Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111504 - 111504
Published: April 1, 2025
Language: Английский
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.
Language: Английский
Citations
6
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Long-term inflammation and persistent bacterial infection are primary contributors to unhealed chronic wounds. The use of conventional antibiotics often leads bacteria drug resistance, diminishing wound healing effectiveness. Nanozymes have become a promising alternative antimicrobial materials due their low cost, easy synthesis, good stability. Herein, we develop novel sprayable hydrogel based on carboxymethyl chitosan (CMCS) oxidized hyaluronic acid (OHA), incorporating Au nanoparticle-carbon nitride (AuNPs-C3N4) nanozyme, glucose, Mn2+ for bacteria-infected healing. forms rapidly in situ upon spraying gradually degrades the area, releasing AuNPs-C3N4 which exhibits robust glucose oxidase-like (GOx-like) activity, initiating comprehensive catalytic cascade through Mn2+-mediated Fenton-like reaction that generates hydroxyl radicals (•OH) eliminate Staphylococcus aureus (S. aureus) Methicillin-resistant S. (MRSA). Computational results indicate interactions between AuNPs g-C3N4 maximize synergistic effects heterojunction, improving O2 adsorption facilitating electron-O2 optimize activity. Further experiments demonstrate can cover wounds situ, while CMCS promotes collagen production fibroblast proliferation, offering viable strategy
Language: Английский
Citations
3
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: July 15, 2024
Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease symptoms. Nanomaterials (NMs) have been engineered monitor macrophage metabolism, enabling evaluation of progression and replication intricate physiological signal patterns. They achieve this either directly or by delivering regulatory signals, thereby mapping phenotype effector functions through metabolic repurposing customize fate for therapy. However, a comprehensive summary regarding NM-mediated visualization coordinated rewiring maintain phenotypic equilibrium is currently lacking. This review aims address gap outlining recent advancements in NM-based immunotherapy. We initially explore relationship between polarization, disease, before delving into NM innovations that visualize activity elucidate onset fine-tune its remodeling macrophage-centered Finally, we discuss prospects challenges immunotherapy, aiming accelerate clinical translation. anticipate will serve as valuable reference researchers seeking leverage novel intervention-matched immunomodulators macrophages other fields engineering.
Language: Английский
Citations
13
Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 052001 - 052001
Published: July 8, 2024
Abstract Wound healing is a critical but complex biological process of skin tissue repair and regeneration resulting from various systems working together at the cellular molecular levels. Quick wound problems associated with traditional techniques are being overcome multifunctional materials. Over time, this research area has drawn significant attention. Metal-organic frameworks (MOFs), owning to their peculiar physicochemical characteristics, now considered promising class well-suited porous materials for in addition other applications. This detailed literature review provides an overview latest developments MOFs We have discussed synthesis, essential biomedical properties, wound-healing mechanism, MOF-based dressing materials, The possible major challenges limitations been discussed, along conclusions future perspectives. addresses MOFs-based several angles covers most current subject. readers may discover how advanced discipline by producing more inventive, useful, successful dressings. It influences development generations biomaterials wounds.
Language: Английский
Citations
11
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 3, 2024
Abstract Intelligent antibacterial agent with controllable activities adaptive to the wound microenvironment is appealing reduce drug resistance and enhance efficiency. In this study, celery chosen as carbon source construct celery‐based dots (CECDs) double activities, i.e., reactive oxygen species (ROS)‐production ROS‐clearance activities. The ROS‐production capability of CECDs dependent on oxidase (OXD)‐mimicking activity, which only photo‐activated thus artificially controlled by light avoid production excess ROS. Meanwhile, optimal OXD‐mimicking activity occurrs at pH 5, close microenvironmental bacterial infection site, will efficacy. On other hand, exhibit antioxidant neutral or weak alkaline pH, assist healing wound. Thus, conversion ability can be dynamically intelligently switched automatically different stages treatment (from acid neutral/weak basic). proposed exert adorable selective against Gram‐positive bacteria satisfactory therapeutic effect infected mice. This study paves a new avenue design intelligent nanoagent sensitive condition, reducing assisting precise medicine.
Language: Английский
Citations
10
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299
Published: Nov. 1, 2024
Language: Английский
Citations
10
Theranostics, Journal Year: 2025, Volume and Issue: 15(8), P. 3474 - 3489
Published: Feb. 24, 2025
Background: Diabetic wounds infected with methicillin-resistant Staphylococcus aureus (MRSA) are challenging to heal due biofilm formation, which impairs conventional antibiotics limited penetration and severe side effects. Near-infrared (NIR)-driven nanomotors autonomous motion photothermal effects show promise for antibacterial therapy but often lack targeted specificity. Lysostaphin (Ly), an enzyme targeting bacterial cell walls, offers excellent potential against drug-resistant MRSA. Methods: A novel NIR-driven CSIL nanomotor has fabricated by co-loading indocyanine green (ICG) lysostaphin onto spinous yolk-shell structured C/SiO2@C nanoparticles. The motion, penetration, efficacy of evaluated in vitro, while their eradication wound healing performance assessed MRSA-infected diabetic mouse model using a cascade photodynamic (CPDT) strategy. Results: exhibit properties MRSA-targeting They can effectively eradicate MRSA biofilms both vitro vivo, suppress virulence biofilm-related genes, thus promoting shaping microenvironment dominated M2 macrophages. CPDT strategy is able avoid excessive ROS production thermal damage, enabling safe effective therapy. Conclusion: nanomotors, integrated photothermal, photodynamic, properties, represent novel, efficient approach wounds, offering significant advantages over antibiotics.
Language: Английский
Citations
2
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 24, 2025
Exosomes-loaded hydrogels have potential value in wound treatment. Current studies focus on improving hydrogels' biocompatibility and optimizing different stem cell-derived exosomes for better therapeutic effect. Herein, we present a novel biocompatible recombinant human collagen (RHC) hydrogel loading with MSCs-derived promoting healing. We modify the RHC methacrylate anhydride (MA) at optimal concentration, generating (RHCMA) ideal physiochemical properties exosome delivery (MSC-exos@RHCMA). Exosomes derived from adipose-derived MSCs (ADSC-exos), bone marrow-derived (BMSC-exos) umbilical cord (ucMSC-exos) are harvested culture supernatants loaded into RHCMA, respectively. These three systems exhibit desired sustained release features, can significantly improve cell proliferation migration. In addition, these MSC-exos@RHCMAs show excellent performance treating wounds of rats. Notably, demonstrated that healing effect occurs best under treatment ucMSC-exos@RHCMA, following inflammatory resolution, angiogenesis, formation. results would supply important clinical application MSC-exos future.
Language: Английский
Citations
2
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 89 - 100
Published: Sept. 13, 2024
Language: Английский
Citations
8
Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: 174, P. 114006 - 114006
Published: Jan. 27, 2025
Language: Английский
Citations
1