Challenges of visibility and inclusion in Long COVID: a population-based interview study DOI Creative Commons
Emily Cooper, Adam Lound, Kathryn Jones

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Abstract Introduction People with Long Covid report a wide range of symptoms and inconsistent responses when seeking clinical diagnosis support. Much the qualitative research on has been based people attending specialist services or who have accessed support groups. We describe varied ways in which diverse group community sample experience, recognise manage persistent following COVID-19. Methods Qualitative interview study nested within large, community-based REal-time Assessment Community Transmission (REACT) England. Participants reporting COVID-19 were asked for consent to be contacted about follow-up interview. then purposively sampled by age, gender, ethnicity symptom severity conducted 60 interviews. Analysis was carried out using reflexive thematic analysis approach. Results an ethnically aged between 18 80 years reported few months more than two years. Many had not care specific support, some did identify category long covid, rendering their experiences largely invisible. highlighted they self-manage this context, burden coping ongoing health problems. Conclusion This challenges managing emerging contested condition, uncertainty affecting own understanding validation receive from professionals, family friends. These intersect others such as racism, are compounded lack resources well over-stretched UK. Nevertheless, show resilience self-management, information sources. Patient Public Contribution Study design, outputs informed Advisory Group.

Язык: Английский

Long COVID science, research and policy DOI Creative Commons
Ziyad Al‐Aly, Hannah Davis, Lisa McCorkell

и другие.

Nature Medicine, Год журнала: 2024, Номер 30(8), С. 2148 - 2164

Опубликована: Авг. 1, 2024

Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every organ system be severely disabling. The cumulative global incidence long around 400 million individuals, which estimated to have an annual economic impact approximately $1 trillion-equivalent about 1% economy. Several mechanistic pathways are implicated in COVID, including viral persistence, immune dysregulation, mitochondrial dysfunction, complement endothelial inflammation microbiome dysbiosis. devastating impacts on individual lives and, due its complexity prevalence, also has major ramifications for systems economies, even threatening progress toward achieving Sustainable Development Goals. Addressing challenge requires ambitious coordinated-but so far absent-global research policy response strategy. In this interdisciplinary review, we provide synthesis state scientific evidence assess human health, systems, economy metrics, forward-looking roadmap.

Язык: Английский

Процитировано

106
The lived experience of long COVID: A qualitative study of mental health, quality of life, and coping DOI Creative Commons

C Kennelly,

Anh T. P. Nguyen,

Natasha Y. Sheikhan

и другие.

PLoS ONE, Год журнала: 2023, Номер 18(10), С. e0292630 - e0292630

Опубликована: Окт. 13, 2023

The majority of people who contract COVID-19 experience a short period symptomatic infection. However, symptoms persist for months or years following initial exposure to the virus in some cases. This has been described as long COVID. Little is known about lived this condition, it only recently emerged. study aimed explore experiences mental health, quality life, and coping among living with A sample 47 adults participated web-based focus groups. Separate groups were held 24 individuals pre-existing health conditions 23 without conditions. Data analyzed using codebook thematic analysis approach. Five themes identified integral COVID experience: Emotional Landscape Long COVID, New Limits Daily Functioning, Grief Loss Former Identity, COVID-related Stigmatization, Learning Cope Persisting Symptoms. These findings illustrate immense impact on life. Minimal differences found between those conditions, both substantially impacted by condition. Attention perspectives necessary inform future directions research clinical practice.

Язык: Английский

Процитировано

23
Explaining Long COVID: A Pioneer Cross-Sectional Study Supporting the Endocrine Hypothesis DOI Creative Commons
Taïeb Ach,

Nassim Ben Haj Slama,

Asma Gorchane

и другие.

