Gum Arabic-mediated liquid exfoliation of transition metal dichalcogenides as photothermic anti-breast cancer candidates

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 244, С. 124982 - 124982

Опубликована: Май 25, 2023

Язык: Английский

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An overview of plant-mediated biogenic synthesis of nano-catalysts and their application in Fenton and photo-Fenton processes for wastewater remediation

Chemical Engineering Journal, Год журнала: 2023, Номер 477, С. 146941 - 146941

Опубликована: Окт. 27, 2023

Язык: Английский

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Journal of Medicinal and Chemical Sciences, Год журнала: 2022, Номер 5(6)

Опубликована: Июнь 12, 2022

There is an unequivocal relationship between oxidative stress and diabetes development, progression, or both. In recent years, some novel bioactive compounds derived from plants have shown antidiabetic activity with more efficacy than the oral hypoglycaemic medications used in clinical therapy, implying a bright future for treatment. this work, powdered quince dried seeds were subjected to extract ethanol, ethyl acetate, chloroform, n-hexane, diethyl ether using sonication-catalyzed extraction. Then, set of tests conduct preliminary phytochemical screening. vitro, hydroxyl radical- DPPH radical-snaring assays assess antioxidant acquired extracts. The inhibition α-glucosidase α-amylase determine Compared ethanol extract, extracts had weaker free radical-snaring, α-amylase, inhibitory activities. results study revealed that crude are good sources key components significant properties can be considered promising source lead management mellitus.

Язык: Английский

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Journal of Medicinal and Chemical Sciences, Год журнала: 2022, Номер 5(5)

Опубликована: Май 5, 2022

In recent times, many researchers in pharmaceutical chemistry have been preoccupied with the quest for new potent anti-infective agents to combat antimicrobial resistance. A novel series of naphthalene-based derivatives were synthesized as part these studies. Different spectral techniques, such UV–Vis, FTIR, 13C-NMR, and 1H-NMR used affirm compounds' chemical structures, while an ADME study was conducted investigate their pharmacokinetics drug-like properties. The potential candidates versus pathogenic microbes evaluated using a broth microdilution assay. These involved six aerobic gram-negative bacteria, four anaerobic two fungi. addition, safety assessed normal bacterial flora. From obtained results, authors reported following principal outcomes: Compound SF5 revealed significant bactericidal impact indicating high non-pathological strain. Most demonstrated outstanding fungicidal candidates, but compound SF1 most one. According analysis, almost all good theoretical drug-likeness characteristics making them suitable oral-derived agents.

Язык: Английский

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Intraoperative Fluid Management for Major Neurosurgery: Narrative study

2022 International Symposium on Multidisciplinary Studies and Innovative Technologies (ISMSIT), Год журнала: 2022, Номер unknown, С. 311 - 314

Опубликована: Окт. 20, 2022

neuroanesthesia and critical care for neurosurgical patients, the anesthesiologist plan should have a judicious regimen of fluid management because it will be obliging in improve surgical outcomes. When fluids is replaced by good regimen, help neurosurgeon to avoid brain edema formation intravenous congestion whereas enhancing patient's volume status maintain both adequate cerebral perfusion oxygenation. We searched current available literature RCTs on MEDLINE, EMBASE Cochrane Evidence Based Medicine Reviews. Furthermore, citation review hand search new journals related therapy neuro-surgeries were done. Because absent any specific evidence which concerning optimal replacement, at least that are demonstrated harmful avoided. Thoughtful preoperative appreciatin pathophysiology individual patient an effective maner suitable desion type amount fluid. Every thing normal, this main objective from during neurosurgery can achieved maintaining continuity each glocuse level, sodium level intravascular within normality.

Язык: Английский

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Modified frankincense resin stabilized gold nanoparticles for enhanced antioxidant and synergetic activity in in-vitro anticancer studies

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134935 - 134935

Опубликована: Авг. 22, 2024

For the first time, Frankincense resin (FR) has been carboxymethylated to produce CMFR - AuNPs and conjugate was utilized for Doxorubicin drug loading. The carboxymethylation of carboxylic, phenolic, hydroxyl functional groups FR developed into (CMFR). A novel CMFR-AuNPs synthesized using as a stabilizing reducing agent. antibacterial, antioxidant, in-vitro anticancer activities were investigated by AuNPs@DOX. demonstrated antioxidative properties quenching DPPH radicals effectively. DOX@CMFR-AuNPs strong antibacterial activity against K. pneumoniae, S. aureus, B. subtilis, E. coli. cell viability tested -AuNPs at various concentrations Dox-loaded (CMFR-AuNPs + Dox1, Dox 2, & 3). highest inhibition observed on MCF-7 HeLa lines 3, respectively. Various techniques such UV, FTIR, TGA, XRD, SEM, EDAX TEM used characterize designed CMFR-AuNPs. After carboxy methylation, amorphous nature changed crystallinity, reflected in XRD spectra. spectrum CMFR- showed FCC structure due involvement carboxylic strongly bound with AuNPs. TGA results revealed that is thermally more stable than FR. well dispersed, spherical, hexagonal an average diameter 7 10 nm, while size doxorubicin loaded (DOX@CMFR-AuNPs) 11 13 nm. Green have potential enhance loading efficacy drugs.

