Journal of Infection and Public Health,
Год журнала:
2024,
Номер
18(2), С. 102631 - 102631
Опубликована: Дек. 26, 2024
In
2022,
Langya
henipavirus
was
identified
in
patients
with
fever
eastern
China.
This
study
provides
an
overview
of
the
scientific
landscape,
highlights
research
focus
areas,
and
outlines
potential
future
investigations.
The
relevant
literature
systematically
searched
reviewed
via
advanced
bibliometric
techniques.
Over
past
two
decades,
has
increased
at
annual
rate
8.82
%.
United
States
leads
output,
Australian
Animal
Health
Laboratory
as
top
institution.
Most
articles
are
published
Journal
Virology,
most
influential
journal
along
researcher
Wang
LF.
Current
focuses
on
"zoonosis,"
"vaccine,"
"pathogenesis,"
whereas
areas
may
include
"molecular
docking,"
"immunoinformatics,"
"climate
change,"
"antibodies,"
"vaccines,"
"glycoprotein,"
"ephrin-b2."
details
research,
highlighting
key
players,
trends,
directions.
These
insights
will
guide
efforts
to
address
risks
posed
by
novel
Henipaviruses,
such
Langya.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 17, 2023
Hendra
virus
(HeV)
and
Nipah
(NiV)
are
biosafety
level
4
zoonotic
pathogens
causing
severe
often
fatal
neurological
respiratory
disease.
These
agents
have
been
recognized
by
the
World
Health
Organization
as
top
priority
expected
to
result
in
future
outbreaks.
HeV
has
caused
sporadic
infections
horses
a
small
number
of
human
cases
Australia
since
1994.
The
NiV
Malaysia
genotype
(NiV-M)
was
responsible
for
1998–1999
epizootic
outbreak
pigs
with
spillover
humans
Singapore.
Since
2001,
Bangladesh
(NiV-B)
predominant
strain
leading
outbreaks
almost
every
year
India,
hundreds
humans.
natural
reservoir
hosts
fruit
bats,
which
carry
viruses
without
clinical
manifestation.
transmission
pathways
henipaviruses
from
bats
remain
poorly
understood.
Transmissions
bridged
an
intermediate
animal
host,
amplifies
spreads
Horses
known
NiV-M
epidemic
Singapore,
respectively.
During
NiV-B
Bangladesh,
following
initial
thought
be
through
consumption
date
palm
sap,
spread
infection
largely
human-to-human
transmission.
Spillover
recent
India
is
less
understood,
primary
route
bat
case(s)
unknown
no
host
established.
This
review
aims
provide
concise
update
on
epidemiology
covering
their
previous
current
emphasis
potential
role
livestock
disease
Also
included
up-to-date
summary
newly
emerging
henipa-like
hosts.
In
these
contexts
we
discuss
knowledge
gaps
new
challenges
field
propose
directions.
Pathogens and Disease,
Год журнала:
2024,
Номер
82
Опубликована: Янв. 1, 2024
Abstract
Acute
Undifferentiated
Febrile
Illness
(AUFI)
presents
a
clinical
challenge,
often
characterized
by
sudden
fever,
non-specific
symptoms,
and
potential
life-threatening
implications.
This
review
highlights
the
global
prevalence,
types,
challenges,
implications
of
AUFI,
especially
in
tropical
subtropical
regions
where
infectious
diseases
thrive.
It
delves
into
difficulties
diagnosis,
prevalence
rates,
regional
variations,
causes,
ranging
from
bacterial
viral
infections
to
zoonotic
diseases.
Furthermore,
it
explores
treatment
strategies,
preventive
measures,
critical
role
One
Health
approach
addressing
AUFI.
The
paper
also
addresses
emerging
risks
ongoing
outbreaks,
including
COVID-19,
Rickettsia
spp.,
other
novel
pathogens,
emphasizing
their
impact
on
AUFI
diagnosis
management.
