Lecture notes in computer science, Год журнала: 2022, Номер unknown, С. 14 - 27
Опубликована: Янв. 1, 2022
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(10), С. 5680 - 5680
Опубликована: Май 19, 2022
Cardiovascular diseases (CVDs) are a major healthcare burden on the population worldwide. Early detection of this disease is important in prevention and treatment to minimise morbidity mortality. Biomarkers critical tool either diagnose, screen, or provide prognostic information for pathological conditions. This review discusses historical cardiac biomarkers used detect these conditions, discussing their application limitations. Identification new have since replaced now use routine clinical practice, but still do not all disease. Future showing promise early studies, further studies required show value improving CVD above current biomarkers. Additionally, analytical platforms that would allow them be adopted yet established. There also need identify whether can diagnostic, prognostic, screening purposes, which will impact implementation practice.
Язык: Английский
Процитировано
45
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 163, С. 114817 - 114817
Опубликована: Май 2, 2023
Cardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem have high morbidity mortality worldwide, as well substantial health economic burdens, representing urgent clinical need. In recent years, the focus of research has shifted from use mesenchymal stem cells (MSCs) for transplantation to their secretory exosomes (MSC-exosomes) treatment numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusion (I/R), aneurysm, stroke. MSCs are pluripotent with multiple differentiation pathways that exert pleiotropic effects by producing soluble factors, most effective components which exosomes. MSC-exosomes considered be excellent promising cell-free therapy CVDs due higher circulating stability, improved biocompatibility, reduced toxicity, immunogenicity. addition, play critical roles in repairing inhibiting apoptosis, regulating inflammation, ameliorating cardiac remodeling, promoting angiogenesis. Herein, we describe knowledge about biological characteristics MSC-exosomes, investigate mechanism mediate therapeutic repair, summarize advances efficacy a view toward future applications.
Язык: Английский
Процитировано
32
Experimental Eye Research, Год журнала: 2022, Номер 222, С. 109152 - 109152
Опубликована: Июнь 14, 2022
Язык: Английский
Процитировано
36
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 17, 2025
Circular RNAs (circRNAs), constituting a novel class of endogenous non-coding generated through the reverse splicing mRNA precursors, possess capacity to regulate gene transcription and translation. Recently, pivotal role circRNAs in controlling vascular aging, as well pathogenesis progression aging-related diseases, has garnered substantial attention. Vascular aging plays crucial increased morbidity mortality elderly. Endothelial cells (ECs) smooth muscle (VSMCs) are components intima media layers wall, respectively, closely involved mechanisms underlying diseases. The review aims provide comprehensive exploration connection between Besides, circRNAs, potential diagnostic markers or therapeutic targets for will be discussed thoroughly, along with challenges limitations their clinical application. Investigating molecular diseases insight into early diagnosis therapy, even effective prognosis assessment these conditions.
Язык: Английский
Процитировано
1
Cardiovascular Drugs and Therapy, Год журнала: 2024, Номер unknown
Опубликована: Янв. 30, 2024
Язык: Английский
Процитировано
5
Pharmacological Research, Год журнала: 2024, Номер 206, С. 107279 - 107279
Опубликована: Июнь 26, 2024
Transfer RNA-derived small RNAs (tsRNAs) are a class of non-coding RNA (sncRNA) molecules derived from tRNA, including tRNA fragments (tRFs) and halfs (tiRNAs). tsRNAs can affect cell functions by participating in gene expression regulation, translation intercellular signal transduction, immune response. They have been shown to play an important role various human diseases, cardiovascular diseases (CVDs). Targeted regulation the progression CVDs. The induced pathological conditions be detected when released into extracellular, giving them enormous potential as disease biomarkers. Here, we review biogenesis, degradation process related functional mechanisms tsRNAs, discuss research progress application prospects different CVDs, provide new perspective on treatment
Язык: Английский
Процитировано
5
Biochemistry (Moscow), Год журнала: 2024, Номер 89(S1), С. S1 - S13
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
4
Non-coding RNA Research, Год журнала: 2024, Номер 9(3), С. 930 - 944
Опубликована: Апрель 17, 2024
From a global perspective, cardiovascular diseases (CVDs), the leading factor accounting for population mortality, and circRNAs, RNA molecules with stable closed-loop structures, have been proven to be closely related. The latent clinical value potential role of circRNAs in CVDs attracting increasing, active research interest, but bibliometric studies this field are still lacking. Thus, study, we conducted analysis by using software such as VOSviewer, CiteSpace, Microsoft Excel, R package determine current progress hotspots ultimately provide an overview development trends future frontiers field. In our based on search strategy, total 1206 publications published before July 31, 2023 were accessed from WOSCC database. According findings, there is notable increasing trend circRNA CVDs. China was found dominant country terms publication number, lack high-quality articles significant fault. A cluster co-cited references indicated that dilated cardiomyopathy, AMI, cardiac hypertrophy greatest objects concern. contrast, keywords high importance has ascribed MI, abdominal aortic aneurysm, cell proliferation, coronary artery diseases.
Язык: Английский
Процитировано
4
Gene, Год журнала: 2022, Номер 851, С. 146950 - 146950
Опубликована: Окт. 10, 2022
Язык: Английский
Процитировано
16
Journal of Orthopaedic Surgery and Research, Год журнала: 2023, Номер 18(1)
Опубликована: Сен. 22, 2023
Abstract Background Circular RNAs (circRNAs) are important regulators on the onset and progression of rheumatoid arthritis (RA). Our purpose is to explore role underpin mechanism circ_0000396 in RA progression. Methods patients ( n = 39) healthy volunteers 33) were recruited from Affiliated Hospital Shaanxi University Chinese Medicine for present work. Circ_0000396, microRNA-574-5p (miR-574-5p) R-spondin 1 (RSPO1) RNA levels analyzed by reverse transcription-quantitative polymerase chain reaction. Cell proliferation was 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, colony formation 5-ethynyl-2′-deoxyuridine (EDU) assay. apoptosis assessed flow cytometry. Protein expression proliferating cell nuclear antigen (PCNA), Cyclin D1, E1, BCL2-associated × protein (Bax), B-cell lymphoma-2 (Bcl2), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) RSPO1 detected western blot Enzyme-linked immunosorbent assay (ELISA) conducted analyze secretion pro-inflammatory cytokines including IL-1β TNF-α. The interaction between miR-574-5p or confirmed dual-luciferase reporter RNA-pull down Results Circ_0000396 notably down-regulated compared with controls. overexpression suppressed inflammatory response triggered synovial fibroblasts (RASFs), accompanied decreases PCNA, Bcl2, TNF-α an increase Bax expression. acted as a molecular sponge miR-574-5p, overexpression-mediated protective effects RASFs dysfunction largely reversed introduction mimics. interacted 3’ untranslated region (3’UTR) RSPO1, negatively regulated RASFs. could up-regulate sponging interference overturned Conclusion restrained inflammation induced mediating miR-574-5p/RSPO1 axis, which provided novel potential targets treatment.
Язык: Английский
Процитировано
9