Journal of Complementary and Integrative Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Abstract
Objectives
To
evaluate
the
antidepressant-like
effects
of
Phenylthiazolyl-1,3,5-triazine
derivatives
through
behavioral
tests,
molecular
docking,
and
histopathological
analysis
in
a
rat
brain
model
depression.
Methods
were
synthesized
administered
at
dose
30
mg/kg
albino
rats.
Behavioral
assessed
using
Forced
Swim
Test
Tail
Suspension
Test.
Molecular
docking
with
MD
simulations
via
CDocker
was
employed
to
analyze
ligand-receptor
interactions.
Histological
tissues
conducted
assess
structural
vascular
changes.
Results
Among
derivatives,
PS1
PS5
showed
significant
activity
compared
standard
imipramine.
revealed
that
hydrogen
bonding,
pi-pi
interactions,
intermolecular
neighbor
stabilized
complexes.
Histopathological
PS1-treated
rats
demonstrated
preserved
integrity,
reduced
edema,
absence
hydrophobic
alterations.
Conclusions
Phenylthiazolyl-1,3,5-triazines,
particularly
PS1,
exhibit
promising
potential
as
antidepressant
agents.
Their
efficacy
protective
histological
suggest
therapeutic
relevance.
Further
studies
integrating
biomarkers
gene
expression
analyses
are
needed
optimize
these
for
clinical
application.
Cellular and Molecular Neurobiology,
Год журнала:
2024,
Номер
44(1)
Опубликована: Окт. 8, 2024
The
increasing
prevalence
of
neurological
disorders
such
as
Alzheimer's,
Parkinson's,
and
multiple
sclerosis
presents
a
significant
global
health
challenge.
Despite
extensive
research,
the
precise
mechanisms
underlying
these
conditions
remain
elusive,
with
current
treatments
primarily
addressing
symptoms
rather
than
root
causes.
Emerging
evidence
suggests
that
gut
permeability
kynurenine
pathway
are
involved
in
pathogenesis
conditions,
offering
promising
targets
for
novel
therapeutic
preventive
strategies.
Gut
refers
to
intestinal
lining's
ability
selectively
allow
essential
nutrients
into
bloodstream
while
blocking
harmful
substances.
Various
factors,
including
poor
diet,
stress,
infections,
genetic
predispositions,
can
compromise
integrity,
leading
increased
permeability.
This
condition
facilitates
translocation
toxins
bacteria
systemic
circulation,
triggering
widespread
inflammation
impacts
via
gut-brain
axis.
axis
(GBA)
is
complex
communication
network
between
central
nervous
system.
Dysbiosis,
an
imbalance
microbiota,
increase
inflammation,
exacerbating
neuroinflammation-a
key
factor
disorders.
pathway,
primary
route
tryptophan
metabolism,
significantly
implicated
this
process.
Dysregulation
context
leads
production
neurotoxic
metabolites,
quinolinic
acid,
which
contribute
neuronal
damage
progression
narrative
review
highlights
potential
progress
understanding
mechanisms.
Interventions
targeting
maintaining
balanced
microbiota
through
probiotics,
lifestyle
modifications
show
promise
reducing
neuroinflammation
supporting
brain
health.
In
addition,
pharmacological
approaches
aimed
at
modulating
directly,
inhibitors
indoleamine
2,3-dioxygenase,
offer
avenues
new
treatments.
Understanding
interconnected
pathways
crucial
developing
effective
strategies
prevent
manage
Pharmacological Research,
Год журнала:
2024,
Номер
207, С. 107322 - 107322
Опубликована: Июль 20, 2024
Depression
is
a
common
mental
disorder,
the
effective
treatment
of
which
remains
challenging
issue
worldwide.
The
clinical
pathogenesis
depression
has
been
deeply
explored,
leading
to
formulation
various
pathogenic
hypotheses.
Among
these,
monoamine
neurotransmitter
hypothesis
holds
prominent
position,
yet
it
significant
limitations
as
more
than
one-third
patients
do
not
respond
conventional
treatments
targeting
transmission
disturbances.
Over
past
few
decades,
growing
body
research
highlighted
link
between
inflammation
and
potential
key
factor
in
pathophysiology
depression.
In
this
review,
we
first
summarize
relationship
depression,
with
focus
on
pathophysiological
changes
mediated
by
mechanisms
linking
well
multiple
anti-inflammatory
strategies
are
also
discussed,
their
efficacy
safety
assessed.
This
review
broadens
perspective
specific
aspects
using
for
treating
laying
groundwork
advancing
precision
medicine
individuals
suffering
from
"inflamed"
European Journal of Neuroscience,
Год журнала:
2023,
Номер
57(11), С. 1913 - 1928
Опубликована: Апрель 18, 2023
Abstract
The
pro‐inflammatory
cytokines
IL‐1α,
IL‐6
and
TNF‐α
are
associated
with
major
depressive
disorder,
psychological
distress,
cardiovascular
health
obesity.
However,
there
is
limited
research
that
has
examined
multiple
associations
between
these
variables,
particularly
among
individuals
disorder
who
treatment
free,
in
comparison
a
control
cohort,
including
analyses
of
sex
differences.
In
this
study,
data
were
analysed
from
60
controls,
plasma
TNF‐α,
adiposity
measures
(body
mass
index,
waist
circumference),
indices
(blood
pressure,
heart
rate)
symptoms
(depressive
severity,
anxiety,
hostility,
stress).
compared
by
group
correlated
adiposity,
health.
Plasma
IL‐1α
higher
versus
control,
but
interaction
for
IL‐6,
difference
only
females.
did
not
differ
groups.
hostility
stress,
whereas
anxiety
hostility.
Psychopathology
was
males
females
only.
None
the
body
circumference,
blood
pressure
or
rate.
result
sex‐specific
psychometrics
could
be
aetiologically
important
depression
interventions
treatments
males,
warranting
further
investigation.
European journal of psychotraumatology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 13, 2025
Background:
Depression
is
a
prevalent
mental
disorder
with
high
morbidity
and
mortality
globally.
Methylmalonic
acid
(MMA)
involved
in
the
pathogenesis
of
numerous
diseases.
However,
it
unclear
whether
there
an
association
between
MMA
prevalence
depression.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Окт. 4, 2023
The
microbiota
gut
brain
(MGB)
axis
has
been
shown
to
play
a
significant
role
in
the
regulation
of
inflammatory
and
infective
diseases.
Exploring
structure
communication
mode
MGB
is
crucial
for
understanding
its
diseases,
studying
signaling
pathways
regulatory
methods
diseases
also
profound
significance
future
clinical
research.
This
article
reviews
composition,
mechanism
including
Parkinson’s
disease
(PD),
Alzheimer’s
(AD),
multiple
sclerosis
(MS),
autism
spectrum
disorder
(ASD),
depression,
psoriasis,
irritable
bowel
syndrome
(IBS),
(IBD).
In
addition,
our
investigation
delved
into
functions
inflammasome,
IFN-I,
NF-κB,
PARK7/DJ-1
innate
immune
pathway
context
Ultimately,
we
discussed
efficacy
various
interventions,
fecal
transplantation
(FMT),
antibiotics,
probiotics,
prebiotics,
synbiotics,
postbiotics,
management
Understanding
might
make
positive
effects
treatment
