Mechanisms of Ageing and Development,
Год журнала:
2023,
Номер
211, С. 111792 - 111792
Опубликована: Фев. 17, 2023
Geroscience
puts
mechanisms
of
aging
as
a
driver
the
most
common
age-related
diseases
and
dysfunctions.
Under
this
perspective,
addressing
basic
will
produce
better
understanding
than
each
disease
pathophysiology
individually.
Worldwide,
despite
greater
functional
impairment,
life
expectancy
is
higher
in
women
men.
Gender
differences
prevalence
multimorbidity
lead
mandatory
to
underlying
gender-related
patterns
disability-free
expectancy.
Extensive
literature
suggested
that
inflammaging
at
crossroad
diseases.
In
review,
we
highlight
main
evidence
on
sex/gender
foster
inflammaging,
i.e.
age-dependent
triggering
innate
immunity,
modifications
adaptive
accrual
senescent
cells,
underpinning
some
biomarkers
show
sex-related
differences.
framework
"gender
medicine
perspective",
also
discuss
how
can
affect
sex
COVID-19
severe
outcomes.
The journal of nutrition health & aging,
Год журнала:
2024,
Номер
28(1), С. 100004 - 100004
Опубликована: Янв. 1, 2024
This
study
aimed
to
explore
the
links
of
handgrip
strength
and
asymmetry
with
cognitive
impairment.
was
a
seven-year
prospective
cohort
study.
We
used
data
from
wave
3
(2015-2017)
5
(2019-2022)
ongoing
Taiwan
Initiative
Geriatric
Epidemiological
Research
(TIGER),
as
baseline
(n
=
446).
The
included
community-dwelling
participants
aged
65
years
or
older.
Handgrip
measured,
abnormalities
were
determined
based
on
weakness
asymmetry.
categorized
into
three
groups
at
ratio
(left
strength/right
strength).
Cognitive
tests
evaluating
global
specific
domains
conducted
two
biennial
follow-ups.
Generalized
linear
mixed
models
utilized
assess
associations
abnormal
cognition
multiple
domain
progression
over
time.
392
dementia-free
participants,
an
average
age
75.8
179
(45.7%)
males.
Mild
present
in
88
(22.4%),
while
53
(13.5%)
exhibited
moderate
In
men,
coexistence
low
linked
impairment
These
observed
(β^
-1.76,
95%
CI:
-2.79
-0.74),
memory
(immediate
free
recall:
β^
-0.67,
-1.17
-0.17),
executive
function
(Trail
Making
Test-A:
-0.54,
-0.94
-0.13),
attention
(Digit
span-forward:
-1.00,
-1.46
-0.54).
found
that
individuals
reduced
had
increased
risk
across
various
domains.
Moreover,
this
association
appears
be
more
pronounced
among
men
than
women.
Incorporating
these
simple
assessments
regular
clinical
practice
improves
allocation
limited
screening
resources
timely
interventions
older
adults.
BMJ Open,
Год журнала:
2025,
Номер
15(4), С. e084766 - e084766
Опубликована: Апрель 1, 2025
Objective
We
aimed
to
investigate
the
relationship
between
serum
neurofilament
light
chain
(NfL)
and
grip
strength
using
data
from
2013–2014
US
National
Health
Nutrition
Examination
Survey
(NHANES).
Design
Secondary
analysis
of
cross-sectional,
population-based
data.
Setting
NHANES
sample,
2013–2014.
Participants
studied
1925
participants
aged
20–75
years.
Outcome
measures
applied
a
multivariable
generalised
linear
regression
model,
adjusted
for
several
potential
confounders,
restrictive
cubic
spline
models
evaluate
association
NfL
strength.
Subgroup
analyses
were
conducted
stratified
analysis.
Results
included
(average
age:
44.8±0.44
years)
database.
with
higher
levels
had
significantly
prevalence
medical
conditions
(hypertension,
diabetes,
cardiovascular
disorder,
chronic
kidney
disease
(CKD)
cancer)
compared
those
lower
(all
p<0.001).
After
adjusting
confounding
factors,
there
was
negative
(β=−2.07;
95%
CI
−3.47,
−0.67;
p=0.007).
In
addition,
significant
interactions
found
by
age,
physical
activity
CKD
(p
value
interaction=0.002,
0.023
0.006).
