Perspectives for Uses of Propolis in Therapy against Infectious Diseases

Molecules, Год журнала: 2022, Номер 27(14), С. 4594 - 4594

Опубликована: Июль 19, 2022

Propolis has gained wide popularity over the last decades in several parts of world. In parallel, literature about propolis composition and biological properties increased markedly. A great number papers have demonstrated that from different world is composed mainly phenolic substances, frequently flavonoids, derived plant resins. a relevant role increasing social immunity bee hives. Experimental evidence indicates its components activity against bacteria, fungi, viruses. Mechanisms action on viruses are known for components. Experiments shown may act synergistically with antibiotics, antifungals, antivirus drugs, permitting administration lower doses drugs higher antimicrobial effects. The current trend growing resistance microbial pathogens to available encouraged introduction therapy infectious diseases. Because widely variable, standardized extracts been produced. Successful clinical trials included as medicine dentistry an adjuvant treatment patients COVID-19. Present health conditions encourage initiatives toward spread niche propolis, not only traditional alternative but also protagonist anti-infectious therapy. Production other apiary products environmentally friendly contribute alleviating crisis decline populations. production had social-economic relevance Brazil, providing benefits underprivileged people.

Язык: Английский

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Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(18), С. 10479 - 10479

Опубликована: Сен. 9, 2022

In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps the cancer progression process. Anticancer activity propolis its compounds relies on various mechanisms: cell-cycle arrest attenuation cells proliferation, reduction number stem cells, induction apoptosis, modulation oncogene signaling pathways, inhibition matrix metalloproteinases, prevention metastasis, anti-angiogenesis, anti-inflammatory effects accompanied tumor microenvironment (by modifying macrophage activation polarization), epigenetic regulation, antiviral bactericidal activities, gut microbiota, chemotherapy-induced deleterious side effects. Ingredients from also ”sensitize“ to chemotherapeutic agents, likely blocking transcription factor nuclear kappa-light-chain-enhancer activated B (NF-κB). this review, we summarize current knowledge related flavonoids other polyphenolic growth metastasizing ability, discuss possible molecular cellular mechanisms involved inflammatory pathways processes that affect survival, invasion, angiogenesis, metastasis tumor.

Язык: Английский

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Propolis and Their Active Constituents for Chronic Diseases

Biomedicines, Год журнала: 2023, Номер 11(2), С. 259 - 259

Опубликована: Янв. 18, 2023

Propolis is a mass of chemically diverse phytoconstituents with gummy textures that are naturally produced by honeybees upon collection plant resins for utilization in various life processes beehives. Since ancient times, propolis has been unique traditional remedy globally utilized several purposes, and it secured value pharmaceutical nutraceutical areas recent years. The chemical composition comprises constituents deviations the precise honeybee species, source used production bees, climate conditions harvesting season. Over 300 molecular structures have discovered from propolis, important classes include phenolic acids, flavonoids, terpenoids, benzofurans, benzopyrene chalcones. also reported to pharmacological activities, such as antidiabetic, anti-inflammatory, antioxidant, anticancer, immunomodulatory, antibacterial, antiviral, antifungal, anticaries. As chronic diseases risen global health threat, abundant research conducted track its alternative therapies diseases. Several clinical trials revealed potency preventing curing some This review explores beneficial effect active credible mechanisms computational studies on

Язык: Английский

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The Effects of Propolis on Viral Respiratory Diseases

Molecules, Год журнала: 2023, Номер 28(1), С. 359 - 359

Опубликована: Янв. 1, 2023

Propolis remains an interesting source of natural chemical compounds that show, among others, antibacterial, antifungal, antiviral, antioxidative and anti-inflammatory activities. Due to the growing incidence respiratory tract infections caused by various pathogenic viruses, complementary methods prevention therapy supporting pharmacotherapy are constantly being sought out. The properties propolis may be important in treatment diseases viruses such as severe acute syndrome coronavirus 2, influenza parainfluenza virus rhinoviruses. One main challenges recent years has been 2 (SARS-CoV-2), causing COVID-19. Recently, increasing number studies focusing on activity preparations against SARS-CoV-2 adjuvant for this infection. shown a few key mechanisms anti-SARS-CoV-2 action as: inhibition interaction S1 spike protein ACE-2 protein; decreasing replication diminishing synthesis RNA transcripts cells; particles coronaviruses. anti-viral effect is observed not only with extracts but also single biologically active found (e.g., apigenin, caffeic acid, chrysin, kaempferol, quercetin). Moreover, effective hyperglycemia, which increases risk infections. aim literature review was summarize from PubMed database evaluating antiviral terms (in vitro, vivo, clinical trials). Based upon review, it have focused mainly assessment effectiveness its components exerts wide-spectrum antimicrobial activities; thus, can option co-infections associated tract.

