Plant antimicrobial peptides: structures, functions, and applications

Botanical studies, Год журнала: 2021, Номер 62(1)

Опубликована: Апрель 29, 2021

Abstract Antimicrobial peptides (AMPs) are a class of short, usually positively charged polypeptides that exist in humans, animals, and plants. Considering the increasing number drug-resistant pathogens, antimicrobial activity AMPs has attracted much attention. with broad-spectrum against many gram-positive bacteria, gram-negative fungi an important defensive barrier pathogens for organisms. With continuing research, other physiological functions plant have been found addition to their roles, such as regulating growth development treating diseases high efficacy. The potential applicability agricultural production, food additives disease treatments, garnered interest. This review focuses on types AMPs, mechanisms action, parameters affecting activities applications industry, breeding medical field.

Язык: Английский

---

Plant Antimicrobial Peptides: State of the Art, In Silico Prediction and Perspectives in the Omics Era

Bioinformatics and Biology Insights, Год журнала: 2020, Номер 14, С. 117793222095273 - 117793222095273

Опубликована: Янв. 1, 2020

Even before the perception or interaction with pathogens, plants rely on constitutively guardian molecules, often specific to tissue stage, further expression after contact pathogen. These guardians include small molecules as antimicrobial peptides (AMPs), generally cysteine-rich, functioning prevent pathogen establishment. Some of these AMPs are shared among eukaryotes (eg, defensins and cyclotides), others plant snakins), while some certain families (such heveins). When compared other organisms, tend present a higher amount AMP isoforms due gene duplications polyploidy, an occurrence possibly also associated sessile habit plants, which prevents them from evading biotic environmental stresses. Therefore, arise rich resource for new AMPs. As difficult retrieve databases using simple sequence alignments, description their characteristics in silico (bioinformatics) approaches used is provided, considering resources available. The possibilities applications based tools versus database considerable have been so far underestimated.

Язык: Английский

---

Agroecological Management of the Grey Mould Fungus Botrytis cinerea by Plant Growth-Promoting Bacteria

Plants, Год журнала: 2023, Номер 12(3), С. 637 - 637

Опубликована: Фев. 1, 2023

Botrytis cinerea is the causal agent of grey mould and one most important plant pathogens in world because damage it causes to fruits vegetables. Although application botrycides common protection strategies used world, plant-beneficial bacteria might replace facilitating agroecological production practices. Based on this, we reviewed different stages B. infection plants biocontrol mechanisms exerted by bacteria, including well-known growth-promoting (PGPB). Some PGPB control disease include antibiosis, space occupation, nutrient uptake, ethylene modulation, induction defence mechanisms. In addition, recent studies action anti-Botrytis compounds produced how they conidial mycelial structures pathogen are reviewed. Likewise, advantages individual inoculations versus those that require joint antagonist agents (microbial consortia) discussed. Finally, should be emphasised an excellent option prevent crops their use expanded for environmentally friendly agricultural

Язык: Английский

---

Functional Peptides for Plant Disease Control

Annual Review of Phytopathology, Год журнала: 2023, Номер 61(1), С. 301 - 324

Опубликована: Июнь 2, 2023

Plant disease control requires novel approaches to mitigate the spread of and losses caused by current, emerging, re-emerging diseases adapt plant protection global climate change restrictions on use conventional pesticides. Currently, management relies mainly biopesticides, which are required for sustainable plant-protection products. Functional peptides candidate biopesticides because they originate from living organisms or synthetic analogs provide mechanisms action against pathogens. Hundreds compounds exist that cover an extensive range activities viruses, bacteria phytoplasmas, fungi oomycetes, nematodes. Natural sources, chemical synthesis, biotechnological platforms may at large scale industry growers. The main challenges their in (a) requirement stability environment counteracting resistance pathogen populations, (b) need develop suitable formulations increase shelf life methods application, (c) selection with acceptable toxicological profiles, (d) high cost production agricultural purposes. In near future, it is expected several functional will be commercially available control, but more effort needed validate efficacy field level fulfill requirements regulatory framework.