Challenges
resource-limited
settings
are
analyzed,
highlighting
need
for
bolstered
healthcare
infrastructure,
enhanced
diagnostics,
collaborative
strategies.
Amidst
complexity
threats,
this
underscores
urgency
multifaceted
mitigate
growing
burden
ensuring
early
appropriate
treatment,
effective
prevention
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 23, 2024
Abstract
The
Hendra
and
Nipah
viruses
(HeV
NiV)
are
zoonotic
biosafety
level-4
pathogens
within
the
Paramyxoviridae
family.
We
previously
showed
that
their
W
proteins
form
amyloid-like
fibrils
in
vitro
.
Here,
we
demonstrate
also
forms
cellula
cysteine
residues
crucial
dictating
ability
of
to
fibrillate.
oxidation
state
acts
as
a
switch
generate
either
amorphous
aggregates
or
flexible
fibrils.
Ectopic
expression
HeV
induces
an
oxidative
stress
were
observed
nuclei
different
cell
lines,
with
fibrillation
being
impaired
by
substitutions.
Finally,
nuclear
associated
impairment
NF-κB
pathway
transfected
cells.
This
work
provides
experimental
evidence
for
Henipavirus
fibrillate
cells
first
clues
on
functional
impact.
Significance
Statement
severe
infecting
humans
livestock,
classified
among
8
highest
priorities
research
WHO.
protein,
along
V
is
virulence
factor
responsible
antiviral
response
inhibition
here
its
into
occurs
nucleus
cells,
formation
dependent
redox
residues.
sole
transfection
provokes
production
reactive
oxygen
species,
creating
suitable
environment
form.
show
enhance
repression
response,
thus
pointing
new
promising
target.
Viruses,
Год журнала:
2024,
Номер
16(5), С. 787 - 787
Опубликована: Май 15, 2024
Neuroinfections
rank
among
the
top
ten
leading
causes
of
child
mortality
globally,
even
in
high-income
countries.
The
crucial
determinants
for
successful
treatment
lie
timing
and
swiftness
diagnosis.
Although
viruses
constitute
majority
infectious
neuropathologies,
diagnosing
treating
viral
neuroinfections
remains
challenging.
Despite
technological
advancements,
etiology
disease
undetermined
over
half
cases.
identification
pathogen
becomes
more
difficult
when
infection
is
caused
by
atypical
pathogens
or
multiple
simultaneously.
Furthermore,
modern
surge
global
passenger
traffic
has
led
to
an
increase
cases
infections
not
endemic
local
areas.
This
review
aims
systematize
summarize
information
on
neuroinvasive
pathogens,
encompassing
their
geographic
distribution
transmission
routes.
Emphasis
placed
rare
involving
aiming
offer
a
comprehensive
structured
catalog
agents
with
neurovirulence
potential.
Infectious Diseases & Immunity,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Abstract
Langya
henipavirus
(LayV)
and
Mojiang
(MojV)
are
emerging
zoonotic
pathogens
that
were
first
identified
in
China
2018
2012
respectively,
classified
within
the
Henipavirus
genus.
This
article
presents
an
in-depth
review
of
LayV
MojV,
focusing
on
their
structural
properties,
viral
entrance,
consequences
for
human
health.
The
pathogenic
potential
these
viruses
is
investigated
depth
as
well
current
diagnostic
methods
identifying
MojV.
Furthermore,
treatment
controlling
MojV
infections
assessed,
with
a
particular
emphasis
critical
need
tailored
antiviral
research.
serves
resource
researchers
healthcare
professionals,
offering
up-to-date
synthesis
knowledge
while
underscoring
significance
public
Emerging infectious diseases,
Год журнала:
2025,
Номер
31(3)
Опубликована: Фев. 21, 2025
Henipaviruses,
such
as
Hendra
and
Nipah
viruses,
are
major
zoonotic
pathogens
that
cause
encephalitis
respiratory
infections
in
humans
animals.