Journal of the Endocrine Society, Год журнала: 2024, Номер 8(3)

Опубликована: Янв. 10, 2024

Abstract Context In some patients, symptoms may persist after COVID-19, defined as long COVID. Its pathogenesis is still debated and many hypotheses have been raised. Objective Our primary objective was to evaluate the corticotroph somatotroph functions of patients previously infected with SARS-CoV-2 experiencing post–COVID-19 syndrome detect any deficiencies that explain Methods A cross-sectional study conducted including who had contracted a postinfection period 3 months or less 15 months, divided into 2 groups. The first group (G1) comprised fully recovered while second (G2) included outcome comparison functions. Results total 64 were groups, each consisting 32 patients. G2 exhibited more frequently anterior pituitary deficits compared G1 (P = .045): for axis (G1: 6.3% vs G2: 28.1%) 31.3% 59.4%). Baseline cortisol level significantly lower in 13.37 µg/dL 11.59 µg/dL) .045). peak also 23.60 19.14 .01). For axis, insulin growth factor-1 146.03 ng/mL 132.25 ng/mL) .369). hormone 4.82 2.89 .041). Conclusion results showed COVID our cohort likely deficiencies. endocrine hypothesis involving insufficiency can be considered

Язык: Английский

Процитировано

15
Cognitive dysfunction after covid-19 DOI Creative Commons
Emma Ladds, Julie Darbyshire, Nawar Diar Bakerly

и другие.

BMJ, Год журнала: 2024, Номер unknown, С. e075387 - e075387

Опубликована: Фев. 1, 2024

Язык: Английский

Процитировано

14
Disparities by Social Determinants of Health: Links Between Long COVID and Cardiovascular Disease DOI Creative Commons
Amitava Banerjee

Canadian Journal of Cardiology, Год журнала: 2024, Номер 40(6), С. 1123 - 1134

Опубликована: Фев. 28, 2024

Long COVID has been defined by World Health Organization as "continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these lasting for at least 2 no other explanation". Cardiovascular disease is implicated a risk factor, concomitant condition and consequence COVID. As well heterogeneity in definition, presentation likely underlying pathophysiology COVID, disparities social determinants health, extensively studied described cardiovascular disease, have observed three ways. First, long-term conditions, such its factors, are associated incidence severity previously socioeconomic factors important exacerbating Second, management COVID-19 may themselves lead to distal Third, there way that diagnosed, managed prevented. Together, age, sex, deprivation ethnicity far-reaching implications this post-viral syndrome across spectrum. There similarities differences compared disease. Some fact, inequalities, i.e. rather than simply variations, they represent injustices costs individuals, communities economies. In review current literature, I consider opportunities prevent, least, attenuate special challenges research, clinical practice, public health policy which evolving.

Язык: Английский

Процитировано

8
Return-to-work with long COVID: An Episodic Disability and Total Worker Health® analysis DOI
Elisabeth Stelson, Devanshi Dash, Lisa McCorkell

и другие.

Social Science & Medicine, Год журнала: 2023, Номер 338, С. 116336 - 116336

Опубликована: Окт. 20, 2023

Язык: Английский

Процитировано

19
Long COVID among healthcare workers: a narrative review of definitions, prevalence, symptoms, risk factors and impacts DOI Creative Commons
Brendan Dempsey, Ira Madan, Sharon A. M. Stevelink

и другие.

British Medical Bulletin, Год журнала: 2024, Номер 151(1), С. 16 - 35

Опубликована: Авг. 25, 2024

Long COVID (LC) occurs when people experience symptoms for weeks, months or even years after a COVID-19 infection. This review looks at research exploring the LC definitions, prevalence, symptoms, risk factors, and associated impacts in on healthcare workers (HCWs).

Язык: Английский

Процитировано

7
Illness presentation and quality of life in myalgic encephalomyelitis/chronic fatigue syndrome and post COVID-19 condition: a pilot Australian cross-sectional study DOI Creative Commons
Breanna Weigel, Natalie Eaton-Fitch, Kiran Thapaliya

и другие.

