Role of gut microbiota in infectious and inflammatory diseases

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Март 27, 2023

Thousands of microorganisms compose the human gut microbiota, fighting pathogens in infectious diseases and inhibiting or inducing inflammation different immunological contexts. The microbiome is a dynamic complex ecosystem that helps proliferation, growth, differentiation epithelial immune cells to maintain intestinal homeostasis. Disorders cause alteration this microbiota lead an imbalance host's regulation. Growing evidence supports microbial community associated with development progression inflammatory diseases. Therefore, understanding interaction between modulation system fundamental mechanisms involved pathologies, as well for search new treatments. Here we review main bacteria capable impacting response pathologies discuss by which can alter disease outcomes.

Язык: Английский

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Precise oral delivery systems for probiotics: A review

Journal of Controlled Release, Год журнала: 2022, Номер 352, С. 371 - 384

Опубликована: Окт. 30, 2022

Язык: Английский

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About Functional Foods: The Probiotics and Prebiotics State of Art

Antibiotics, Год журнала: 2023, Номер 12(4), С. 635 - 635

Опубликована: Март 23, 2023

Poor diet, obesity and a sedentary lifestyle have significant impact on natural microbiota disorders; specifically, the intestinal one. This in turn can lead to multitude of organ dysfunctions. The gut contains more than 500 species bacteria constitutes 95% total number cells human body, thus contributing significantly host’s resistance infectious diseases. Nowadays, consumers turned purchased foods, especially those containing probiotic or prebiotics, that constitute some functional food market, which is constantly expanding. Indeed, there are many products available incorporate probiotics, such as yogurt, cheese, juices, jams, cookies, salami sausages, mayonnaise, nutritional supplements, etc. probiotics microorganisms that, when taken sufficient amounts, contribute positively health host focus interest for both scientific studies commercial companies. Thus, last decade, introduction DNA sequencing technologies with subsequent bioinformatics processing contributes in-depth characterization vast biodiversity microbiota, their composition, connection physiological function—known homeostasis—of organism, involvement several Therefore, this study, we highlighted extensive investigation current research association types foods prebiotics diet composition microbiota. As result, study form foundation new path based reliable data from literature, acting guide continuous effort monitor rapid developments field.

Язык: Английский

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Gut Microbiota–Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms

Circulation, Год журнала: 2023, Номер 147(14), С. 1079 - 1096

Опубликована: Апрель 3, 2023

Large-scale human and mechanistic mouse studies indicate a strong relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) several cardiometabolic diseases. This study aims to investigate role of TMAO in pathogenesis abdominal aortic aneurysm (AAA) target its parent microbes as potential pharmacological intervention.

Язык: Английский

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Gut and airway microbiota dysbiosis and their role in COVID-19 and long-COVID

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Март 8, 2023

The gut microbiota plays a crucial role in human health and disease. Gut dysbiosis is known to be associated with increased susceptibility respiratory diseases modifications the immune response homeostasis of lungs (the so-called gut-lung axis). Furthermore, recent studies have highlighted possible neurological disturbances, introducing notion "gut-brain axis." During last 2 years, several described presence during coronavirus disease 2019 (COVID-19) its relationship severity, SARS-CoV-2 gastrointestinal replication, inflammation. Moreover, persistence after resolution may linked long-COVID syndrome particularly manifestations. We reviewed evidence on association between COVID-19, investigating epidemiologic confounding factors like age, location, sex, sample size, severity disease, comorbidities, therapy, vaccination status airway microbial selected both COVID-19 long-COVID. we analyzed strictly related microbiota, specifically diet investigation previous use antibiotics/probiotics, methodology used study (α- β-diversity parameters relative abundance tools). Of note, only few focused longitudinal analyses, especially for long-term observation Lastly, there lack knowledge regarding transplantation other therapeutic approaches their impact progression severity. Preliminary data seem suggest that might play symptoms. Indeed, development interpretation these could important implications future preventive strategies.

