Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons DOI Creative Commons

Huiying Zhao,

Jinrong Liu,

Yujin Shao

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 11(4)

Published: Feb. 13, 2024

ABSTRACT The nucleus of Darkschewitsch (ND), mainly composed GABAergic neurons, is widely recognized as a component the eye-movement controlling system. However, functional contribution ND neurons (NDGABA) in animal behavior largely unknown. Here, we show that NDGABA were selectively activated by different types fear stimuli, such predator odor and foot shock. Optogenetic chemogenetic manipulations revealed mediate freezing behavior. Moreover, using circuit-based optogenetic neuroanatomical tracing methods, identified an excitatory pathway from lateral periaqueductal gray (lPAG) to induces exciting inhibitory outputs motor-related gigantocellular reticular nucleus, ventral part (GiV). Together, these findings indicate population novel hub for defensive response relaying fearful information lPAG GiV, mechanism critical understanding how encoded mammalian brain.

Language: Английский

Glutamatergic Projection from the Ventral Tegmental Area to the Zona Incerta Regulates Fear Response DOI
Xinyi Wang, Hongquan Zhang,

Kun Tong

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

7
Disentangling the identity of the zona incerta: a review of the known connections and latest implications DOI Creative Commons

Giulia Arena,

Fabrizio Londei, Francesco Ceccarelli

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 93, P. 102140 - 102140

Published: Nov. 24, 2023

The zona incerta (ZI) is a subthalamic region composed by loosely packed neurochemically mixed neurons, juxtaposed to the main ascending and descending bundles. extreme neurochemical diversity that characterizes this area, together with diffuseness of its connections entire neuraxis hard-to-reach positioning in brain caused ZI keep halo mystery for over century. However, last decades, rich albeit fragmentary body knowledge regarding both incertal anatomical functional implications has been built mostly based on rodent studies lack cohesion makes difficult depict an integrated, exhaustive picture roles. This review aims provide unified resource summarizes current profile interactions rodents non-human primates significance connections, highlighting aspects still unbeknown research.

Language: Английский

Citations

12
Abnormal iron metabolism in the zona incerta in Parkinson’s disease mice DOI

Minxia Xiu,

Yanhong Liu, Zhaobo Wang

et al.

Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

Citations

0
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease DOI
Juan Wang, Xiaoting Wang, Hui Li

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102097 - 102097

Published: Oct. 28, 2023

Language: Английский

Citations

7
Reactive astrocytes mediate postoperative surgery-induced anxiety through modulation of GABAergic signalling in the zona incerta of mice DOI Creative Commons
Kun Tong, Yutong Song,

Si-Qi Jing

et al.

British Journal of Anaesthesia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Surgery can induce severe neuroinflammation and negative emotional symptoms, such as anxiety-like behaviour. We studied whether reactive astrocytes in the zona incerta (ZI) mediate surgery-induced anxiety mice.

Language: Английский

Citations

2
Up-regulating GABA transporter-3 in the zona incerta prevents surgery-induced memory impairment in mice DOI
Kun Tong, Jingwei Zhang,

Si-Qi Jing

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 257, P. 110034 - 110034

Published: June 13, 2024

Language: Английский

Citations

1
Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice DOI Creative Commons
Kun Cui, Xuetao Qi, Zilong Liu

et al.

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(7), P. e3002679 - e3002679

Published: July 12, 2024

Over-generalized fear is a maladaptive response to harmless stimuli or situations characteristic of posttraumatic stress disorder (PTSD) and other anxiety disorders. The dorsal dentate gyrus (dDG) contains engram cells that play crucial role in accurate memory retrieval. However, the coordination mechanism neuronal subpopulations within dDG network during generalization not well understood. Here, with Tet-off system combined immunostaining two-photon calcium imaging, we report labeled conditioned context constitutes significantly higher proportion neurons activated similar where mice show generalized fear. activation these encoding both sufficient necessary for inducing context. Activities mossy ventral (vMCs) are suppressed showing context, activating vMCs-dDG pathway suppresses but Finally, modifying engrams “safety” signals effectively rescues generalization. These findings reveal competitive advantage underlies generalization, which can be rescued by engrams, provide novel insights into as basis

Language: Английский

Citations

1
Projections from the ventral tegmental area to zona incerta regulate fear generalization in a mouse model of PTSD DOI Creative Commons

Kun Tong,

Shuang Wang, Yi-Jie Zhu

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 217, P. 111079 - 111079

Published: Sept. 11, 2024

Language: Английский

Citations

1
Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons DOI Creative Commons

Huiying Zhao,

Jinrong Liu,

Yujin Shao

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 11(4)

Published: Feb. 13, 2024

ABSTRACT The nucleus of Darkschewitsch (ND), mainly composed GABAergic neurons, is widely recognized as a component the eye-movement controlling system. However, functional contribution ND neurons (NDGABA) in animal behavior largely unknown. Here, we show that NDGABA were selectively activated by different types fear stimuli, such predator odor and foot shock. Optogenetic chemogenetic manipulations revealed mediate freezing behavior. Moreover, using circuit-based optogenetic neuroanatomical tracing methods, identified an excitatory pathway from lateral periaqueductal gray (lPAG) to induces exciting inhibitory outputs motor-related gigantocellular reticular nucleus, ventral part (GiV). Together, these findings indicate population novel hub for defensive response relaying fearful information lPAG GiV, mechanism critical understanding how encoded mammalian brain.

Language: Английский

Citations

0