Quality of Life Research, Год журнала: 2024, Номер 33(9), С. 2489 - 2507

Опубликована: Июль 3, 2024

Abstract Purpose Post COVID-19 Condition (PCC), being persistent symptoms, is reminiscent of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—a chronic multi-systemic illness characterised by neurocognitive, autonomic, endocrinological and immunological disturbances. This novel cross-sectional investigation aims to: (1) compare symptoms among people with ME/CFS (pwME/CFS) PCC (pwPCC) to inform developing diagnostic criteria; (2) health outcomes between patients without acute or (controls) highlight the burdens PCC. Methods Sociodemographic outcome data were collected from n = 61 pwME/CFS, 31 pwPCC 54 controls via validated, self-administered questionnaires, including 36-Item Short-Form Health Survey version 2 (SF-36v2) World Organization Disability Assessment Schedule 2.0 (WHODAS 2.0). PwME/CFS also provided self-reported severity frequency derived Canadian International Consensus Criteria for case definition Results Both cohorts similarly experienced key symptoms. Few differences in observed, memory disturbances, muscle weakness, lymphadenopathy nausea more prevalent, light-headedness severe, unrefreshed sleep frequent, heart palpitations less frequent pwME/CFS (all p < 0.05). The participants’ SF-36v2 WHODAS scores comparable > 0.05); however, both returned significantly lower all domains when compared 0.001). Conclusion Australian-first demonstrates congruent debilitating nature PCC, thereby emphasising need multidisciplinary care maximise patient outcomes.

Язык: Английский

Процитировано

6
Definitions and symptoms of the post-COVID syndrome: an updated systematic umbrella review DOI Creative Commons
Julian Gutzeit, Mark A. Weiss, Carolin Nürnberger

и другие.

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Июль 25, 2024

Abstract Post-COVID syndrome (PCS) describes a persistent complex of symptoms following COVID-19 episode, lasting at least 4 to 12 weeks, depending on the specific criteria used for its definition. It is often associated with moderate severe impairments daily life and represents major burden many people worldwide. However, especially during first two years pandemic, therapeutic diagnostic uncertainties were prominent due novelty disease non-specific definitions that overlooked functional deficits lacked objective assessment. The present work comprehensively examines status PCS as depicted in recent reviews meta-analyses, alongside exploring impairments. We searched database Pubmed meta-analysis evaluating period between May 31, 2022, December 2023. Out 95 studies, 33 selected inclusion our analyses. Furthermore, we extended upon prior research by systematically recording linked identified studies. found fatigue, neurological complaints, exercise intolerance most frequently reported symptoms. In conclusion, over past eighteen months, there has been notable increase quantity quality studies PCS. still remains clear need improvement, particularly regard definition necessary diagnosing this syndrome. Enhancing aspect will render future more comparable precise, thereby advancing understanding

Язык: Английский

Процитировано

6
Post-COVID-19 Syndrome in Non-Hospitalized Individuals: Healthcare Situation 2 Years after SARS-CoV-2 Infection DOI Creative Commons
Inge Kirchberger, Christa Meisinger, Tobias Dominik Warm

и другие.

Viruses, Год журнала: 2023, Номер 15(6), С. 1326 - 1326

Опубликована: Июнь 5, 2023

Although “post-COVID-19 syndrome” (PCS) is reported to be common even in non-hospitalized individuals, long-term information on symptom burden, healthcare needs, utilization, and satisfaction with scarce. The objectives of this study were describe utilization experiences the offered for PCS a German sample persons 2 years after SARS-CoV-2 infection. Individuals past COVID-19 confirmed by positive polymerase chain reaction testing examined at University Hospital Augsburg from 4 November 2020 26 May 2021 completed postal questionnaire between 14 June 2022 1 2022. Participants who self-reported presence fatigue, dyspnea exertion, memory problems or concentration classified as having PCS. Of 304 participants (58.2% female, median age 53.5), 210 (69.1%) had Among these, 18.8% slight moderate functional limitations. showed significantly higher large proportion complained about lacking persistent symptoms finding competent providers. results indicate need optimize patient PCS, facilitate access specialized providers, provide treatment options primary care setting improve education

Язык: Английский

Процитировано

16