Design, Synthesis, and Inhibition of α-Glucosidase by Novel L-Phenylalanine-Derived Hydrazones: Kinetic, Molecular Docking, and Dynamics Studies DOI
Erbay Kalay, Şevki Adem, Yeliz Demir

и другие.

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер unknown, С. 110368 - 110368

Опубликована: Март 1, 2025

Язык: Английский

Investigations into the anti-inflammatory and anti-diabetic activity of newly synthesized derivatives of 4AP2BOB utilizing DFT, molecular docking and spectroscopic characterization DOI

M. Selvakumaran,

Predhanekar Mohamed Imran, Attar Kubaib

и другие.

Journal of Molecular Liquids, Год журнала: 2024, Номер 396, С. 123983 - 123983

Опубликована: Янв. 7, 2024

Язык: Английский

Процитировано

9
Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies DOI Open Access
Michael Tapera, Hüseyin Kekeçmuhammed, Emin Sarıpınar

и другие.

Journal of Molecular Liquids, Год журнала: 2023, Номер 391, С. 123242 - 123242

Опубликована: Окт. 5, 2023

Язык: Английский

Процитировано

20
Aldose reductase with quinolone antibiotics interaction: In vitro and in silico approach of its relationship with diabetic complications DOI
Cüneyt Türkeş

Archives of Biochemistry and Biophysics, Год журнала: 2024, Номер unknown, С. 110161 - 110161

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

7
Design, synthesis, characterization, antimicrobial activity, cytotoxicity, molecular docking, and in-silico ADMET analysis of the novel cefuroxime derivatives DOI Creative Commons
Ananta Kumar Das,

Prosenjit Paul,

Mahian Parveg Pranto

и другие.

European Journal of Medicinal Chemistry Reports, Год журнала: 2024, Номер 10, С. 100129 - 100129

Опубликована: Янв. 8, 2024

This research aims to design and synthesize novel derivatives of Cefuroxime evaluate their antibacterial effectiveness in comparison decrease resistance. Schotten Baumann's reaction synthesizes anhydride from acyl chlorides carboxylate anion. sodium was reacted with benzoyl chloride, 4-bromobenzoyl 4-nitrobenzoyl chloride make derivatives. The were characterized using spectral analysis. Antimicrobial activity, cytotoxicity, in-silico molecular docking nine different class (Penicillin Binding Proteins) PBPs, ADMET analysis assessed for the analogs. Three molecules, Cef-1, Cef-2, Cef-3, are synthesized In various organisms, outperformed antimicrobial activity. many Cef-1 has highest zone inhibition. Cef-3 inhibit Klebsiella pneumoniae better than Cef-2 Cefuroxime. greatest Cef-2-induced inhibition Salmonella Typhimurium 29.33 ± 0.47 mm. Significant susceptibility test activity observed lower inhibitory concentration (12.5 μg/ml) compared across species. Compound cytotoxicity is low, according research. consensus scores show that all bind cefuroxime. According results study, strongest correlation PBP1a, PBP2a, PBP3, PBP4, PBP6, whereas a stronger association PBP1b, PBP2b, PBP2x, PBP5. Like greater affinity PBP2x. Docking indicated drugs bound Cefuroxime, indicating superior efficacy. studies showed oral bioavailability increased by increasing lipophilicity score 0.17 cefuroxime 0.11.

Язык: Английский

Процитировано

6
In Vitro Inhibitory Activity and Molecular Docking Study of Selected Natural Phenolic Compounds as AR and SDH Inhibitors** DOI Open Access
Cüneyt Türkeş, Yeliz Demir, Şükrü Beydemir

и другие.

