Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 23, 2023
Regulated
cell
death
(RCD)
is
a
strategy
employed
by
host
cells
to
defend
invasions
of
pathogens,
such
as
viruses
and
bacteria.
Ferroptosis
type
RCD
characterized
excessive
accumulation
iron
lipid
peroxidation.
While
ferroptosis
primarily
considered
mechanism
associated
with
tumorigenesis,
emerging
evidence
begin
suggest
that
it
may
play
essential
role
during
virus
infections.
Recent
studies
illustrated
activation
could
either
induce
or
prohibit
various
types
RCDs
facilitate
replication
evade
surveillance.
More
experimental
has
demonstrated
how
regulate
influence
replication,
transmission,
pathogenesis.
This
review
summarizes
ferroptosis-related
metabolism,
including
peroxidation,
antioxidant
metabolism.
Furthermore,
we
discuss
the
interplay
between
viral
infections
process,
focus
on
exploit
for
its
own
replication.
Understanding
impacts
infection
can
offer
valuable
insights
into
development
effective
therapeutic
strategies
combat
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114312 - 114312
Опубликована: Май 19, 2023
Neurodegenerative
diseases,
such
as
Alzheimer's
disease
(AD),
are
characterized
by
massive
loss
of
specific
neurons.
It
is
a
progressive
disabling,
severe
and
fatal
complex
disease.
Due
to
its
pathogenesis
limitations
clinical
treatment
strategies,
it
poses
serious
medical
challenge
burden
worldwide.
The
AD
not
clear,
potential
biological
mechanisms
include
aggregation
soluble
amyloid
form
insoluble
plaques,
abnormal
phosphorylation
tau
protein
formation
intracellular
neurofibrillary
tangles
(NFT),
neuroinflammation,
ferroptosis,
oxidative
stress
metal
ion
disorders.
Among
them,
ferroptosis
newly
discovered
programmed
cell
death
induced
iron-dependent
lipid
peroxidation
reactive
oxygen
species.
Recent
studies
have
shown
that
closely
related
AD,
but
the
mechanism
remains
unclear.
may
be
iron
metabolism,
amino
acid
metabolism
affecting
accumulation
ions.
Some
chelating
agents
(deferoxamine,
deferiprone),
chloroiodohydroxyquine
derivatives,
antioxidants
(vitamin
E,
lipoic
acid,
selenium),
derivatives
Fer-1,
tet,
etc.
been
in
animal
effective
exert
neuroprotective
effects.
This
review
summarizes
regulation
natural
plant
products
on
order
provide
reference
information
for
future
research
development
inhibitors.
Pharmacological Research,
Год журнала:
2024,
Номер
200, С. 107056 - 107056
Опубликована: Янв. 15, 2024
Sepsis
is
a
dysregulated
response
to
infection
that
can
result
in
life-threatening
organ
failure,
and
septic
cardiomyopathy
serious
complication
involving
ferroptosis.
Olaparib,
classic
targeted
drug
used
oncology,
has
demonstrated
potential
protective
effects
against
sepsis.
However,
the
exact
mechanisms
underlying
its
action
remain
be
elucidated.
In
our
study,
we
meticulously
screened
ferroptosis
genes
associated
with
sepsis,
conducted
comprehensive
functional
enrichment
analyses
delineate
relationship
between
mitochondrial
damage.
Eight
sepsis-characterized
were
identified
sepsis
patients,
including
DPP4,
LPIN1,
PGD,
HP,
MAPK14,
POR,
GCLM,
SLC38A1,
which
significantly
correlated
quality
imbalance.
Utilizing
DrugBank
molecular
docking,
robust
interaction
of
Olaparib
these
genes.
Lipopolysaccharide
(LPS)-stimulated
HL-1
cells
monocytes
establish
an
vitro
model.
Additionally,
vivo
model
was
developed
using
mice
subjected
cecal
ligation
perforation
(CLP).
Intriguingly,
low-dose
(5
mg/kg)
effectively
mitigated
markers
ferroptosis,
concurrently
improving
quality.
This
led
marked
enhancement
cardiac
function
significant
increase
survival
rates
(p
<
0.05).
The
mechanism
through
ameliorates
leukocyte
post-sepsis
attributed
facilitation
mitophagy,
thus
favoring
integrity.
conclusion,
findings
suggest
improve
by
accelerating
mitophagy
flux,
consequently
inhibiting
preserving
after
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 20, 2023
Triple-negative
breast
cancer
(TNBC)
is
a
highly
heterogeneous
tumor
type
that
malignant,
invasive,
and
recurrent.
