The alarming link between environmental microplastics and health hazards with special emphasis on cancer

Life Sciences, Год журнала: 2024, Номер 355, С. 122937 - 122937

Опубликована: Авг. 3, 2024

Язык: Английский

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Micro(nano)plastics in human urine: A surprising contrast between Chongqing's urban and rural regions

The Science of The Total Environment, Год журнала: 2024, Номер 917, С. 170455 - 170455

Опубликована: Янв. 28, 2024

Язык: Английский

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Detection and analysis of microplastics in tissues and blood of human cervical cancer patients

Environmental Research, Год журнала: 2024, Номер 259, С. 119498 - 119498

Опубликована: Июнь 26, 2024

Язык: Английский

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Important Factors Affecting Induction of Cell Death, Oxidative Stress and DNA Damage by Nano- and Microplastic Particles In Vitro

Cells, Год журнала: 2024, Номер 13(9), С. 768 - 768

Опубликована: Апрель 30, 2024

We have described the influence of selected factors that increase toxicity nanoplastics (NPs) and microplastics (MPs) with regard to cell viability, various types death, reactive oxygen species (ROS) induction, genotoxicity. These include plastic particle size (NPs/MPs), zeta potential, exposure time, concentration, functionalization, environmental type. Studies unequivocally shown smaller particles are more cytotoxic, penetrate cells easily, ROS formation, induce oxidative damage proteins, lipids, DNA. The toxic effects also concentration incubation time. NPs positive potential than those a negative because negatively charged, inducing stronger interactions. deleterious MPs increased by functionalization anionic or carboxyl groups, due greater interaction membrane components. Cationic NPs/MPs particularly their cellular uptake and/or on lysosomal membranes. polystyrene (PS) vary from one type another, normal sensitive cancerous ones. can be enhanced factors, including UV radiation, as they cause shrink change shape, which is important consideration when working environmentally-changed NPs/MPs. In summary, cytotoxicity, properties, genotoxicity depends duration action, Also, diameter exposed functionalized amino demonstrate higher larger, non-functionalized environmentally-unchanged potential.

Язык: Английский

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Microplastics exposure promotes the proliferation of skin cancer cells but inhibits the growth of normal skin cells by regulating the inflammatory process

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 267, С. 115636 - 115636

Опубликована: Ноя. 1, 2023

Cutaneous squamous cell carcinoma (CSCC) is one of the most common malignant tumors skin, occurring primarily in elderly population. CSCC second nonmelanoma skin malignancy humans. The development cutaneous closely linked to environmental factors. Microplastics, as a new pollutant, are currently being intensively studied for their potential health effects. However, effect microplastics on cancer not yet known and an important scientific question that needs be addressed. To this end, current study, two lines (SCL-1 A431) were utilized investigate effects cancer, behavior experiments showed internalized into line time- dose-dependent manner. Further promoted proliferation cells by MTT, flow cytometry, laser confocal microscopy, Western blotting other experimental techniques. Mechanistic studies could lead increased mitochondrial ROS cells, which turn caused change membrane potential, thus opening mPTP, release mt-DNA from mitochondria cytoplasm, activating NLRP3 ultimately causing proliferation. We further evaluated HaCaT normal model damage through NLRP3-mediated inflammation scorch death. study suggests microplastics, contaminant, may promote tumor while skin.

Язык: Английский

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Polystyrene nanoparticle exposure accelerates ovarian cancer development in mice by altering the tumor microenvironment

The Science of The Total Environment, Год журнала: 2023, Номер 906, С. 167592 - 167592

Опубликована: Окт. 5, 2023

Язык: Английский

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Uptake, transport and accumulation of micro- and nano-plastics in terrestrial plants and health risk associated with their transfer to food chain - A mini review

The Science of The Total Environment, Год журнала: 2023, Номер 902, С. 166045 - 166045

Опубликована: Авг. 6, 2023

Язык: Английский

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The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development

Cancers, Год журнала: 2024, Номер 16(3), С. 676 - 676

Опубликована: Фев. 5, 2024

Traditionally considered a disease common in the older population, colorectal cancer is increasing incidence among younger demographics. Evidence suggests that populational- and generational-level shifts composition of human gut microbiome may be tied to recent trends gastrointestinal carcinogenesis. This review provides an overview current research putative mechanisms behind rising with insight into future interventions prevent or reverse rate early-onset carcinoma.

Язык: Английский

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Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(4), С. 3109 - 3121

Опубликована: Июль 20, 2024

Язык: Английский

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Intravenous hypertonic fluids as a source of human microplastic exposure

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 107, С. 104411 - 104411

Опубликована: Март 5, 2024

Язык: Английский

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