Environmental Science and Pollution Research, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Язык: Английский
Applied Biochemistry and Biotechnology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Abstract Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential new drug development. Their ability to address growing issue resistance has drawn attention from researchers seeking novel, nature-derived lead molecules that can be produced on large scale meet global demand. Recent advancements in genomics, metabolomics, bioinformatics, and improved cultivation techniques have significantly aided identification characterization fungal endophytes their metabolites. Current estimates suggest there are approximately 1.20 million globally, yet only around 16% (190,000) been identified studied detail. This underscores vast untapped pharmaceutical research. Research increasingly focused transformation bioactive compounds by through chemical enzymatic processes. A notable example is anthraquinone derivative 6-O-methylalaternin, whose cytotoxic enhanced addition hydroxyl group, sharing structural similarities with its parent compound macrosporin. These structure-bioactivity studies open up avenues developing safer more effective therapeutic agents synthesizing targeted derivatives. Despite immense promise, challenges remain, particularly large-scale understanding complexities biosynthetic pathways. Additionally, genetic manipulation optimized metabolite production still infancy. Future research should aim overcome these limitations focusing efficient methods deeper exploration endophytes’ metabolic capabilities fully harness potential. Graphical
Язык: Английский
Процитировано
7
Antibiotics, Год журнала: 2024, Номер 13(3), С. 271 - 271
Опубликована: Март 18, 2024
Infectious diseases are a significant challenge to global healthcare, especially in the face of increasing antibiotic resistance. This urgent issue requires continuous exploration and development new antimicrobial drugs. In this regard, secondary metabolites derived from endophytic microorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing within internal tissues plants, have demonstrated capacity produce diverse bioactive compounds with substantial pharmacological potential. Therefore, numerous been isolated endophytes, particularly fungi actinomycetes. However, only limited number these subjected comprehensive studies regarding their mechanisms action against bacterial cells. Furthermore, investigation effects on antibiotic-resistant bacteria identification biosynthetic gene clusters responsible synthesizing conducted subset compounds. Through analysis current research findings, review describes drugs antibacterial activities natural endophytes bacteria, synthesis metabolites.
Язык: Английский
Процитировано
18
Medicinal Plant Biology, Год журнала: 2024, Номер 3(1), С. 0 - 0
Опубликована: Янв. 1, 2024
Medicinal plants are vital in synthesizing crucial substrates, fortifying stress resilience, and serving clinical industrial domains. The optimization of pharmacological potential necessitates a nuanced understanding the factors governing synthesis secondary metabolites sourced from plants. Cultivation success hinges upon many dictating production these compounds. Biotic factors, encompassing pathogens herbivores, alongside abiotic such as light exposure, altitude, temperature variations, irrigation patterns, soil fertility, drought susceptibility, salinity levels, collectively orchestrate medicinal plants' growth, development, metabolic pathways. This comprehensive review delves into intricate interplay influencing formation metabolites, exploring roles endophytes, pathogens, availability, fluctuations, stress, pollution impacts, plant growth regulators. Grasping dynamics is imperative for devising strategic interventions to enhance metabolite production, thereby ensuring sustainable efficient cultivation
Язык: Английский
Процитировано
12
Pest Management Science, Год журнала: 2024, Номер 80(12), С. 6033 - 6040
Опубликована: Июль 24, 2024
Abstract Entomopathogenic fungi capable of establishing mutualistic endophytic relationships with plants have a tremendous potential as biocontrol agents insect pests. While long played an important and highly effective role in pest suppression, the utility entomopathogenic management is relatively new emerging topic biocontrol. Here we discuss relevance to plant health general, synthesize current knowledge effectiveness against diverse pests, indirect plant‐mediated effects on arthropods, describe benefits that are likely affect herbivores pathogens well. Lastly, consider major challenges incorporating biocontrol, such their non‐target field efficacy, which can be variable influenced by environmental factors. Continued research endophyte–insect–plant–environment interactions critical advancing our these sustainable tactic. © 2024 The Author(s). Pest Management Science published John Wiley & Sons Ltd behalf Society Chemical Industry.
Язык: Английский
Процитировано
9
Mycobiology, Год журнала: 2024, Номер 52(6), С. 335 - 387
Опубликована: Ноя. 1, 2024
Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to increasing applications healthcare, environmental cleanup, biotechnology-based industries. The fungi produce these metabolites (SMs) during different phases of growth, which are categorized into terpenoids, alkaloids, polyketides, non-ribosomal peptides. These SMs exhibit significant biological activity, contributes formulation novel pharmaceuticals, biopesticides, bioremediation agents. Nowadays, fungal-derived widely used food beverages, for fermentation, preservatives, protein sources, dairy In it is being as an antimicrobial, anticancer, anti-inflammatory, immunosuppressive drug. usage modern tools biotechnology can achieve increase large-scale production. present review comprehensively analyses diversity fungal along with emerging agriculture, sustainability, nutraceuticals. Here, authors reviewed recent advancements genetic engineering, metabolic pathway manipulation, synthetic biology improve production yield SMs. Advancement fermentation techniques, bioprocessing, co-cultivation approaches Investigators further highlighted importance omics technologies understanding regulation biosynthesis SMs, offers drug discovery sustainable agriculture. Finally, addressed potential manipulation biotechnological innovations exploitation commercial benefits.
