Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 5, 2024
Several
diseases
affect
the
alveoli,
and
efficacy
of
medical
treatments
pharmaceutical
therapies
is
hampered
by
lack
pre-clinical
models
able
to
recreate
in
vitro
diseases.
Microfluidic
devices,
mimicking
key
structural
compositional
features
offer
several
advantages
medium
high-throughput
analysis
new
candidate
therapies.
Here,
we
developed
an
alveolus-on-a-chip
recapitulating
microanatomy
physiological
tissue
including
epithelium,
fibrous
interstitial
layer
capillary
endothelium.
A
PDMS
device
was
obtained
assembling
a
top
bottom
replica
molding.
polycaprolactone/gelatin
(PCL-Gel)
electrospun
membrane
included
within
two
layers
supporting
seeding
3
cell
phenotypes.
Epithelial
cells
were
grown
on
fibroblast-laden
collagen
hydrogel
located
side
PCL-Gel
mats
while
endothelial
seeded
basolateral
membrane.
The
innovative
design
microfluidic
allows
replicate
both
cell-cell
cell-extracellular
matrix
interactions
according
vivo
arrangement
along
with
establishment
physiologically
relevant
air-liquid
interface
conditions.
Indeed,
high
viability
confirmed
for
up
10
days
formation
tight
epithelial
barrier
assessed
immunofluorescence
assays.
Polymers,
Год журнала:
2023,
Номер
15(10), С. 2341 - 2341
Опубликована: Май 17, 2023
In
this
brief
review,
we
discuss
the
recent
advancements
in
using
poly(ethylene
glycol)
diacrylate
(PEGDA)
hydrogels
for
tissue
engineering
applications.
PEGDA
are
highly
attractive
biomedical
and
biotechnology
fields
due
to
their
soft
hydrated
properties
that
can
replicate
living
tissues.
These
be
manipulated
light,
heat,
cross-linkers
achieve
desirable
functionalities.
Unlike
previous
reviews
focused
solely
on
material
design
fabrication
of
bioactive
cell
viability
interactions
with
extracellular
matrix
(ECM),
compare
traditional
bulk
photo-crosslinking
method
latest
three-dimensional
(3D)
printing
hydrogels.
We
present
detailed
evidence
combining
physical,
chemical,
bulk,
localized
mechanical
characteristics,
including
composition,
methods,
experimental
conditions,
reported
3D
printed
Furthermore,
highlight
current
state
applications
organ-on-chip
devices
over
last
20
years.
Finally,
delve
into
obstacles
future
possibilities
field
layer-by-layer
(LbL)
devices.
Biomimetics,
Год журнала:
2024,
Номер
9(7), С. 390 - 390
Опубликована: Июнь 26, 2024
This
review
explores
the
extensive
applications
of
plants
in
areas
biomimetics
and
bioinspiration,
highlighting
their
role
developing
sustainable
solutions
across
various
fields
such
as
medicine,
materials
science,
environmental
technology.
Plants
not
only
serve
essential
ecological
functions
but
also
provide
a
rich
source
inspiration
for
innovations
green
nanotechnology,
biomedicine,
architecture.
In
past
decade,
focus
has
shifted
towards
utilizing
plant-based
vegetal
waste
creating
eco-friendly
cost-effective
with
remarkable
properties.
These
are
employed
making
advancements
drug
delivery,
remediation,
production
renewable
energy.
Specifically,
discusses
use
(nano)bionic
capable
detecting
explosives
contaminants,
underscoring
potential
improving
quality
life
even
lifesaving
applications.
The
work
refers
to
architectural
inspirations
drawn
from
plant
world
develop
novel
design
concepts
that
both
functional
aesthetic.
It
elaborates
on
how
engineered
have
been
transformed
into
value-added
through
innovative
applications,
especially
roles
wastewater
treatment
electronic
components.
Moreover,
integration
synthesis
biocompatible
medical
tissue
engineering
scaffolds
artificial
muscles
demonstrates
versatility
capacity
replace
more
traditional
synthetic
materials,
aligning
global
sustainability
goals.
paper
provides
comprehensive
overview
current
uses
living
technological
advancements,
advocating
deeper
exploration
address
pressing
challenges.
