The microbial metabolite trimethylamine N-oxide and the kidney diseases DOI Creative Commons
Jian Su,

Xiangqi Wu,

Qi Wang

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Март 11, 2025

Trimethylamine N-oxide (TMAO), a metabolite, is co-metabolite produced by both gut microbiota and livers, originating from foods rich in choline or carnitine. Emerging evidence suggests that TMAO may play role the pathogenesis of various kidney diseases, including acute injury chronic disease. Research has demonstrated heightened levels are correlated with likelihood disease advancement cardiovascular incidents among individuals Furthermore, been observed to stimulate inflammation, oxidative stress, fibrosis animal models Mechanistically, contribute inhibiting autophagy, activating NLRP3 inflammasome, inducing mitochondrial dysfunction. Therefore, targeting represent promising therapeutic strategy for treatment diseases. Future studies needed further investigate develop TMAO-targeted therapies prevention

Язык: Английский

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation DOI Creative Commons

Ziqi Ma,

Tao Zuo, Norbert Frey

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 23, 2024

Язык: Английский

Процитировано

19
Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites DOI Creative Commons
Yun Teng, Chao Luo,

Xiaolan Qiu

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 3, 2025

Abstract Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. Here we investigate plant-derived nanoparticles (PNP) on and metabolites in context cancer immunotherapy with humanized gnotobiotic mouse model. Specifically, show that ginger-derived exosome-like nanoparticle (GELN) preferentially taken up by Lachnospiraceae Lactobacillaceae mediated digalactosyldiacylglycerol (DGDG) glycine, respectively. We further demonstrate GELN aly-miR159a-3p enhances anti-PD-L1 therapy melanoma inhibiting expression recipient bacterial phospholipase C (PLC) increases accumulation docosahexaenoic acid (DHA). An increased level circulating DHA inhibits PD-L1 tumor cells binding promoter subsequently prevents c-myc-initiated transcription PD-L1. Colonization germ-free male mice bacteria from non-responding patients supplemented efficacy compared controls. Our findings reveal previously unknown mechanistic PNP human modulating metabolic pathways.

Язык: Английский

Процитировано

4
Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans-differentiation potential into 25 cell types DOI Creative Commons

Qiaoxi Yang,

Fatma Saaoud,

Yifan Lu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 24, 2024

Introduction Vascular smooth muscle cells (VSMCs) are the predominant cell type in medial layer of aorta, which plays a critical role aortic diseases. Innate immunity is main driving force for cardiovascular Methods To determine roles innate VSMC and pathologies, we performed transcriptome analyses on aortas from ApoE –/– angiotensin II (Ang II)-induced aneurysm (AAA) time course, atherosclerosis as well VSMCs stimulated with danger-associated molecular patterns (DAMPs). Results We made significant findings: 1) 95% 45% upregulated immune pathways (UIIPs, based data 1226 genes) Ang II-induced AAA at 7 days were different that 14 28 days, respectively; showed twin peaks UIIPs major peak minor days; 2) all 6 weeks 32 78 (two waves); 3) additional 12 lists immune-related genes 1325 cytokine chemokine genes, 2022 plasma membrane protein 373 clusters differentiation (CD) marker 280 nuclear 1425 nucleoli 6750 nucleoplasm 1496 transcription factors (TFs) including 15 pioneer TFs, 164 histone modification enzymes, 102 oxidative death 68 necrotic 47 efferocytosis confirmed two-wave inflammation twin-peak AAA; 4) DAMPs-stimulated judged by upregulation lists; 5) increased trans-differentiation potential upregulating not only some 82 markers VSMC-plastic types, fibroblast, osteogenic, myofibroblast, macrophage, adipocyte, foam cell, mesenchymal but also 18 new types (out 79 human 8065 markers); 6) analysis gene deficient transcriptomes indicated antioxidant factor NRF2 suppresses, however, other five inflammatory master regulators, AHR, NF-KB, NOX (ROS enzyme), PERK, SET7 promote twelve atherosclerosis, AAA, DAMP-stimulated VSMCs; 7) both trained tolerance-promoting metabolite itaconate contributed to cytokines AAA. Discussion Our findings have provided novel insights responses stresses development immunology therapeutic targets treating those cerebrovascular

Язык: Английский

Процитировано

15
Puerarin alleviates atherosclerosis via the inhibition ofPrevotella copriand its trimethylamine production DOI
Z H Li,

Jun Weng,

Jing‐Kun Yan

и другие.

Gut, Год журнала: 2024, Номер 73(12), С. 1934 - 1943

Опубликована: Май 22, 2024

Puerarin (PU) is a natural compound that exhibits limited oral bioavailability but has shown promise in the treatment of atherosclerosis (AS). However, precise mechanisms underlying its therapeutic effects remain incompletely understood. This study aimed to investigate PU and mitigating AS both mice humans.

Язык: Английский

Процитировано

12
The Interplay Between Dietary Choline and Cardiometabolic Disorders: A Review of Current Evidence DOI Creative Commons
Natalia G. Vallianou, Dimitris Kounatidis,

Sotiria Psallida

и другие.

