Oleuropein alleviates myocardial ischemia–reperfusion injury by suppressing oxidative stress and excessive autophagy via TLR4/MAPK signaling pathway

Chinese Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Апрель 8, 2024

Abstract Background Myocardial ischemia/reperfusion injury (MIRI) is an important complication of reperfusion therapy, and has a lack effective prevention treatment methods. Oleuropein (OP) natural strong antioxidant with many protective effects on cardiovascular diseases, but its effect MIRI not yet been studied in depth. Methods Tert-Butyl hydroperoxide (tBHP) was used to establish vitro oxidative stress model. Cell viability detected by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) lactate dehydrogenase (LDH). Flow cytometry fluorescence assays were performed for evaluating the ROS levels mitochondrial membrane potential (MMP). Immunofluorescence analysis NRF2 nuclear translocation autophagy indicators. Further, Western blotting quantitative real-time PCR evaluate expression proteins mRNAs. Molecular docking, CETSA, molecular interaction explored binding between OP TLR4. The vivo determined using preclinical rat Results protected against tBHP-treated injury, reduced reversed damaged MMP. Mechanistically, activated NRF2-related pathways, inhibited attenuated TLR4/MAPK signaling pathway H9C2 cells high affinity TLR4 ( K D = 37.5 µM). inhibitor TAK242 showed similar as OP. In vivo, could alleviate cardiac it ameliorated adverse remodeling. Consistent studies, NRF2-dependent pathways vivo. Conclusion This study shows that binds regulate protecting cardiomyocytes, supporting can be therapeutic agent MIRI.

Язык: Английский

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Polyphenol-Rich Extracts from Agroindustrial Waste and Byproducts: Results and Perspectives According to the Green Chemistry and Circular Economy

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(23), С. 12871 - 12895

Опубликована: Июнь 3, 2024

Polyphenols are natural secondary metabolites found in plants endowed with multiple biological activities (antioxidant, anti-inflammatory, antimicrobial, cardioprotective, and anticancer). In view of these properties, they find many applications used as active ingredients nutraceutical, food, pharmaceutical, cosmetic formulations. accordance green chemistry circular economy strategies, can also be recovered from agroindustrial waste reused various sectors, promoting sustainable processes. This review described structural characteristics, methods for extraction, polyphenolic extracts obtained two selected plant materials the Mediterranean area olive (Olea europaea L.) pomegranate (Punica granatum based on recent literature, highlighting future research perspectives.

Язык: Английский

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Hydrogen sulfide mitigates mitochondrial dysfunction and cellular senescence in diabetic patients: Potential therapeutic applications

Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116556 - 116556

Опубликована: Сен. 1, 2024

Язык: Английский

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From antiquity to contemporary times: how olive oil by-products and waste water can contribute to health

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Окт. 16, 2023

Since antiquity, numerous advantages of olive oil and its by-products have been recognized in various domains, including cooking, skincare, healthcare. Extra virgin is a crucial component the Mediterranean diet; several compounds exert antioxidant, anti-proliferative, anti-angiogenic pro-apoptotic effects against variety cancers, also affect cellular metabolism, targeting cancer cells through their metabolic derangements. Numerous tree parts, leaves, can contribute metabolites useful to human health. Olive mill waste water (OMWW), dark pungent liquid residue produced vast amounts during extraction, contains high organic matter concentrations that may seriously contaminate soil surrounding waters if not managed properly. However, OMWW rich source phytochemicals with health benefits. In ancient Rome, farmers would employ what was known as amurca, mulch-like by-product production, for many purposes applications. Several studies investigated chemopreventive activities extracts. The most prevalent polyphenol extracts hydroxytyrosol (HT). Verbascoside oleuperin are abundant. We assessed impact one such extract, A009, on endothelial (HUVEC) cells. A009 vitro assays (growth, migration, adhesion) inhibited angiogenesis vivo , outperforming HT alone. from tumors showed potential cardioprotective mitigating cardiotoxicity induced by chemotherapy drugs, commonly used treatment, reducing up-regulation pro-inflammatory markers cardiomyocytes. Extracts other evaluated biological international research teams. results obtained make them promising candidates further development nutraceutical cosmeceutical agents or dietary supplement, especially prevention even co-treatments anti-cancer drugs. Furthermore, offer benefits opens up avenues application field cardio-oncology.