Язык: Английский
Процитировано
7
Archives of Microbiology, Год журнала: 2025, Номер 207(2)
Опубликована: Янв. 22, 2025
Язык: Английский
Процитировано
1
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Дек. 8, 2023
In the ever-evolving realm of agriculture, convoluted interaction between plants and microorganisms have assumed paramount significance. Fungal endophytes, once perceived as mere bystanders within plant tissues, now emerged dynamic defenders health. This comprehensive review delves into captivating world fungal endophytes their multifaceted biocontrol mechanisms. Exploring unique ability to coexist with hosts, unlocked a treasure trove biological weaponry fend off pathogens enhance resilience. From synthesis bioactive secondary metabolites intricate signaling pathways these silent allies are masters warfare. The is quite fascinating they engage in delicate dance immune system, orchestrating symphony defense that challenges traditional notions plant-pathogen interactions. journey through various mechanisms employed by enigmatic combat diseases, will lead revelational understanding sustainable agriculture. cutting-edge research promising prospects, shedding light on how hold key reduction chemical inputs Their ecological significance, potential for bioprospecting avenues future also explored. exploration promise not only enrich our comprehension plant-microbe relationships but also, shape ecofriendly agricultural practices. this web life, indeed unsung heroes, silently guarding crops illuminating path towards greener, healthier tomorrow.
Язык: Английский
Процитировано
16
Journal of Fungi, Год журнала: 2024, Номер 10(9), С. 606 - 606
Опубликована: Авг. 26, 2024
The yield and quality of cultivated food crops are frequently compromised by the prevalent threat from fungal pathogens that can cause widespread damage in both pre-harvest post-harvest stages. This paper investigates challenges posed to sustainability essential crops, leading significant economic security repercussions. critiques long-standing reliance on synthetic fungicides, emphasizing environmental health concerns arising their occasionally inappropriate use. In response, explores potential biological control agents, specifically endophytic fungi advancing sustainable agricultural practices. Through diverse symbiotic relationships with host plants, these exhibit strong antagonistic capabilities against phytopathogenic producing various bioactive compounds promoting plant growth. review elaborates direct indirect mechanisms antagonism, such as antibiosis, mycoparasitism, induction resistance, competition for resources, which collectively contribute inhibiting pathogenic consolidates crucial role fungi, i.e.,
Язык: Английский
Процитировано
5
Marine Drugs, Год журнала: 2024, Номер 22(4), С. 161 - 161
Опубликована: Март 31, 2024
Bacillus cereus, a common food-borne pathogen, forms biofilms and generates virulence factors through quorum sensing (QS) mechanism. In this study, six compounds (dankasterone A, demethylincisterol A3, zinnimidine, cyclo-(L-Val-L-Pro), cyclo-(L-Ile-L-Pro), cyclo-(L-Leu-L-Pro)) were isolated from the endophytic fungus Pithomyces sacchari of Laurencia sp. in South China Sea. Among them, sterol derivative, exhibited strong QS inhibitory activity against B. cereus. The A3 was evaluated experiments. minimum concentration (MIC) cereus 6.25 μg/mL. At sub-MIC concentrations, it significantly decreased biofilm formation, hindered mobility, diminished production protease hemolysin activity. Moreover, RT-qPCR results demonstrated that markedly inhibited expression QS-related genes (plcR papR) exposure to resulted downregulation (comER, tasA, rpoN, sinR, codY, nheA, hblD, cytK) associated with factors. Hence, is potentially effective compound pipeline innovative antimicrobial therapies.
Язык: Английский
Процитировано
4
International Journal of Science and Research Archive, Год журнала: 2024, Номер 11(2), С. 302 - 321
Опубликована: Март 12, 2024
Antimicrobial discovery has traditionally focused on sources from plants, animals and microorganisms. However, with the reoccurring incidences of multidrug-resistant organisms (MDROs) towards in-use antibiotics problem over- exploration plants that is heavily altering ecosystem, need for other sustainable means acquiring novel drugs becomes imperative. In a bid to ameliorate these issues, researchegrs have resorted use some endosymbiotic microorganisms, known as endophytes. These are microorganisms inhabiting internal part which been verified possess great potentials bioengineer products, therapeutic purposes. The endophytic come so many promises alleviating challenges an increasingly daunting multidrug- resistant strain pathogenic microbes, become global issue in health care delivery. They can be harnessed utilized generation active ingredients drug production, instead incessant cutting down or harvesting plant parts, destroys nature, resulting warming world climate problems. This systematic review technology new alternative discovery.
Язык: Английский
Процитировано
3