthesized findings: complex physical problems, psychosocial crises COVID, slow recovery rehabilitation, digital resources information management, changes in social support, healthcare providers, services, systems. Ten UK, others Denmark Italy, which highlights critical lack other countries. Conclusions More representative research is needed understand COVID-related diverse communities populations. The available informs high burden biopsychosocial challenges among would require multilevel interventions such strengthening policies engaging patients caregivers making decisions developing resources, addressing socioeconomic disparities associated through evidence-based

Язык: Английский

Процитировано

70
Cellular and molecular biomarkers of long COVID: a scoping review DOI Creative Commons
Estefanía Espín, Chengliang Yang, Casey P. Shannon

и другие.

EBioMedicine, Год журнала: 2023, Номер 91, С. 104552 - 104552

Опубликована: Апрель 8, 2023

Язык: Английский

Процитировано

70
A cohort study of post-COVID-19 condition across the Beta, Delta, and Omicron waves in South Africa: 6-month follow-up of hospitalized and nonhospitalized participants DOI Creative Commons
Waasila Jassat, Caroline Mudara, Caroline Vika

и другие.

International Journal of Infectious Diseases, Год журнала: 2022, Номер 128, С. 102 - 111

Опубликована: Дек. 30, 2022

The study aimed to describe the prevalence of and risk factors for post-COVID-19 condition (PCC).

Язык: Английский

Процитировано

55
Phenotyping Post-COVID Pain as a Nociceptive, Neuropathic, or Nociplastic Pain Condition DOI Creative Commons
César Fernández‐de‐las‐Peñas, Jo Nijs, Randy Neblett

и другие.

Biomedicines, Год журнала: 2022, Номер 10(10), С. 2562 - 2562

Опубликована: Окт. 13, 2022

Pain after an acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) condition (post-COVID pain) is becoming a new healthcare emergency. Precision medicine refers to evidence-based method of grouping patients based on their diagnostic/symptom presentation then tailoring specific treatments accordingly. Evidence suggests that post-COVID pain can be categorized as nociceptive (i.e., attributable the activation peripheral receptive terminals primary afferent neurons in response noxious chemical, mechanical, or thermal stimuli), neuropathic associated with lesion somatosensory nervous system limited “neuroanatomically plausible” distribution system), nociplastic arising from altered nociception despite no clear evidence actual threatened tissue damage causing nociceptors for pain), mixed type (when two phenotypes co-exist). Each these may require different treatment approach maximize effectiveness. Accordingly, ability classify into one would likely critical producing successful outcomes. The 2021 International Association Study (IASP) clinical criteria grading provide framework classifying within precision approach. Here we present data supporting possibility phenotypes, using IASP classification criteria, focus pain, which probably mechanism involved pain. Nociplastic usually comorbid symptomology (e.g., poor sleep quality, fatigue, cognitive–emotional disturbances, etc.) considered more difficult treat than other types, nuanced multimodal achieve better

Язык: Английский

Процитировано

42
Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning DOI Creative Commons
Maitray A. Patel, Michael J. Knauer,

Michael Nicholson

и другие.

Molecular Medicine, Год журнала: 2023, Номер 29(1)

Опубликована: Фев. 21, 2023

Survivors of acute COVID-19 often suffer prolonged, diffuse symptoms post-infection, referred to as "Long-COVID". A lack Long-COVID biomarkers and pathophysiological mechanisms limits effective diagnosis, treatment disease surveillance. We performed targeted proteomics machine learning analyses identify novel blood Long-COVID.A case-control study comparing the expression 2925 unique proteins in outpatients versus inpatients healthy control subjects. Targeted was accomplished with proximity extension assays, used most important for identifying patients. Organ system cell type patterns were identified Natural Language Processing (NLP) UniProt Knowledgebase.Machine analysis 119 relevant differentiating (Bonferonni corrected P < 0.01). Protein combinations narrowed down two optimal models, nine five each, both having excellent sensitivity specificity status (AUC = 1.00, F1 1.00). NLP highlighted organ involvement Long-COVID, well involved types, including leukocytes platelets, key components associated Long-COVID.Proteomic plasma from patients highly models proteins, respectively. The reflected widespread expression. Optimal protein individual hold potential accurate diagnosis therapeutics.

Язык: Английский

Процитировано

26
Pulmonary Rehabilitation for People With Persistent Symptoms After COVID-19 DOI
Enya Daynes, George Mills, James H. Hull

и другие.

CHEST Journal, Год журнала: 2024, Номер 166(3), С. 461 - 471

Опубликована: Янв. 19, 2024

Язык: Английский

Процитировано

11