The
recent
emergence
of
Langya
virus
China
highlights
the
need
to
understand
henipavirus
host
diversity
geographic
spread
prevent
future
outbreaks.
Our
analysis
National
Center
for
Biotechnology
Information
Virus
VIRION
databases
revealed
≈1,117
sequences
142
complete
genomes.
Bats
(64.7%)
shrews
(11.7%)
dominated
species
record,
genera
Pteropus
Crocidura
contained
key
hosts
Asia,
Australia,
Africa.
Henipaviruses
found
Eidolon
bat
genus
exhibited
highest
within-host
genetic
distance.
Phylogenetic
batborne
rodent-
or
shrew-derived
henipaviruses
diverged
≈11,000
years
ago
first
known
lineage
originating
bats
≈9,900
ago.
Pathogenic
from
their
ancestors
2,800-1,200
Including
atypical
regions
investigations
is
necessary
control
The
Hendra
(HeV)
and
Nipah
(NiV)
viruses
are
high-priority,
biosafety
level-4
pathogens
that
cause
fatal
neurological
respiratory
disease.
Their
P
gene
encodes
not
only
the
protein,
an
essential
polymerase
cofactor,
but
also
virulence
factors
V
W.
We
previously
showed
W
protein
of
HeV
(WHeV)
forms
amyloid-like
fibrils
one
its
subdomains,
PNT3,
fibrillates
in
isolation.
However,
fibrillation
kinetics
is
much
faster
case
full-length
WHeV
compared
to
suggesting
another
region
contributes
process.
In
this
work,
we
identified
spanning
residues
2-110
(PNT1)
as
crucial
implicated
fibrillation.
Through
site-directed
mutagenesis,
combined
with
thioflavin
T
binding
experiments
negative-staining
transmission
electron
microscopy,
a
predicted
cryptic
amyloidogenic
(CAR)
within
PNT1
main
driver
deciphered
underlying
molecular
mechanism.
Using
FTIR,
enriched
cross
β-sheets.
Sequence
alignment
revealed
conservation
CAR
across
Henipavirus
genus
enabled
identification
hitherto
never
reported
pro-amyloidogenic
motif.
ability
form
was
experimentally
shown
be
common
property
shared
by
proteins.
Overall,
study
sheds
light
on
mechanisms
calls
for
future
studies
aimed
at
exploring
relevance
newly
motif
valuable
target
antiviral
approaches.
Biosafety and Health,
Год журнала:
2024,
Номер
6(2), С. 80 - 87
Опубликована: Фев. 8, 2024
The
emerging
viruses
within
the
genus
Henipavirus
in
family
Paramyxoviridae
pose
a
great
threat
to
public
biosafety.
To
develop
quadruple
real-time
fluorescence-based
quantitative
reverse
transcription
polymerase
chain
reaction
(qRT-PCR)
assay
is
pivotal
for
early
warning
of
potential
zoonotic
infectious
diseases.
Specific
primers
and
probes
were
designed
relatively
conserved
regions
based
on
whole
genome
sequences
Langya
virus
(LayV),
Mojiang
(MojV),
Nipah
(NiV),
Cedar
(CedV),
followed
by
establishment
qRT-PCR
detection
method.
No
cross-reactivity
was
observed
with
other
viral
nucleic
acids.
optimal
linear
range
LayV,
MojV,
NiV,
CedV
101-108
copies/μL,
lower
limit
10
copies/μL.
Three
different
DNA
concentrations
(104,
105,
106
copies/μL)
tested
14
times,
achieving
good
repeatability.
standard
deviation
cycle
threshold
values
each
concentration
<0.5
coefficient
variation
<3
%.
Furthermore,
amplification
efficiency
>90
%,
correlation
>0.99.
established
exhibits
sensitivity,
specificity,
Therefore,
it
can
be
used
detect
related
clinical
specimens.