Ferroptosis
unique
mode
of
programmed
cell
death
(PCD)
at
the
morphological,
physiological,
molecular
levels,
mainly
characterized
by
induced
iron-dependent
accumulation
lipid
peroxides,
which
plays
substantial
role
in
variety
diseases,
including
tumors
inflammatory
diseases.
TNBC
cells
have
been
reported
to
display
peculiar
equilibrium
metabolic
profile
iron
glutathione,
may
increase
sensitivity
ferroptosis.
possesses
higher
ferroptosis
than
other
types.
also
occurred
between
immune
cells,
suggesting
regulating
remodel
modulating
response.
Many
ferroptosis-related
genes
or
molecules
characteristic
expression
patterns
are
expected
be
diagnostic
targets
for
TNBC.
Besides,
therapeutic
strategies
based
on
ferroptosis,
isolation
extraction
natural
drugs
use
inducers,
urgent
personalized
treatment.
Thus,
this
review
will
explore
contribution
progression,
diagnosis,
treatment,
provide
novel
perspectives
management.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 4, 2023
Diabetic
nephropathy
(DN)
is
a
chronic
inflammatory
disease
that
affects
millions
of
diabetic
patients
worldwide.
The
key
to
treating
DN
early
diagnosis
and
prevention.
Once
the
patient
enters
clinical
proteinuria
stage,
renal
damage
difficult
reverse.
Therefore,
developing
treatment
methods
critical.
pathogenesis
results
from
various
factors,
among
which
immune
response
inflammation
play
major
roles.
Ferroptosis
newly
discovered
type
programmed
cell
death
characterized
by
iron-dependent
lipid
peroxidation
excessive
ROS
production.
Recent
studies
have
demonstrated
activation
closely
related
occurrence
development
ferroptosis.
Moreover,
hyperglycemia
induces
iron
overload,
peroxidation,
oxidative
stress,
inflammation,
fibrosis,
all
are
pathogenesis,
indicating
ferroptosis
plays
role
in
DN.
this
review
focuses
on
regulatory
mechanisms
ferroptosis,
mutual
processes
involved
inflammation.
By
discussing
analyzing
relationship
between
DN,
we
can
deepen
our
understanding
develop
new
therapeutics
targeting
or
inflammation-related
for
with
Redox Biology,
Год журнала:
2024,
Номер
73, С. 103179 - 103179
Опубликована: Май 8, 2024
Increasing
evidences
demonstrate
that
environmental
stressors
are
important
inducers
of
acute
kidney
injury
(AKI).
This
study
aimed
to
investigate
the
impact
exposure
Cd,
an
stressor,
on
renal
cell
ferroptosis.
Transcriptomics
analyses
showed
arachidonic
acid
(ARA)
metabolic
pathway
was
disrupted
in
Cd-exposed
mouse
kidneys.
Targeted
metabolomics
oxidized
ARA
metabolites
were
increased
mice.
Renal
4-HNE,
MDA,
and
ACSL4,
upregulated
Consistent
with
animal
experiments,
vitro
experiments
mitochondrial
lipids
elevated
HK-2
cells.
Ultrastructure
membrane
rupture
Mitochondrial
cristae
accordingly
reduced
SIRT3,
NAD
Objective
Sirt6,
reactive
oxygen
species
and
ferroptosis
may
participate
in
the
pathogenesis
of
Diabetic
Nephropathy
(DN).
Exploring
relationship
between
oxidative
stress,
provides
new
scientific
ideas
to
DN.
Cell Death Discovery,
Год журнала:
2023,
Номер
9(1)
Опубликована: Июль 12, 2023
Abstract
Pulmonary
hypertension
(PH)
is
a
clinical
and
pathophysiological
syndrome
caused
by
changes
in
pulmonary
vascular
structure
or
function
that
results
increased
resistance
arterial
pressure,
it
characterized
endothelial
dysfunction,
artery
media
thickening,
remodeling,
right
ventricular
hypertrophy,
all
of
which
are
driven
an
imbalance
between
the
growth
death
cells.
Programmed
cell
(PCD),
different
from
necrosis,
active
cellular
mechanism
activated
response
to
both
internal
external
factors
precisely
regulated
More
than
dozen
PCD
modes
have
been
identified,
among
apoptosis,
autophagy,
pyroptosis,
ferroptosis,
necroptosis,
cuproptosis
proven
be
involved
pathophysiology
PH
varying
degrees.
This
article
provides
summary
regulatory
patterns
their
potential
effects
on
PH.
Additionally,
describes
current
understanding
this
complex
interconnected
process
analyzes
therapeutic
targeting
specific
as
molecular
targets.
