PubMed,
Journal Year:
2024,
Volume and Issue:
27(2), P. 157 - 164
Published: Jan. 1, 2024
The
primary
gene
mutations
associated
with
nasopharyngeal
carcinoma
(NPC)
are
located
within
the
phosphoinositide
3-kinase-mammalian
target
of
rapamycin
signaling
pathways,
which
have
inhibitory
effects
on
autophagy.
Compounds
that
autophagy
could
potentially
be
used
to
treat
NPC.
However,
autophagy-related
molecular
targets
in
NPC
remain
elucidated.
We
aimed
examine
levels
genes,
including
4B
cysteine
peptidase
(ATG4B)
and
gamma-aminobutyric
acid
(GABA)
type
A
receptor-associated
protein-like
1
(GABARAPL1),
cells
explored
their
potential
role
as
novel
for
treatment
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 12, 2024
Abstract
Cancer
treatment
faces
many
hurdles
and
resistance
is
one
among
them.
Anti-cancer
strategies
are
evolving
due
to
innate
acquired
capacity,
governed
by
genetic,
epigenetic,
proteomic,
metabolic,
or
microenvironmental
cues
that
ultimately
enable
selected
cancer
cells
survive
progress
under
unfavorable
conditions.
Although
the
mechanism
of
drug
being
widely
studied
generate
new
target-based
drugs
with
better
potency
than
existing
ones.
However,
broader
flexibility
in
resistance,
advanced
therapeutic
options
efficacy
need
be
explored.
Combination
therapy
an
alternative
a
success
rate
though
risk
amplified
side
effects
commonplace.
Moreover,
recent
groundbreaking
precision
immune
ways
overcome
has
revolutionized
anticancer
greater
extent
only
limitation
individual-specific
needs
further
attention.
This
review
will
focus
on
challenges
opted
withstand
current
therapies
at
molecular
level
also
highlights
emerging
-like
immunological,
stem
cell-based
may
prove
have
potential
challenge
problem
resistance.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 428 - 428
Published: Feb. 9, 2023
Autophagy
is
a
fundamental
homeostatic
process
in
which
certain
cellular
components
are
ingested
by
double-membrane
autophagosomes
and
then
degraded
to
create
energy
or
maintain
homeostasis
survival.
It
typically
observed
nutrient-deprived
cells
as
survival
mechanism.
However,
it
has
also
been
identified
crucial
maintaining
disease
progression.
Normal
metabolism
produces
reactive
oxygen
(ROS)
nitrogen
species
at
low
levels.
increased
production
causes
oxidative
stress,
can
lead
diabetes,
cardiovascular
diseases,
neurological
disorders,
cancer.
was
recently
shown
that
redox
equilibrium
via
autophagy
critical
for
responses
stress.
little
understood
about
the
molecular
cancer
processes
connect
control
of
autophagy.
In
cells,
oncogenic
mutations,
carcinogens,
metabolic
reprogramming
cause
ROS
generation
Recent
studies
have
suggested
activates
pathways
promote
development
metastasis.
Moreover,
relationship
between
programming
involved
malignant
phenotype.
Currently,
while
signaling
events
governing
how
affects
cascades
well
understood,
very
known
related
this
review,
we
focus
on
current
knowledge
modulation
role
further
stress
progression
regulation.
Therefore,
review
focuses
understanding
oxidation/reduction
fine-tune
help
understand
govern
cancer,
either
leading
cell
death
strategies
Current Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
24(6), P. 702 - 711
Published: May 19, 2023
Abstract:
Natural
remedies
from
a
range
of
sources,
including
plants,
animals,
microorganisms,
and
marine
life,
have
made
significant
contribution
to
the
treatment
many
ailments.
Lavender
is
Mediterranean
shrub
Lamiaceae
family.
flowers
(Lavandula
flores)
include
active
ingredients
(3%),
anthocyanins,
sugars,
phytosterols,
minerals,
tannins
are
majorly
used
for
herbal
applications.
essential
oil's
descriptive
analytical
composition
varies
depending
on
genotype,
growing
region,
climatic
circumstances,
propagation,
morphological
characteristics.
There
around
300
chemical
components
in
oil.