Current Nutrition Reports, Год журнала: 2024, Номер 13(2), С. 152 - 165

Опубликована: Март 1, 2024

Abstract Purpose of Review Choline is an essential nutrient for human health and cellular homeostasis as it necessary the synthesis lipid cell membranes, lipoproteins, neurotransmitter acetylcholine. The aim this review to analyze beneficial effects choline its significance in metabolism various inflammatory pathways, such inflammasome. We will discuss dietary cardiometabolic disorders, non-alcoholic fatty liver disease (NAFLD), cardiovascular (CVD), chronic kidney (CKD) well cognitive function associated neuropsychiatric disorders. Recent Findings deficiency has been related development NAFLD disability offspring adulthood. In sharp contrast, excess intake mediated via increased production trimethylamine by gut microbiota trimethylamine-N-oxide (TMAO) levels atherosclerosis most studies. context, CVD CKD through accumulation TMAO, p-Cresyl-sulfate (pCS), indoxyl-sulfate (IS) serum may be result interplay between choline, TMAO microbiota, resulting activation responses fibrosis. Summary A balanced diet, with no nor any outmost importance regarding prevention disorders function. Large-scale studies use next-generation probiotics, especially Akkermansia muciniphila Faecalibacterium prausnitzii , should further examine their therapeutic potential context.

Язык: Английский

Процитировано

8
Unraveling the Complex Relationship Between Gut Microbiome and Cardiovascular Diseases DOI
W.H. Wilson Tang, Stanley L. Hazen

Circulation, Год журнала: 2024, Номер 149(20), С. 1543 - 1545

Опубликована: Май 13, 2024

Язык: Английский

Процитировано

8
When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development DOI
Bo Chen,

Guangyi Zeng,

Lulu Sun

и другие.

Science China Life Sciences, Год журнала: 2024, Номер 67(5), С. 854 - 864

Опубликована: Янв. 19, 2024

Язык: Английский

Процитировано

6
Targeting the Gut-Kidney Axis in Diarrhea with Kidney-Yang Deficiency Syndrome: The Role of Sishen Pills in Regulating TMAO-Mediated Inflammatory Response DOI Creative Commons

Shiqin Xie,

Leyao Fang,

Na Deng

и другие.

Medical Science Monitor, Год журнала: 2024, Номер 30

Опубликована: Май 15, 2024

Background:Sishen Pills (SSPs) are commonly used to treat diarrhea with kidney-yang deficiency syndrome.Trimethylamine-N-oxide (TMAO) is produced through the metabolism of gut microbiota and can participate in syndrome by mediating "gut-kidney axis" transmit inflammatory factors.This study combined network pharmacology animal experiments explore whether SSPs affecting interaction between TMAO microbiota. Material/Methods:A mouse model was constructed using adenine Folium sennae decoction, SSP decoction for treatment.This utilized predict potential mechanisms treating syndrome.16S rRNA high-throughput sequencing analyze mucosal microbial characteristics.ELISA measure TMAO, NOD-like receptor thermal protein domain associated 3 (NLRP3), interleukin-1b (IL-1b), transforming growth factor-b1 (TGF-b1) levels.We performed Masson immunohistochemical (Occludin, ZO-1) staining kidney small intestinal tissues.The fluorescein diacetate (FDA) hydrolysis spectrophotometric method assess activity contents intestine. Results:Network analysis revealed that modulate 108 target points involved development diarrhea, including IL-1b TNF.The experimental results demonstrated significantly improved general behavioral profiles mice, also reduced NLRP3, IL-1b, TGF-b1 levels (P<0.05).Correlation significant positive correlations concentrations (P<0.05).Pathological improvements renal fibrosis increased expression Occludin ZO-1 proteins tissue.In group, there a increase (P<0.001).According results, characteristic bacteria NR groups included Succinatimonas hippei, uncultured Solirubrobacter sp., Clostridium tyrobutyricum.Furthermore, were positively correlated (P<0.05) hippei tyrobutyricum.By modulating Firmicutes, tyrobutyricum, lowers alleviate syndrome. Conclusions:TMAO likely plays role syndrome.By adjusting reduce response transmitted as result elevated levels,

Язык: Английский

Процитировано

6
Soluble Glycoprotein VI Predicts Abdominal Aortic Aneurysm Growth Rate and is a Novel Therapeutic Target DOI

Tyler W. Benson,

Mindy Pike, Anthony Spuzzillo

и другие.

Blood, Год журнала: 2024, Номер 144(16), С. 1663 - 1678

Опубликована: Июнь 20, 2024

Язык: Английский

Процитировано

5
Simultaneous determination of choline, L-carnitine, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in plasma, liver, and feces of hyperlipidemic rats by UHPLC-MS/MS DOI Creative Commons

Changqian Xu,

Min Zhang, Shuo Zhang

и другие.

Journal of Chromatography B, Год журнала: 2024, Номер 1243, С. 124210 - 124210

Опубликована: Июнь 25, 2024

Due to the close correlation between choline, L-carnitine, betaine and their intestinal microbial metabolites, including trimethylamine (TMA) N-oxide (TMAO), creatinine, there has been an increasing interest in study of these compounds vivo.

Язык: Английский

Процитировано

5