The
results
restricted
splines
(RCS)
showed
no
evidence
against
non-linearity=0.334).
Conclusion
Our
study
demonstrates
strong,
correlation
elevated
Notably,
our
findings
indicate
that
individuals
60
75
years,
inactivity
exhibit
more
pronounced
reduction
in
increasing
levels.
Aging Clinical and Experimental Research,
Год журнала:
2024,
Номер
36(1)
Опубликована: Март 7, 2024
Although
anemia
is
associated
with
low
muscle
strength,
hemoglobin
has
been
rarely
studied
considering
ferritin.
To
analyze
the
association
between
and
grip
strength
in
community-dwelling
older
adults.
We
used
data
from
a
German
cohort
of
adults
≥
65
years,
excluding
those
CRP
>
10
mg/L
or
taking
iron
supplements.
Grip
(kg)
was
measured
using
Jamar
dynamometer.
Analysis
performed
multiple
linear
regression,
adjusted
for
established
confounders.
Due
to
interaction,
age-stratified
(<
80,
80
+),
further
sex-stratified
analysis
<
years
old
ferritin-stratified
men
were
performed.
In
total,
1294
participants
included
this
(mean
age
75.5
549
(42.3%)
women,
910
(70.3%)
years).
On
average,
14.9
g/dL
41.3
kg
men,
13.9
25.1
women.
Hemoglobin
significantly
positively
only
among
women
(β
0.923
[95%
CI
0.196,
1.650]).
For
significant
when
ferritin
300
µg/L
2.028
0.910,
3.146]).
No
detected
+
.
Our
show
an
old.
levels
µg/L.
Considering
decreasing
high
prevalence
deficiency
analyses
investigating
relationship
more
specific
parameters
such
as
transferrin
saturation
are
warranted.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 31, 2024
Aging
involves
physical
and
cognitive
deterioration
in
older
adults.
Detecting
predictors
of
dementia
early
is
crucial
to
identify
its
onset.
This
study
aimed
associate
psychological
determinants
with
performance
Observational
221
adults,
classified
according
impairment.
We
evaluated
function
by
Mini-Mental
State
Examination.
Physical
encompassed
muscle
strength,
functional
mobility,
cardiorespiratory
fitness,
while
consisted
quality
life
activities
daily
living.
Multiple
linear
regression
was
performed
investigate
this
relationship.
were
significantly
linked
impairment,
including
lower
reduced
mobility
fitness.
The
influence
environment,
autonomy,
engagement
on
impairment
also
observed.
analysis
could
help
aid
distinguishing
individuals
Environmental Research,
Год журнала:
2024,
Номер
251, С. 118547 - 118547
Опубликована: Март 6, 2024
Glyphosate
is
the
most
widely
used
herbicide
worldwide,
both
in
domestic
and
industrial
settings.
Experimental
research
animal
models
has
demonstrated
changes
muscle
physiology
reduced
contractile
strength
associated
with
glyphosate
exposure,
while
epidemiological
studies
have
shown
associations
between
exposure
adverse
health
outcomes
critical
biological
systems
affecting
function.
This
study
data
from
a
nationally
representative
survey
of
non-institutionalized
U.S.
general
population
(NHANES,
n
=
2132).
Urine
concentrations
were
determined
by
ion
chromatography
tandem
mass
spectrometry.
Hand
grip
(HGS)
was
measured
using
Takei
Dynamometer,
relative
estimated
as
ratio
HGS
dominant
hand
appendicular
lean
(ALM)
to
body
index
(ALMBMI)
ratio.
Low
low
defined
1
sex-,
age-
race-specific
SD
below
mean.
Physical
function
limitations
identified
significant
difficulty
or
incapacity
various
activities.
In
fully-adjusted
models,
Mean
Differences
(MD)
95%
confidence
intervals
[95%CI]
per
doubling
increase
−0.55
[-1.09,
−0.01]
kg
for
hand,
−0.90
[-1.58.
−0.21]
HGS/ALMBMI.
The
Odds
Ratios
(OR)
[95%
CI]
HGS,
functional
1.27
[1.03,
1.57]
HGS;
1.43
[1.05;
1.94]
1.33
[1.08,
1.63]
stooping,
crouching
kneeling
difficulty;
1.17
[0.91,
1.50]
lifting
carrying
items
weighting
up
10
pounds
1.21
[1.01,
1.40]
standing
armless
chair
1.47
[1.05,
2.29]
ascending
ten
steps
without
pause
difficulty.
may
be
risk
factor
decreased
increased
physical
limitations.
