Role of estrogen in treatment of female depression

Aging, Год журнала: 2024, Номер unknown

Опубликована: Фев. 2, 2024

Depression is a neurological disorder that profoundly affects human physical and mental health, resulting in various changes the central nervous system. Despite several prominent hypotheses, such as monoaminergic theory, hypothalamic-pituitary-adrenal (HPA) axis neuroinflammation, neuroplasticity, current understanding of depression's pathogenesis remains incomplete. Importantly, depression gender-dimorphic disorder, with women exhibiting higher incidence rates than men. Given estrogen's pivotal role menstrual cycle, it reasonable to postulate its fluctuating levels could contribute depression. Estrogen acts by binding diversity receptors, which are widely distributed An abundance research has established estrogen receptors play crucial depression, spanning treatment. In this comprehensive review, we provide an in-depth analysis fundamental focus on neuroendocrinology, neuroplasticity. Furthermore, discuss potential mechanisms underlying therapeutic effects treatment may pave way for new antidepressant drug development alternative options.

Язык: Английский

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Temporal trends and age-period-cohort analysis of depression in U.S. adults from 2013 to 2022

Journal of Affective Disorders, Год журнала: 2024, Номер 362, С. 237 - 243

Опубликована: Июнь 27, 2024

Язык: Английский

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Multidimensional social support and associations between COVID-19 stress and depressive/anxiety outcomes among Hispanic/Latinx and White first-year college students

Journal of American College Health, Год журнала: 2024, Номер unknown, С. 1 - 12

Опубликована: Янв. 16, 2024

Objective: The COVID-19 pandemic has led to greater depression and anxiety among college students. Social support may alleviate this risk. We examined how social from family, friends, romantic partners influence internalizing psychopathology outcomes associated with COVID-19-related stressful events. Participants: Participants were first-years (N = 425, 34.8% Hispanic/Latinx, 74.9% female) enrolled in a United States public university. Methods: completed an online survey Fall of 2020. Linear regression models associations between stressors, support, depressive symptoms, differences White Hispanic/Latinx Results: Reported stressors elevated symptoms higher Family friend negatively both outcomes. Partner was more predictive students whereas for students' anxiety. Conclusions: These findings demonstrate the importance connectedness during pandemic.

Язык: Английский

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The impact of COVID-19 pandemic on gambling: A systematic review

Addictive Behaviors, Год журнала: 2024, Номер 155, С. 108037 - 108037

Опубликована: Апрель 10, 2024

Since the COVID-19 outbreak, people's habits changed radically. In fact, to limit spread of SARS-CoV-2, governments implemented restrictive measures that influenced lives individuals. The aim this systematic review is analyze impact on gambling by examining three different outcomes: frequency, expenditure, and transition among possible types gambling.

Язык: Английский

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Glucose metabolism impairment in major depressive disorder

Brain Research Bulletin, Год журнала: 2025, Номер 221, С. 111191 - 111191

Опубликована: Янв. 7, 2025

Major depressive disorder (MDD) is a common mental with chronic tendencies that seriously affect regular work, life, and study. However, its exact pathogenesis remains unclear. Patients MDD experience systemic localized impairments in glucose metabolism throughout the disease course, disrupting various processes such as uptake, glycoprotein transport, glycolysis, tricarboxylic acid cycle (TCA), oxidative phosphorylation (OXPHOS). These may result from mechanisms including insulin resistance, hyperglycemia-induced damage, stress, astrocyte abnormalities, mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, functional structural damage reward networks. mechanical changes contribute of severely interfere prognosis. Herein, we summarized impairment pathophysiological patients MDD. In addition, briefly discussed potential pharmacological interventions for alleviate MDD, glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, pioglitazone, encourage development new therapeutics.

Язык: Английский

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COVID-19 and immune dysfunction: Consequences and natural remedies for management

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 235 - 264

Опубликована: Янв. 1, 2025

Язык: Английский

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Challenges faced by older adults caring for their parents and their relationship with depressive status: Examining internet use as a moderator

Acta Psychologica, Год журнала: 2025, Номер 255, С. 104889 - 104889

Опубликована: Март 15, 2025

Язык: Английский

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Mental health disorders among medical students during the COVID-19 pandemic in the area with no mandatory lockdown: a multicenter survey in Tanzania

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 11, 2024

Abstract The COVID-19 pandemic brought about a major public health concern worldwide. It forced many countries to enforce lockdowns, leading the closure of higher learning institutions. abrupt shift in lifestyle students had profound impact on their mental health. This study aims determine prevalence and factors associated with conditions among university Tanzania during pandemic. A sample 425 from six medical universities colleges completed an online survey was included analysis. questionnaire consisted validated Depression, Anxiety Stress Scale—21 Items (DASS-21) questions (Cronbach’s alpha = 0.92) assessing presence symptoms: depression, anxiety, stress. Multivariable logistic regression models were fitted explain conditions. P -value < 0.05 considered statistically significant all inferential analyses. median age (interquartile range) participants 24 (22–26). 28.94%, 54.12%, 15.06% for stress, respectively, while having any condition 58.59%. In adjusted model, being fourth fifth years living spouse significantly increased odds depression: AOR 5.99 (1.31–27.47), 5.52 (1.18–25.81), 1.84 (1.08–3.15), respectively. Moreover, studying private likelihood anxiety: 2.35 (1.72–2.76), 2.32 (1.20–4.50), stress only universities; 2.90 (1.60–5.27). revealed alarmingly high rates findings suggest need regular checkups regarding status. Additionally, it recommends that government other stakeholders establish services within effective prevention rising burden problems similar settings.

Язык: Английский

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Study protocol: A national cross-sectional study on psychology and behavior investigation of Chinese residents in 2023, PBICR

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 29, 2024

Abstract Background This study protocol specifies the primary research line and theoretical framework of 2023 Survey Psychology Behavior on Chinese Population. It aims to establish a database focused psychology behavior among residents through multicenter, large-sample cross-sectional survey provide strong data support for development in related fields. will track public’s physical psychological health more comprehensively systematically. Methods The was conducted from 20 June 31 August 2023, using stratified quota sampling methods, total 150 cities, 202 districts counties, 390 townships/streets, 800 communities/villages were surveyed (excluding Taiwan, which selected 23 provinces, five autonomous regions, four municipalities directly under central government China). questionnaires distributed face-to-face by trained surveyors. included basic information about individual, personal status, family, social environment individual lives, condition scales, behavioral level other attitudes towards topical issues. Supervisors quality control during distribution process returned questionnaires, logically checked cleaned analysis. Discussion Data collection has been finished, scientific outputs based this promotion strategies China globally. In aftermath pandemic, it guide policymakers healthcare organizations improve their existing policies services maximize mental population.

Язык: Английский

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Efficacy of systemic therapy on adults with depressive disorders: A meta-analysis

Psychotherapy Research, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Май 22, 2024

Objective This meta-analysis evaluates the efficacy of systemic therapy approaches on adult clients with depressive disorders.

Язык: Английский

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