ACS Sensors,
Год журнала:
2024,
Номер
9(7), С. 3466 - 3488
Опубликована: Июль 11, 2024
Organ-on-a-Chip
(OOC)
technology,
which
emulates
the
physiological
environment
and
functionality
of
human
organs
on
a
microfluidic
chip,
is
undergoing
significant
technological
advancements.
Despite
its
rapid
evolution,
this
technology
also
facing
notable
challenges,
such
as
lack
vascularization,
development
multiorgan-on-a-chip
systems,
replication
body
single
chip.
The
progress
has
played
crucial
role
in
steering
OOC
toward
mimicking
microenvironment,
including
microenvironment
replication,
multiorgan
microphysiological
systems.
Additionally,
advancements
detection,
analysis,
organoid
imaging
technologies
have
enhanced
efficiency
Organs-on-Chips
(OOCs).
In
particular,
integration
artificial
intelligence
revolutionized
imaging,
significantly
enhancing
high-throughput
drug
screening.
Consequently,
review
covers
research
Human-on-a-chip,
sensors
OOCs,
latest
applications
biomedical
field.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 16, 2024
Nanotechnology-based
approaches
are
promising
for
the
treatment
of
musculoskeletal
(MSK)
disorders,
which
present
significant
clinical
burdens
and
challenges,
but
their
translation
requires
a
deep
understanding
complex
interplay
between
nanotechnology
MSK
biology.
Organ-on-a-chip
(OoC)
systems
have
emerged
as
an
innovative
versatile
microphysiological
platform
to
replicate
dynamics
tissue
microenvironment
studying
nanotechnology-biology
interactions.
This
review
first
covers
recent
advances
applications
OoCs
ability
mimic
biophysical
biochemical
stimuli
encountered
by
tissues.
Next,
integrating
into
OoCs,
cellular
responses
behaviors
may
be
investigated
precisely
controlling
manipulating
nanoscale
environment.
Analysis
disease
mechanisms,
particularly
bone,
joint,
muscle
degeneration,
drug
screening
development
personalized
medicine
greatly
facilitated
using
OoCs.
Finally,
future
challenges
directions
outlined
field,
including
advanced
sensing
technologies,
integration
immune-active
components,
enhancement
biomimetic
functionality.
By
highlighting
emerging
this
aims
advance
intricate
nanotechnology-MSK
biology
interface
its
significance
in
management,
therapeutic
interventional
strategies.
Biosensors,
Год журнала:
2024,
Номер
14(5), С. 225 - 225
Опубликована: Май 1, 2024
Organ-on-a-chip
(OOC)
is
an
emerging
technology
that
simulates
artificial
organ
within
a
microfluidic
cell
culture
chip.
Current
biology
research
focuses
on
in
vitro
cultures
due
to
various
limitations
of
vivo
testing.
Unfortunately,
in-vitro
culturing
fails
provide
accurate
microenvironment,
and
expensive
has
historically
been
source
ethical
controversy.
OOC
aims
overcome
these
shortcomings
the
best
both
research.
The
critical
component
design
utilizing
microfluidics
ensure
stable
concentration
gradient,
dynamic
mechanical
stress
modeling,
reconstruction
cellular
microenvironment.
also
advantage
complete
observation
control
system,
which
impossible
recreate
in-vivo
Multiple
throughputs,
channels,
membranes,
chambers
are
constructed
polydimethylsiloxane
(PDMS)
array
simulate
organs
Various
experiments
can
be
performed
technology,
including
drug
delivery
toxicology.
technological
expansions
involve
multiple
microenvironments
single
chip,
allowing
for
studying
inter-tissue
interactions.
Other
developments
include
finding
more
suitable
material
as
replacement
PDMS
minimizing
artefactual
error
non-translatable
differences.
Engineered Regeneration,
Год журнала:
2024,
Номер
5(2), С. 153 - 169
Опубликована: Март 7, 2024
Microfluidic
is
a
technology
that
allows
the
precise
control
of
fluid
in
micro-channel.
With
its
advantages
high
throughput
and
low
cost,
microfluidic
has
achieved
good
performance
various
fields
recent
years.
Arthritis
general
term
for
variety
joint
diseases,
which
can
be
clinically
manifested
as
pain
swelling,
seriously
affecting
people's
physical
mental
health.