More
investigating
influence
this
other
environmental
pollutants
on
aging
are
needed.
Applied Sciences,
Год журнала:
2024,
Номер
14(4), С. 1500 - 1500
Опубликована: Фев. 12, 2024
This
research
examined
the
association
between
risk
of
falls
and
cognitive
function
in
older
individuals
at
mild
impairment.
One
hundred
seventy-five
adults
were
included
2021.
Balance
confidence
was
scored
using
Activities-Specific
Confidence
Scale
(ABC),
gait
speed
assessed
by
4
m
test,
handgrip
strength
a
digital
dynamometer,
balance
Timed
Up-and-Go
Test
(TUG).
The
Mini-Mental
State
Examination
(MMSE),
Controlled
Oral
Word
Association
Test,
Boston
Naming
short-version
questionnaires
global
function,
verbal
fluency,
language,
respectively.
A
bivariate
correlation
analysis
multivariate
linear
regressions
applied,
adjusting
for
confounders
(BMI,
sex,
age,
educational
level).
Shorter
time
TUG
greater
status
independently
associated
with
improved
scores
on
MMSE.
Lower
age
increased
phonological
fluency.
Better
ABC
performance
higher
attainment
enhanced
semantic
Higher
education
level
language
(all
p
<
0.05).
Improved
physical
factors,
such
as
speed,
grip
strength,
balance,
particularly
over
60,
potential
confounder.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 6, 2024
Abstract
In
this
study,
we
aimed
to
investigate
the
association
between
handgrip
strength
(HGS)
and
cognitive
performance
in
stage
3-5
chronic
kidney
disease
(CKD)
patients
aged
≥
60
years.
This
cross-sectional
study
analyzed
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
database
2011–2014.
Three
tests
were
used
assess
performance,
including
consortium
establish
a
registry
for
Alzheimer’s
(CERAD),
animal
fluency
test
(AFT),
digit
symbol
substitution
(DSST).
The
multivariate
linear
regression
analyses
adjusting
confounding
factors
utilized
evaluate
of
HGS
with
performance.
A
total
678
older
CKD
included
study.
After
multiple
factors,
higher
was
positively
associated
CERAD-delayed
recall
DSST
score.
addition,
our
analysis
indicated
that
probably
correlated
better
immediate
learning
ability
male,
while
working
memory,
sustained
attention,
processing
speed
female.
may
be
an
important
indicator
deficits
patients,
especially
executive
function.
Further
research
explore
sex-specific
domain-specific
possible
mechanisms
are
required.
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1461 - 1461
Опубликована: Июль 1, 2024
Introduction:
Sarcopenia
and
diabetes
mellitus
(DM)
have
been
shown
to
be
related.
It
has
demonstrated
that
pesticides/insecticides
are
linked
various
health
issues,
including
DM.
This
study
investigated
the
relationships
between
exposure
muscle
strength
among
community-dwelling
DM
patients
in
a
national
sample
of
United
States
(US).
Methods:
Data
from
2011–2012
2013–2014
U.S.
National
Health
Nutrition
Examination
Survey
(NHANES)
on
people
aged
20
years
with
were
retrieved.
A
digital
dynamometer
was
used
quantify
handgrip
strength,
urine
pesticide
concentrations
determined
through
laboratory
testing.
Regression
models
investigate
relationship
pesticide/insecticide
strength.
Results:
After
weighting,
data
412
NHANES
participants
represented
6,696,865
inhabitants.
The
mean
age
58.8
years.
High
para-nitrophenol
levels
(tertile
3
vs.
tertile
1)
associated
lower
both
males
(aBeta
=
−7.25,
95%
CI:
−11.25,
−3.25)
females
−3.73,
−6.89,
−0.56).
Further,
elevated
2-isopropyl−4-methyl-pyrimidinol
had
decreased
Desethyl
hydroxy
N,
N-diethyl-m-toluamide
(DEET)
inversely
related
men
≥60
DEET
acid
correlated
women
over
60
Conclusions:
certain
diabetes.
Para-nitrophenol,
particular,
is
negatively
muscular
females,
2-isopropyl-4-methyl-pyrimidinol
females.
