Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101098 - 101098
Опубликована: Май 22, 2024
Developing
patches
that
effectively
merge
intrinsic
deformation
characteristics
of
cardiac
with
superior
tunable
mechanical
properties
remains
a
crucial
biomedical
pursuit.
Currently
used
traditional
block-shaped
or
mesh
patches,
typically
incorporating
positive
Poisson's
ratio,
often
fall
short
matching
the
tissue
satisfactorily,
thus
diminishing
their
repairing
capability.
By
introducing
auxeticity
into
this
study
is
trying
to
present
beneficial
approach
address
these
shortcomings
patches.
The
featuring
auxetic
effect,
offer
unparalleled
conformity
complex
challenges.
Initially,
scaffolds
demonstrating
effect
were
designed
by
merging
chiral
rotation
and
concave
angle
units,
followed
integrating
composite
hydrogel
through
thermally
triggering,
ensuring
excellent
biocompatibility
closely
mirroring
heart
tissue.
Tensile
tests
revealed
possessed
elasticity
strain
capacity
exceeding
tissue's
physiological
activity.
Notably,
Model
III
showed
an
equivalent
modulus
ratio
toward
tissue,
underscoring
its
outstanding
potential
as
Cyclic
tensile
loading
demonstrated
withstood
continuous
heartbeats,
showcasing
cyclic
recovery
capabilities.
Numerical
simulations
further
elucidated
failure
mechanisms
leading
exploration
influence
on
alternative
design
parameters,
which
enabled
customization
strength
ratio.
Therefore,
research
presents
substantial
for
designing
can
emulate
possess
adjustable
parameters.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(35), С. 46771 - 46788
Опубликована: Авг. 21, 2024
Electronic
skin
(e-skin)
is
considered
as
a
highly
promising
interface
for
human-computer
interaction
systems
and
wearable
electronic
devices.
Through
elaborate
design
assembly
of
various
materials,
it
possesses
multiple
characteristics
similar
to
human
skin,
including
remarkable
flexibility,
stretchability,
sensitivity
temperature
humidity,
biocompatibility,
efficient
interfacial
ion/electron
transport
capabilities.
Here,
we
innovatively
integrate
multifunctional
carbon
quantum
dots
(CQDs),
which
exhibit
conductivity,
antibacterial
properties,
ultraviolet
absorption,
fluorescence
emission,
with
poly(acrylic
acid)
glycerin
(Gly)
into
three-dimensional
network
structure
natural
goatskin
collagen
fibers.
top-down
strategy
enhanced
by
hydrogen
bond
reconstruction,
successfully
fabricated
novel
transparent
e-skin
(PAC-eSkin).
This
exhibited
significant
tensile
properties
(4.94
MPa
strength
263.42%
maximum
breaking
elongation),
while
also
possessing
Young's
modulus
(2.32
MPa).
It
noteworthy
that
the
functionalized
CQDs
used
was
derived
from
discarded
goat
hair,
addition
Gly
gave
PAC-eSkin
excellent
antifreezing
moisturizing
properties.
Due
presence
ultrasmall
CQDs,
creates
channels
within
PAC-eSkin,
could
rapidly
sense
motion
physiological
signals
(with
gauge
factor
(GF)
1.88).
Furthermore,
had
potential
replace
traditional
electrode
patches
real-time
monitoring
electrocardiogram,
electromyogram,
electrooculogram
signals,
higher
SNR
(signal-to-noise
ratio)
25.1
dB.
Additionally,
customizable
size
shape
offer
vast
possibilities
construction
single-electrode
triboelectric
nanogenerator
systems.
We
have
reason
believe
development
this
based
on
CQDs-functionalized
dermal
matrices
can
pave
new
way
innovations
in
human–computer
interfaces
their
sensing
application
diverse
scenarios.
ACS Nano,
Год журнала:
2024,
Номер
18(33), С. 21779 - 21803
Опубликована: Авг. 12, 2024
Aqueous
zinc-ion
batteries
(AZIBs)
are
widely
regarded
as
desirable
energy
storage
devices
due
to
their
inherent
safety
and
low
cost.
Hydrogel
polymer
electrolytes
(HPEs)
cross-linked
polymers
filled
with
water
zinc
salts.