At
present,
causes
arthritis
disease
are
still
unknown,
existing
models
treatment
methods
limited,
so
more
treatments
need
to
developed.
organ
chip
cutting-edge
build
bionic
human
model,
reflect
structure
function
characteristics
organs
by
simulating
physiological
environment
tissues
cells
vitro.
This
paper
reviews
application
modeling
arthritis,
hoping
open
up
new
vision
study
arthritis.
Lab on a Chip,
Год журнала:
2024,
Номер
24(7), С. 2094 - 2106
Опубликована: Янв. 1, 2024
Organ-on-chip
(OOC)
technology
has
recently
emerged
as
a
powerful
tool
to
mimic
physiological
or
pathophysiological
conditions
through
cell
culture
in
microfluidic
devices.
One
of
its
main
goals
is
bypassing
animal
testing
and
encouraging
more
personalized
medicine.
The
recent
incorporation
hydrogels
3D
scaffolds
into
devices
changed
biomedical
research
since
they
provide
biomimetic
extracellular
matrix
recreate
tissue
architectures.
However,
this
presents
some
drawbacks
such
the
necessity
for
physical
structures
pillars
confine
these
hydrogels,
well
difficulty
reaching
different
shapes
patterns
create
convoluted
gradients
realistic
biological
structures.
In
addition,
can
also
interfere
with
fluid
flow,
altering
local
shear
forces
and,
therefore,
modifying
mechanical
environment
OOC
model.
work,
we
present
methodology
based
on
plasma
surface
treatment
that
allows
building
chambers
abutment-free
capable
producing
precise
stress
distributions.
Therefore,
pillarless
arbitrary
geometries
are
needed
obtain
versatile,
reliable,
experimental
models.
Through
computational
simulation
studies,
changes
demonstrated
designed
fabricated
geometries.
To
prove
versatility
new
technique,
blood-brain
barrier
model
been
recreated,
achieving
an
uninterrupted
endothelial
emulates
part
neurovascular
network
brain.
Finally,
developed
could
avoid
limitations
mentioned
above,
allowing
development
models
complex
adaptable
geometries,
cell-to-cell
contact
if
required,
where
flow
be
controlled.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Июнь 1, 2023
Viral
and
bacterial
infections
continue
to
pose
significant
challenges
for
numerous
individuals
globally.
To
develop
novel
therapies
combat
infections,
more
insight
into
the
actions
of
human
innate
adaptive
immune
system
during
infection
is
necessary.
Human
in
vitro
models,
such
as
organs-on-chip
(OOC)
have
proven
be
a
valuable
addition
tissue
modeling
toolbox.
The
incorporation
an
component
needed
bring
OOC
models
next
level
enable
them
mimic
complex
biological
responses.
affects
many
(patho)physiological
processes
body,
those
taking
place
infection.
This
tutorial
review
introduces
reader
building
blocks
model
acute
investigate
recruitment
circulating
cells
infected
tissue.
multi-step
extravasation
cascade
vivo
described,
followed
by
in-depth
guide
on
how
this
process
chip.
Next
chip
design,
creation
chemotactic
gradient
endothelial,
epithelial,
cells,
focuses
hydrogel
extracellular
matrix
(ECM)
accurately
interstitial
space
through
which
extravasated
migrate
towards
site
Overall,
practical
developing
cell
migration
from
blood
Materials,
Год журнала:
2023,
Номер
16(6), С. 2174 - 2174
Опубликована: Март 8, 2023
Nowadays,
lab-on-chip
(LOC)
devices
are
attracting
more
and
attention
since
they
show
vast
prospects
for
various
biomedical
applications.
Usually,
an
LOC
is
a
small
device
that
serves
single
laboratory
function.
LOCs
massive
potential
organ-on-chip
(OOC)
manufacturing
could
allow
research
on
the
avoidance
of
diseases
or
drug
testing
animals
humans.
However,
this
technology
still
under
development.
The
dominant
technique
fabrication
such
molding,
which
very
attractive
efficient
mass
production,
but
has
many
drawbacks
prototyping.
This
article
suggests
femtosecond
laser
microprocessing
prototyping
OOC-type
device-a
liver-on-chip.
We
demonstrate
production
liver-on-chip
out
glass
by
using
laser-based
selective
etching
(SLE)
welding
techniques.
fabricated
was
tested
with
HepG2(GS)
liver
cancer
cells.
During
test,
cells
proliferated
in
chip,
thus
showing
suggested
further
OOC