ChemistrySelect, Год журнала: 2022, Номер 7(48)

Опубликована: Дек. 20, 2022

Abstract Polyol pathway enzymes, aldose reductase (EC 1.1.1.21; AR, ALR2), and sorbitol dehydrogenase 1.1.1.14; SDH, SORD) have been widely investigated as the enzymes crucially involved in pathogenesis of several chronic complications, including nephropathy, neuropathy, retinopathy, cataracts associated with diabetes mellitus. Although phenolic compounds reported to possess many other biological activities, continuation our interest designing discovering potent inhibitors AR herein, we evaluated these agents’ inhibitory potential against polyol enzymes. Our vitro studies revealed that all derivatives show activity recombinant human (r h AR) SDH SDH), K I constants ranging from 9.37±0.16 μM 77.22±2.49 2.51±0.10 42.16±1.03 μM, respectively. Among agents, Prunetin Phloridzin showed prominent versus r while some were also determined perfect dual activity. Moreover, silico performed rationalize binding site interactions agents target enzyme SDH. According ADME‐Tox was be exhibiting suitable drug‐like properties. The identified therapeutic potentials this study may promising for developing lead prevent complications.

Язык: Английский

Процитировано

24
A new series of hydrazones as small‐molecule aldose reductase inhibitors DOI
Mehlika Dilek Altıntop, Yeliz Demir, Cüneyt Türkeş

и другие.

Archiv der Pharmazie, Год журнала: 2023, Номер 356(4)

Опубликована: Янв. 5, 2023

In the search for small-molecule aldose reductase (AR) inhibitors, new tetrazole-hydrazone hybrids (1-15) were designed. An efficient procedure was employed synthesis of compounds 1-15. All hydrazones subjected to an in vitro assay assess their AR inhibitory profiles. Compounds 1-15 caused inhibition with Ki values ranging between 0.177 and 6.322 µM IC50 0.210 0.676 µM. 2-[(1-(4-Hydroxyphenyl)-1H-tetrazol-5-yl)thio]-N'-(4-fluorobenzylidene)acetohydrazide (4) most potent inhibitor this series. Compound 4 markedly inhibited (IC50 = 0.297 µM) a competitive manner (Ki compared epalrestat 0.857 µM, 0.267 µM). Based on data obtained by applying MTT test, compound showed no cytotoxic activity toward normal (NIH/3T3) cells at tested concentrations, indicating its safety as inhibitor. exhibited proper interactions crucial amino acid residues within active site AR. silico QikProp all also determined pharmacokinetic Taken together, stands out promising further vivo studies.

Язык: Английский

Процитировано

14
The Role of Immune Cells in DKD: Mechanisms and Targeted Therapies DOI Creative Commons

Qiu-Yue Peng,

Ying An,

Zongzhe Jiang

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 2103 - 2118

Опубликована: Апрель 1, 2024

Diabetic kidney disease (DKD), is a common microvascular complication and major cause of death in patients with diabetes.Disorders immune cells cytokines can accelerate DKD development number ways.As the composed complex highly differentiated cells, interactions among different cell types play important regulatory roles development.Here, we summarize latest research into molecular mechanisms underlying various renal DKD.In addition, discuss most recent studies related to single technology bioinformatics analysis field DKD.The aims our review were explore as potential therapeutic targets provide some guidance for future clinical treatments.

Язык: Английский

Процитировано

5
Synthesis, characterization and sensor properties of a new sulfonyl hydrazone derivative molecule: potentiometric determination of Pb(II) ions DOI
Oğuz Özbek, Erbay Kalay, Çağlar Berkel

и другие.

Chemical Papers, Год журнала: 2024, Номер 78(4), С. 2621 - 2633

Опубликована: Янв. 5, 2024

Язык: Английский

Процитировано

4
Selectivity Challenges for Aldose Reductase Inhibitors: A Review on Comparative SAR and Interaction Studies DOI

Preety Kumari,

Rupali Kohal,

Bhavana

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер 1318, С. 139207 - 139207

Опубликована: Июль 4, 2024

Язык: Английский

Процитировано

4
Biological and Molecular Efficiency of Paracentrotus lividus Shell in vitro Study: Antioxidant and Angiogenesis Effects Against T47D Breast Cancer Cell Line Via Nrf2/HMOX-1/ and HIF-1α /VEGF Signaling Pathways DOI
Abeer A. Khamis, Mai M. El-Keiy, M.M. El-Gamal

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Язык: Английский

Процитировано

0