Язык: Английский

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Positive Health Outcomes Associated with Live Microbe Intake from Foods, Including Fermented Foods, Assessed using the NHANES Database

Journal of Nutrition, Год журнала: 2023, Номер 153(4), С. 1143 - 1149

Опубликована: Фев. 22, 2023

Live dietary microbes have been hypothesized to contribute human health but direct evidence is lacking. This study aimed determine whether the consumption of live linked improved outcomes. Data from NHANES 2001–2018 were used assess microbial intake and their adjusted associations with selected physiological parameters (e.g., blood pressure, anthropometric measures, biomarkers) among adults aged 19 y older. Regression models constructed each parameter for demographics other covariates. Microbial was assessed as both a continuous variable 3-level categorical variable. Fermented foods in separate model. In models, an additional 100-g microbe–containing associated lower systolic pressure (regression coefficient: −0.331; 95% CI: −0.447, −0.215 mm Hg), C-reactive protein (−0.013; −0.019, −0.008 mg/dL), plasma glucose −0.347; −0.570, −0.124 insulin (−0.201; −0.304, −0.099 μU/mL), triglyceride (−1.389; −2.672, −0.106 waist circumference (−0.554; −0.679, −0.428 cm), BMI −0.217; −0.273, −0.160 kg/m2) levels higher level high density lipoprotein cholesterols (0.432; 0.289, 0.574 mg/dL). Patterns broadly similar when categorically fermented separately. To our knowledge, this first quantify, nationally representative data set American using stable sets covariates regression intakes variety outcomes, such biomarkers, levels. Our findings suggest that concentrations are modest improvements across range

Язык: Английский

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Effects of ultra-processed foods on the microbiota-gut-brain axis: The bread-and-butter issue

Food Research International, Год журнала: 2023, Номер 167, С. 112730 - 112730

Опубликована: Март 21, 2023

Язык: Английский

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The Contribution of the Human Oral Microbiome to Oral Disease: A Review

Microorganisms, Год журнала: 2023, Номер 11(2), С. 318 - 318

Опубликована: Янв. 26, 2023

The oral microbiome is an emerging field that has been a topic of discussion since the development next generation sequencing and implementation human project. This article reviews current literature surrounding microbiome, briefly highlighting most recent methods characterization including cutting edge omics, databases for areas with gaps in knowledge. also describes reports on microorganisms contained which include viruses, archaea, fungi, bacteria, provides in-depth analysis their significant roles tissue homeostasis. Finally, we detail key bacteria involved disease, cancer, research role stimulation inflammatory cytokines, gingival crevicular fluid periodontal creation network interactions between microorganisms, influence planktonic cospecies biofilms, implications antibiotic resistance. paper comprehensive while identifying knowledge to enable future studies be conducted.

Язык: Английский

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Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota

Nutrients, Год журнала: 2023, Номер 15(7), С. 1767 - 1767

Опубликована: Апрель 4, 2023

Aging is a multi-faceted process caused by the accumulation of cellular damage over time, associated with gradual reduction physiological activities in cells and organs. This degeneration results reduced ability to adapt homeostasis perturbations an increased incidence illnesses such as cognitive decline, neurodegenerative cardiovascular diseases, cancer, diabetes, skeletal muscle pathologies. Key features aging include chronic low-grade inflammation state decrease autophagic process. The Mediterranean diet has been longevity counteract onset age-related disorders. Extra virgin olive oil, fundamental component this diet, contains bioactive polyphenolic compounds hydroxytyrosol (HTyr) oleuropein (OLE), known for their antioxidant, anti-inflammatory, neuroprotective properties. review focused on brain, muscle, gut microbiota, these systems are interact at several levels. After description chemistry pharmacokinetics HTyr OLE, we summarize studies reporting effects vivo vitro models diseases central/peripheral nervous system, adult neurogenesis depression, senescence lifespan, disorders, well impact composition microbiota.

Язык: Английский

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Importance of gut microbiota metabolites in the development of cardiovascular diseases (CVD)

Life Sciences, Год журнала: 2023, Номер 329, С. 121947 - 121947

Опубликована: Июль 16, 2023

Язык: Английский

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