Glutamatergic Projection from the Ventral Tegmental Area to the Zona Incerta Regulates Fear Response
Neuroscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Disentangling the identity of the zona incerta: a review of the known connections and latest implications
Ageing Research Reviews,
Год журнала:
2023,
Номер
93, С. 102140 - 102140
Опубликована: Ноя. 24, 2023
The
zona
incerta
(ZI)
is
a
subthalamic
region
composed
by
loosely
packed
neurochemically
mixed
neurons,
juxtaposed
to
the
main
ascending
and
descending
bundles.
extreme
neurochemical
diversity
that
characterizes
this
area,
together
with
diffuseness
of
its
connections
entire
neuraxis
hard-to-reach
positioning
in
brain
caused
ZI
keep
halo
mystery
for
over
century.
However,
last
decades,
rich
albeit
fragmentary
body
knowledge
regarding
both
incertal
anatomical
functional
implications
has
been
built
mostly
based
on
rodent
studies
lack
cohesion
makes
difficult
depict
an
integrated,
exhaustive
picture
roles.
This
review
aims
provide
unified
resource
summarizes
current
profile
interactions
rodents
non-human
primates
significance
connections,
highlighting
aspects
still
unbeknown
research.
Язык: Английский
Abnormal iron metabolism in the zona incerta in Parkinson’s disease mice
Journal of Neural Transmission,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 22, 2025
Язык: Английский
Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice
PLoS Biology,
Год журнала:
2024,
Номер
22(7), С. e3002679 - e3002679
Опубликована: Июль 12, 2024
Over-generalized
fear
is
a
maladaptive
response
to
harmless
stimuli
or
situations
characteristic
of
posttraumatic
stress
disorder
(PTSD)
and
other
anxiety
disorders.
The
dorsal
dentate
gyrus
(dDG)
contains
engram
cells
that
play
crucial
role
in
accurate
memory
retrieval.
However,
the
coordination
mechanism
neuronal
subpopulations
within
dDG
network
during
generalization
not
well
understood.
Here,
with
Tet-off
system
combined
immunostaining
two-photon
calcium
imaging,
we
report
labeled
conditioned
context
constitutes
significantly
higher
proportion
neurons
activated
similar
where
mice
show
generalized
fear.
activation
these
encoding
both
sufficient
necessary
for
inducing
context.
Activities
mossy
ventral
(vMCs)
are
suppressed
showing
context,
activating
vMCs-dDG
pathway
suppresses
but
Finally,
modifying
engrams
“safety”
signals
effectively
rescues
generalization.
These
findings
reveal
competitive
advantage
underlies
generalization,
which
can
be
rescued
by
engrams,
provide
novel
insights
into
as
basis
Язык: Английский
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease
Ageing Research Reviews,
Год журнала:
2023,
Номер
92, С. 102097 - 102097
Опубликована: Окт. 28, 2023
Язык: Английский
Reactive astrocytes mediate postoperative surgery-induced anxiety through modulation of GABAergic signalling in the zona incerta of mice
British Journal of Anaesthesia,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Surgery
can
induce
severe
neuroinflammation
and
negative
emotional
symptoms,
such
as
anxiety-like
behaviour.
We
studied
whether
reactive
astrocytes
in
the
zona
incerta
(ZI)
mediate
surgery-induced
anxiety
mice.
Язык: Английский
Up-regulating GABA transporter-3 in the zona incerta prevents surgery-induced memory impairment in mice
Neuropharmacology,
Год журнала:
2024,
Номер
257, С. 110034 - 110034
Опубликована: Июнь 13, 2024
Язык: Английский
Projections from the ventral tegmental area to zona incerta regulate fear generalization in a mouse model of PTSD
Brain Research Bulletin,
Год журнала:
2024,
Номер
217, С. 111079 - 111079
Опубликована: Сен. 11, 2024
Язык: Английский
Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons
National Science Review,
Год журнала:
2024,
Номер
11(4)
Опубликована: Фев. 13, 2024
ABSTRACT
The
nucleus
of
Darkschewitsch
(ND),
mainly
composed
GABAergic
neurons,
is
widely
recognized
as
a
component
the
eye-movement
controlling
system.
However,
functional
contribution
ND
neurons
(NDGABA)
in
animal
behavior
largely
unknown.
Here,
we
show
that
NDGABA
were
selectively
activated
by
different
types
fear
stimuli,
such
predator
odor
and
foot
shock.
Optogenetic
chemogenetic
manipulations
revealed
mediate
freezing
behavior.
Moreover,
using
circuit-based
optogenetic
neuroanatomical
tracing
methods,
identified
an
excitatory
pathway
from
lateral
periaqueductal
gray
(lPAG)
to
induces
exciting
inhibitory
outputs
motor-related
gigantocellular
reticular
nucleus,
ventral
part
(GiV).
Together,
these
findings
indicate
population
novel
hub
for
defensive
response
relaying
fearful
information
lPAG
GiV,
mechanism
critical
understanding
how
encoded
mammalian
brain.
Язык: Английский