Long non-coding RNAs in the failing heart and vasculature DOI Creative Commons

Steffie Hermans-Beijnsberger,

Marc van Bilsen, Blanche Schroen

и другие.

Non-coding RNA Research, Год журнала: 2018, Номер 3(3), С. 118 - 130

Опубликована: Апрель 14, 2018

Following completion of the human genome, it became evident that majority our DNA is transcribed into non-coding RNAs (ncRNAs) instead protein-coding messenger RNA. Deciphering function these ncRNAs, including both small- and long ncRNAs (lncRNAs), an emerging field research. LncRNAs have been associated with many disorders a number identified as key regulators in development progression disease, cardiovascular disease (CVD). CVD causes millions deaths worldwide, annually. Risk factors include coronary artery high blood pressure ageing. In this review, we will focus on roles lncRNAs cellular molecular processes underlie CVD: cardiomyocyte hypertrophy, fibrosis, inflammation, vascular Finally, discuss biomarker therapeutic potential lncRNAs.

Язык: Английский

Noncoding RNAs in gastric cancer: implications for drug resistance DOI Creative Commons
Ling Wei,

Jujie Sun,

Nasha Zhang

и другие.

Molecular Cancer, Год журнала: 2020, Номер 19(1)

Опубликована: Март 19, 2020

Gastric cancer is the fourth most common malignancy and third leading cause of cancer-related deaths worldwide. Advanced gastric patients can notably benefit from chemotherapy including adriamycin, platinum drugs, 5-fluorouracil, vincristine, paclitaxel as well targeted therapy drugs. Nevertheless, primary drug resistance or acquisition eventually lead to treatment failure poor outcomes patients. The detailed mechanisms involved in have been revealed. Interestingly, different noncoding RNAs (ncRNAs), such microRNAs (miRNAs), long (lncRNAs) circular (circRNAs), are critically development. Multiple lines evidences demonstrated that ncRNAs play a vital role reagents In this review, we systematically summarized emerging molecular impact cancer. Additionally, propose potential clinical implications novel therapeutic targets prognostic biomarkers for

Язык: Английский

Процитировано

403

Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation DOI Creative Commons
Sen Guo, Chu‐Xia Deng

International Journal of Biological Sciences, Год журнала: 2018, Номер 14(14), С. 2083 - 2093

Опубликована: Янв. 1, 2018

The cellular environment where tumor cells reside is called the microenvironment (TME), which consists of borders, blood vessels, lymph extracellular matrix (ECM), stromal cells, immune/inflammatory secreted proteins, RNAs and small organelles.By dynamically interacting with participate in all stages initiation, progression, metastasis, recurrence drug response, consequently, affect fate patients.During processes evolution metastasis TME also experience some changes play roles both suppression promotion while overall function beneficial for cancer cell survival movement.In this review, we examine effects on including angiogenesis, epithelial-mesenchymal transition (EMT) invasion.We highlight functions organelles by their influences multiple metastasis.

Язык: Английский

Процитировано

274

The emerging role of lncRNAs in the regulation of cancer stem cells DOI

Rosario Castro‐Oropeza,

Jorge Meléndez-Zajgla, Vilma Maldonado

и другие.

Cellular Oncology, Год журнала: 2018, Номер 41(6), С. 585 - 603

Опубликована: Сен. 14, 2018

Язык: Английский

Процитировано

168

Cancer drug resistance induced by EMT: novel therapeutic strategies DOI Creative Commons
Javier De Las Rivas, Anamaria Brozović,

Sivan Izraely

и другие.

Archives of Toxicology, Год журнала: 2021, Номер 95(7), С. 2279 - 2297

Опубликована: Май 18, 2021

Over the last decade, important clinical benefits have been achieved in cancer patients by using drug-targeting strategies. Nevertheless, drug resistance is still a major problem most therapies. Epithelial-mesenchymal plasticity (EMP) and tumour microenvironment described as limiting factors for effective treatment many types. Moreover, epithelial-to-mesenchymal transition (EMT) has also associated with therapy different preclinical models, although limited evidence obtained from studies samples. In this review, we particularly deepen into mechanisms of which intermediate epithelial/mesenchymal (E/M) states its interconnection to influence resistance. We describe how use bioinformatics pharmacogenomics will help figure out biological impact EMT on develop novel pharmacological approaches future.