Язык: Английский

---

Natural antimicrobials from fruits and plant extract for food packaging and preservation

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 133 - 152

Опубликована: Янв. 1, 2024

Язык: Английский

---

Molecular and Biological Properties of Snakins: The Foremost Cysteine-Rich Plant Host Defense Peptides

Journal of Fungi, Год журнала: 2020, Номер 6(4), С. 220 - 220

Опубликована: Окт. 12, 2020

Plant host defense peptides (HDPs), also known as antimicrobial (AMPs), are regarded one of the most prevalent barriers elaborated by plants to combat various infective agents. Among multiple classes HDPs, Snakin class attracts special concern, they carry 12 cysteine residues, being foremost cysteine-rich plant HDPs. Also, their cysteines present at very highly conserved positions and arranged in an extremely similar way among different members. Like other Snakins have been shown exhibit strong antifungal antibacterial activity against a wide range pathogens. Moreover, display diversified biological activities many aspects growth development process. This review is devoted general characters well individual features family Specifically, sequence properties, spatial structures, distributions, expression patterns described. In addition, further detailed classification members, along with possible mode action potential applications field agronomy pathology discussed.

Язык: Английский

---

Application of antimicrobial peptides in plant protection: making use of the overlooked merits

Frontiers in Plant Science, Год журнала: 2023, Номер 14

Опубликована: Июль 19, 2023

Pathogen infection is one of the major causes yield loss in crop field. The rapid increase antimicrobial resistance plant pathogens has urged researchers to develop both new pesticides and management strategies for protection. peptides (AMPs) showed potential on eliminating pathogenic fungi bacteria. Here, we first summarize several overlooked advantages merits AMPs, which includes steep dose-response relations, fast killing ability, broad synergism, slow selection. We then discuss possible application AMPs protection with above merits, highlight how can be incorporated into a more efficient integrated system that increases reduce evolution pathogens.

Язык: Английский

---

Plant chitinases: Types, structural classification, antifungal potential and transgenic expression in plants for enhanced disease resistance

Plant Cell Tissue and Organ Culture (PCTOC), Год журнала: 2024, Номер 156(3)

Опубликована: Фев. 13, 2024

Язык: Английский

---

Synthetic Peptides against Plant Pathogenic Bacteria

Microorganisms, Год журнала: 2022, Номер 10(9), С. 1784 - 1784

Опубликована: Сен. 3, 2022

The control of plant diseases caused by bacteria that seriously compromise crop productivity around the world is still one most important challenges in food security. Integrated approaches for disease generally lack protection products with high efficacy and low environmental health adverse effects. Functional peptides, either from natural sources or synthetic, are considered as novel candidates to develop biopesticides. Synthetic peptides can be obtained based on structure compounds de novo designed, considering features antimicrobial peptides. advantage this approach analogues conveniently prepared, enabling identification sequences improved biological properties. Several peptide libraries have been designed synthetized, best showed strong bactericidal activity against pathogenic bacteria, a good profile biodegradability toxicity. Among these sequences, there bacteriolytic antibiofilm work target defense elicitor multifunctional display several Here, we report research performed our groups during last twenty years, well ongoing work. We also highlight those used biopesticides, main prospects.

Язык: Английский

---

Small and Versatile Cyclotides as Anti-infective Agents

ACS Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Plants provide an abundant source of potential therapeutic agents, including a diverse array compounds, such as cyclotides, which are peptides known for their antimicrobial activity. Cyclotides multifaceted molecules with wide range biological activities. Their unique topology forms head-to-tail cyclic structure reinforced by cysteine knot, confers chemical and thermal stability. These can directly target membranes infectious agents binding to phosphatidylethanolamine in lipid membranes, leading membrane permeabilization. Additionally, they function carriers cell-penetrating molecules, demonstrating antiviral, antibacterial, antifungal, nematicidal properties. The cyclotides is also amenable synthesis, facilitating drug design through residue substitutions or grafting bioactive epitopes within the cyclotide scaffold enhance peptide In this review, we explore multifunctionality these biomolecules anti-infective emphasizing novel class drugs.

Язык: Английский

---