They
not
only
used
in
flexible
but
also
represent
an
ideal
electrolyte
candidate
for
addressing
the
issues
associated
Zn
anode,
including
dendrite
formation
side
reactions.
In
HPEs,
abundance
of
hydrophilic
groups
can
form
strong
hydrogen
bonds
molecules,
reducing
activity
inhibiting
decomposition.
At
same
time,
special
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 15, 2024
Abstract
Hydrogels
are
a
class
of
highly
absorbent
and
easily
modified
polymer
materials
suitable
for
use
as
slow-release
carriers
drugs.
Gene
therapy
is
specific
can
overcome
the
limitations
traditional
tissue
engineering
techniques
has
significant
advantages
in
repair.
However,
therapeutic
genes
often
affected
by
cellular
barriers
enzyme
sensitivity,
carrier
loading
essential.
Therapeutic
gene
hydrogels
well
these
difficulties.
Moreover,
gene-therapeutic
have
made
considerable
progress.
This
review
summarizes
recent
research
on
treatment
damage
through
summary
most
current
frontiers.
We
initially
introduce
classification
their
cross-linking
methods,
followed
detailed
overview
types
modifications
genes,
discussion
characterization
features,
design
release,
an
applications
engineering.
Finally,
we
provide
comments
look
forward
to
shortcomings
future
directions
therapy.
hope
that
this
article
will
researchers
related
fields
with
more
comprehensive
systematic
strategies
repair
further
promote
development
field
Graphical
abstract
European journal of medical research,
Год журнала:
2025,
Номер
30(1)
Опубликована: Фев. 4, 2025
Abstract
Brain
tumor
treatment
remains
a
significant
challenge
due
to
their
high
mortality
and
resistance
current
therapies.
This
paper
discusses
the
promising
potential
of
hydrogel-based
nanoparticles
as
innovative
drug
delivery
systems
for
brain
therapy.
Extensive
characterization
techniques
reveal
ability
these
Nano-systems
demonstrate
prolonged
blood
circulation
targeted
delivery,
leading
improved
survival
rates.
Designed
with
optimized
physicochemical
characteristics,
effectively
cross
blood–brain
barrier,
circumventing
major
impediment
brain.
By
delivering
drugs
directly
bed,
enhance
therapeutic
outcomes
minimize
adverse
effects.
In
addition,
this
review
investigates
characterizing,
visualizing,
modifying
nanoparticles,
well
standing
challenges
research
avenues
clinical
application.
Further
investigations
are
encouraged
by
investigate
advancements
in
nanoparticle
approaches
tumors.
includes
investigating
tailored
hydrogels,
hybrid
systems,
computational
modeling,
integration
gene
therapy
immunotherapy
techniques.
The
study
also
addresses
need
enhanced
synthesis
techniques,
stability,
scalability,
cost-cutting
measures
overcome
obstacles
advance
use
treating
Graphical
abstract
A
new
green
hydrogel
consisting
of
cherry
stone
(CS)
powder
and
sodium
alginate
(SA)
was
synthesized
through
physical
crosslinking.
The
product
had
a
mean
diameter
3.95
mm,
moisture
content
92.28%,
bulk
density
0.58
g/cm3,
swelling
ratio
45.10%.
analyses
its
morphological
structure
functional
groups
by
scanning
electron
microscopy
(SEM)
Fourier-transform
infrared
spectroscopy
(FTIR)
showed
the
successful
entrapping
CS
in
SA
polymeric
matrix.
viability
prepared
as
adsorbent
tested
towards
Orange
II
(OII)
anionic
dye.
influence
pH,
amount,
contact
time,
initial
dye
concentration
evaluated.
Then,
impact
three
accelerating
factors
(stirring
speed,
ultrasound
exposure
duration,
temperature)
on
OII
retention
investigated.
highest
recorded
removal
efficiency
adsorption
capacity
were
82.20%
6.84
mg/g,
respectively.
followed
Elovich
pseudo-second-order
kinetics,
adequately
described
Freundlich
Khan
isotherms,
can
be
defined
spontaneous,
endothermic,
random.
experiments
confirmed
that
obtained
used
acceptably
for
at
least
two
consecutive
cycles,
sustaining
effectiveness
water
decontamination.
