Materials & Design, Год журнала: 2025, Номер unknown, С. 113691 - 113691
Опубликована: Фев. 1, 2025
Smart Medicine, Год журнала: 2024, Номер 3(1)
Опубликована: Фев. 1, 2024
Abstract Immune engineering, a burgeoning field within regenerative medicine, involves spectrum of strategies to optimize the intricate interplay between tissue biomaterials and host tissue. These are applied across different types various disease models, which encompasses finely modulating immune response at levels cells factors, aiming mitigate adverse effects like fibrosis persistent inflammation that may arise injury site consequently promote regeneration. With continuous progress in electrospinning technology, immunoregulatory capabilities electrospun fibers have gained substantial attention over years. Electrospun fibers, with their extracellular matrix‐like characteristics, high surface‐area‐to‐volume ratio, reliable pharmaceutical compound capacity, emerged as key players among engineering materials. This review specifically focuses on role fiber‐based emphasizing unique design strategies. Notably, actively engages by responses through four essential strategies: (i) surface modification, (ii) drug loading, (iii) physicochemical parameters, (iv) biological grafting. presents comprehensive overview mechanisms system injured tissues while unveiling adopted orchestrate regulation. Furthermore, explores current developmental trends limitations concerning function drive advancements its full potential.
Язык: Английский
Процитировано
62
Chemical Society Reviews, Год журнала: 2024, Номер 53(8), С. 4086 - 4153
Опубликована: Янв. 1, 2024
This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts balancing degradation with repair for improved applications.
Язык: Английский
Процитировано
47
Bioactive Materials, Год журнала: 2024, Номер 37, С. 348 - 377
Опубликована: Апрель 23, 2024
Setting time as the fourth dimension, 4D printing allows us to construct dynamic structures that can change their shape, property, or functionality over under stimuli, leading a wave of innovations in various fields. Recently, smart biomaterials, biological components, and living cells into 3D constructs with effects has led an exciting field bioprinting. bioprinting gained increasing attention is being applied create programmed cell-laden such bone, cartilage, vasculature. This review presents overview on for engineering tissues organs, followed by discussion approaches, technologies, biomaterials design, bioink requirements, applications. While much progress been achieved, complex process facing challenges need be addressed transdisciplinary strategies unleash full potential this advanced biofabrication technology. Finally, we present future perspectives rapidly evolving bioprinting, view its potential, increasingly important roles development basic research, pharmaceutics, regenerative medicine.
Язык: Английский
Процитировано
21
BioMedical Engineering OnLine, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 21, 2025
With precise control of smart materials deformation in time dimension, doctors can customize orthopedic implants. This review focuses on the advances 4D printing technology orthopedics, including its applications bone repair and reconstruction, personalized treatment, drug delivery. enables creation bionic scaffolds fixation devices for repair, customized implants matching patients' conditions specific carriers accurate release delivery, which together contribute to accelerating healing, providing exclusive treatments, enhancing therapeutic effects reducing side effects, thus helping improve medicine. It offers comprehensive reference relevant medical personnel.
Язык: Английский
Процитировано
3
Biomedicines, Год журнала: 2024, Номер 12(7), С. 1586 - 1586
Опубликована: Июль 17, 2024
Fibroblasts are typical mesenchymal cells widely distributed throughout the human body where they (1) synthesise and maintain extracellular matrix, ensuring structural role of soft connective tissues; (2) secrete cytokines growth factors; (3) communicate with each other cell types, acting as signalling source for stem niches; (4) involved in tissue remodelling, wound healing, fibrosis, cancer. This review focuses on developmental heterogeneity dermal fibroblasts, their ability to sense changes biomechanical properties surrounding aging, skin repair, pathologic conditions tumour development. Moreover, we describe use fibroblasts different models (e.g., vivo animal vitro systems from 2D 6D cultures) bioengineering informative potential high-throughput assays study under disease contexts personalized healthcare regenerative medicine applications.