Linalool,
terpinen-4-ol,
linalyl
acetate,
ocimene,
acetate
lavandulol,
cineole
most
prominent
constituents.
oil
has
antibacterial
antioxidant
properties.
The
lavender
extract
helps
prevent
dementia
may
slow
cancer
cell
growth,
while
treat
skin
problems.
This
review
will
cover
recent
medical,
economic
regional
advancements
levander
propagation
how
Council
Scientific
&
Industrial
Research
Indian
Institute
Integrative
(CSIR
IIIM)
aroma
mission
actively
acting
as
bridge
between
farmers
their
improvement
by
attracting
them
field
medicinal
plant
cultivation.
Applied Sciences,
Journal Year:
2023,
Volume and Issue:
13(5), P. 2893 - 2893
Published: Feb. 23, 2023
Reactive
oxygen
species
(ROS)-the
byproduct
of
regular
cell
activity
formed
by
various
cellular
components—play
a
significant
role
in
pathological
and
physiological
conditions.
Alternatively,
antioxidants
are
compounds
that
reduce
or
scavenge
reactive
cells.
An
asymmetry
between
the
antioxidant
defense
system
ROS
from
intracellular
extracellular
sources
cause
chronic
diseases
such
as
cancer,
inflammation,
tumorigenesis,
cardiovascular
neurogenerative
diseases.
However,
Panax
ginseng
its
secondary
metabolites
(known
ginsenosides,
phenolic
compounds,
peptides,
acid
polysaccharides,
polyacetylene,
alkaloids)
well-recognized
many
vitro
vivo
experiments
which
show
beneficial
regulating
these
There
extensive
evidences
P.
can
destroy
cancer
cells
specifically
increasing
oxidative
stress
through
generation
without
significantly
harming
normal
Additionally,
numerous
studies
have
examined
derivatives
on
ROS-mediated
signaling
pathways
discussed
herein.
This
review
summarizes
potential
several
diseases,
gives
updated
research
evidence
with
related
mechanisms
future
possibilities
nano-formulated
other
polyphenols.
Biologics,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 7 - 19
Published: Jan. 1, 2024
Abstract:
N-acetylcysteine
(NAC)
is
a
membrane-permeable
cysteine
precursor
capable
of
enhancing
the
intracellular
pool,
cellular
glutathione
(GSH)
synthesis,
and
thus
potentiating
endogenous
antioxidant
mechanism.
Late
administration
NAC
after
cisplatin
has
been
shown
in
different
vivo
studies
to
reduce
side
effects
caused
by
various
toxicities
at
levels
without
affecting
antitumor
efficacy
platinum,
improving
total
enzymatic
capacity
decreasing
oxidative
stress
markers.
These
characteristics
provide
with
rationale
as
potentially
effective
chemo
protectant
cisplatin-based
therapeutic
cycles.
represents
potential
candidate
chemoprotective
agent
decrease
secondary
treatment.
It
suggests
that
it
could
be
used
clinical
trials,
whereby
dose,
timing,
route
should
adjusted
optimize
chemoprotection.
This
review
provides
an
overview
effect
on
toxicity,
drug
widely
clinic
adults
children.
Keywords:
cisplatin,
protectant,
stress,
Medical Oncology,
Journal Year:
2025,
Volume and Issue:
42(3)
Published: Feb. 3, 2025
Natural
drugs
have
the
advantages
of
multi-pathway,
multi-target,
low
toxicity,
and
high
efficiency,
which
make
them
widely
used
effective
in
anti-tumor
therapy.
Dioscin
is
a
steroidal
saponin
compound
that
can
be
extracted
from
Dioscaceae
plants.
In
recent
years,
it
has
been
found
potent
effects,
inhibit
tumor
cell
proliferation,
induce
apoptosis
autophagy,
inhibits
metastasis,
reverses
multidrug
resistance,
increases
sensitivity
to
anticancer
drugs,
thus
progression.
Meanwhile,
construction
nanocarriers
improve
efficiency
drug
use,
reduce
realize
precise
delivery
bioavailability
Dioscin.
this
paper,
mechanism
targets
years
were
reviewed,
thereby
providing
new
ideas
theoretical
basis
for
further
research
promotion
