Association between methylmalonic acid and prevalence of depression in US adults: evidence from NHANES 2011–2014 DOI Creative Commons
Siqi Li,

Wenbin Nan,

Zhenyu Peng

et al.

European journal of psychotraumatology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 13, 2025

Background: Depression is a prevalent mental disorder with high morbidity and mortality globally. Methylmalonic acid (MMA) involved in the pathogenesis of numerous diseases. However, it unclear whether there an association between MMA prevalence depression.

Language: Английский

Uncovering the complex role of interferon-gamma in suppressing type 2 immunity to cancer DOI
Asif Ahmad Bhat, Ahsas Goyal, Riya Thapa

et al.

Cytokine, Journal Year: 2023, Volume and Issue: 171, P. 156376 - 156376

Published: Sept. 23, 2023

Language: Английский

Citations

49
Gut–Brain Axis and Neuroinflammation: The Role of Gut Permeability and the Kynurenine Pathway in Neurological Disorders DOI Creative Commons
Rowan Kearns

Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)

Published: Oct. 8, 2024

The increasing prevalence of neurological disorders such as Alzheimer's, Parkinson's, and multiple sclerosis presents a significant global health challenge. Despite extensive research, the precise mechanisms underlying these conditions remain elusive, with current treatments primarily addressing symptoms rather than root causes. Emerging evidence suggests that gut permeability kynurenine pathway are involved in pathogenesis conditions, offering promising targets for novel therapeutic preventive strategies. Gut refers to intestinal lining's ability selectively allow essential nutrients into bloodstream while blocking harmful substances. Various factors, including poor diet, stress, infections, genetic predispositions, can compromise integrity, leading increased permeability. This condition facilitates translocation toxins bacteria systemic circulation, triggering widespread inflammation impacts via gut-brain axis. axis (GBA) is complex communication network between central nervous system. Dysbiosis, an imbalance microbiota, increase inflammation, exacerbating neuroinflammation-a key factor disorders. pathway, primary route tryptophan metabolism, significantly implicated this process. Dysregulation context leads production neurotoxic metabolites, quinolinic acid, which contribute neuronal damage progression narrative review highlights potential progress understanding mechanisms. Interventions targeting maintaining balanced microbiota through probiotics, lifestyle modifications show promise reducing neuroinflammation supporting brain health. In addition, pharmacological approaches aimed at modulating directly, inhibitors indoleamine 2,3-dioxygenase, offer avenues new treatments. Understanding interconnected pathways crucial developing effective strategies prevent manage

Language: Английский

Citations

19
Unraveling the genetic links between depression and type 2 diabetes DOI
Ancha Baranova, Dongming Liu,

Vikas Chandhoke

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 137, P. 111258 - 111258

Published: Jan. 19, 2025

Language: Английский

Citations

3
Pro‐inflammatory cytokines IL‐1α, IL‐6 and TNF‐α in major depressive disorder: Sex‐specific associations with psychological symptoms DOI Creative Commons
Asmahan Elgellaie, Susan J. Thomas,

Jacqueline Kaelle

et al.

European Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 57(11), P. 1913 - 1928

Published: April 18, 2023

Abstract The pro‐inflammatory cytokines IL‐1α, IL‐6 and TNF‐α are associated with major depressive disorder, psychological distress, cardiovascular health obesity. However, there is limited research that has examined multiple associations between these variables, particularly among individuals disorder who treatment free, in comparison a control cohort, including analyses of sex differences. In this study, data were analysed from 60 controls, plasma TNF‐α, adiposity measures (body mass index, waist circumference), indices (blood pressure, heart rate) symptoms (depressive severity, anxiety, hostility, stress). compared by group correlated adiposity, health. Plasma IL‐1α higher versus control, but interaction for IL‐6, difference only females. did not differ groups. hostility stress, whereas anxiety hostility. Psychopathology was males females only. None the body circumference, blood pressure or rate. result sex‐specific psychometrics could be aetiologically important depression interventions treatments males, warranting further investigation.

Language: Английский

Citations

23
“Inflamed” depression: A review of the interactions between depression and inflammation and current anti-inflammatory strategies for depression DOI Creative Commons

Yishu Yin,

Ting Ju,

Deyong Zeng

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107322 - 107322

Published: July 20, 2024

Depression is a common mental disorder, the effective treatment of which remains challenging issue worldwide. The clinical pathogenesis depression has been deeply explored, leading to formulation various pathogenic hypotheses. Among these, monoamine neurotransmitter hypothesis holds prominent position, yet it significant limitations as more than one-third patients do not respond conventional treatments targeting transmission disturbances. Over past few decades, growing body research highlighted link between inflammation and potential key factor in pathophysiology depression. In this review, we first summarize relationship depression, with focus on pathophysiological changes mediated by mechanisms linking well multiple anti-inflammatory strategies are also discussed, their efficacy safety assessed. This review broadens perspective specific aspects using for treating laying groundwork advancing precision medicine individuals suffering from "inflamed"

Language: Английский

Citations

15
Exploring Ubiquitin-Specific Proteases as Therapeutic Targets in Glioblastoma DOI

Vijaya Paul Samuel,

Ehssan Moglad, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155443 - 155443

Published: Aug. 1, 2024

Language: Английский

Citations

9
Association between dietary patterns and suicide ideation among depressed adults: Insights from NHANES 2007–2020 DOI
Kun Li,

Honggang Lyu,

Lihong Zhang

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 377, P. 235 - 244

Published: Feb. 21, 2025

Language: Английский

Citations

1
IDO/Kynurenine; novel insight for treatment of inflammatory diseases DOI
Naser‐Aldin Lashgari, Nazanin Momeni Roudsari, Maryam Shayan

et al.

Cytokine, Journal Year: 2023, Volume and Issue: 166, P. 156206 - 156206

Published: April 28, 2023

Language: Английский

Citations

22
Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases DOI Creative Commons
Chongshan Yuan, Yuhong He,

Kunyu Xie

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Oct. 4, 2023

The microbiota gut brain (MGB) axis has been shown to play a significant role in the regulation of inflammatory and infective diseases. Exploring structure communication mode MGB is crucial for understanding its diseases, studying signaling pathways regulatory methods diseases also profound significance future clinical research. This article reviews composition, mechanism including Parkinson’s disease (PD), Alzheimer’s (AD), multiple sclerosis (MS), autism spectrum disorder (ASD), depression, psoriasis, irritable bowel syndrome (IBS), (IBD). In addition, our investigation delved into functions inflammasome, IFN-I, NF-κB, PARK7/DJ-1 innate immune pathway context Ultimately, we discussed efficacy various interventions, fecal transplantation (FMT), antibiotics, probiotics, prebiotics, synbiotics, postbiotics, management Understanding might make positive effects treatment

Language: Английский

Citations

21
Liraglutide and Naringenin relieve depressive symptoms in mice by enhancing Neurogenesis and reducing inflammation DOI

Yara S. Abdelkawy,

Mona Elharoun, Eman Sheta

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 971, P. 176525 - 176525

Published: March 30, 2024

Language: Английский

Citations

6