Язык: Английский
Процитировано
15
Small, Год журнала: 2024, Номер unknown
Опубликована: Окт. 8, 2024
Abstract The repair and reconstruction of large‐scale bone defects face enormous challenges because the failure to reconstruct osteo‐vascularization network. Herein, a near‐infrared (NIR) light‐responsive hydrogel system is reported achieve programmed tissue regeneration through synergetic effects on‐demand drug delivery mild heat stimulation. spatiotemporal (HG/MPa) composed polydopamine‐coated Ti 3 C 2 T x MXene (MP) nanosheets decorated with acidic fibroblast growth factor (aFGF, potent angiogenic drug) hydroxypropyl chitosan/gelatin (HG) developed orchestrate network boost regeneration. Upon exposure NIR light irradiation, engineered HG/MPa can initial complete release aFGF induce rapid angiogenesis provide sufficient blood supply, maximizing its biofunction in defect area. This integrated demonstrated good therapeutic efficacy promoting cell adhesion, proliferation, migration, angiogenesis, osteogenic differentiation periodic irradiation. In vivo, animal experiments further revealed that spatiotemporalized platform synergized photothermal treatment significantly accelerated critical‐sized healing by increasing density, recruiting endogenous stem cells, facilitating production osteogenesis/angiogenesis‐related factors. Overall, smart‐responsive could enhance
Язык: Английский
Процитировано
12
Exploration of Medicine, Год журнала: 2024, Номер 5(1), С. 17 - 47
Опубликована: Фев. 6, 2024
Three-dimensional (3D) and four-dimensional (4D) printing have emerged as the next-generation fabrication technologies, covering a broad spectrum of areas, including construction, medicine, transportation, textiles. 3D printing, also known additive manufacturing (AM), allows complex structures with high precision via layer-by-layer addition various materials. On other hand, 4D technology enables smart materials that can alter their shape, properties, functions upon stimulus, such solvent, radiation, heat, pH, magnetism, current, pressure, relative humidity (RH). Myriad biomedical (BMMs) currently serve in many engineering fields aiding patients’ needs expanding life-span. BMMs provides geometries are impossible conventional processing techniques, while yields dynamic BMMs, which intended to be long-term contact biological systems owing time-dependent stimuli responsiveness. This review comprehensively covers most recent technological advances towards fabricating for tissue engineering, drug delivery, surgical diagnostic tools, implants prosthetics. In addition, challenges gaps printed along future outlook, extensively discussed. The current addresses scarcity literature on composition, performances medical applications pros cons. Moreover, content presented would immensely beneficial material scientists, chemists, engineers engaged AM clinicians field. Graphical abstract.
Язык: Английский
Процитировано
10
Accounts of Materials Research, Год журнала: 2024, Номер unknown
Опубликована: Июль 24, 2024
ConspectusIn the rapidly evolving landscape of regenerative medicine, field bone tissue engineering stands as a beacon innovative progress, pushing boundaries what is achievable in realm medical science. A pivotal leap forward this domain involves integration vascularization and innervation into engineered tissues, propelling toward realization biomimetic functionally superior constructs. In recent years, considerable significant progress has been made on promising topic. Vascularization considered an essential strategy for regeneration. Meanwhile, emerged novel developmental trend vascularized engineering. The goes beyond merely replicating structural aspects native bone. It opens new possibilities creating biohybrid constructs that not only restore function but also actively participate dynamic interplay musculoskeletal system. innervated scaffolds could potentially accelerate healing processes, respond to mechanical stimuli, exhibit enhanced biological compatibility with host organism, making them highly desirable researchers field. concept biomaterials fundamental important. expected be extensive future work based Account generalizing other medicines. Thus, elucidate effect mechanism important theoretical significance provides idea design repair materials. Account, we present our group engineering, including designing principle, preparation method, involved mechanism. First, provide brief introduction basic importance innervation. Then, summarize principle favorable by focusing several material types, microstructure construction, drug delivery. Subsequently, strategies promoting are classified underlying Furthermore, developed evaluation osteogenesis vivo imaging, which continuous monitoring osteogenic vivo. Finally, conclude offering perspective open challenges development trends This highlighting interesting insights regeneration processing biomaterials.
Язык: Английский
Процитировано
8
Nano-Micro Letters, Год журнала: 2024, Номер 17(1)
Опубликована: Сен. 29, 2024
Abstract Hydrogel scaffolds have numerous potential applications in the tissue engineering field. However, tough hydrogel implanted vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical properties. Inspired by Chinese ramen, we propose a universal fabricating method (printing-P, training-T, cross-linking-C, PTC & PCT) for fill this gap. First, 3D printing fabricates scaffold with desired structures (P). Then, could extraordinarily properties functional surface structure cycle training salting-out assistance (T). Finally, results fixed photo-cross-linking processing (C). The gelatin exhibit excellent tensile strength of 6.66 MPa (622-fold untreated) biocompatibility. Furthermore, possesses from nanometer micron millimeter, which can efficiently induce directional cell growth. Interestingly, strategy produce bionic human 10 kPa-10 changing type salt, many hydrogels, such as silk, be improved or PCT strategies. Animal experiments show that effectively promote new generation muscle fibers, blood vessels, nerves within 4 weeks, prompting rapid regeneration large-volume loss injuries.
Язык: Английский
Процитировано
8
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 17, 2024
As a transdermal drug delivery method, microneedles offer minimal invasiveness, painlessness, and precise in-situ treatment. However, current rely on passive diffusion, leading to uncontrollable penetration. To overcome this, we developed pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines actively control delivery. These microbes generate gas, driving drugs into deeper tissues, with adjustable glucose concentration allowing over the process. Our results showed this microorganism-powered system increases depth by 200%, reaching up 1000 μm below skin. In psoriasis animal model, technology effectively delivered calcitriol subcutaneous offering rapid symptom relief. This innovation addresses limitations of conventional microneedles, enhancing efficiency, permeability, introducing creative paradigm for on-demand controlled
Язык: Английский
Процитировано
8