Язык: Английский

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Journal of Medicinal and Chemical Sciences, Год журнала: 2022, Номер 5(6)

Опубликована: Июнь 12, 2022

Microbial infection and microbial resistance to the classical antibiotics have been immense challenges which portend health of societies. This has directed researchers straight their attention onto plants discover new possible antimicrobial compounds. In this work, 5 solvents were employed extract dried seeds powder quince by ultrasound including ethanol, ethyl-acetate, chloroform, n-hexane, diethyl-ether. Each was subjected three in vitro tests using broth-dilution method. The antibacterial effect against following aerobic bacteria are Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumonia 700603, Haemophilus influenzae 49247, Escherichia coli 25922, Salmonella typhi 6539, Shigella dysenteriae 13313, non-pathogenic BAA-1427 applying ciprofloxacin antibiotic as a standard reference, study anaerobic include Bacteroides fragilis 25285, Clostridium perfringens 13124, Fusobacterium necrophorum 25286, Prevotella melaninogenica 25845 employing metronidazole antifungal versus Candida albicans 10231 Aspergillus niger 16888, nystatin reference. toxicity normal bacterial flora evaluated verify safety profile extracts. results revealed that extracts activities with supremacy linked ethanol extract. accordance activity evidence values, displayed bactericidal fungicidal activities, having least harmful strain.

Язык: Английский

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Journal of Medicinal and Chemical Sciences, Год журнала: 2022, Номер 5(6)

Опубликована: Июнь 12, 2022

Even with the significant advancements in medical and therapeutical fields, finding efficient anti-diabetic anti-oxidative entities is of high significance recent era. New coumarin-disubstituted benzene conjugates were prepared to evaluate their antidiabetic antioxidative effects. The (MT0-MT7) characterized utilizing various analytical techniques, including FTIR, UV–Vis, 1H-NMR, 13C-NMR. Also, drug-likeness properties assessed in-silico. effect was estimated in-vitro based on inhibitory impact porcine α-amylase yeast α-glucosidase enzymes; whereas appraised snaring hydroxide DPPH radicals. findings evaluating these effects demonstrated that MT2 MT3 had a prominent related standard. In addition, MT0 conjugate showed distinct comparable Thus, MT2, MT3, could be used as scaffolds develop new class entities. Moreover, in-silico analysis revealed majority convenient for oral drug-delivery system.

Язык: Английский

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The Effects of Different Concentrations of Vitamin D3 on Immunological Parameters of Immunosuppressed Rats Induced

World s Veterinary Journal, Год журнала: 2024, Номер unknown, С. 145 - 150

Опубликована: Март 25, 2024

Vitamin D3 receptor is expressed in several types of immune cells suggesting that could have regulatory roles. The current study was conducted to investigate the role reducing toxicity cisplatin on some Immunological parameters rat model. experiment 80 adult white male rats within age range 9-12 weeks. animals were divided into eight groups (10 each group). control group dosed with physiological solution until end (C). Rats second treatment injected (2 mg/kg, T1). third (T2), fourth (T3), and fifth (T4) at a concentration mg/kg) received levels 5000 IU, 10,000 15,000 respectively. sixth (T5), seventh (T6), eighth (T7) subjected concentrations IU,10,000 At experiment, which lasted 21 days, anesthetized, their weights recorded, blood samples collected. findings revealed significant elevation interleukin-12, tumor necrosis factor-alpha, C-reactive protein, lymphocyte percentage, monocyte eosinophil percentage T1 compared other D3. average neutrophils significantly lesser than groups. It can be concluded supplementation different (5000-10,000 IU) positive influences immunological immunosuppressed rats.

Язык: Английский

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Journal of Medicinal and Chemical Sciences, Год журнала: 2022, Номер 5(5)

Опубликована: Май 5, 2022

This work involves the synthesis of eight novel fused coumarin compounds, which were confirmed by various spectrophotometers and then, assessed for their apoptotic-inducing free radical-quenching activities. The pharmacokinetic parameters evaluated in silico using pre-ADMET, a online program. activity was tested against six tumorigenic cell lines. Also, safety normal cells examined. checking these compounds' ability to eliminate DDPT hydroxyl moieties. Pharmacokinetic investigations showed that synthesized compounds have excellent penetration across GIT mucosa most them poor blood-brain barrier. These findings suggest good oral bioavailability along with low neurological toxicity profiles. evaluation revealed all weaker as compared reference. Among SA4 potent one. Nevertheless, new had an profile cells. On other hand, assessment also indicated less active than In this field, SA0 strongest compound. From realizations, apparent characteristics accordance study, are considered promising agents. authors hope can be utilized coming years production powerful drugs potentials help battle many diseases.

Язык: Английский

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