Язык: Английский

Процитировано

150

Microfluidics for detection of exosomes and microRNAs in cancer: State of the art DOI Creative Commons
Seyed Mojtaba Mousavi,

Seyed Mohammad Amin Mahdian,

Mohammad Saeid Ebrahimi

и другие.

Molecular Therapy — Nucleic Acids, Год журнала: 2022, Номер 28, С. 758 - 791

Опубликована: Апрель 27, 2022

Exosomes are small extracellular vesicles with sizes ranging from 30–150 nanometers that contain proteins, lipids, mRNAs, microRNAs, and double-stranded DNA derived the cells of origin. can be taken up by target cells, acting as a means cell-to-cell communication. The discovery these in body fluids their participation cell communication has led to major breakthroughs diagnosis, prognosis, treatment several conditions (e.g., cancer). However, conventional isolation evaluation exosomes microRNA content suffers high cost, lengthy processes, difficult standardization, low purity, poor yield. emergence microfluidics devices increased efficiency sieving, trapping, immunological separation volumes could provide improved detection monitoring involved cancer. Microfluidics techniques hold promise for advances development diagnostic prognostic devices. This review covers ongoing research on microRNAs biomarkers translation point-of-care clinical applications.

Язык: Английский

Процитировано

74

Serum exosomal miR-301a as a potential diagnostic and prognostic biomarker for human glioma DOI

Fengming Lan,

Qing Qin, Qiang Pan‐Hammarström

и другие.

Cellular Oncology, Год журнала: 2017, Номер 41(1), С. 25 - 33

Опубликована: Окт. 26, 2017

Язык: Английский

Процитировано

158

Lung cancer-associated brain metastasis: Molecular mechanisms and therapeutic options DOI
Meysam Yousefi, Tayyeb Bahrami, Arash Salmaninejad

и другие.

Cellular Oncology, Год журнала: 2017, Номер 40(5), С. 419 - 441

Опубликована: Сен. 18, 2017

Язык: Английский

Процитировано

149

Decreased levels of serum exosomal miR‐638 predict poor prognosis in hepatocellular carcinoma DOI
Min Shi, Ye Jiang, Lu Yang

и другие.

Journal of Cellular Biochemistry, Год журнала: 2017, Номер 119(6), С. 4711 - 4716

Опубликована: Дек. 26, 2017

Abstract Currently available studies have implicated that exosome‐delivered microRNAs (miRNAs) play crucial roles in human cancer. However, the association of serum exosomal miR‐638 and hepatocellular carcinoma (HCC) remains largely unknown. We aim to investigate expression HCC patients its prognostic role this deadly disease. Kaplan‐Meier Cox regression analyses were used determine survival histologically diagnosed with HCC. Reduced levels samples from identified by real‐time PCR. Negative tumor size, vascular infiltration, TNM stage was observed patients. Besides, proliferation Huh7 SMCC7721 cells significantly inhibited when over‐expressed these cells. In addition, lower had poor overall than those higher serum. Our study strongly suggests may serve as a novel circulating biomarker for Downregulation predicts prognosis

Язык: Английский

Процитировано

148

Role of Exosomes and Exosomal microRNAs in Cancer DOI Creative Commons
Nihat Dilsiz

Future Science OA, Год журнала: 2020, Номер 6(4)

Опубликована: Фев. 26, 2020

A growing body of evidence indicates that exosomes play a critical role in the cell–cell communication process. Exosomes are biological nanoparticles with an average diameter 30–100 nm size and produced by almost all cell types human body; however, cancer cells contain higher concentrations than healthy cells. They released into fluids double-stranded DNA (originated from nucleus mitochondria), variety RNA species, specific protein biomarkers can be utilized as therapeutic targets, lipids. Therefore, secreted tumor could used to predict existence presence patients. This review summarizes development their potential utility clinic.

Язык: Английский

Процитировано

129

Exosomal miR-21 secreted by IL-1β-primed-mesenchymal stem cells induces macrophage M2 polarization and ameliorates sepsis DOI

Mengying Yao,

Bing Cui, Weihong Zhang

и другие.

Life Sciences, Год журнала: 2020, Номер 264, С. 118658 - 118658

Опубликована: Окт. 25, 2020

Язык: Английский

Процитировано

119