Язык: Английский

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Propolis Use in Dentistry: A Narrative Review of Its Preventive and Therapeutic Applications

International Dental Journal, Год журнала: 2024, Номер 74(3), С. 365 - 386

Опубликована: Фев. 19, 2024

Propolis is a resinous substance produced naturally by bees, and it consists of the exudates plants mixed with enzymes, wax, pollen. continues to gain considerable scientific interest due its potential health benefits. The modern-day use propolis in pharmaceutical preparations, such as toothpastes, mouthwashes, chewable tablets, mucoadhesive gels, sprays, increasing. However, effectiveness using propolis-containing pharmaceuticals dentistry not clear. present paper aims review literature on dental applications preventive dentistry, periodontics, oral medicine, restorative discuss clinical effectiveness. A search was conducted Scopus, PubMed, Web Science databases. In total, 104 studies were included, which 46 laboratory studies, 5 animal 53 human studies. Overall, revealed range antimicrobial effects pathogens. Clinical investigations biofilm caries control well adjuvant periodontal therapies reported positive outcomes terms plaque control, pathogenic microbial count reduction, tissue inflammation control. Additional included for management recurrent aphthous stomatitis, mucositis, cavity disinfection after removal development materials. Based usage has potential. majority evidence derived from flaws their methodological design, making results conclusions questionable. As consequence, properly designed well-reported are required affirm applications. Additionally, safety optimal concentrations extraction methods warrant further investigation. Utilisation standardised extracts will help quality propolis-based products lead achievement reproducible research

Язык: Английский

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Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Cells, Год журнала: 2024, Номер 13(5), С. 390 - 390

Опубликована: Фев. 24, 2024

Aging populations worldwide are placing age-related diseases at the forefront of research agenda. The therapeutic potential natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular molecular-level changes associated with diseases. With this in mind, scientists have introduced a contextual framework guide future aging research, called hallmarks aging. This encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, altered intercellular communication. Propolis, rich array bioactive compounds, functions as potent functional food, modulating metabolism, gut microbiota, immune response, offering significant health benefits. Studies emphasize propolis' properties, such antitumor, cardioprotective, neuroprotective effects, well ability mitigate oxidative stress, DNA damage, pathogenic bacteria growth. article underscores current scientific evidence supporting role controlling molecular characteristics linked hallmarks, hypothesizing geroscience research. aim is discover novel strategies improve quality life older individuals, addressing existing deficits perspectives area.

Язык: Английский

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Process design and thermal integration for efficient separation of alpha-bisabolol via vacuum distillation

Separation and Purification Technology, Год журнала: 2025, Номер unknown, С. 132830 - 132830

Опубликована: Апрель 1, 2025

Язык: Английский

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Antibiofilm and Anti-Quorum Sensing Potential of Cycloartane-Type Triterpene Acids from Cameroonian Grassland Propolis: Phenolic Profile and Antioxidant Activity of Crude Extract

Molecules, Год журнала: 2022, Номер 27(15), С. 4872 - 4872

Опубликована: Июль 29, 2022

Propolis is very popular for its beneficial health properties, such as antimicrobial activity and antioxidant effects. It one of the most long-serving traditional medicines to mankind due interesting chemical diversity therapeutic properties. The detailed information propolis samples necessary guarantee safety it be accepted into care systems. phenolic profile hydroethanolic extract was determined using HPLC-DAD, evaluated five complementary methods. Triterpenoids were isolated column chromatography characterized

Язык: Английский

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Exploring the Functional Properties of Propolis, Geopropolis, and Cerumen, with a Special Emphasis on Their Antimicrobial Effects

Foods, Год журнала: 2023, Номер 12(21), С. 3909 - 3909

Опубликована: Окт. 25, 2023

Bee propolis has been touted as a natural antimicrobial agent with the potential to replace antibiotics. Numerous reports and reviews have highlighted functionalities applications of compound. Despite much clamor for downstream application propolis, there remain many grounds cover, especially in upstream production, factors affecting quality propolis. Moreover, geopropolis cerumen, akin hold promise diverse human applications, yet their benefits intricate manufacturing processes subjects intensive research. Specialized cement bees are pivotal gathering transporting plant resins from suitable sources nests. Contrary common belief, these directly applied within hive, smoothed out by bees, blended beeswax trace components create raw Beekeepers subsequently harvest perform extraction form final extract that is sold on market. As result production process, intrinsic extrinsic factors, such botanical origins, bee species, direct impact extract. Towards end this paper, section dedicated highlighting potency

Язык: Английский

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Stingless bee propolis: composition, biological activities and its applications in the food industry

Food Production Processing and Nutrition, Год журнала: 2023, Номер 5(1)

Опубликована: Май 4, 2023

Abstract The breeding of stingless bees, known as meliponiculture, can be found throughout the world, and is closely linked to history first human communities in Americas. This activity provides products industrial interest (food, cosmetics, pharmaceuticals), among them propolis stands out. matrix a resinous material but being difficult classify conceptualize due its variability according environment producing species. produced by these bees source compounds with nutritional functional potential, main focused on phenolic compounds. potential makes product that used prospection new molecules antimicrobial antioxidant activity. Thus, scientific literature describes (generally extracts) against bacteria fungi, higher microbicidal gram-positive bacteria. high this bee consequence presence several use from SBP (Stingless propolis) still quite limited, generally restricted studies application other sectors benefit productive sector, Apis mellifera . work presents discusses composition consequent biological activities, well applications food industry. Graphical

Язык: Английский

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