Язык: Английский

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The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects

Advanced Science, Год журнала: 2024, Номер 11(38)

Опубликована: Авг. 9, 2024

Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain-gut-bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing its profound effects on occurrence development neurodegenerative diseases. No comprehensive review been conducted clarify triangular relationship involving axis potential for innovative therapies disorders. In light this, new perspective is aimed propose interplay between brain, gut, bone highlighting their dynamic communication in diseases, as they modulate including nervous, immune, endocrine, metabolic systems. Therapeutic strategies maintaining balance brain regulation, intestinal microbiota improving skeletal health, also explored. intricate interactions within pose challenge effective treatments can comprehensively target this system. Furthermore, safety these requires further evaluation. This offers novel insights prevention treatment which have important implications clinical practice patient well-being.

Язык: Английский

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Systemic Health Effects of Oleuropein and Hydroxytyrosol Supplementation: A Systematic Review of Randomized Controlled Trials

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1040 - 1040

Опубликована: Авг. 27, 2024

Non-communicable diseases (NCDs) cause 41 million deaths annually, accounting for 74% of global fatalities. The so-called Mediterranean diet, with its especially significant consumption olive oil, has shown promising results in reducing the risk developing NCDs, such as cardiovascular, liver, or bone diseases. In context nutritional health benefits foods, phenolic compounds oil's main components, oleuropein (OLE) and hydroxytyrosol (HT), have been to possess different beneficial effects. However, no systematic review evaluated health-promoting effects OLE HT until now. Consequently, this analyzed 12 human randomized controlled trials (RCTs), involving 683 participants, assess supplements, pure compounds, enriched foods containing regarding systemic outcomes, including CVD factors, liver parameters, bone, joint, cognitive health. found contrasting but encouraging results, some studies reporting modulation body weight, lipid profile, glucose metabolism, improvements functions. described dosages forms supplementation, ranging from 5 mg/d 990 mL/d leaf infusion (320.8 mg 11.9 HT), highlighting need further research determine optimal dosing duration. Despite mixed supplementation show potential improving cardiometabolic outcomes are necessary understand their better address existing limitations.

Язык: Английский

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Neuroprotective effect of hydroxytyrosol-rich-olive mill wastewater extract on retinal degeneration in Tunisian Psammomys obesus, a model of diabetic retinopathy like human

Euro-Mediterranean Journal for Environmental Integration, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Язык: Английский

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Impact of pharmacokinetic enhancement strategies on the antimicrobial and antioxidant activities of hydroxytyrosol

RSC Advances, Год журнала: 2025, Номер 15(5), С. 3448 - 3464

Опубликована: Янв. 1, 2025

Investigation of the impact two approaches, chemical modification by lipophilization and liposomal encapsulation, on antioxidant antimicrobial properties hydroxytyrosol.

Язык: Английский

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Multi‐Plant Concentrated Powder Improved Skin Whitening: A Double‐Blinded, Randomized, and Placebo‐Controlled Clinical Study

Journal of Cosmetic Dermatology, Год журнала: 2025, Номер 24(2)

Опубликована: Фев. 1, 2025

ABSTRACT Introduction With the growing demand for skin‐enhancing products in market, research into edible plants has expanded significantly. Numerous studies have shown that plant extracts rich phytochemicals can effectively improve skin issues such as wrinkles, pigmentation, and dullness. However, clinical focusing on effects of combined ingredients are still limited. Objective This study three known their skin‐beautifying clinically tested functional properties. Methods Sixty healthy subjects were screened randomly divided two groups: a test group (TG) placebo (PG). TG took tablets multi‐plant concentrated powder daily, while PG without active ingredients. The lasted 12 weeks. Plasma Trolox equivalent antioxidant capacity (TEAC), superoxide dismutase (SOD), glutathione peroxidase (GPx) measured at week 0 (W0), 8 (W8), (W12). Skin brightness ( L * value), tone (Individual Typological Angle (ITA°)), erythema spots, wrinkles assessed 4 (W4), Results showed significant improvements all markers blood after consuming compound ingredient compared to p < 0.01). value ITA° significantly increased from weeks 0.1). spots decreased W8 W12 While noticeable reductions within 0.1), there no differences PG. Conclusions Consumption improved whitening, brightened tone, reduced some improvement erythema. Trial Registration ClinicalTrials.gov identifier: NCT05988567

Язык: Английский

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Microbial signatures and therapeutic strategies in neurodegenerative diseases

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117905 - 117905

Опубликована: Фев. 10, 2025

Язык: Английский

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